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Material basis for inhibition of Dragon's Blood on evoked discharges of wide dynamic range neurons in spinal dorsal horn of rats

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Science china(Life Sciences) 2008年第11期51卷 1025-1038页

作者： GUO Min, CHEN Su & LIU XiangMing department of Biological & Medical Engineering, South-Central university for Nationalities, Wuhan 43.074, china department of Biological & Medical Engineering South-Central University for Nationalities Wuhan China

In vivo experiments were designed to verify the analgesic effect of Dragon’s Blood and the material basis for this effect. Extracellular microelectrode recordings were used to observe the effects of Dragon’s Blood and various combinations of the three components (cochinchinenin A, cochinchinenin B, and loureirin B) extracted from Dragon’s Blood on the discharge activities of wide dynamic range (WDR) neurons in spinal dorsal horn (SDH) of intact male Wistar rats evoked by electric stimulation at sciatic nerve. When the Hill's coefficients describing the dose-response relations of drugs were dif-ferent, based on the concept of dose equivalence, the equations of additivity surfaces which can be applied to assess the interaction between three drugs were derived. Adopting the equations and Tal-larida's isobole equations used to assess the interaction between two drugs with dissimilar dose-response relations, the effects produced by various combinations of the three components in modulating the evoked discharge activities of WDR neurons were evaluated. Results showed that Dragon’s Blood and its three components could inhibit the evoked discharge frequencies of WDR neurons in a concentration-dependent way. The Hill's coefficients describing dose-response relations of three components were different. Only the combined effect of cochinchinenin A, cochinchinenin B and loureirin B was similar to that of Dragons Blood. Furthermore, the combined effect was synergistic. This investigation demonstrated that through the synergistic interaction of the three components Dragon’s Blood could interfere with the transmission and processing of pain signals in spinal dorsal horn. All these further proved that the combination of cochinchinenin A, cochinchinenin B, and loureirin B was the material basis for the analgesic effect of Dragon’s Blood.

关键词： Dragon’s Blood material basis for the efficacy extracellular microelectrode recordings wide dynamic range neurons interaction between drugs

THE PERTURBATION SOLUTIONS OF THE FLOW IN A ROTATING CURVED ANNULAR PIPE

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Journal of Hydrodynamics 2001年第1期13卷 75-80页

作者： Zhang Ben-zhao, Chen Qian, Zhang Jin-suo, Cui Liang-chen department of Mechanics, Zhejiang university, Hangzhou, 3.0027, china[WT5”HZ] Dep. of Mechanics Zhejiang Univ. Hangzhou 310027 China

WT5”BZ]In this paper, the flow in a rotating curved annular pipe is examined by a perturbation method. A second order perturbation solution is presented. The characteristics of the secondary flow and the axial flow are studied in detail. The study indicates that the loops of the secondary flow are more complex than those in a curved annular pipe without rotation and its numbers depend on the ratio of the Coriolis force to centrifugal force F. As F≈-1, the secondary flow has eight loops and its intensity reaches the minimum value, and the distribution of the axial flow is like that of the Poiseuille flow. The position of the maximum axial velocity is pushed to either outer bend or inner bend, which is also determined by F. [WT5”HZ]

关键词： rotating curved annular pipe secondary flow Coriolis force centrifugal force perturbation solution

NONHOMOGENEOUS HOPF EQUATIONS IN HIGHER DIMENSIONS

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Systems Science and Mathematical Sciences 1999年第2期12卷 115-122页

作者： JIU Quansen(department of Mathematics, Capital Normal university, Beijing 10003., china) 首都师范大学数学系北京

The existence and uniqueness of the local classical solution of nonhomogenuous Hopf equations in higher dimensions are proved in this paper. This solution is obtained by vanishing the viscosity term of Burger’s equat... 详细信息

关键词： Existence uniqueness non-strictly hyperbolic equations Hopf equations.

An Important Rule-Jeans Rule

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紫金山天文台台刊 1996年第3期15卷 93-97页

作者： Gao Chong-yi department of Physics,Lanzhou university,Lanzhou,73.000,china

From theoretical physics,Jeans rule can be derived *** is applicable to the planets,satellites,asteroids and meteoroids in the solar *** condition satisfying Jeans rule,is just the necessary condition for a given spec... 详细信息

关键词： An Important Rule-Jeans Rule net

The Mechanism of the Formation and Transformation of Ettringite

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Journal of Wuhan university of Technology(Materials Science) 2006年第3期21卷 158-161页

作者：彭家惠 department of Building Materials Chongqing University Chongqing 400045 China

The formation and transformation of ettringite were studied by measuring the ion concentration in liquid phase and analyzing the composition in solid phase. The effects of C3., gypsum lime and C-S-H gel on ettringite formation and transformation were also investigated. The experimental results shuw, that, when gypsum was presented in solid phase, the composition of liquid phase was in favor of ettringite formation. Ettringite formation consisted of three reactions including the formation of [ Al （OH）6 ]^3. octahedral, formation of Ca-Al polyhedra prism in which Ca and Al polyhedra arranged alternately, as well as entrance of SO4^2- into the channel of polyhedra. [ Al （OH）6 ]^3. formation, which was the slowest reaction, controlled ettringite formation. The concentration of AlO2^- was a main factor that influenced ettringite formation. After gypsum in solid phase was consumed, [ SO4^2- ] decreased quickly and [ AlO2^- ] increased, and it was possible that ettringite transformed into hydrated monsulfate calcium aluminate （ be called M in short） in thermodymanics. The rate of transformation was controlled by diffusion of AlO2^- .

关键词： ettringite hydrated monsulfate calcium aluminate stability transform control step

NONLINEAR MODELING AND CONTROLLING OF ARTIFICIAL MUSCLE SYSTEM USING NEURAL NETWORKS

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Chinese Journal of Mechanical Engineering 2004年第2期17卷 306-310页

作者： Tian Sheping Ding Guoqing Yan Detian Lin Liangming department of Information Measurement and Instrumentation,Shanghai Jiaotong university,Shanghai 20003., china department of Information Measurement and Instrumentation Shanghai Jiaotong University 上海 200030

The pneumatic artificial muscles are widely used in the fields of medicalrobots, etc. Neural networks are applied to modeling and controlling of artificial muscle system. Asingle-joint artificial muscle test system is designed. The recursive prediction error (RPE)algorithm which yields faster convergence than back propagation (BP) algorithm is applied to trainthe neural networks. The realization of RPE algorithm is given. The difference of modeling ofartificial muscles using neural networks with different input nodes and different hidden layer nodesis discussed. On this basis the nonlinear control scheme using neural networks for artificialmuscle system has been introduced. The experimental results show that the nonlinear control schemeyields faster response and higher control accuracy than the traditional linear control scheme.

关键词： Artificial muscle Neural networks Recursive prediction error algorithm Nonlinear modeling and controlling

Uniqueness Theorem of Solutions for Stochastic Differential Equation in the Plane

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Acta Mathematica Sinica,English Series 1998年第4期14卷 495-500,201+502-506页

作者： Liang Zongxia, department of Applied Mathematics, Tsinghua university Beijing 100084, china department of Applied Mathematics Tsinghua University Beijing 100084 China

Let M = {Mz, z∈R+2} be a continuous square integrable martingale and A = {Az, z∈ R+2} be a continuous adapted increasing process. Consider the following stochastic partial differential equations in the plane: dXz=α（z, Xz）dM2+β（z,Xz）dAz, z∈R+2, Xz=Zz, z∈R+2, where R+2=[0,+∞)×[0,+∞) and R+2 is its boundary, Z is a continuous stochastic process on R+2. We establish a new theorem on the pathwise uniqueness of solutions for the equation under a weaker condition than the Lipschitz one. The result concerning the one-parameter analogue of the problem we consider here is immediate （see [1, Theorem 3.2]）. Unfortunately, the situation is much more complicated for two-parameter process and we believe that our result is the first one of its kind and is interesting in itself. We have proved the existence theorem for the equation in.

关键词： Two-parameter S. D. E., Two-parameter martingale ITO’s formula Pathwise uniqueness Gronwall’s-Bellman lemma

FAST SOLUTION OF TURBULENT SEPARATION BY STRAWN'S METHOD

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Transactions of nanjing university of Aeronautics and Astronautics 1994年第1期11卷 110-113页

作者： Yin Junfei(department of Power Engineering,NUAA 29 Yudao Street,nanjing 210016,P.R.china)

A quasi-simultaneous viscous/inviscid interaction model and a new integral method are tried to predict twodimensional incompressible turbulent boundary-layer separating flows. The results are compared with experiment... 详细信息

关键词： separation of now trubulent flow boundary layer computational aerodynamics viscous/inviscid interaction mode two-dimensional diffuse

A measurement error model for microarray data analysis

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Progress in Natural Science:Materials International 2005年第7期15卷 614-620页

作者： ZHOU Yiming and CHENG Jing ( department of Biological Sciences and Biotechnology, Tsinghua university, Beijing 100084, china State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua university, Beijing 100084, china National Engineering Research Center for Beijing Biochip Technology, 18 Life Science Parkway, Beijing 102206, china) department of Biological Sciences and Biotechnology Tsinghua University Beijing 100084 China State Key Laboratory of Biomembrane and Membrane Biotechnology Tsinghua University Beijing 100084 China National Engineering Research Center for Beijing Biochip Technology 18 Life Science Parkway Beijing 102206 China

Microarray technology has been widely used to analyze the gene expression levels by detecting fluorescence intensity in a high throughput fashion. However, since the measurement error produced from various sources in microarray experiments is heterogeneous and too large to be ignored, we propose here a measurement error model for microarray data processing, by which the standard deviation of the measurement error is demonstrated to be linearly increased with fluorescence intensity. A robust algorithm, which estimates the parameters of the measurement error model from a single microarray without replicated spots, is provided. The model and algorithm for estimating of the parameters from a given data set are tested on both the real data set and the simulated data set, and the result has been proven satisfactory. And, combining the measurement error model with traditional Z-test method, a full statistical model has been developed It can significantly improve the statistical inference for identifying differentially expressed genes.

关键词： microarray measurement error model parameter estimation differentially expressed genes.