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Correlation of Behavior Changes and BOLD Signal in Alzheimer-like Rat Model

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Acta Biochimica et Biophysica Sinica 2004年第12期36卷 803-810页

作者： Zheng-Hui HU#, Xiao-Chuan WANG1#, Li-Yun LI3. Mai-Li LIU3. Rong LIU1, Zhiqun LING1, Qing TIAN1, Xiao-Wei TANG, Yi-Gen WU2*, and Jian-Zhi WANG1* Department of physics and Bio-X disciplinary Laboratory, Zhejiang university, Hangzhou 3.0027,China 1 Department of Pathophysiology, Tongji Medical College, Huazhong university of Science and Technology, Wuhan 43.03., China 2{3. of High Energy physics and Key Laboratory of Nuclear Analysis Techniques, Chinese Academy of Sciences, P.O. Box 918, Beijing 10003., China 3.uhan {3. of physics and Mathematics, State Key Laboratory of Magnetic Resonance and atomic and molecular physics, Chinese Academy of Sciences, Wuhan 43.071, China Department of physics and Bio-X disciplinary Laboratory Zhejiang UniversityHangzhou 310027China Department of Pathophysiology Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030 China Wuhan institute of physics and Mathematics State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Chinese Academy of SciencesWuhan 430071 China institute of High Energy physics and Key Laboratory of Nuclear Analysis Techniques Chinese Academy of SciencesP.O. Box 918 Beijing 100039 China

To explore a potential means for the early diagnosis of Alzheimer disease, we studied the relationship of resting T2* signal and tau hyperphosphorylation/spatial memory deficit. The rat model with tau hyperphosphorylation and spatial memory deficit was established by bilateral hippocampi injection of isoproterenol (IP). Then, the correlative alteration between resting T2* signal and spatial memory retention was assessed with blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) study and Morris Water Maze test, and Western blot was employed to confirm tau hyperphosphorylation. The analysis showed following results. (1) Tau phosphorylation at Ser3.6/Ser404 and Ser199/Ser202 was signifi- cantly increased in IP-injected rats as detected by PHF-1 and tau-1, respectively. (2) An AD-like spatial memory retention disturbance was induced at 24 h after isoproterenol injection. (3. A sensitivity threshold of resting T2* signal intensity, which separated the IP-treated rats from vehicle control, was obtained by applying linear regression analysis, and an estimated sensitivity statistical threshold was at 3..62. These results suggest that resting T2* signal may serve as a noninvasive quantitative marker in predicting AD-like spatial memory deficits and tau hyperphosphorylation.

关键词： Alzheimer disease (AD) functional magnetic resonance imaging (fMRI) isoproterenol (IP) Morris Water Maze diagnosis

Stability of Titanium-aluminium Nitride (Ti_2AlN) at High Pressure and High Temperatures

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Journal of Wuhan university of Technology(Materials Science) 2011年第5期26卷 914-919页

作者：安佩寇自力 institute of atomic and molecular {3. Sichuan University

The stability of Ti2AlN at high pressure of 5 GPa and different temperatures of 700-1 600 ℃ was investigated using X-ray diffraction （XRD）,scanning electron microscopy （SEM） equipped with an energy dispersive spectrometer （EDS）.Ti2AlN was found to be stable at temperatures as high as 1 400 ℃under 5 GPa for 20 min,and was proved that it held better structure stability than Ti2AlC under 5 GPa through comparative experiments of Ti2AlN and Ti2AlC （representative compounds of M2AX phases （211 phase））.The reaction process at high pressure had some difference from that at ambient pressure/vacuum,and Ti2AlN directly decomposed to TiN and TiAl at 5 GPa and 1 500 ℃ for 20 ***,the mechanism of phase segregation was *** addition,the behavior of Ti2AlN contacting with Zr at high pressure and high temperature （HPHT） was also studied.

关键词： Ti2AlN high pressure and high temperature stability X-rMechanism and Kinetic Model of

Numerical experiment of anharmonic oscillators by using the symplectic scheme-shooting method

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原子与分子物理学报 2002年第2期19卷 119-125页

作者： LIU Xue-shen, DING Pei-zhu (institute of atomic and molecular {3., Jilin university, Changchun 13.023. P.R.China) institute of atomic and molecular {3. Jilin University Changchun 130023

Symplectic scheme-shooting method (SSSM) is applied to solve the energy eigenvalues of anharmonic oscillators characterized by the potentials V(x)=λx 4 and V(x)=(1/2)x 2+λx 2α with α=2,3.4 and doubly anharmonic oscillators characterized by the potentials V(x)=(1/2)x 2+λ 1x 4 +λ 2x 6, and a high order symplectic scheme tailored to the "time"-dependent Hamiltonian function is presented. The numerical results illustrate that the energy eigenvalues of anharmonic oscillators with the symplectic scheme-shooting method are in good agreement with the numerical accurate ones obtained from the non-perturbative method by using an appropriately scaled basis for the expansion of each eigenfunction; and the energy eigenvalues of doubly anharmonic oscillators with the sympolectic scheme-shooting method are in good agreement with the exact ones and are better than the results obtained from the four-term asymptotic series. Therefore, the symplectic scheme-shooting method, which is very simple and is easy to grasp, is a good numerical algorithm.

关键词： SSSM 量子力学哈密顿量数值实验非线性振荡能量特征

MORPHOLOGICAL STUDY ON THE ORIENTED CHITOSAN FILM OBTAINED FROM PRE-SHEARED LIQUID CRYSTALLINE SOLUTION IN DICHLOROACETIC ACID

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Chinese Journal of Polymer Science 2001年第4期19卷 385-390页

作者： Zhong-ming Hu Li-heng Wu Da-cheng Wu Shou-xi Chen State Key Laboratory of Polymer physics and Chemistry, Center for molecular Science, institute of Chemistry Chinese Academy of Sciences, Beijing 100080, China China Textile Academy Beijing 100025, China Textile College,{3. chengdu 610065, China 中科院化学所高分子物理与化学国家重点实验室北京中国纺织研究院北京四川大学四川成都

The oriented chitosan films obtained from pre-sheared liquid crystalline chitosan/dichloroacetic acid (DCA) solutions were studied by means of polarized optical microscopy (POM), scanning electron microscopy (SEM), infra-red dichroism technique and wide angle X-ray diffraction (WAXD). The sheer induced band texture in the film was found to correspond to the sinusoidal fibrillar microstructure along the shearing direction on the basis of POM and SEM observations. The sinusoidal fibril was found to be lying within the film plane. The model of chitosan molecular orientation in the pre-sheared film with band texture can be established assuming that the main chain orients in the shearing direction and the side group is perpendicular to the shearing direction. The WAXD azimuthal scanning at 2 theta = 20 degrees indicates that the (002) plane orients perpendicular to the shearing direction.

关键词： chitosan morphology orientation shear induced band texture liquid crystalline solution

MEASUREMENTS　OF　Fe　AND　Cu　K-Shell　IONIZATION　CROSS　SECTIONS　BY　SLOW　ELECTRON　IMPACT

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原子与分子物理学报 1997年第1期 70-74页

作者： Li Taihua An Zhu Luo Zhengming Center for Radiation physics, institute of Nuclear Science and Technology, sichuan Union {3. chengdu 610064

ＭＥＡＳＵＲＥＭＥＮＴＳＯＦＦｅＡＮＤＣｕＫ－ＳｈｅｌＩＯＮＩＺＡＴＩＯＮＣＲＯＳＳＳＥＣＴＩＯＮＳＢＹＳＬＯＷＥＬＥＣＴＲＯＮＩＭＰＡＣＴＬｉＴａｉｈｕａＡｎＺｈｕＬｕｏＺｈｅｎｇｍｉｎｇＣｅｎｔｅｒｆｏｒＲａｄ... 详细信息

ＭＥＡＳＵＲＥＭＥＮＴＳＯＦＦｅＡＮＤＣｕＫ－ＳｈｅｌＩＯＮＩＺＡＴＩＯＮＣＲＯＳＳＳＥＣＴＩＯＮＳＢＹＳＬＯＷＥＬＥＣＴＲＯＮＩＭＰＡＣＴＬｉＴａｉｈｕａＡｎＺｈｕＬｕｏＺｈｅｎｇｍｉｎｇＣｅｎｔｅｒｆｏｒＲａｄｉａｔｉｏｎＰｈｙｓｉｃｓ，Ｉｎｓ...

关键词： Electron induced K shell ionization cross sections Thin target with thick substrate Electron transport

氦对LaNi5晶体结构的影响及其扩散特性研究

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物理学报 2008年第7期57卷 4379-4385页

作者：张传瑜高涛张云光周晶晶朱正和陈波四川大学原子与分子物理研究所中国工程物理研究院核物理与化学研究所绵阳621900

从密度泛函理论为基础的第一性原理出发,运用全势能线性缀加平面波(FLAPW)方法,对氚衰变后氦在合金中的占位以及LaNi5He晶体结构进行了理论计算,并系统给出了氦在间隙间的迁移曲线.结果表明,氦原子在十二面体(1b)格位最稳定,并且氦从6m... 详细信息

从密度泛函理论为基础的第一性原理出发,运用全势能线性缀加平面波(FLAPW)方法,对氚衰变后氦在合金中的占位以及LaNi5He晶体结构进行了理论计算,并系统给出了氦在间隙间的迁移曲线.结果表明,氦原子在十二面体(1b)格位最稳定,并且氦从6m格位向1b格位迁移不存在势垒,而从2d格位向1b格位迁移则需越过1.55eV高的势垒.另外,氦从12n格位穿过12o格位最后到达6m格位也无明显势垒存在,并且处于4h格位之间的氦原子可以自由迁移,而相应12n格位之间的直接迁移则需跨越13.6eV高的势垒.最后还计算给出了氚衰变后合金的态密度、电子密度以及势能分布图,并与相应的LaNi5H结构作了详细比较.

关键词：全势能线性缀加平面波(FLAPW) LaNi5He 态密度扩散

Satellites in Photoionizationof atomic Sodium

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原子与分子物理学报 1995年第4期 399-402页

作者： Yang Xiangdong Liu Jinchao Wang WanpingYang Feng Xie Wen Cheng Xinlu(sichuan Union university chengdu 610065)

ＳａｔｅｌｌｉｔｅｓｉｎＰｈｏｔｏｉｏｎｉｚａｔｉｏｎｏｆＡｔｏｍｉｃＳｏｄｉｕｍ￥ＹａｎｇＸｉａｎｇｄｏｎｇ；ＬｉｕＪｉｎｃｈａｏ；ＷａｎｇＷａｎｐｉｎｇＹａｎｇＦｅｎｇ；ＸｉｅＷｅｎＣｈｅｎｇＸｉｎｌｕ（Ｓｉｃｈ... 详细信息

ＳａｔｅｌｌｉｔｅｓｉｎＰｈｏｔｏｉｏｎｉｚａｔｉｏｎｏｆＡｔｏｍｉｃＳｏｄｉｕｍ￥ＹａｎｇＸｉａｎｇｄｏｎｇ；ＬｉｕＪｉｎｃｈａｏ；ＷａｎｇＷａｎｐｉｎｇＹａｎｇＦｅｎｇ；ＸｉｅＷｅｎＣｈｅｎｇＸｉｎｌｕ（ＳｉｃｈｕａｎＵｎｉｏｎＵｎｉｖｅｒｓｉｔ...

关键词： Photoionization Excitation Many-body perturbation theory

用多极矩展开方法计算H_2分子间的相互作用对势

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四川大学学报（自然科学版） 2004年第4期41卷 795-798页

作者：张红何英杰程新路杨向东胡栋四川大学物理科学与技术学院成都610065 四川大学原子与分子物理研究所成都610065 四川大学高温高压物理研究所成都610065

分子间相互作用对势是利用分子动力学研究物态性质的重要基础 .作者利用多极矩展开方法 ,获得了H2 -H2 的从头算相互作用对势 .采用从头算分子结构程序 ,先计算了 3.不同数目特定构型下的相互作用势 ,再由此获取多极矩的展开系数 ,构... 详细信息

分子间相互作用对势是利用分子动力学研究物态性质的重要基础 .作者利用多极矩展开方法 ,获得了H2 -H2 的从头算相互作用对势 .采用从头算分子结构程序 ,先计算了 3.不同数目特定构型下的相互作用势 ,再由此获取多极矩的展开系数 ,构造相互作用对势 ,并对不同的展开方法下获取的H2 -H2 的相互作用对势进行了分析比较 .

关键词：从头算相互作用对势多极矩展开方法氢分子

The potential energy curves for the two structures of H4(英文)

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原子与分子物理学报 2000年第2期17卷 256-260页

作者： GOU Qing quan, ZHOU Qi nian (institute of atomic and molecular {3., sichuan university, chengdu, Peoples Republic of China) 中科院大气物理所北京成都

Two potential energy curves for the tetrahedron structure and the centered equilateral triangle structure of the H 4 system are calculated by a simple method. The results of the calculation show that the tetrahedron s... 详细信息

关键词： cluster of hydrogen atoms potential energy curves arrangement channel quantum mechanies