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血液透析患者相关并发症和中性粒细胞与淋巴细胞比值关系的研究进展

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中国血液净化 2024年第4期23卷 290-293页

作者：李甜伍杨何喜梅万立平王学良苑书婷席春生甘肃中医药大学第一临床医学院兰州730000 中国人民解放军联勤保障部队第九四〇医院肾脏病科兰州730050

近年来,中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)已被公认为一种新型预测生物标志物,由于其创伤小、经济、简便、敏感性和特异性高等优点,在心血管疾病、肾脏疾病、自身免疫性疾病等预后指标中广泛应用。血液透析... 详细信息

近年来,中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)已被公认为一种新型预测生物标志物,由于其创伤小、经济、简便、敏感性和特异性高等优点,在心血管疾病、肾脏疾病、自身免疫性疾病等预后指标中广泛应用。血液透析(haemodialysis,HD)作为危重症或晚期肾病患者延长寿命的治疗手段,不可避免会导致很多并发症,因此及时识别和治疗HD相关并发症至关重要。有研究发现在HD相关并发症中NLR似乎具有一定的识别和预测能力,故本综述通过总结当前HD患者相关并发症中NLR研究进展,为临床医生评估HD患者相关并发症的发生和预后提供依据。

关键词：血液透析中性粒细胞与淋巴细胞比值并发症研究进展

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9-硝基喜树碱胶囊在肿瘤病人体内的药动学

中国新药与临床杂志 2009年第5期28卷 346-350页

作者：朱仲玲阎昭王华庆薛津怀杨华郝希山天津医科大学附属肿瘤医院、天津市“肿瘤防治”重点实验室天津300060

目的评价单次和连续口服9-硝基喜树碱胶囊在肿瘤病人体内的药动学特征。方法恶性肿瘤病人随机分为:单次给药(n=22)分3.,给药剂量分别为1.25、1.5和1.75mg·m-2;连续给药(n=13.分3.,每日给药剂量分别为1.25、1.5和1.75mg·m-2,连续服... 详细信息

目的评价单次和连续口服9-硝基喜树碱胶囊在肿瘤病人体内的药动学特征。方法恶性肿瘤病人随机分为:单次给药(n=22)分3.,给药剂量分别为1.25、1.5和1.75mg·m-2;连续给药(n=13.分3.,每日给药剂量分别为1.25、1.5和1.75mg·m-2,连续服用4d。HPLC-UV法测定人血浆中9-硝基喜树碱的浓度,采用DAS2.0药动学软件分析和计算药动学参数。结果单次给药3.剂量组ρmax分别为(76±s49)、(81±3.)和(98±3.)μg·L-1,AUC0～24h分别为(0.5±0.3.、(0.8±0.5)和(0.9±0.4)mg·h·L-1;连续给药3.剂量组ρssav分别为(75±108)、(43.28)和(56±46)μg·L-1,AUCss分别为(1.8±2.6)、(1.0±0.7)及(1.3.1.1)mg·h·L-1。体内未见药物蓄积。结论在1.25～1.75mg·m-2剂量范围内,9-硝基喜树碱的ρmax和AUC0～24h随着给药剂量的增加而增加。

关键词：喜树碱药动学色谱法高压液相肿瘤 9-硝基喜树碱

基于网络药理学和裸鼠实验探讨芪术增力方治疗癌因性疲乏的作用机制

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中国中医基础医学杂志 2024年第7期30卷 1173-1177页

作者：卢茜罗溢昌许双洁王云启广州中医药大学广州510000 广州医科大学附属中医医院广州510000 湖南省肿瘤医院长沙410013

目的观察芪术增力方对裸鼠癌因性疲乏的影响,探讨其可能的作用机制。方法在TCMSP平台搜索芪术增力方活性成分,通过Uniprot数据库转化为相关靶点;在Gene Cards数据库、OMIM数据库、DrugBank数据库搜索癌因性疲乏相关靶点,通过Jvenn平台... 详细信息

目的观察芪术增力方对裸鼠癌因性疲乏的影响,探讨其可能的作用机制。方法在TCMSP平台搜索芪术增力方活性成分,通过Uniprot数据库转化为相关靶点;在Gene Cards数据库、OMIM数据库、DrugBank数据库搜索癌因性疲乏相关靶点,通过Jvenn平台绘制药物、疾病靶点交集图,String平台制作蛋白质互作网络(protein-protein interaction networks,PPI),Metascape平台进行GO和KEGG富集分析,选取癌症蛋白聚糖(proteoglycans in cancer)信号通路进行研究。将25只裸鼠随机分为空白组、模型组、中药组、化疗组(顺铂)及地塞米松组。构建癌因性疲乏模型,干预3.后,ELISA法检测裸鼠瘤体内磷脂酰肌酶聚糖受体(glypican,GPC)1、GPC5、多配体蛋白聚糖(syndecan,SDC)2、丝甘蛋白聚糖(serglycin gene,SRGN)表达;观察光镜下各组裸鼠瘤体组织的病理形态。结果与模型组比较,中药组及化疗组的GPC1水平显著降低(P<0.01);中药组SDC2水平降低(P<0.05);中药组、化疗组、地塞米松组瘤体内SRGN水平均降低(P<0.05)。结论芪术增力方通过降低裸鼠瘤体内GPC1、SDC2、SRGN水平达到缓解疲乏的效果,其机制可能与抑制肿瘤生长、转移有关。

关键词：网络药理学癌因性疲乏芪术增力方肺复康方蛋白聚糖

Roles of integrin β3.cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition model

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Frontiers of Medicine 2016年第3期10卷 311-319页

作者： Jiansong Huang Yulan Zhou xiaoyu Su Yuanjing Lyu Lanlan Tao xiaofeng Shi Ping Liu Zhangbiao Long Zheng Ruan Bing xiao Wenda xi Quansheng Zhou Jianhua Mao xiaodong xi State Key Laboratory of medical Genomics Shanghai Institute of Hematology Collaborative Innovation Center of Hematology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Institute of Hematology The First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Department of Hematology The First Affiliated Hospital of Nanchang University Nanchang 330006 China Department of Hematology Affiliated Hospital of Jiangsu University Zhenjiang 212001 China Department of Pediatrics Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200001 China Department of Hematology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100073 China Shanghai Institute of Hypertension Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Cyrus Tang Hematology Center Jiangsu Institute of Hematology 2011 Collaborative Innovation Center of Hematology Soochow University Suzhou 215123 China Sino-French Research Centre for Life Sciences and Genomics Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

We evaluated the roles of calpain cleavage-related mutations of the integrin β3.cytoplasmic tail in integrin αIIbβ3.bidirectional signaling using a trans-dominant inhibition model. Chimeric Tac-β3.proteins （i.e., Tac-β3. Tac-β3.741, Tac-β3.747, Tac-β3.754, Tac-β3.759, and Tac-β3.NITY） consisting of the extracellular and transmembrane domains of human IL-2 receptor （Tac） and the human integrin β3.cytoplasmic domain were stably expressed in the 123.CHO cells harboring human glycoprotein Ib-IX and wild-type integrin uIIbβ3. The different cells were assayed for stable adhesion and spreading on immobilized fibrinogen, and for binding soluble fibrinogen representing outside-in and inside-out signaling events, respectively. The chimeric protein Tac-β3.inhibited, and Tac-β3.NITY partially attenuated stable adhesion and spreading. Tac-β3. Tac-β3.759, Tac-β3.NITY, and Tac-β3.754, but not Tac-β3.747 or Tac-β3.741, impaired the soluble fibrinogen binding. Results indicated that the bidirectional signaling was significantly inhibited by Tac-β3. and Tac-β3.NITY, albeit to a much lesser extent. Moreover, only inside-out signaling was impaired in the 123.Tac-β3.759 and 123.Tac-β3.754 cells in contrast to an intact bidirectional signaling in the 123.Tac-β3.747 and 123.Tac-β3.741 cells. In conclusion, the calpain cleavage of integrin β3.resulted in the regulatory effects on signaling by interrupting its interaction with cytoplasmic proteins rather than altering its conformation, and may thus regulate platelet function.

关键词： integrin β3 signal transduction tmns-dominant inhibition model

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微视野计在偏心注视性弱视诊治中的应用

国际眼科纵览 2024年第1期48卷 60-63页

作者：王韶奕王佳薇席瑞洁柴松河北医科大学第二医院眼科石家庄050000

弱视是儿童常见眼病,根据注视性质可分为中心注视性弱视及偏心注视性弱视。偏心注视性弱视治疗效果差,且容易贻误最佳治疗时机。如何及时诊断并规范系统地治疗偏心注视性弱视是十分必要的,微视野技术的出现为解决这一难题提供了新的思... 详细信息

弱视是儿童常见眼病,根据注视性质可分为中心注视性弱视及偏心注视性弱视。偏心注视性弱视治疗效果差,且容易贻误最佳治疗时机。如何及时诊断并规范系统地治疗偏心注视性弱视是十分必要的,微视野技术的出现为解决这一难题提供了新的思路。本文针对偏心注视性弱视近年临床治疗进展进行综述,希望能对偏心注视性弱视的诊疗提供帮助。

关键词：弱视偏心注视微视野计

Cardiac injury in patients with pandemic 2009 influenza A(H1N1) infection

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Cardiac injury in patients with pandemic 2009 influenza A(H1...

2011年浙江省心电生理与起搏学术年会

作者： Department of Cardiology,First Affiliated Hospital,College of Medicine,Zhejiang university, Institute of Cardiology,Zhejiang university,Hangzhou,People’s Republic of china. Qiqi Wang Yuangang Qiu TaoWu Lili Zhao Department of Emergency,First People’ s Hospital of Hangzhou,Zhejiang Province,People’s Republic of china. Ziying Ni Zhidong Guo Department of Infectious Diseases,First Affiliated Hospital,College of Medicine,Zhejiang university, Institute of Infectious Diseases,Zhejiang university,Hangzhou,People’s Republic of china. Yida Yang Department of Respiratory Diseases,First Affiliated Hospital,College of Medicine, Zhejiang university,Hangzhou,People’s Republic of china. xi Chen

Background In March 2009,novel 2009 influenza A(HlNl) was first reported in the southwest Mexico, and rapidly spread *** investigated the clinical features of cardiovascular involvement of patients infected with the 2009 influenza A(HlNl) virus in china. Methods It was a retrospective *** hundred and seventy-two patients with 2009 influenza A(HlNl) of different severity(non-severe,severe,critically severe) and 21 patients who were influenza A(HlNl)- negative but who had an influenza-like illness were *** was obtained for measurement of the concentration of creatine kinase(CK),creatine kinase-MB(CK-MB) and high sensitivity C-reactive protein(hs-CRP) in plasma. Chest radiography was also undertaken to calculate the cardiothoracic ratio(CTR). Results Influenza A(HlNl) caused more illness in middle-aged *** patients in the non-severe group were younger than those in the severe group(p<0.05) and the non-influenza A(HlNl) group(p<0.01).The level of CK,CK-MB,hs-CRP and the CTR was higher in the critically severe group than in the other three groups (p<0.001,p<0.05,p<0.01,p<0.01,respectively). Conclusions Myocardial injury was quite serious in severe infection by the influenza A(HlNl) virus, particularly in critically severe *** with 2009 influenza A(HlNl) had injury and dilation of the heart,which may be a potential cause of death.

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人输卵管细胞对精子存活的影响

生殖医学杂志 2002年第4期11卷 222-225页

作者：周寒鹰姚元庆尹国武黄飞杨瑛罗亚宁西安第四军医大学唐都医院妇产科第四军医大学唐都医院妇产科西安710038

目的 :研究人输卵管细胞对精子存活的影响。方法 :人精子与人输卵管细胞进行体外共培养 ,并以 Earle' s平衡盐液培养的精子作为对照。每日观察精子存活情况 ,并以伊红染色检测精子的存活率。结果 :在共培养组 ,人精子存活时间明显高于... 详细信息

目的 :研究人输卵管细胞对精子存活的影响。方法 :人精子与人输卵管细胞进行体外共培养 ,并以 Earle' s平衡盐液培养的精子作为对照。每日观察精子存活情况 ,并以伊红染色检测精子的存活率。结果 :在共培养组 ,人精子存活时间明显高于对照组 ( P3..55± 5.3.6) %、( 46.46± 4.59) %、( 1 8.3.6± 4.1 1 ) % ,差异显著 ( P均 <0 .0 1 )。结论 :人输卵管细胞及其培养液能延长精子的存活时间。

关键词：人输卵管细胞精子共培养存活率

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胸部爆震伤3.救治分析并文献复习

海军军医大学学报 2024年第1期45卷 127-131页

作者：王俊男奚望黎涛王云颜荣林单红卫侯立军王志农海军军医大学(第二军医大学)第二附属医院胸心外科上海200003 中国人民解放军海军第九七一医院胸心外科青岛266071 海军军医大学(第二军医大学)第二附属医院胃肠外科上海200003 海军军医大学(第二军医大学)第二附属医院急救科上海200003 海军军医大学(第二军医大学)第二附属医院神经外科上海200003

战争、恐怖袭击中爆炸性武器(如炸药、燃料空气炸弹及航弹等)爆炸、日常工业生产和生活突发爆炸事件(如瓦斯爆炸、煤气爆炸等)产生的冲击波、高能碎片、热能等作用于机体发生的冲击伤、烧伤、吸入性损伤等多因素复合性损伤统称为爆震伤... 详细信息

战争、恐怖袭击中爆炸性武器(如炸药、燃料空气炸弹及航弹等)爆炸、日常工业生产和生活突发爆炸事件(如瓦斯爆炸、煤气爆炸等)产生的冲击波、高能碎片、热能等作用于机体发生的冲击伤、烧伤、吸入性损伤等多因素复合性损伤统称为爆震伤[1]。

关键词：胸部爆震伤临床特征治疗策略

Preparation and Identification of Rat Monoclonal Anti-idiotope Antibody to the Antibody against Erythrocytic Stages of Plasmodium Falciparum

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Journal of medical Colleges of PLA(china) 1989年第1期4卷 57-59页

作者：李纪良巢穗欧阳明辉李英杰 Department of Malaria Immunology First Military Medical University Guangzhou

A hybridoma cell line secreting monoclonal antibody to idiotope of the monoclonalantibody 94D1 specific for asexual erythrocytic stages of Plasmodium falciparum was established byfusion of SP2/0 mouse myeloma cells with spleen cells of Wistar rats immunized with monoclonalIgG of 94D1 purified from ascitic fluid of BALB/C mouse by affinity chromatography on ProteinA- Sepharose CL- 4B. Specificity of the anti - idiotope antibody (anti - Id), 41RF5, was deter-mined with indirect enzyme-linked immunosorbent assay (ELISA). The results showedthat 41RF5 reacted only with 94D1 IgG2b, not with normal mouse IgG and other seven mousemonoclonal antibodies - five specific for erythrocytic stages of P. falciparum, one for erythrocyticstages of P. inui, and one for Dengue fever virus type III, which indicates that 41RF5 does recognizespecifically the idiotope of 94D1 monoclonal antibody. In 41RF5 heterohybrid culture supernatant,anti-Id titre measured by ELISA was above 1:1 280. Up to the present, the heterohybrid cell linehas been cultured stably for 16 months.

关键词： idiotype monoclonal anti-idiotope antibody mouse-rat heterohybridoma Plasmodium falciparum