检索结果-南通市图书馆

Bradykinin potentiates 5-HT3.receptor-mediated current in rat trigeminal ganglion neurons

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2005年第4期26卷 428-434页

作者： Wang-ping HU~(1,2) Xue-mei LI~2 Ji-liang WU~3.Min ZHENG~3.Zhi-wang LI~4 2 department of Physiology,3.department of Pharmacology,Xianning College,Xianning 43.100,china 4 department of Neurobiology,Tongji Medical College of Huazhong University of Science and technology,Wuhan 43.03.,china department of Physiology Xianning College Xianning China department of Pharmacology Xianning College Xianning China department of Neurobiology Tongji Medical College of Huazhong University of Science and Technology Wuhan China

Aim:To explore the modulatory effect of bradykinin （BK） on 5-HT3.eceptor-mediated current in trigeminal ganglion （TG） neurons in ***:The whole-cell patch-clamp technique was used to record 5-HT-activated currents (I5-HT) inneurons freshly dissociated from rat *** were applied by rapid ***:The majority of the neurons examined responded to 5-HTapplied externally with an inward current （76.3.,74/97） that could be blocked bythe 5-HT3.eceptor antagonist,ICS-205,93. (1×10-6mol/L).In 66 of the 74 cellssensitive to 5-HT （89.2%）,pretreatment for 3. s with BK (1×10-6-1×10-10mol/L)could potentiate I5-HTwith the maximal modulatory effect occurring at10-7mol/L BK （71.6%+4.9%）.BK shifted the 5-HT concentration-response curveupwards with an increase of 68.9%±7.2% in the maximal current response,but withno significant change in the EC50value （19.1±3.2 μmol/L vs 20.9±3.5 μmol/L;t-test,P>0.05;n=8）.BK potentiated I5-HTin a holding potential-independent manner anddid not alter the reverse potential of *** BK-induced potentiation ofI5-HTwas almost completely blocked by Hoe 140 (5×10-7mol/L),a selective B2BKreceptor antagonist,and was removed after intracellular dialysis of GF-109203.（2 μmol/L）,a selective protein kinase C （PKC） inhibitor,with the re-patch ***:Pre-application of BK exerts an enhancing effect on I5-HTvia a PKC-dependent pathway in rat TG neurons,which may explain the peripheral'mecha-nism of pain and hyperalgesia caused by,for example,tissue damage andinflammation.

关键词： bradykinin 5-HT3.serotonin receptor regulation patch-clamp techniques trigeminal ganglion

Chaotic Synchronization with Filter Based onWavelet Transformation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Communications in Nonlinear Science and Numerical Simulation 1999年第4期4卷 3-5页

作者： Xiaoan ZHOU Junfeng LAN Shuisheng QIU(Deplartmeat of Electronic Engineering, South china University of technology, guangzhou510640, china) department of Electronic Engineering South China University of Technology Guangzhou 510640 China

IntroductionInreceatyears,synchronizationofchaoticsystemsanditspotelltialapplicationtocommunicationshavebecomeareaofactiveresearch[1--5],becauseofthebroadbandpropediesofchaoticsignal,itsshazprelativityandsensitiveness... 详细信息

关键词： colpitts oscillator chaotic synchronization wavelet transformation

FRACTURE　MECHANICS　ANALYSIS　OF　THERMAL　STRAINFATIGUE　LIFE　FOR　THE　SINTERING　MACHINE　PALLET

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 1996年第3期9卷 223-226页

作者： LI Zhenzi and LI Ming (department of Architectnre Engineering, Central South University of technology, Changsha 410083. china)LIAO Fuchang ({3. School of technology, {3. 518029, china)

In recent years elastic-plastic fracture mechanics has developed rapidly and is widely used to solve various engineering problems. The application of elastic-plastic fracture mechanics on the pallet of sintering machine is approached in detail for the first time in the present study. The theoretical results were compared with the actual data determined from sintering machine pallet. Results show that good agreement was achieved between the method suggested by the author and the actual data. The basis of determining design of the sintering machine pallet in iron and steel engineering has been provided and it will result in great economic benefits.

关键词： pallet thermal strain fatigue life fracture mechanics

The performance of ultra wideband acquisition system based on energy detection over IEEE 802.15.3. channel

在线全文

学校读者我要写书评

暂无评论

Science china(Information Sciences) 2011年第2期54卷 360-370页

作者： YANG ZhiHua, ZHANG QinYu, ZHANG NaiTong & WANG Ye Communication Engineering Research Center, shenzhen Graduate School, Harbin Institute of technology, shenzhen 518055,{3. Communication Engineering Research Center Shenzhen Graduate School Harbin Institute of Technology Shenzhen China

In this paper, we propose a theoretical framework to analyze the performance of ultra wideband acquisition (UWB) system based on energy detection (ED) over IEEE 802.15.3. channel. The proposed framework enables to calculate probability density function (PDF) of square-sum of multipath components (MPCs) gain collected by receiver, and the averaged criteria. In particular, the expectation and variance of the sum variant characterized approximately by log-normal distribution are expressed in a closed form based on cluster point process. Moreover, the calculating methods of averaged criteria, through Markov chain model and signal flow graph, are clearly demonstrated for different applicable scenarios. The proposed framework is well consistent with simulation results with respect to each calculation method.

关键词： UWB energy detection unconditional criterion cluster point process

Comprehensive evaluation of mechanism of "chimney effect" using principles of magnetism, geochemistry and mineralogy

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Science Bulletin 1998年第9期43卷 743-748页

作者： LIU Qingsheng 1, CHENG Tongjin 2 and LIU Shugen 3.1. department of Applied Geophysics, china University of Geosciences, Wuhan 43.074, china 2. Center of Petroleum Geochemistry, china National Star Petroleum Corporation, Hefei 23.022, china 3. The St department of Applied Geophysics China University of Geosciences Wuhan China Center of Petroleum Geochemistry China National Star Petroleum Corporation Hefei China The State Key Laboratory of Oil/Gas Reservoir Geology and Exploitation of china Chengdu Institute of Technology Chengdu China

Study of forming mechanism of "chimney-effect" (CE) has important significance for basic theory and applications of non-seismic geophysical and geochemical methods locating oil/gas reservoirs. The theoretical basis of comprehensive evaluation of mechanism of CE using principles of magnetism, geochemistry and mineralogy has been reviewed, with the problems to be solved: (ⅰ) study for the relationship between process of oil/gas migration and geochemical field; (ⅱ) analysis of genesis of magnetic, geochemical and mineralogical anomaly; (ⅲ) interpretation of surface soil magnetism and geochemical anomaly combined with seismic data.

关键词： chimney effect (CE) hydrocarbon microseepage oil/gas accumulation.

S-Nitrosoglutathione and glutathione act as NMDA receptor agonists in cultured hippocampal neurons

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2006年第7期27卷 853-860页

作者： Ting-yu CHIN~2 Sheau-huei CHUEH~(3.5) Pao-luh TAO~42 department of Bioseience technology,Chung-Yuan Christian University,Chung-Li,Taiwan,china 3.department of Biochemistry,National Defense Medical Center,Taipei,Taiwan,china 4 department of Pharmacology,National Defense Medical Center Taipei,Taiwan,china department of Bioscience technology Chung-Yuan Christian University Chung-Li China department of Biochemistry National Defense Medical Center Taipei China department of Pharmacology National Defense Medical Center Taipei China

Aim:To characterize the effect of combined pre-and postnatal morphine exposureon N-methyl-D-aspartate receptor（NMDA）receptor signaling in hippocampalneurons of the offspring of morphine-addicted female ***:Culturedhippocampal neurons and synaptosomes were prepared from neonatal and 2-week-old offspring,respectively,of control or morphine-addicted female *** in the cytosolic Ca2+concentration([Ca2+]i)of cultured cells was mea-sured using Fura-2,and glutamate release from synaptosomes was ***:Both glutamate and NMDA caused a dose-dependentincrease in the[Ca2+]*** nitric oxide（NO）donor,S-nitrosoglutathione（GSNO）,but not 3.morpholinosydnonimine,sodium nitroprusside,and S-nitroso-N-acetylpenicillamine,also induced a[Ca2+]*** and glutathione causeda dose-dependent increase in the[Ca2+]iwith respective EC50values of 56 and 414μmol/*** effects were inhibited by Mg2+or an NMDA receptor antagonistand were unaffected by the presence of a glutamate *** other glu-tathione derivatives,oxidized glutathione,S-methylglutathione,S-ethylglutathione,S-propylglutathione,and S-butylglutathione,the dipeptides,Glu-Cys and Cys-Gly,and the antioxidants,dithiothreitol and mercaptoethanol,failed to induce a[Ca2+]*** addition,glutathione caused a dose-dependent increase inglutamate release from *** maximal responses and the EC50val-ues for the glutamate-,NMDA-,GSNO-,and glutathione-induced[Ca2+]iincreasesand the glutathione-induced glutamate release were indistinguishable in the neu-rons of the offspring from control and morphine-addicted female ***:GSNO and glutathione act as NMDA receptor agonists and,in contrast to hippoc-ampal brain slice,combined pre-and postnatal morphine exposure does not modu-late NMDA receptor signaling in the cultured hippocampal neurons.

关键词： cytosolic Ca2+ concentration S-Nitrosoglutathione glutathione cultured hippocampal neuron morphine glutamate N-methyl-D-aspartate receptor

Effects of crystallization fractions on mechanical properties of Zr-based metallic glass matrix composites

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science china(Physics,Mechanics & Astronomy) 2010年第3期53卷 424-429页

作者： QIU ShengBao1,2, YAO KeFu1 & GONG Pan1 1 KLAMPT, department of Mechanical Engineering, Tsinghua University, Beijing 100084, china 2 Institute of Industry technology, {3. & Chinese Academy of Sciences, {3. 511458, china KLAMPT Department of Mechanical Engineering Tsinghua University Beijing China Institute of Industry technology Guangzhou & Chinese Academy of Sciences Guangzhou China

The Zr41Ti14Cu12.5Ni10Be22.5 (at.%) bulk metallic glass composites with various crystallization fractions were prepared by pretreating the bulk metallic glassy samples with pulsing current, and then by isothermal annealing at near initial crystallization temperature for different periods of time. The precipitations and crystallization fractions were studied by X-ray diffraction (XRD) and differential scanning calorimetry (DSC), and their effects on mechanical properties of the composite were studied by microhardness, uniaxial compression test and scanning electron microscopy (SEM). The experimental results show that the primary precipitate is quasicrystalline phase and other metastable phases including Be2Zr, Zr2Cu and FCC would precipitate subsequently. In the initial crystallization process, in which the crystallization fraction increases from 0 to 8.2%, both fracture strength and plastic strain increase, with the maximum plastic strain up to 6.4%. When the crystallization fraction is larger than 8.2%, the fracture strength and the plastic strain decrease sharply. Furthermore, the alloy with low crystallization fraction is fractured by shearing, while for high crystallization fraction it is fractured by splitting and cleavage. The results show that the mechanical properties of the glassy alloy could be optimized by controlling the processing parameters.

关键词： bulk metallic glass pulsing current crystallization fraction plasticity shear band

A multicast routing algorithm with multiple trees

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2005年第2期16卷 426-432页

作者： Cui Xunxue 1,2 , Gao Wei3.& Fang Hongyu41. New Star Research Institute of Applied technology, Hefei 23.03., P. R. china 2. Jiangsu Key Laboratory of Computer Information Processing technology,Soochow University, Suzhou 215006, P. R. china 3. department of Electronic Engineering and Information Science,University of Science and technology of china, Hefei 23.027, P. R. china 4. School of Electronic Science and technology, Anhui University, Hefei 23.03., P. R. china New Star Research Institute of Applied technology Hefei 230031 P. R. China 2. Jiangsu Key Laboratory of Computer Information Processing technology Soochow University Suzhou 215006 P. R. China department of Electronic Engineering and Information Science University of Science and Technology of China Hefei 230027 P. R. China School of Electronic Science and technology Anhui University Hefei 230039 P. R. China

Quality of service (QoS) multicast routing has continued to be a very important research topic in the Internet. A method of multicast routing is proposed to simultaneously optimize several parameters based on multiobjective genetic algorithm, after the related work is reviewed. The contribution lies on that the selection process of such routing is treated with multiobjective optimization. Different quality criterions in IP network are taken into account for multicast communications. A set of routing trees is generated to approximate the Pareto front of multicast problem. Multiple trees can be selected from the final set of nondominated solutions, and applied to obtain a good overall link cost and balance traffic distribution according to some simulation results.

关键词： multicast routing quality of service multiobjective optimization genetic algorithms.

Bayesian cognitive trust model based self-clustering algorithm for MANETs

在线全文

学校读者我要写书评

暂无评论

Science china(Information Sciences) 2010年第3期53卷 494-505页

作者： WANG Wei1,2,3.& ZENG GuoSun1,2,3.department of Computer Science & technology, Tongji University, Shanghai 200092, china 2Tongji {3., National Engineering & technology Center of High Performance Computer, Shanghai 200092, china 3.ey Loboratory of Embedded System and Service Computing, Ministry of Education, Shanghai 200092, china department of Computer Science & technology Tongji University Shanghai China Tongji branch National Engineering & Technology Center of High Performance Computer Shanghai China Key Loboratory of Embedded System and Service Computing Ministry of Education Shanghai China

With the introduction of mobile Ad hoc networks (MANETs), nodes are able to participate in a dynamic network which lacks an underlying infrastructure. Before two nodes agree to interact, they must trust that each will satisfy the security and privacy requirements of the other. In this paper, using the cognition inspired method from the brain informatics (BI), we present a novel approach to improving the search efficiency and scalability of MANETs by clustering nodes based on cognitive trust mechanism. The trust relationship is formed by evaluating the level of trust using Bayesian statistic analysis, and clusters can be formed and maintained autonomously by nodes with only partial knowledge. Simulation experiments show that each node can form and join proper clusters, which improve the interaction performance of the entire network. The essence of the underlying reason is analyzed through the theory of complex networks, revealing great scalability of this method.

关键词： trust model MANET self-clustering Bayesian method cognitive mobile