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Risk factors and incidence of acute pyogenic cholangitis

Hepatobiliary & Pancreatic Diseases International 2012年第6期11卷 650-654页

作者： Yun-Sheng Qin, Qi-Yong Li, Fu-Chun Yang , Shu-Sen Zheng Division of Hepatobiliary and Pancreatic Surgery Key Laboratory of Combined Multi-organ Transplantation, Ministry of public health Key Laboratory of Organ Transplantation Zhejiang Province, First Affiliated Hospital, Zhejiang University school of Medicine, Hangzhou 3.0003. China Division of Hepatobiliary and Pancreatic Surgery Key Laboratory of Combined Multi-organ Transplantation Ministry of Public Health and Key Laboratory of Organ Transplantation Zhejiang Province First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China

BACKGROUND: Acute cholangitis varies from mild to severe form. Acute suppurative cholangitis (ASC), the severe form of acute cholangitis, is a fatal disease and requires urgent biliary decompression. Which patients are at a high risk of ASC and need emergency drainage is still unclear. The present study aimed to identify the factors for determining early-stage ASC and distinguishing ASC from acute cholangitis. METHODS: We analyzed 3.9 consecutive patients with acute cholangitis who had been admitted to the First Affiliated Hospital, Zhejiang University school of Medicine from January 2004 to May 2011. Emergency endoscopic retrograde cholangiopancreatography (ERCP) was carried out in all patients to decompress or clear the stones by experienced endoscopists Clinical and therapeutic data were collected, and univariate and multivariate analyses were performed to identify the potential risk factors of ASC. RESULTS: Of the 3.9 patients, 1 was excluded because of failure of ERCP drainage. Of the remaining 3.8 patients with an average age of 62.7 years (range 17-90), 162 were diagnosed with ASC, and 196 with non-ASC. ENBD catheters were placed in 3.3.patients (95.8%), of whom 182 patients had stones removed at the same time, and plastic stent was placed in 25 patients (7.0%) Clinical conditions were improved quickly after emergency biliary drainage in all patients. Complications were identified in 11 patients (3.1%): mild pancreatitis occurred in 8 patients and hemorrhage in 3.patients. There was no mortality. Univariate analysis showed that several variables were associated with ASC: age, fever, decreased urine output, hypotension, tachycardia abnormal white blood cell count (WBC), low platelet, high C reactive protein (CRP), and duration of the disease. Multivariateanalysis revealed that advanced age, hypotension, abnormal WBC, high CRP, and duration of the disease were independent risk factors for ASC. CONCLUSIONS: This study demonstrates that advanced age, hypotension,

关键词： acute cholangitis suppurative endoscopic retrograde cholangiopancreatography

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Optimizing the callus induction protocol of catharanthus roseus by uniform design and Proliferation

Optimizing the Callus induction protocol of Catharanthus ros...

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2009中国植物学会植物细胞生物学学术年会

作者： WU Chun-lian~(1*),FAN Jian-ming~2,YANG Jun~1,CHEN Wei-ying~1,SUN Min~3.1.school of Life Sciences,China West Normal University,Nanchong,Sichuan province 63.002,China 2.The Laboratory of Toxicology,College of public health,Zhengzhou University, Zhengzhou 450001,China 3.school of Life Science,Southwest University,Chongqing 400715,China

catharanthus roseus(L.) *** is one of the most extensively investigated medicinal plants and is known mainly for its pharmacologically important indole *** leaves of catharanthus roseus which were used as *** parameters,two hormones and Vitamin C(Vc),with four concentrations,were designed for callus induction of catharanthus roseus by uniform design(UD),and 8 experiments were *** results showed that MS medium with 2.0 mg·L 6-BA,1.0 mg·L 2,4-D and 20 mg·L Vc was the optimum medium for callus induction(100%).The optimum proliferation medium was MS+6-BA O.5 mg·L+2,4-D 0.5 mg·L+20 mg·L *** results indicated UD could be used to optimize conditions for callus induction of catharanthus *** could inhibit browning of callus induction of catharanthus roseus.

关键词： catharanthus Roseus optimum culture medium uniform design callus induction

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Adolescent violence-related behavior:associations with cognitive emotion regulation

Adolescent violence-related behavior:associations with cogni...

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中华预防医学会儿少卫生分会第九届学术交流会、中国教育学会体育与卫生分会第一届学校卫生学术交流会、中国健康促进与教育协会学校分会第三届学术交流会

作者： Peng Bao a,Jin Jing a,Wenhan Yang a (a Faculty of Maternal and Child health,school of public health,Sun Yat-Sen University, Guangzhou,China)

Introduction Violence is one of the most common problem behaviors that could seriously influence adolescents' health. The World health Organization(WHO) promotes a broad definition of violence:"The intentional use of physical force or power,threatened or actual,against oneself,another person,or against a group or community,that either results in or has a high likelihood of resulting in injury,death,psychological harm, maldevelopment or deprivation".Studies from many countries have shown that the rate of prevalence of adolescent violence has been increasing year by *** are also many evidence illustrating children with problem behaviors often have difficulty with aspects of emotional functioning,such as emotional activity and emotion regulation.

关键词： Adolescent violence-related behavior:associations with cognitive emotion regulation

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大学生手机成瘾与孤独感、手机使用动机的关系

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心理科学 2011年第6期34卷 1453-1457页

作者：刘红王洪礼贵州安顺学院教管系安顺561000 贵州省心理健康教育协会贵阳550001 贵州师范大学教育科学学院贵阳550001

为探讨手机成瘾与孤独感、手机使用动机的关系,采用手机成瘾指数量表、UCLA孤独量表和手机使用动机问卷对442名大学生进行测量,并综合运用相关分析、多元方差分析和路径分析考察变量间的关系。结果表明:(1)孤独感影响手机成瘾的路径有两... 详细信息

为探讨手机成瘾与孤独感、手机使用动机的关系,采用手机成瘾指数量表、UCLA孤独量表和手机使用动机问卷对442名大学生进行测量,并综合运用相关分析、多元方差分析和路径分析考察变量间的关系。结果表明:(1)孤独感影响手机成瘾的路径有两条:一是直接预测大学生的手机成瘾,二是通过网娱动机间接预测手机成瘾。(2)孤独感是影响手机成瘾的重要因素,对大学生手机成瘾的干预可以从降低孤独感入手。

关键词：手机成瘾手机使用动机孤独感网娱动机大学生

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知识关联:内涵、特征与类型

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图书馆 2011年第4期 32-35页

作者：文庭孝龚蛟腾张蕊刘晓英刘进军湘潭大学公共管理学院湖南湘潭411105 杭州电子科技大学管理学院浙江杭州310018 湘潭大学图书馆湖南湘潭411105

知识关联是指知识单元(包括文献、人脑等知识载体和概念、词语等知识内容)之间存在的各种关系的总和。知识关联具有相互性、普遍性、传递性、隐含性、结构性、累积性等特征,是我们认识和利用知识关联的基础。知识关联有多种类型,其中显... 详细信息

知识关联是指知识单元(包括文献、人脑等知识载体和概念、词语等知识内容)之间存在的各种关系的总和。知识关联具有相互性、普遍性、传递性、隐含性、结构性、累积性等特征,是我们认识和利用知识关联的基础。知识关联有多种类型,其中显性知识关联、隐性知识关联、学科知识关联、主题知识关联、知识载体关联和知识内容关联具有重要的意义。

关键词：知识知识单元知识关联概念特征类型

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Application of YLD calculation in Assessing Disease Data──An Analysis of 4 Diseases in 2 Regions

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Biomedical and Environmental Sciences 1999年第4期12卷 260-269页

作者： MA EN-BO WANG RUO-TAO YANG GONG-HUAN AND MICHAEL R. PHILIPS(Union school of public health, Peking Union Medical college, 7 Pan Jia YuanNan Li, Beijing 100027, China)(Institute of Epidemiology and Microbiology,Chinese Academy of Preventive Medicine, 27 Union school of public health Peking Union Medical College Beijing China

The objective of the curtent study is to discuss the problems related to how data is used to calculate Yeare Lost with Disability (YLD) with the method recommended by the World Bank. The study includes collecting useful data, estimating disease duration and average age of disease onset,adjusting incidence and prevalence data by means of a software programme, DISMOD (Harvard University Incidence & Prevalence Model), and assessing the importance of YLD calculation for different *** and fatality rates of 3.diseases were estimated by experts at 2 round *** rates, disease duration and average age of disease onset were calculated and adjusted by DISMOD. YLD due to schizothrenia is the highest among 4 diseases in two regions. YLD is 18. 88 % in disability adjusted life year for 4 diseases in Xiacheng District, and 19 .97 % in Fuyang *** data can be used for the calculation of YLD after being adjusted. DISMOD is a useful instrument to test the internal consistency of incidence, prevalence, rendssion and fatality rate. The adjusted data are acceptable to experts and DISMOD. To get rational remission and fatality rates, we can use a cohort method through expert consultations. To renect overall burden of disease, YLD calculation should be used.

关键词： An Analysis of 4 Diseases in 2 Regions

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Roles of Fas signaling pathway in vitamin E succinateinduced apoptosis in human gastric cancer SGC-7901 cells

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World Journal of Gastroenterology 2002年第6期8卷 982-986页

作者： Kun Wu Yao Li Yan Zhao Yu-Juan Shah Wei Xia Lan Zhao,Department of Nutrition and Food Hygiene,public health school,Harbin Medical University,Harbin 150001,Heilongjiang Province,China Wei-Ping Yu,Genetics Institute,Texas University of {3.,Austin,{3. Department of Nutrition and Food Hygiene Public Health School Harbin Medical University Heilongjiang Province China. wukun@***

AIM: To investigate the roles of Fas signaling pathway in vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 ***: Human gastric cancer SGC-7901 cells were treated with VES at 5, 10, 20 mg@L-1, succinic acid and vitamin E as vehicle control and condition media only as untreated (UT) control. Apoptotic morphology was observed by DAPI staining. Western blot analysis was applied to measure the expression of Fas, FADD and caspase-8 proteins. After the cells were transiently transfected with Fas and FADD antisense oligonucleotides, respectively, caspase-8 activity was determined by flurometric ***: The morphologically apoptotic changes were observed after VES treatment by DAPI staining. 23.7 % and 89.6 % apoptosis occurred after 24 h and 48 h of 20 mg@L-1 VES treatment, respectively. The protein levels of Fas, FADD and caspase-8 were evidently increased in a dose-dependent manner after 24 h of VES treatment. The blockage of Fas by transfection with Fas antisense oligonucleotides obviously inhibited the expression of FADD protein. After SGC-7901 cells were transfected with Fas and FADD antisense oligonucleotides, caspase-8 activity was obviously decreased (P＜0.01), whereas Fas blocked more than ***: VES-induced apoptosis in human gastric cancer SGC-7901 cells involves Fas signaling pathway including the interaction of Fas, FADD and caspase-8.

关键词：人胃癌细胞 SGC-7091细胞系 Ve琥珀酸酯维生素E 诱发凋亡 Fas信号通路作用机制

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类固醇5-α还原酶样基因Srd5α2l2的克隆及表达分析

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生物化学与生物物理进展 2003年第6期30卷 894-899页

作者：陈祥贵李勇张德礼成君朱文丽刀京晶北京大学公共卫生学院营养学系北京大学分子毒理与发育分子生物学实验室北京100083 四川工业学院生物工程系成都610039 清华大学信息科学技术学院自动化系智能技术与系统国家重点实验室北京100084

采用表达序列标签 (EST)介导的基因克隆和表达谱分析 ,从小鼠心脏克隆了一个cDNA为 2 3.4 8bp ,主要在心脏表达的新基因Srd5α2l2 (GenBankAccNo .AF5483.65) .该基因由 12个外显子组成 ,3.非翻译区富含ATTTA序列 ,最大开放阅读框编码... 详细信息

采用表达序列标签 (EST)介导的基因克隆和表达谱分析 ,从小鼠心脏克隆了一个cDNA为 2 3.4 8bp ,主要在心脏表达的新基因Srd5α2l2 (GenBankAccNo .AF5483.65) .该基因由 12个外显子组成 ,3.非翻译区富含ATTTA序列 ,最大开放阅读框编码一个由 3.61个氨基酸组成的假定蛋白 ,该蛋白质C端含有类固醇 5 α还原酶的保守结构域 (3. oxo 5 alpha steroid 4 dehydrogenase ,STEROID_DH ) .生物信息学分析表明 ,人cDNA克隆DKFZp3.13.0 82 9(AL83.3.10 8)是Srd5α2l2的人同源基因 .经同源性检索 ,支持Srd5α2l2的全部 41条EST中 2 5条来自小鼠心脏组织 .RT PCR检测初步证实 ,该基因主要在心脏中表达 ,而在其他组织中不表达或弱表达 .综合考虑Srd5α2l2的序列特征和表达谱。

关键词：类固醇5-α还原酶基因克隆表达分析

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含硒康绿保健茶对铅作业工人危害的保护作用

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同济医科大学学报 1995年第2期24卷 152-155页

作者：熊世洲武汉同济医科大学公共卫生学院劳动卫生与职业病学教研室

６名受试者中，３人每天饮茶５ｇ（含硒８０μｇ），另３人每天饮茶１０ｇ（含硒１６０μｇ），连续饮４周。饮茶前抽其中３人血做细胞培养，作为正常对照组（不加铅培养）和阳性对照组（加铅培养）。结果阳性对照组外周血淋巴细胞畸变... 详细信息

６名受试者中，３人每天饮茶５ｇ（含硒８０μｇ），另３人每天饮茶１０ｇ（含硒１６０μｇ），连续饮４周。饮茶前抽其中３人血做细胞培养，作为正常对照组（不加铅培养）和阳性对照组（加铅培养）。结果阳性对照组外周血淋巴细胞畸变率、染色体畸变率、微核率分别高达１３．５％、３．２‰及１２．０‰，淋巴细胞转化率降至５１．６％。４周后，饮茶５ｇ和１０ｇ组培养物加铅培养时，上述指标均恢复至正常对照组范围。结果表明：康绿保健茶能拮抗铅所致的遗传毒性和免疫毒性，可作为铅作业工人的保健饮料。

关键词：硒康绿保健茶铅中毒遗传毒性免疫毒性预防

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Changes in Dietary Patterns and Certain Nutrition-related Diseases in Urban and Rural Residents of Jiangsu Province,China,During the 1990s

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Biomedical and Environmental Sciences 2002年第4期15卷 271-276页

作者： WANG caN-NAN , LIANG ZHI , WEI PING , LIU PEI , YD JiA-Xr, ZHANG DAN-MEI, AND MA FENG-LOUFaculty of public health, Xuzhou Medical College, Xuzhou, Jiangsu 221002, China Bureau ofhealth, Jiangsu Provincial Government, Nanjing, Jiangsu 210008, China Statistical Bureauof Jiangsu Provincial Government Nanjing, Jiangsu 210026, China health andAnti-epidemic Station of Xuzhou, Xuzhou. Jiangsu 221002, China ’ school of publichealth, Nanjing Medical University, Nanjing, Jiangsu 210029, China Faculty of public health Xuzhou Medical College 江苏 Xuzhou 221002 Bureau of health Jiangsu Provincial Government 江苏 Nanjing 210008 Faculty of public health Xuzhou Medical Colleg 江苏 Xuzhou 221002 health and Anti-epidemic Station of Xuzhou 江苏 Xuzhou 221002 school of public health Nanjing Medical University 江苏 Nanjing 210029

Objective To investigate into the changes of dietary patterns and their impacts on health of urban and rural residents in Jiangsu Province, China during the 1990s. Methods On the basis of the results of food consumption survey, the calorie intake was calculated according to the balanced diet method and the quality of diet was assessed by scores of desirable dietary pattern (DDP). Results It was found that food consumption and dietary patterns changed remarkably during the 1990s. Grain consumption was decreasing year by year, but the consumption of animal food was markedly increasing. Although the score of desirable dietary pattern (DDP) in urban residents was more than 90, the deducted score due to over-consumption of animal food increased. The mortality from infectious diseases evidently decreased in the whole province, while the death rates of some chronic diseases, such as diabetes, hypertension, colorectal cancer and breast cancer, were increasing rapidly in urban areas. Conclusions Sufficient attention should be paid to the negative effects of change in dietary patterns on people's health, especially in the urban residents.

关键词： Dietary patterns Nutrition-related diseases

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