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Correlation of Behavior Changes and BOLD Signal in Alzheimer-like Rat Model

Acta Biochimica et Biophysica Sinica 2004年第12期36卷 803-810页

作者： Zheng-Hui HU#, Xiao-Chuan WANG1#, Li-Yun LI3. Mai-Li LIU3. Rong LIU1, Zhiqun LING1, Qing TIAN1, Xiao-Wei TANG, Yi-Gen WU2*, and Jian-Zhi WANG1* Department of physics and Bio-X disciplinary Laboratory, Zhejiang University, Hangzhou 3.0027,China 1 Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 43.03., China 2institute of high {3. physics and Key Laboratory of Nuclear Analysis Techniques, Chinese Academy of Sciences, P.O. Box 918, beijing 10003., China 3.uhan institute of physics and Mathematics, State Key Laboratory of Magnetic Resonance and Atomic and Molecular physics, Chinese Academy of Sciences, Wuhan 43.071, China Department of physics and Bio-X disciplinary Laboratory Zhejiang UniversityHangzhou 310027China Department of Pathophysiology Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030 China Wuhan institute of physics and Mathematics State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Chinese Academy of SciencesWuhan 430071 China institute of high energy {3. and Key Laboratory of Nuclear Analysis Techniques Chinese Academy of SciencesP.O. Box 918 Beijing 100039 China

To explore a potential means for the early diagnosis of Alzheimer disease, we studied the relationship of resting T2* signal and tau hyperphosphorylation/spatial memory deficit. The rat model with tau hyperphosphorylation and spatial memory deficit was established by bilateral hippocampi injection of isoproterenol (IP). Then, the correlative alteration between resting T2* signal and spatial memory retention was assessed with blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) study and Morris Water Maze test, and Western blot was employed to confirm tau hyperphosphorylation. The analysis showed following results. (1) Tau phosphorylation at Ser3.6/Ser404 and Ser199/Ser202 was signifi- cantly increased in IP-injected rats as detected by PHF-1 and tau-1, respectively. (2) An AD-like spatial memory retention disturbance was induced at 24 h after isoproterenol injection. (3. A sensitivity threshold of resting T2* signal intensity, which separated the IP-treated rats from vehicle control, was obtained by applying linear regression analysis, and an estimated sensitivity statistical threshold was at 3..62. These results suggest that resting T2* signal may serve as a noninvasive quantitative marker in predicting AD-like spatial memory deficits and tau hyperphosphorylation.

关键词： Alzheimer disease (AD) functional magnetic resonance imaging (fMRI) isoproterenol (IP) Morris Water Maze diagnosis

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XMM-Newton observation of the eclipsing binary Algol

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Research in Astronomy and Astrophysics 2011年第4期11卷 457-470页

作者： Xue-Juan Yang Fang-Jun Lu Bemd Aschenbach Li Chen Faculty of Materials Optoelectronics and Physics Xiangtan University Xiangtan 411105China Particle Astrophysics Center Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Max-Planck-Institut fur Extraterrestrische Physik 85741 Garching Germany Department of Astronomy Beijing Normal University Beijing 100875 China

We present an XMM-Newton observation of the eclipsing binary Algol which contains an X-ray dark B8V primary and an X-ray bright K2IV secondary. The observation covered the optical secondary eclipse and captured an X-ray flare that was eclipsed by the B star. The XMM-Newton European Photon Imaging Camera and Reflection Grating Spectrometer spectra of Algol in its quiescent state are described by a two-temperature plasma model. The cool component has a temperature around 6.4× 106 K while that of the hot component ranges from 2 to 4.0× 107 K. Coronal abundances of C, N, O, Ne, Mg, Si and Fe were obtained for each component for both the quiescent and the flare phases, generally with upper limits for S and Ar, and upper limits for C, N, and O from the hot component. F-tests show that the abundances do not need to be different between the cool and the hot component and between the quiescent and the flare phase with the exception of Fe. Although the Fe abundance of the cool component remains constant at -0.14, the hot component shows an Fe abundance of -0.28, which increases to -0.44 during the flare. This increase is expected from the chromospheric evaporation model. The absorbing column density NH of the quiescent emission is 2.5 - 1020 cm-2, while that of the flare-only emission is significantly lower and consistent with the column density of the interstellar medium. This observation substantiates earlier suggestions of the presence of X-ray absorbing material in the Algol system.

关键词： stars abundance -- star binaries eclipsing -- stars flare -- stars indi-vidual Algol

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Semi-analytical analysis of the response of the air temperature over the land surface to the global vegetation distribution

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Chinese Science Bulletin 2009年第14期54卷 2499-2505页

作者： LIU Fei1,2 & CHAO JiPing3.4 1 institute of Atmospheric physics, Chinese Academy of Sciences, beijing 100029, China 2 Graduate University of Chinese Academy of Sciences,{3., China 3.National Marine Environmental Forecasting Center, beijing 100081, China 4 First institute of Oceanography, State Oceanic Administration of China, Qingdao 266061, China institute of Atmospheric physics Chinese Academy of Sciences Beijing 100029 China Graduate University of Chinese Academy of Sciences Beijing 100049 China National Marine Environmental Forecasting Center Beijing 100081 China First institute of Oceanography State Oceanic Administration of China Qingdao 266061 China

Response of the air temperature over the land surface to the global vegetation distribution is investigated, using a three-dimensional governing equation to simulate the steady, large-scale, limited amplitude perturbation of the free, inviscid and adiabatic atmosphere. The adoption of the static equation leads to a temperature governing equation in the terrain following coordinate. With the prescribed temperature as the upper boundary condition and the radiation balance as the lower boundary condition, the semi-analytical solution of the global circulation temperature can be calculated. In this article, only the air temperature (at 2 m height) over the land surface is analyzed, and the result suggests that this model can simulate the air temperature pattern over the land surface reasonably. A better simulation occurs when a simple feedback of the albedo on the temperature is included. Two sensitivity experiments are analyzed through this model. One suggests that the air temperature over the land surface descends obviously when the land surface is covered with ice all over, while another suggests that the air temperature rises a little when the land surface is covered with forest except the ice-covered area. This model appears to be a good tool to study the response of the air temperature to the vegetation distribution. Limitations of the model are also discussed.

关键词：空气温度植被分布陆地表面反应解析分析模拟模式控制方程边界条件

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Systematic study of survival probability of excited superheavy nuclei

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Science China(physics,Mechanics & Astronomy) 2011年第S1期54卷 109-113页

作者： XIA ChengJun1, SUN BaoXi1, ZHAO EnGuang2,3.& ZHOU ShanGui2,3.1College of Applied Sciences, beijing University of Technology, beijing 100124, China 2institute of Theoretical {3., Chinese Academy of Sciences, beijing 100190, China 3.enter of Theoretical Nuclear {3., National Laboratory of Heavy Ion Accelerator, Lanzhou 73.000, China Chinese Acad Sci Inst Theoret Phys Beijing 100190 Peoples R China beijing Univ Technol Coll Appl Sci Beijing 100124 Peoples R China Ctr Theoret Nucl Phys Natl Lab Heavy Ion Accelerator Lanzhou 730000 Peoples R China

The stability of excited superheavy nuclei (SHN) with 100 Z 13. against neutron emission and fission is investigated by using a statistical model. In particular, a systematic study of the survival probability against fission in the 1n-channel of these SHN is made. The present calculations consistently take the neutron separation energies and shell correction energies from the calculated results of the finite range droplet model which predicts an island of stability of SHN around Z = 115 and N = 179. It turns out that this island of stability persists for excited SHN in the sense that the calculated survival probabilities in the 1n-channel of excited SHN at the optimal excitation energy are maximized around Z = 115 and N = 179. This indicates that the survival probability in the 1n-channel is mainly determined by the nuclear shell effects.

关键词： survival probability superheavy elements island of stability neutron emission fission

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Electronic structure and magnetism of Fe-doped SiC nanotubes

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Science China(physics,Mechanics & Astronomy) 2010年第9期53卷 1582-1589页

作者： ZHANG WeiHu1,2,3.ZHANG FuChun3.ZHANG ZhiYong4,LU ShuYuan5 & YANG YanNing3.1 Xi’an institute of Optics and Precision Mechanics,Chinese Academy of Sciences,Xi’an 710068,China 2 Graduate University of Chinese Academy of Sciences,beijing 100049,China 3.College of {3. and Electronic Information,Yan’an University,Yan’an 716000,China 4 Information Science and Technology Institution,Northwest University,Xi’an 710127,China 5 Department of Telecommunications,Xi’an institute of Posts and Telecommunications,Xi’an 710121,China 1. Xi’an institute of Optics and Precision Mechanics Chinese Academy of Sciences Xi’an 710068 China2. Graduate University of Chinese Academy of Sciences Beijing 100049 China3. College of Physics and Electronic Information Yan’an University Yan’an 716000 China4. Information Science and Technology Institution Northwest University Xi’an 710127 China5. Department of Telecommunications Xi’an Institute of Posts and Telecommunications Xi’an 710121 China

The electronic structure and magnetic properties of Fe-doped SiC nanotubes are investigated by using the first-principles method based on density functional theory(DFT) in the local spin density approximation(LSDA).The calculation results indicate that the SiC nanotube of Fe substitution for C exhibits antiferromagnetism while ferromagnetism features prominently when Fe substitutes *** is a kind of half-metal magnetic *** formation energy calculation results show that the formation energy of ferromagnetic structure is 3.2 eV lower than that of antiferromagnetic *** atoms are more likely to replace Si ***-orbit coupling induces electron spin polarization in the ground ***,the doping Fe atoms make relaxation towards the outside of the tube to some extent and larger geometric distortion occurs when Fe substitutes C,but the whole geometric structure of SiC nanotubes is not damaged due to the *** is revealed in the calculation of energy band structure and density of states that more dispersed distribution of energy levels is produced near the Fermi *** Fe substitution for Si,obviously there are spin-split and intense p-d hybrid effects by Si 3. electron spins and Fe 3. electron spins localized at the exchanging interactions between magnetic transitional metal(TM) *** electronic density results indicate that system magnetic moments are mainly generated by the unpaired 3. electrons of Fe *** these results show that the transition metal doping SiC nanotube could be a potential route to fabricating the promising magnetic materials.

关键词： SiC nanotube the first-principles doped magnetic properties

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CMS muon trigger system

CMS muon trigger system

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第13.全国计算机、网络在现代科学技术领域的应用学术会议

作者： Mingshui Chen Chunhua Jiang (institute of high energy {3.,beijing,100049)

The LHC at CERN will provide proton-proton collisions at a centre-of-mass energy of 14 TeV with a bunch crossing space of *** will reach IGHz for inelastic proton-proton interaction rate at the design luminosity of *** CMS experiment has a multi-level trigger system to reduce this rate to about *** architecture of muon trigger system is described.

关键词： CMS muon trigger

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Structural stability of infinite-layer CaCuO_2 under high pressure

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Chinese Science Bulletin 2003年第12期48卷 1201-1203页

作者： QIN Xiaomei1,2, HONG Ming1,2, ZHANG Gongmu1,2, MAI Wenjie1,2, LI Fengying1,2, YU Richeng1,2, LIU Jing2,3.& JIN Changqing1,2 1. institute of physics, Chinese Academy of Sciences, beijing 100080, China 2. beijing high Pressure Research Center, beijing 100080, China 3. institute of high energy physics, Chinese Academy of Sciences, beijing 10003., China Correspondence should be addressed to Jin Changqing (e-mail: cqjin@ ***) institute of physics Chinese Academy of Sciences Beijing 100080 China beijing high Pressure Research Center Beijing 100080 China institute of high energy {3. Chinese Academy of Sciences Beijing 100039 China

In situ high-pressure energy dispersive X-ray diffraction measurements on polycrystalline powder Ca-CuO2 with an infinite layer structure (IL CaCuO2) have been performed by using diamond anvil cell (DAC) instrument with synchrotron radiation. The results suggest that the crystal structure of IL CaCuO2 is stable under pressure up to 3. GPa at room temperature. According to Birch-Murn- aghan equation of state, assuming pressure derivative 4,=0Bthe bulk modulus B0=181 ?9 GPa is obtained.

关键词： infinite-layer CaCuO2 synchrotron radiation high pressure energy dispersive X-ray diffraction.

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A REVIEW OF THE STATUS OF THEORETICAL STUDY ON D-physics(I)

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中国科学院研究生院学报 1991年第2期8卷 74-93页

作者： Guo Xinheng(institute of high energy {3., Academia Sinica, beijing) Li Xueqian({3. Department, Nankai University, Tianjing, China)

In this review, the theorelical study on D-physics is summarized including D-(?) mixing, D meson decays, diquark contributions to D-physics, 1/Nc expansion, final state interactions and some discussions about BEPC and... 详细信息

关键词： theoretical study D-physics summary

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A Review of the Status of Theoretical Study on D-physics(Ⅱ)

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中国科学院大学学报 1992年第1期 89-105页

作者： Guo Xinheng (institute of high energy {3.,Academia Sinica,beijing)Li Xueqian ({3. Department,Nankai University,Tianjing,China)

In this review,the theoretical study on D-physics is summarized including D-D mixing,D meson decays,diquark contributions toD-physics,1/Nexpansion,final state interactions and some discussionsabout BEPC and BES.

关键词： review theoretical study D-physics

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Comparison study of trapped water in human erythrocytes by EPC and DSC method and its application

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Science China(Technological Sciences) 2004年第3期47卷 343-351页

作者： ZHAO Gang1, HE Liqun1, GUO Xiaojie2, LIU Zhong3. LUO Dawei1,3.& GAO Dayong1,3.1. Cryobiomedical Engineering Research institute, Department of Thermal Science and energy Engineering, University of Science and Technology of China, Hefei 23.027, China 2. Red Cross Blood Center of Hefei, Hefei 23.022, China 3. Department of Mechanical Engineering, University of Kentucky, Lexington, KY 40506-0108, USA Univ Sci & Technol China Cryobiomed Engn Res Inst Dept Thermal Sci & Energy Engn Hefei 230027 Peoples R China Red Cross Blood Ctr Hefei Hefei 230022 Peoples R China Univ Kentucky Dept Mech Engn Lexington KY 40506 USA

The novel differential scanning calorimetry method for determining trapped water volume of human red blood cell during freezing process has been reexamined. Results show that the final erythrocyte volume is 53. of its isotonic volume after freezing to -40℃. An electronic particle counter (MultisizerTM III, Beckman Coulter Inc., USA) was used to measure cell volume changes in response to hypertonic solution. Using this approach, when extracellular solution was 3.86 mOsm, the equilibrium cell volume was found to be 57% of its isotonic value. Both results indicate that 3.%—40% of intracellular water is trapped and cannot respond to osmotic difference between intra- and extracellular solution. These findings are consistent with the published data: at least 20%—3.% of the isotonic cell water volume is retained within RBCs during freezing. Some applications of the values of trapped water are addressed.

关键词： differential scanning calorimeter/DSC, electronic particle counter/EPC, cell volumetric change, red blood cell/RBC/erythrocyte

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