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叉头框-c2基因在主动脉弓发育过程中的作用

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生物化学与生物物理进展 2003年第5期30卷 726-731页

作者：付艳邓伟国李艺扬李玉林 N.MIURA 吉林大学第一医院妇产科吉林大学公共卫生学院营养与食品卫生教研室吉林大学基础医学院病理教研室 Department of Biochemistry Hamamatsu University School of MedicineHamamatsu4313192Japan

为了研究叉头框 c2 (ForkheadBoxc2 ,Foxc2 )基因在心血管发生和发育中的作用 ,通过制作小鼠的Foxc2基因无效突变 ,解析该基因缺失鼠主动脉弓的异常发育状况 .纯合子胎鼠从 12 5天胚胎 (embryo ,E)开始有宫内死亡 ;即使完成宫内发育过... 详细信息

为了研究叉头框 c2 (ForkheadBoxc2 ,Foxc2 )基因在心血管发生和发育中的作用 ,通过制作小鼠的Foxc2基因无效突变 ,解析该基因缺失鼠主动脉弓的异常发育状况 .纯合子胎鼠从 12 5天胚胎 (embryo ,E)开始有宫内死亡 ;即使完成宫内发育过程 ,新生鼠出生 2 4h后也全部死亡 .这些鼠全部表现出与人的先天性心血管发育缺陷相似的B型或C型主动脉弓离断 .杂合子鼠发育正常 .E10 5胚胎的原位杂交分析显示 ,Foxc2mRNA在第三、第四和第六弓型动脉强烈表达 ,而第四弓型动脉在E10 5胚胎后逐渐消失 .这些结果表明 ,在主动脉弓形成过程中。

关键词：叉头框-c2基因主动脉弓发育过程心血管发生

New developments in small molecular compounds for anti-hepatitis C virus(HCV) therapy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第1期13卷 56-82页

作者： Jing TONG1,2,You-wei WANG2,Yuan-an LU1,2(1Department of public health Sciences,University of Hawaii,Honolulu,Hawaii 96822,usa)(2Key Laboratory of Combinatorial Biosynthesis and Drug Discovery,Ministry of Education,Institute of Traditional Chinese Medicine & Natural Products,{3. of Pharmaceutical Sciences,Wuhan University,Wuhan 43.071,China) Department of public health Sciences University of Hawaii Honolulu Hawaii 96822 USA

Infection with hepatitis C virus （HCV） affects approximately 170 million people worldwide. However, no vaccine or immunoglobulin is currently available for the prevention of HCV infection. The standard of care （SOC） involving pegylated interferon-（] （PEG-IFN a） plus ribavirin （RBV） for 48 weeks results in a sustained virologic re- sponse in less than 50% of patients with chronic hepatitis C genotype 1, the most prevalent type of HCV in North America and Europe. Recently, reliable in vitro culture systems have been developed for accelerating antiviral therapy research, and many new specifically targeted antiviral therapies for hepatitis C （STAT-C） and treatment strategies are being evaluated in clinical trials. These new antiviral agents are expected to improve present treatment significantly and may potentially shorten treatment duration. The aim of this review is to summarize the current developments in new anti-HCV drugs.

关键词： Hepatitis C virus (HCV) Clinical trial Small molecular compounds Review

Smelting,Underground Mining,Smoking,and Lung cancer:A case-Control Study in a Tin Mine Area

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Biomedical and Environmental Sciences 1989年第2期2卷 98-105页

作者： WU KAI-GUO MO CHUNG-ZHENG Department of Preventive Medicine,Guangxi Medical College,Nanning,Guangxi,China FU HUA Department of Occupational Medicine,school of public health,Shanghai Medical University,Shanghai,China YU LI-ZHENG health and Anti-epidemic Station,Dachang Mine,Guangxi,China Department of Preventive Medicine Guangxi Medical College China.

An increased risk of lung cancer in the Dachang tin mine of Guangxi has been *** investigate the factors contributing to the excessive risk of lung cancer,we conducted a matched case-control study in the mine area and analyzed the effects of multiple factors,such as living and housing conditions,occupational exposure,and smoking,with the methods of conditional logistic *** case series consisted of 69 patients with primary bronchial cancer,55 of whom had *** control series consisted of 13. individuals,55 of whom were *** results showed that the factors contributing to the excessive risk of lung cancer in the mine area related mainly to occupational *** significant risk factors were time of exposure to smelting,time of exposure to underground mining,and age at which underground mining was *** study model II where living controls were used,daily consumption of cigarettes was an additional risk ***,there was a synergistic action among these *** relation of the risk factors to lung cancer is discussed.1989 Academic ***.

关键词： work lung Smelting,Underground Mining,Smoking,and Lung cancer

Acute Exposure of Thimerosal Induce Antiproliferative Properties,Apoptosis and Autophagy Activation in Human Chang Conjunctival Cells

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Acute Exposure of Thimerosal Induce Antiproliferative Proper...

3.d Asian Conference on Environmental Mutagens & 15th Conference of Chinese Environmental Mutagen Society

作者： Huina Zhang~1,Han Wu~1,Juan Ye~1,Jun Yang~(2,3. 1 Department of Ophthalmology,the 2~(nd) Affiliated Hospital of Zhejiang University,College of Medicine,Hangzhou,Zhejiang,China 2 Department of Toxicology,Zhejiang University school of public health,Hangzhou,Zhejiang 3.0058,China 3.Department of Toxicology,Hangzhou Normal University school of public health,Hangzhou, Zhejiang 3.003.,China

Purpose:Previously we have shown that acute exposure to thimerosal(Thi) can induce oxidative stress and DNA damage in a human conjunctival cell ***,the long-term effect of Thi on Chang conjunctival cells is not ***,the aim of this study was to further investigate the fate of the cells after acute exposure to Thi. Method:Cells were first exposed to various concentrations of Thi(0.00001%～0.001%)for 3. min,and then cells were assessed after a 24-h recovery *** changes were

关键词： Acute Exposure of Thimerosal Induce Antiproliferative Properties,Apoptosis and Autophagy Activation in Human Chang Conjunctival Cells

In vivo and in vitro Studies on the Antitumor Activities of MCP (Malva crispa L. Powder)

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Biomedical and Environmental Sciences 1998年第4期11卷 297-306页

作者： HUANG CHENG-YU ZENG LING-FU HE TAO WANG CHAO-JUN HONG JUN-RONG ZHANG XIU-QUAN HOU YUN-HUA AND PENG SHU-SHENG (Department of Nutrition and Food Hygiene, school of public health) (Tumor Institute, West China University of Medical Sciences (WCUMS), Che Department of Nutrition and Food Hygiene School of Public Health West China University of Medical Sciences (WCUMS) Chengdu China.

Four short-term in vivo and in vitro tests were used to further confirm the antitumor activities of MCP, a vegetable powder, prepared from Malru crispo L. (i) In the H22 hepatoma-transplanting test, MCP had antitumor action, but MCP residue did not show such action; 5-FU appeared to have more potent antitumor activities and more harmful effects than MCP. (ii) In the micronucleus (MN) test, MCP significantly decreased MN frequency. (iii) In the cancer cell culture systems, the MCP fat-soluble extract revealed inhibitory effects on the growth and proliferation of the human hepatoma and the gastric cancer cells in a dose-response manner. (iv) In the colony formation test, MCP also altered the morphology of human gastric cancer cells. It was suggested that MCP could be consumed not only by healthy subJects for cancer prevention but also by patients with cancer as supplernentary treatrnent in combination with anticarcinogenic drug such as 5-FU, cyclophosphamide (CP)

关键词： MCP Malva crispa L Powder

Tuberculosis diagnostic delay and its influencing factors in counties with or without TB control programme in Jiangsu Province

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Tuberculosis diagnostic delay and its influencing factors in...

2003.中国防痨协会全国学术会议

作者： Xu Biao, Jiang Qingwu, Xiu Yan, Shi Suhong, Tang Jie 1.school of public health, Fudan University, 2.Jianhu County CDC 3.Funing County CDC

＜正＞ Rational: Early passive case finding based on good access to TB care is the cornerstones of effective TB control. The accessibility to TB care could be reflected by the diagnostic delay including the "Patient’ s delay" （from onset of symptoms to the first visit to a hospital）, and the "Doctor’s delay" （from the first hospital visit to obtaining TB diagnosis）.

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Polymorphism in the Tumor Necrosis Factor-α Gene on the Pathogenesis of Silicosis and Tuberculosis in Pottery Factory Workers

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Polymorphism in the Tumor Necrosis Factor-α Gene on the Pat...

2007中国科协年会

作者： Wang Haijiao~1 Su Wenjin~1 Zhang Xiaokang~(1,2) Zhu Xiaomin~3.Dai Qici~3.Weng Shaofan~1 Wu Tangchun~1 Chen Weihong~1 1 MOE Key Lab of Environmental and health,school of public health,Tongji Medical College,Huazhong University of Science & Technology,Wuhan 43.03.,China 2 health bureau of Jingdezhen City 3.The Center of Diseases Control of Jingdezhen

Objective To explore the role of tumor necrosis factor-a(TNF-α)gene polymorphism in genetic susceptibility to ceramic silicosis and tuberculosis,and their interaction with cumulative *** The subjects were selected from a cohort of ceramic workers in Jingdozhen,The information of work history and dust concentrations in workplace were collect from records of *** silicosis and tuberculosis were diagnosed by group of local center of disease *** was extracted from peripheral venous blood for each ***-agene polymorphism were analyzed using real-time polymerass chain reaction *** A total of 902 subjects were included in this *** them,there were 598 were dust-exposed workers,and 157 cases were diagnosed as *** risk of ceramic silicosts in subjects with G/A+AA/A genotype was 1.9-fold of those with G/G genotype (95%CI:0.7-5.1).For male subjects,the subjects with high dust exposure,or smoking subjects,if they were G/A+A/A genotype,the risk of ceramic silicosis were 2.4 (1.1-5.3.,1.8 (0.8-4.4),and 2.4 (1.0-5.6)folds of those of G/G genotype. In addition,the risk of tuberculosis in those with G/G genotype was 1.6-fold of those with G/A+A/A genotype (95%CI:0.7-3.5).Conclusions TNF-α gene polymorphism did not play an important role in susceptibility to silicosis and ***;TNF-α gene polymorphism interacted with cumulative exposure,gender,smoking amount during the process of ceramic *** risk of ceramic silicosis for male ceramic workers who smoked higher than 20 pack·y and worked with cumulative dust exposure higher than＞=180 mg/m.y of G/A+A/A genotype were 8.8-fold of workers of G/G genotype.

关键词： tumor necrosis factor-α gene polymorphism silicosis tuberculosis

The toxic influence of paraquat on hippocampus of mice:Involvement of oxidative stress

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The toxic influence of paraquat on hippocampus of mice:Invol...

Neurotoxicity and Neurodegeneration:Local Effect and Global Impact--13.h International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental health

作者： Rong Zhang Department of Toxicology,school of public health,Hebei Medical University

Purpose: Environmental paraquat(PQ) exposure has been suggested to be a potential risk factor for neurodegenerative disorders such as Parkinson's disease(PD).The hippocampus plays an important

关键词： The toxic influence of paraquat on hippocampus of mice:Involvement of oxidative stress mtDNA

上海市73.例强制戒毒人员丙型病毒性肝炎感染影响因素和基因分型研究

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中华疾病控制杂志 2018年第4期22卷 330-334,362页

作者：王娜刘效峰施大庆陆一涵上海市宝山区疾病预防控制中心慢性传染病防制科上海201901 上海市公安局强制隔离戒毒所上海200439 复旦大学公共卫生学院流行病学教研室上海200032

目的了解强制戒毒人群中丙型病毒性肝炎感染的影响因素和基因分型,为该人群的行为干预和临床治疗提供依据。方法采用横断面调查的方法,选择2015年5~7月间上海市强制隔离戒毒所首次接受戒毒治疗的吸毒对象为研究人群,通过问卷调查了解丙... 详细信息

目的了解强制戒毒人群中丙型病毒性肝炎感染的影响因素和基因分型,为该人群的行为干预和临床治疗提供依据。方法采用横断面调查的方法,选择2015年5~7月间上海市强制隔离戒毒所首次接受戒毒治疗的吸毒对象为研究人群,通过问卷调查了解丙型肝炎病毒(hepatitis C virus,HCV)感染的影响因素,利用巢式逆转录聚合酶链反应(reverse transcription-polymerase chain reaction,RT-PCR)检测血清HCV RNA,并进行基因分型,了解HCV基因分型和地区分布特征。结果 73.例强制戒毒人员中HCV RNA阳性者23.例,阳性率为3..2%。采用多因素Logistic回归分析,结果显示毒品吸食年限(OR_(5~年)=2.79,95%CI:1.64~4.75;OR_(10~年)=9.3.,95%CI:5.3.~16.54;OR_(15~25年)=11.22,95%CI:6.26~20.01)、吸食海洛因(OR=2.02,95%CI:1.3.~3.10)和曾经注射吸毒(OR=6.62,95%CI:4.41~9.94)是HCV感染的主要危险因素;文化程度为"大专及以上"是HCV感染的保护因素(OR=0.11,95%CI:0.02~0.63.。在23.例HCV RNA阳性吸毒者中,HCV亚型以3.(24.1%)、6a(20.2%)、1b(19.5%)为主;同时存在3.、6n、1a、2a、2b和6e,地区分布总体较分散。结论毒品吸食年限、吸食海洛因和曾经注射吸毒仍然是强制戒毒人群中HCV感染的主要危险因素,基因分型以3.和6a为主。

关键词：吸毒人员丙型肝炎病毒影响因素基因分型