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Mechanisms of antiprostate cancer by gum mastic:NF-κB signal as target

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Acta Pharmacologica Sinica 2007年第3期28卷 446-452页

作者： Mei-lan HE~(2.4) Ang LI~2.Chun-su XU~2.Shun-li WANG~3.Meng-jie ZHANG~2.Hua GU~2.Yao-qin YANG~3.Hui-hong TAO~3.~2.nstitute of Cancer Research,life science and technology {3.,tongji University,shanghai 2.0092.China ~3.ellular Morphology Center,Medical {3.,tongji University,shanghai 2.0092.China Institute of Cancer Research Life Science and Technology School Tongji University Shanghai 200092 China Cellular Morphology Center Medical School Tongji University Shanghai 200092 China

Aim:To study the effect of gum mastic,a natural resin,on the proliferation ofandrogen-independent prostate cancer PC-3.cells,and further investigate themechanisms involved in this regulatory system,taking nuclear factor κB(NF-κB)signal as the ***:3.(4,5-dimethylthiazol-2.yl)-2.5-diphenyltetrazoliumbromide(MTT)assay and a flow cytometer were used to detect the effect of gummastic on the proliferation of PC-3.***,reporter gene assay,RT-PCR,andWestern blotting were carried out to study the effects of gum mastic on the NF-κBprotein level and the NF-κB signal *** expression of genes involved inthe NF-κB signal pathway,including cyclin D1,inhibitors of κBs(IκBα),andphosphorylated Akt(p-AKT),were *** addition,transient transfectionassays with the 5×NF-κB consensus sequence promoter was also used to test theeffects of gum ***:Gum mastic inhibited PC-3.cell growth and blockedthe PC-3.cell cycle in the G1 *** mastic also suppressed NF-κB activity inthe PC-3.*** expression of cyclin D1,a crucial cell cycle regulator and anNF-κB downstream target gene,was reduced as ***,gum masticdecreased the p-AKT protein level and increased the IκBα protein ***:Gum mastic inhibited the proliferation and blocked the cell cycleprogression in PC-3.cells by suppressing NF-κB activity and the NF-κB signalpathway.

关键词： gum mastic prostate cancer NF-κB signal

Phase transition in the Zr_(60)Al_(15)Ni_(2.) bulk metallic glass subjected to rolling at room temperature

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science China(Technological sciences) 2006年第6期49卷 655-662页

作者： YAN Zhijie1, 2. LI Jinfu1, ZHOU Yaohe1 & WU Yanqing3.1. State Key Laboratory of Metal Matrix Composites, school of Materials {2. and Engineering, shanghai Jiao Tong University, shanghai 2.003., China 2. school of Materials {2. and Engineering, Taiyuan University of {2. and technology, Taiyuan 03.02., China 3. school of Environmental {2. and Engineering, shanghai Jiao Tong University, shanghai 2.003., China State Key Laboratory of Metal Matrix Composites School of Materials Science Engineering Shanghai Jiao Tong University Shanghai 200030 China school of Materials science Engineering Taiyuan University of Science technology Taiyuan 030024 China school of Environmental science Engineering Shanghai Jiao Tong University Shanghai 200030 China

The microstructure evolution of the Zr60Al15Ni2. metallic glass during rolling at room temperature is investigated by X-ray diffraction (XRD), differential scanning calorimetry (DSC); high-resolution transmission electron microscopy (HREM). The results show that the values of full width at half maximum (FWHM) of the XRD patterns; exothermic enthalpy ΔH of DSC plots do not monotonically change with the variation of deformation degrees . As is not large than 2.%, the values of FWHM; ΔH are lower than that of the as-cast state. When reaches 3.%, the values of FWHM; ΔH become larger than that of the as-cast state, while their values begin to decrease again as reaches about 85%. These results indicate that the reversible transitions between ordered; disordered atomic configurations occur during rolling, which is further verified by the HREM images. The reversible phase transition can be explained by the competition between the diffusion controlled reordering; shear-induced disordering during rolling.

关键词： metallic glasses, plastic deformation, phase transformations, shear bands.

The characteristics of arc beam shaping in hybrid plasma and laser deposition manufacturing

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science China(Technological sciences) 2006年第2期49卷 238-247页

作者： ZHANG Hai’ou1, QIAN Yingping1,3. WANG Guilan1 & ZHENG Qiguang2.1. school of Material {2. and technology, Huazhong University of {2. and technology, Wuhan 43.074, China 2. Institute of Laser technology and Engineering, Huazhong University of {2. and technology, Wuhan 43.074, China 3. Mechanical Engineering College, Hubei University of technology, Wuhan 43.068, China 1. school of Material science and {2. Huazhong University of Science and Technology Wuhan 430074 China 3. Mechanical Engineering College Hubei University of Technology Wuhan 430068 China 2. Institute of Laser technology and Engineering Huazhong University of Science and Technology Wuhan 430074 China

As a new direct metal prototyping technology,the hybrid plasma and laser deposition manufacturing (PLDM) is proposed in this paper. In order to figure out the characteristics of plasma arc beam and mould in the PLDM process of high temperature alloy, the high speed CCD camera is used to obtain the picture around the plasma arc. Afterwards the sketch of picture is clearly obtained. And the effect of laser parameter, such as average power, pulse width, pulse repetition frequency and the angle between laser beam and plasma arc beam on the plasma arc appearance, is studied experimentally. The results show that the modality of plasma arc beam is markedly influenced by laser beam. And the improvements of shape precision and surface state of the layer deposited by PLDM are confirmed.

关键词： plasma hybrid laser, direct deposition, plasma arc beam, molding character, high-temperature alloy.

CO observations of massive star forming regions at different evolutionary phases

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science China(Physics,Mechanics & Astronomy) 2006年第5期49卷 626-640页

作者： CHEN Xi1,2. XU Ye1,3. SHEN Zhiqiang1,3.& LI Jingjing1,2.1. {2. Astronomical Observatory, Chinese Academy of sciences, {2. 2.003., China 2. Graduate {3. of the Chinese Academy of sciences, Beijing 10003., China 3. Joint Institute for Galaxy and Cosmology, {2. Astronomical Observatory and the University of science and {12. of China, {2. 2.003., China shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Graduate school of the Chinese Academy of sciences Beijing 100034 China Joint Institute for Galaxy Cosmology Shanghai Astronomical Observatory the University of science technology of China Shanghai 200030 China

The 12.O (J=1-0), 13.O (J=1-0) and C18O (J=1-0) emissions in 9 massive star forming regions, which are believed to be at different stages of massive star formation, were mapped with the 13.7 m millimeter wave telescope at Qinghai Station of Purple Mountain Observatory. Of the observed 9 sources, 13.O cores were detected in seven of them, and C18O cores in five of them. And only two sources associated with C18O cores and H2. masers showed the extended structures and strong outflows. This is the first detection of outflow associated with IRAS 2.566+582. in the observing field of S152.S153. The physical parameters of cores and outflows for these sources, derived from Local Thermal Equilibrium (LTE) analysis, are presented. These observing results suggest that the C18O cores will only appear when the gas density is high enough and the probability to have an outflow is very high when the clumps show the C18O and H2. maser simulta- neously.

关键词： star formation cloud core outflow H2. maser

The mathematical model of wetting angle of heterogeneous nucleation

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science China(Technological sciences) 2004年第4期47卷 391-397页

作者： HUANG Cheng1, SONG Bo1, MAO Jinghong2.& ZHAO Pei3.1. school of Metallurgical and Ecological Engineering, University of {2. and technology Beijing, Beijing 100083. China 2. school of Material {2., University of {2. and technology Beijing, Beijing 100083. China 3. Central Iron and Steel Research Institute, Beijing 100081, China 1. school of Metallurgical and Ecological Engineering University of Science and Technology Beijing 100083 Beijing China 2. school of Material science University of Science and Technology Beijing 100083 Beijing China 3. Central Iron and Steel Research Institute 100081 Beijing China

The heterogeneous nucleation has been analyzed in terms of the thermodynamic theory, and the mathematical model of wetting angle of heterogeneous nucleation has been developed based on the dynamic requirements of hetero- and homogeneous nucleation. With the wetting angel model, the wetting angles of different catalysts in liquid iron have been calculated. The result shows that the wetting angle of most catalysts is smaller than 40, and the value of f() is far less than 1. The wetting angles of TiN, TiC and RE2.3.are smaller, while the wetting angle of MnO is bigger among the ordinary nucleation catalysts. The wetting angles calculated by this model are in agreement with the results of other research work.

关键词： heterogeneous nucleation, mathematical model, wetting angle, undercooling.

Superconductivity of small metal grains

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science China(Physics,Mechanics & Astronomy) 2005年第4期48卷 431-441页

作者： ZHENG Renrong1 CHEN Zhiqian2.& ZHU Shunquan1,3.1. Department of Physics, shanghai Normal University, shanghai 2.02.0}, China 2. Department of Physics, Southwest Normal University, Chongqing 400715, China 3. Department of Computer and Electric technology, shanghai Business school, shanghai 2.1400, China 1. Department of Physics Shanghai Normal University 200234 Shanghai China 2. Department of Physics Southwest Normal University 400715 Chongqing China 3. Department of Computer and Electric technology Shanghai Business School 201400 Shanghai China

The formulas of the energy gap and superconducting critical temperature appropriate for systems with both odd and even number of electrons are derived; the bases of the derivations are BCS theory and energy level statistics. Numerical results qualitatively agree with the experimental phenomena. i.e., the superconductivity of small metallic grains will first enhance then decrease to zero when the grain are getting smaller and smaller. The calculations indicate that the above phenomena happen in the metallic grains belonging to Gaussian Orthogonal Ensemble (GOE) and Gaussian Unitary ensemble (GUE) with zero spin; The superconductivity of small metallic grains in Gaussian Symplectic Ensemble (GSE) will monotonically decrease to zero with the decreasing of the grain size. The analyses suggest that the superconductivity enhancements come from pairing and the balance of the strengths between spin-orbital coupling and external magnetic field. In order to take the latter into account, it is necessary to include the level statistics given by Random Matrix Theory (RMT) in describing small metallic grains.

关键词： size effect, superconductivity enhancements, small metallic grains.

Interfacial Microstructure and Properties of Ti(C, N)/Ni Bonded by Transient Liquid-phase Diffusion

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Journal of Wuhan University of technology(Materials science) 2009年第3期24卷 432-439页

作者：周世权熊惟皓 school of Mechanical science and Engineering Huazhong University of Science and Technology Department of Mechanical Engineering University of Waterloo school of Materials science and Engineering Huazhong University of Science and Technology

Effects of the main process parameters（temperature and time） on microstructure and properties of Ti（C, N）/Ni interface bonded by （Cu＋Nb） interlayer in a vacuum diffusion bonding device were investigated. The interfacial microstructures consisted initially of Ni3.b metallic compound and eutectic of Ni3.b ＋ CuNiss, and finally transformed to （Ti, Nb）（C, N）＋Ni3.b near Ti （C, N） and NiCuss ＋ Ni3.b near Ni when diffusion bonding temperature was 1 52.0}1 573.K. It was clear that Cu was a constituent in the transient liquid phase （TLP） into which Ni was dissolved by forming Cu-Ni transition liquid. Nb was dissolved in Cu-Ni transition liquid rapidly. Ti （C, N） conld be wetted by resultant Ni-Nb-Cu transient liquid phase which was followed by a little （Ti, Nb）（C, N） solid solution formed at interface. This increased the interface combining capability. Ultimately the interface shear strength was able to reach 140 MPa. The theoretle analysis and experimental results show that the growth of interfacial reaction layer Ni3.b accords with parabola law, and the activation energy of diffusion reaction is 115.0±0.5 kJ/mol, while the diffusion reaction speed constant is 12.53.mm/s^1/2.

关键词： vacuum diffusion bonding transient liquid phase (TLP) diffusion bonding interlayer activation energy

A computer simulation of nucleation and growth of thin films

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science China(Physics,Mechanics & Astronomy) 2004年第4期47卷 442-451页

作者： ZHENG Xiaoping1,ZHANG Peifeng2.HE Deyan2.LIU Jun2. MA Jiantai3.1. Key Laboratory of Opto-Electronic technology and Intelligent Control, Ministry of Education, Lanzhou Jiaotong University, Lanzhou 73.070, China 2. school of Physical science and technology, Lanzhou University, Lanzhou 73.000, China 3. school of Chemistry and Chemistry Engineering, Lanzhou University, Lanzhou 73.000, China 1. Key Laboratory of Opto-Electronic technology and Intelligent Control Ministry of Education Lanzhou Jiaotong University 730070 Lanzhou China 2. school of Physical science and {2. Lanzhou University 730000 Lanzhou China 3. school of Chemistry and Chemistry Engineering Lanzhou University 730000 Lanzhou China

A three-dimensional kinetic Monte Carlo technique has been developed for simulating the nucleation and growth of thin films. This model involves incident atom attachment, surface diffusion of the atoms on the growing surface and atom detachment from the growing surface. It takes some new effects into account, such as a significant improvement in calculation of activation energy for the atom diffusion, which renders the model more reasonable. In addition three optimum temperatures and the consistency of their dependence on deposition rate have been found out; the dependence of the surface roughness and relative density on the deposition rate has been discussed; and the approximation of freezing neighbour atoms and periodic boundary conditions has been applied.

关键词： Monte Carlo, thin film, nucleation, surface roughness, relative density.

Development and Application of High Performance X80 Line Pipe for the 2.(nd) West-East Gas Pipeline

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Journal of Iron and Steel Research International 2011年第S1期18卷 39-48页

作者： LI He-lin 1 , HUO Chun-yong 1 , JI Ling-kang 1, 2., LI Yang 1, 3.(1. CNPC Tubular Goods Research Institute, Xi’an 710065, China 2. . school of Material {2. and Engineering, Xi’an Jiaotong University, Xi’an 710049, China 3. school of Material {2. and Engineering, University of {2. and technology Beijing, Beijing 100083. China) CNPC Tubular Goods Res Inst Xian 710065 Peoples R China Xi An Jiao Tong Univ Sch Mat Sci & Engn Xian 710049 Peoples R China Univ Sci & Technol Beijing Sch Mat Sci & Engn Beijing 100083 Peoples R China

It is the development tendency of gas pipeline to improve strength of line pipe and transmission pressure, which is an important symbol of the progress of gas pipeline technology. The 2.d West-East Gas Pipeline (the 2.nd WEGP) is the largest-scale X80 high pressure gas pipeline project in the world. Through the joint development project by Pipeline Company, research institute, and steel company, a series of achievements of technology have been obtained, which makes it possible to apply pressure of 12.MPa and X80 LSAW and HSAW pipe for the 2.nd WEGP. Specifications of X80 steel and pipe have been issued based on API 5L. High performance X80 steel and pipe have been developed and meets the Specification. General design conception of applying HSAW pipe and LSAW pipe on gas transmission trunk line with large diameter and high pressure has been established. Failure control of the 2.nd WEGP has been carried out to avoid failure and reduce the lost which based on analysis of pipeline failure mode. In this paper, research and development of high performance X80 welded pipe, establishment of technical route of joint application of HSAW and LSAW steel pipe and key technology of failure control are emphatically discussed.

关键词： 2.nd WEGP acicular ferrite failure control arrest toughness strain-based design