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Correlation of Behavior Changes and BOLD Signal in Alzheimer-like Rat Model

Acta Biochimica et Biophysica Sinica 2004年第12期36卷 803-810页

作者： Zheng-Hui HU#, Xiao-Chuan WANG1#, Li-Yun LI3. Mai-Li LIU3. Rong LIU1, Zhiqun LING1, Qing TIAN1, Xiao-Wei TANG, Yi-Gen WU2., and Jian-Zhi WANG1* Department of {2. and Bio-X disciplinary Laboratory, Zhejiang University, Hangzhou 3.002.,china 1 Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 43.03., china 2.3. of high energy {2. and Key Laboratory of Nuclear Analysis Techniques, {12. academy of sciences, P.O. Box 918, Beijing 10003., china 3.uhan {3. of {2. and Mathematics, State Key Laboratory of Magnetic Resonance and Atomic and Molecular {2., {12. academy of sciences, Wuhan 43.071, china Department of physics and Bio-X disciplinary Laboratory Zhejiang UniversityHangzhou 310027China Department of Pathophysiology Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030 China Wuhan institute of physics and Mathematics State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Chinese Academy of SciencesWuhan 430071 China institute of high {2. {3. and Key Laboratory of Nuclear Analysis Techniques Chinese Academy of SciencesP.O. Box 918 Beijing 100039 China

To explore a potential means for the early diagnosis of Alzheimer disease, we studied the relationship of resting T2. signal and tau hyperphosphorylation/spatial memory deficit. The rat model with tau hyperphosphorylation and spatial memory deficit was established by bilateral hippocampi injection of isoproterenol (IP). Then, the correlative alteration between resting T2. signal and spatial memory retention was assessed with blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) study and Morris Water Maze test, and Western blot was employed to confirm tau hyperphosphorylation. The analysis showed following results. (1) Tau phosphorylation at Ser3.6/Ser404 and Ser199/Ser2.2.was signifi- cantly increased in IP-injected rats as detected by PHF-1 and tau-1, respectively. (2. An AD-like spatial memory retention disturbance was induced at 2. h after isoproterenol injection. (3. A sensitivity threshold of resting T2. signal intensity, which separated the IP-treated rats from vehicle control, was obtained by applying linear regression analysis, and an estimated sensitivity statistical threshold was at 3..62. These results suggest that resting T2. signal may serve as a noninvasive quantitative marker in predicting AD-like spatial memory deficits and tau hyperphosphorylation.

关键词： Alzheimer disease (AD) functional magnetic resonance imaging (fMRI) isoproterenol (IP) Morris Water Maze diagnosis

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Cyclic Heating-Annealing and Boltzmann Distribution of Free Energies in a Spin-Glass System

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Communications in Theoretical physics 2007年第7期48卷 179-182页

作者： ZHOU Hai-Jun institute of Theoretical physics,the {2. {3. of sciences,Beijing 100080,china institute of Theoretical physics the Chinese Academy of Sciences Beijing 100080 China

Ergodicity of a spin-glass is broken at low temperatures;the system is trapped in one of many ergodicconfigurational *** between different ergodic domains are achievable through a *** this experiment is repeated infinite times,all ergodic configurational domains will be visited with frequencesthat decreasing exponentially with their free *** mean free energy density of a spin-glass system on a randomgraph is calculated based on this free energy Boltzmann distribution in the present work,by means of the cavity approach.

关键词： spin-glass ergodicity-broken cavity method

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Simulation of energy and water balance in Soil-Vegetation-Atmosphere Transfer system in the mountain area of Heihe River Basin at Hexi Corridor of northwest china

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Science china Earth sciences 2005年第4期48卷 538-548页

作者： KANG Ersi1, CHENG Guodong1, , SONG Kechao1, JIN Bowen1, , LIU Xiande3.2.3.& WANG Jinye3.1. Cold and Arid Regions Environmental and Engineering Research institute, chinese academy of {3., Lanzhou 73.000, china 2. State Key Laboratory of Frozen Soil Engineering, chinese academy of {3., Lanzhou 73.000, china 3. academy of Water Resources Conservation Forest of Qilian Mountains, Gansu Province, Zhangye 73.000, china 1. Cold and Arid Regions Environmental and Engineering Research institute Chinese Academy of Sciences 730000 Lanzhou China 2. State Key Laboratory of Frozen nSoil Engineering Chinese Academy of Sciences 730000 Lanzhou China 3. academy of Water Resources Conservation Forest of Qilian Mountains 734000 Gansu Province Zhangye China

In the mountain area of inland Heihe River Basin at Hexi Corridor of northwest china during the vegetation growing season from May to September, the Simultaneous Heat and Water (SHAW) model of Soil-Vegetation-Atmosphere Transfer (SVAT) system is applied to simulating and studying energy and water balance of the soil-residue-plant canopy layers in the Picea crassifolia forest and the grassland by the forest at the shaded slope and the grassland at the sun-facing slope. The simulation of energy balance indicates that net radiation of the grass- land at the sun-facing slope is more than that of the Picea crassifolia forest and the grassland by the forest at the shaded slope. The energy outgoing components are the first latent heat and next sensible heat from the grassland both at the shaded slope and the sun-facing slope, but those at the former are less. The energy outgoing components are the first sensible heat and next latent heat from the Picea crassifolia forest. The composition and distribution of energy in the soil-residue-plant canopy layers in the Picea crassifolia forest and the grassland by the forest at the shaded slope make the soil layer receive less energy, which therefore, especially the forest possesses the energy conditions for soil water conservation. The simulation of water balance indicates that the water loss of the grassland at the sun-facing slope is mainly caused by soil evaporation, while evapotranspiration of the Picea crassifolia forest and the grassland by the forest at the shaded slope is less than that of the grassland at the sun-facing slope. Half of the evapotranspiration of the Picea crassifolia forest and the grassland by the forest at the shaded slope is consumed by transpiration. After precipitation, the soil water storage is increased much more for the Picea crassifolia forest and also more for the grassland by the forest at the shaded slope. Therefore the shaded slope vegetation, especially the forest is favorable for soil water s

关键词： inland rivers, mountain vegetation zone, Soil-Vegetation-Atmosphere Transfer (SVAT) system, energyand water balance, simulation.

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Comparison of dark energy models:A perspective from the latest observational data

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中国科学：物理学、力学、天文学英文版 2010年第9期53卷 1631-1645页

作者： LI Miao1,2.LI XiaoDong2.3.& ZHANG Xin1,4 1Kavli institute for Theoretical {2. china,{3. academy of sciences,Beijing 100190,china 2.ey Laboratory of Frontiers in Theoretical {2.,institute of Theoretical {2.,{3. academy of sciences,Beijing 100190,china 3.nterdisciplinary Center for Theoretical Study,University of Science and Technology of china,Hefei 2.0}02.,china 4Department of {2.,College of sciences,Northeastern University,Shenyang 110004,china 1. Kavli institute for Theoretical physics{2. Chinese Academy of Sciences Beijing 100190 China2. Key Laboratory of Frontiers in Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences Beijing 100190 China3. Interdisciplinary Center for Theoretical Study University of Science and Technology of China Hefei 230026 China4. Department of Physics College of Sciences Northeastern University Shenyang 110004 China

We compare some popular dark energy models under the assumption of a flat universe by using the latest observational data including the type Ia supernovae Constitution compilation,the baryon acoustic oscillation measurement from the Sloan Digital Sky Survey,the cosmic microwave background measurement given by the seven-year Wilkinson Microwave Anisotropy Probe observations and the determination of H0 from the Hubble Space *** comparison statistics such as the Bayesian and Akaike information criteria are applied to assess the worth of the *** statistics favor models that give a good fit with fewer *** on this analysis,we find that the simplest cosmological constant model that has only one free parameter is still preferred by the current *** other dynamical dark energy models,we find that some of them,such as the αdark energy,constant w,generalized Chaplygin gas,Chevalliear-Polarski-Linder parametrization,and holographic dark energy models,can provide good fits to the current data,and three of them,namely,the Ricci dark energy,agegraphic dark energy,and Dvali-Gabadadze-Porrati models,are clearly disfavored by the data.

关键词： dark energy models observational constraints model comparison information criteria

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Electronic structure and magnetism of R(Fe,Si)_(12. (R=Y,Nd)

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Science china(physics,Mechanics & Astronomy) 2006年第2期49卷 195-202页

作者： SUN Guang’ai1, CHEN Bo1, DU Honglin2. FAN Zhijian1, GAO Tao3.& QI Xinhua3.. {2. of Nuclear physics and Chemistry, china {3. of Engineering physics, Mianyang 62.900, china 2. Department of physics, Peking university, Beijing 100871, china 3. {2. of Atomic and Molecular physics, Sichuan University, Chengdu 610065, china 1. institute of Nuclear physics and Chemistry China Academy of Engineering Physics Mianyang 621900 China 2. Department of physics Peking university Beijing 100871 China 3. institute of Atomic and Molecular {2. Sichuan University Chengdu 610065 China

The newly developed full-potential linearized augmented plane wave (LAPW) and local orbitals (lo) based on standard APW methods are briefly introduced, and the structure and magnetic properties of R(Fe, Si)12.compounds (R = Y, Nd) are calculated using the method. The distribution of Si at different sites is analyzed based on total energy of one crystal unit with structure having been optimized. The characters of magnetic mo-ments, total density of states (TDOS) and partial density of states (PDOS) for different crystal sites Si occupies are obtained and analyzed. The results show that the total mag-netic moments of RFe10Si2.(R = Y, Nd) are larger than those of RFe10M2.(M = Ti, V, Cr, Mn, Mo and W) and the hybridization mechanism is seen as follows. Si(8j) reduce the mag-netic moments of Fe at three sites, however, Si(8f) mainly reduce the magnetic moments of Fe(8i) and Fe(8j) atoms. The Curie temperature is markedly enhanced by the introduc-tion of Si atoms according to spin fluctuation of DOS at Fermi level.

关键词： (L)APW+lo method R(Fe Si)12.R = Y Nd) magnetic moment Density of state.

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Prediction method for October 2.03.solar storm

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Science china(Technological sciences) 2006年第5期49卷 629-640页

作者： XIE Yanqiong1, 2. 3. WEI Fengsi1, FENG Xueshang1 & ZHONG Dingkun1, 2.1. State Key Laboratory of Space Weather, Center for Space Science and Applied Research, chinese {2. of sciences, Beijing 100080,{3. 2. Graduate School, chinese {2. of sciences, Beijing 10003.,{3. 3. institute of Meteorology, PLA University of Science and Technology, Nanjing 2.1101,{3. State Key Laboratory of Space Weather Center for Space Science Applied Research Chinese Academy of Sciences Beijing 100080 China Graduate School Chinese Academy of Sciences Beijing 100039 China institute of Meteorology PLA University of Science Technology Nanjing 211101 China

Aiming at two intense shock events on October 2. and 2., 2.03. this paper presents a two-step method, which combines synoptic analysis of space weather ——“observing” and quantitative prediction ——“palpating”, and then uses it to test predictions. In the first step of “observing”, on the basis of observations of the solar source surface magnetic field, interplanetary scintillation (IPS) and ACE spacecraft, we find that the propagation of the shocks is asymmetric relative to the normal direction of their solar sources, and the Earth is located near the direction of the fastest speed and the greatest energy of the shocks. As the two fast ejection shock events, the fast explosion of coronal mass of the extremely {2. temperature, the strong magnetic field, and the {2. speed background solar wind are also helpful to their rapid propagation. In the second step of “palpating”, we adopt a new membership function of the fast shock events for the ISF method. The predicted results show that for the onset time of the geomagnetic disturbance, the relative errors between the observational and the predicted results are 1.8% and 6.7%; and for the magnetic disturbance magnitude, the relative errors are 4.1% and 3.1%, re- spectively. Furthermore, the comparison among the predicted results of our two-step method with those of five other prevailing methods shows that the two-step method is advantageous. The results tell us that understanding the physical features of shock propagation thoroughly is of great importance in improving the prediction precision.

关键词： solar storm, interplanetary shock, interplanetary scintillation, two-step method, ISF method.

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Simulation study of real-time monitor for BEPC-Ⅱ luminosity

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Science china(Technological sciences) 2010年第5期53卷 1215-1219页

作者： SHAN Qing1,2.WU Jian2.XUE Zhen2.XU ZiZong2.HU Tao3.WANG YiFang3.& WANG XiaoLian2.1 College of Material Science and Technology,Nanjing University of Aeronautics and Astronautics,Nanjing 2.0016,{2. 2.Department of Modern physics,University of Science and Technology of china,Hefei 2.0}02.,{2. 3.institute of high energy physics,{12. academy of sciences,Beijing 100049,{2. College of Material Science and Technology Nanjing University of Aeronautics and Astronautics Nanjing China Department of Modern physics University of Science and Technology of China Hefei China institute of high {2. {3. Chinese Academy of Sciences Beijing China

A fast and real time luminosity monitor system will be used in the BEPC-Ⅱ(Beijing Electron Positron Collider,china).Photons generated in radiative Bhabha scattering at the interaction point are transformed into charged particles,and then the luminosity of each bunch pair is measured through collecting the Cherenkov light produced by charged particles in fused *** whole process happening in the detector is *** physics acceptance and detection threshold with the monitor accu-racy of 1% are set based on the simulation spectra of photoelectron yield calibrated by e-beam data.

关键词： luminosity BEPC-Ⅱ Cherenkov detector radiative Bhabha

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MODELLING AND NUMERICAL SOLUTIONS OF A GAUGE PERIODIC TIME DEPENDENT GINZBURG-LANDAU MODEL FOR TYPE-Ⅱ SUPERCONDUCTORS

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Journal of Computational Mathematics 1997年第4期15卷 365-384页

作者： Zhi-ming Chen (institute of Mathematics, chinese {2. of {3., Beijing, china) 中科院数学所北京

In this paper we seek the solutions of the time dependent Ginzburg-Landau model for type-Ⅱ superconductors such that the associated physical observables are spatially periodic with respect to some lattice whose basic lattice cell is not necessarily rectangular. After appropriately foring the gange, the model can be formulated as a system of nonlinear parabolic partial differential equations with quasi-periodic boundary conditions. We first give some results concerning the existence, uniqueness and regularity of solutions and then we propose a semiimplicit finite element scheme solving the system of nonlinear partial dmerential equations and show the optimal error estimates both in the L2.and energy *** also report on some numerical results at the end of the paper.

关键词： Math QT MODELLING AND NUMERICAL SOLUTIONS OF A GAUGE PERIODIC TIME DEPENDENT GINZBURG-LANDAU MODEL FOR TYPE SUPERCONDUCTORS

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Potential land for plantation of Jatropha curcas as feedstocks for biodiesel in china

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Science china Earth sciences 2010年第1期53卷 120-127页

作者： WU WeiGuang 1,2.3.HUANG JiKun 1,3.& DENG XiangZheng 1,3.1 institute of Geographic sciences and Natural Resources Research,chinese {3. of sciences,Beijing 100101,china 2.Department of Economics and Management,Zhejiang Forestry University,Linan 3.13.0,china 3.Center for chinese Agricultural Policy,chinese {3. of sciences,Beijing 100101,china 1. institute of Geographic sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China2. Department of Economics and Management Zhejiang Forestry University Linan 311300 China3. Center for Chinese Agricultural Policy Chinese Academy of Sciences Beijing 100101 China

As a renewable energy,biofuel has attracted great attention in china and the rest of *** with the national food security,{2. recently has shifted its biofuel development priority from grain-based to non-grain-based biofuels,including forest-based biodiesel,since *** curcas is one of major biodiesel ***,there is rising debate on availability of land for expanding Jatropha curcas *** overall goal of this paper is to evaluate potential land for Jatropha curcas used as feedstock for biodiesel in *** on remote sensing data on land use,data on meteorological,soil and land slope,and suitable environment for Jatropha curcas plantation,this study uses Agro Ecological Zone method and considers social-economic constraints to evaluate potential suitable land for Jatropha curcas plantation in china's major Jatropha curcas production region,Southwest *** results show that while there are some potential lands to expand Jatropha curcas areas,amount of these lands will hardly meet the government's target for Jatropha curcas-based biodiesels development in the *** may need to reconsider its long-term targets on the development of Jatropha curcas-based biodiesels.

关键词： biodiesel Jatropha curcas potential land suitability evaluation Southwest china

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Hard X-ray lags of Cygnus X-1 on short timescales

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Science china(physics,Mechanics & Astronomy) 2010年第S1期53卷 150-152页

作者： JIN Jing1,LU Yu2.3.QU JinLu2.& LI TiPei1,2.1 Department of Engineering physics & Center for Astrophysics,Tsinghua University,Beijing 100084,china 2.Key Laboratory of Particle Astrophysics,institute of high energy physics,chinese academy of sciences,Beijing 100049,china 3.Graduate University of chinese academy of sciences,Beijing 100049,china 1. Department of Engineering physics & Center for Astrophysics Tsinghua University Beijing 100084 China2. Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China3. Graduate University of Chinese Academy of Sciences Beijing 100049 China

Calculating the time lags over different timescales using the cross-correlation technique may lead to a biased estimate of small *** a timescale for lightcurve binning,we propose to subtract the local average instead of the global average during the cross-correlation,in order to filter variations on timescales larger than the bin *** new method allows us to make an unbiased estimate of the time lags using RXTE/PCA data on timescales as small as-5 ms,where the Fourier technique becomes *** calculate the time lag spectra of Cygnus X-1 at different spectral states with the new method,and find that the source appears to have similar X-ray lags on small timescales independent of its spectral states.

关键词： spectral lags Cygnus X-1 data analysis

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