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In vivo and in vitro Studies on the Antitumor Activities of MCP (Malva crispa L. Powder)

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Biomedical and environmental sciences 1998年第4期11卷 297-306页

作者： HUANG CHENG-YU ZENG LING-FU HE TAO WANG CHAO-JUN HONG JUN-RONG ZHANG XIU-QUAN HOU YUN-HUA AND PENG SHU-SHENG (department of Nutrition and Food Hygiene, school of public health) (Tumor Institute, West china {3. of Medical sciences (WCUMS), Che department of Nutrition and Food Hygiene School of Public Health West China University of Medical Sciences (WCUMS) Chengdu China.

Four short-term in vivo and in vitro tests were used to further confirm the antitumor activities of MCP, a vegetable powder, prepared from Malru crispo L. (i) In the H22 hepatoma-transplanting test, MCP had antitumor action, but MCP residue did not show such action; 5-FU appeared to have more potent antitumor activities and more harmful effects than MCP. (ii) In the micronucleus (MN) test, MCP significantly decreased MN frequency. (iii) In the cancer cell culture systems, the MCP fat-soluble extract revealed inhibitory effects on the growth and proliferation of the human hepatoma and the gastric cancer cells in a dose-response manner. (iv) In the colony formation test, MCP also altered the morphology of human gastric cancer cells. It was suggested that MCP could be consumed not only by healthy subJects for cancer prevention but also by patients with cancer as supplernentary treatrnent in combination with anticarcinogenic drug such as 5-FU, cyclophosphamide (CP)

关键词： MCP Malva crispa L Powder

Discovery and character of the Kunlun-Yellow River Movement

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Chinese Science Bulletin 1998年第10期43卷 833-836页

作者： CUI Zhijiu 1, WU Yongqiu 2,3.and LIU Gengnian 1 1. department of Geography, peking university, beijing 100871,{3. 2. Open Research Laboratory of environmental Changes and Natural Disaster of State Education Commission, beijing 100875,{3. department of Geography Peking University Beijing China Open Research Laboratory of environmental Changes and Natural Disaster of State Education Commission Beijing China department of Geography Sichuan Normal Uni-versity Chengdu China

Based on geomorphological, tectonic and sedimentary data, a Kunlun Yellow River Tectonic Movement has been recognized in 1 10-0 60 Ma B.P. This tectonic movement, which leads to uplift of the Qinghai_Xizang (Tibet) Plateau from 1 500 to 3.000-3.500 m, is periodic, abrupt and changeable in the movement rate of uplifting and slide slipping.

关键词： Kunlun Mountain Pass 700 kaB.P. tectonic movement.

Aerosol retrieval over land by exploiting the synergy of TERRA and AQUA MODIS DATA

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Science china Earth sciences 2006年第6期49卷 641-649页

作者： TANG Jiakui1, XUE Yong1,2, YU Tong3. GUAN Yanning1, CAI Guoyin1 & HU Yincui1 1. State Key Laboratory of Remote Sensing Science, Jointly Sponsored by the Institute of Remote Sensing Applications of Chinese Academy of sciences and beijing Normal university, beijing 100101, china 2. department of Computing, London Metropolitan university, 166-220 Holloway Road, London N7 8DB, UK 3. beijing environmental Monitor Center, beijing 100044, china 1. State Key Laboratory of Remote Sensing Science Jointly Sponsored by the Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University Beijing 100101 China 2. department of Computing London Metropolitan University 166-220 Holloway Road London N7 8DB UK 3. beijing environmental Monitor Center Beijing 100044 China

Aerosol retrieval over land from satellite remotely sensed data remains internationally a difficult task. By using MODIS data, the Dark Dense Vegetation (DDV) algorithm aerosol distribution and properties retrieval over land has shown excellent competence. However, this algorithm is re-stricted to lower surface reflectance such as water bodies and dense vegetation, which limits its actual application, and is unable to be used for high reflective surface such as over urban areas. In this paper, we introduce a new aerosol retrieval model by exploiting the Synergy of TERRA and AQUA MODIS data (SYNTAM), which can be used for various ground surfaces, including for high reflective surface. Preliminary validations have been carried out by comparing with AERONET measured data, which shows good accuracy and promising potential. Further research work is undergoing.

关键词： aerosol retrieval, aerosol optical thickness, MODIS, TERRA, AQUA.

Application of the HY-1 satellite to sea ice monitoring and forecasting

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Acta Oceanologica Sinica 2004年第2期23卷 251-266页

作者： LUOYawei WUHuiding ZHANGYunfei SUNCongrong LIUYu departmentofenvironmentalsciences PekingUniversityBeijing100871China NationalMarineEnvironmentForecastingCenter Beijing100081China NationalSatellitesOceanicApplicationService Beijing100081China

The HY-1A satellite is the first oceanic satellite of china. During the winter of 2002-2003. the data of the HY-1A were applied to the sea ice monitoring and forecasting for the Bohai Sea of china for the first time. The sea ice retrieval system of the HY-1 A has been constructed. It receives 1B data from the satellite, outputs sea ice images and provides digital products of ice concentration, ice thickness and ice edge, which can be used as important information for sea ice monitoring and the initial fields of the numeric sea ice forecast and as one of the reference data for the sea ice forecasting verification. The sea ice retrieval system of the satellite is described, including its processes, methods and parameters. The retrieving results and their application to the sea ice monitoring and forecasting for the Bohai Sea are also discussed.

关键词： oceanic satellite sea ice retrieval sea ice monitoring and forecasting CCD COCTS

The roles of a decision support system in applying forest ecosystem management in Northeast china

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Science china(Technological sciences) 2006年第z1期49卷 9-18页

作者： DAI Limin, ZHENG Bofu, Guofan Shao & ZHOU Li State Key Lab of Systems Ecology, Research Center for Eco-environmental sciences, Chinese Academy of sciences, {3. 100085, china Institute of Applied Ecology, Chinese Academy of sciences, Shenyang 110016, china department of Forestry and Natural Resources, Purdue university, West Lafayette, IN 47907, USA Graduate university of Chinese Academy of sciences, {3. 100101, china 1. State Key Lab of Systems Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China2. Institute of Applied Ecology Chinese Academy of Sciences Shenyang 110016 China3. Department of Forestry and Natural Resources Purdue University West Lafayette IN 47907 USA4. Graduate University of Chinese Academy of Sciences Beijing 100101 China

Forest ecosystems provide a variety of services and forest ecosystem management (FEM) is an effective approach to maximize the services. Because of the complexity of forest ecosystems, the applications of FEM can be facilitated with decision support systems (DSS) that recognize and incorporate ecological and socio-economic variables. With the rapid development of computation and information technologies, DSS have been advanced in many ways. Traditional forest management within a forestry unit in china is planned on a yearly basis. The planning itself remains primarily a verbal concept as there are no quantitative decision-support tools available to translate the concept into forest management actions. For the purposes of FEM at the management level, a forest management DFF, FORESTAR, has been developed under a framework of geographic information system (GIS) and forest models. The paper explained the intelligent modeling mechanisms and demonstrated how the applications of FEM can be strengthened with the applications of FORESTAR.

关键词： forest functions, forested landscapes, forest services, forest models, geographic information systems.

Soil Properties in Two Soil Profiles from Terraces of the Nam Co Lake in Tibet,china

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Journal of Mountain Science 2009年第4期6卷 354-361页

作者： WANG Liqiang YI Chaolu Brigitta Sehiitt LIU Kexin ZHOU Liping Institute of Tibetan Plateau Research Chinese Academy of Sciences Beijing 100085 China department of Physical Geography Freie University of Berlin Berlin12249 Germany State Key Laboratory of Nuclear Physics and Technology Peking University Beijing 100871 China College of Urban and environmental sciences Peking University Beijing100871 China

This article investigates the soil properties in two soil profiles from the terraces of the Nam Co Lake in Tibet,china. Profile 1,with a slope aspect to east,is 3. m,and profile 2,to southwest,is 3. m above the lake level. Twelve and nine layers were identified in profile 1 and profile 2,respectively,based on the color,texture,structure,moisture content,presence of carbonate,and root density. Grain sizes and measurements of water content,total organic carbon,total inorganic carbon,total carbon,pH value and electrical conductivity were all analyzed for each sample. The results show that soil is poorly developed because of sparse vegetation coverage and weak chemical weathering in the cold and arid area. The results also indicate that the soil properties are different between the two profiles and suggest that soil is better developed in profile 1 than in profile 2. These differences are ascribed to the dissimilarity of landform,vegetation and timing. Profile 1 faces to east as compared with profile 2 facing to southwest and gets less insolation and therefore less evaporation. Thus,vegetation grows better in profile 1 than in profile 2. Radiocarbon dating and OSL dating show that profile 1 underwent a longer soil forming process than profile 2,which is helpful for the soil development in profile 1.

关键词： Soil property Soil genesis environmental change Marine isotope stage 3.(MIS 3.

Effects of genistein, daidzein and glycitein on the osteogenic and adipogenic differentiation of bone marrow stromal cells and on the adipogenic trans-differentiation of osteoblasts

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Progress in Natural Science:Materials International 2005年第11期15卷 993-999页

作者： LI Xianghui, ZHANG Jinchao, SUI Senfang and YANG Mengsu (State Key Laboratory of Biomembrane, department of Biological sciences and Biotechnology, Tsinghua university, {3. 100084, china department of Chemistry, College of Chemistry & environmental Science, Hebei university, Baoding 071002, china department of Biology and Chemistry, City university of Hong Kong, Hong Kong, china) State Key Laboratory of Biomembrane Department of Biological Sciences and Biotechnology Tsinghua University Beijing 100084 China. department of Chemistry College of Chemistry & Environmental Science Hebei University Baoding 071002 China. department of Biology and Chemistry City University of Hong Kong Hong Kong China

The 3.(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT), alkaline phosphatase (ALP) activity and oil red O assays were used to examine the effects of genistein, daidzein and glycitein on the osteogenic and adipogenic differentiation of primary mouse bone marrow stromal cells (MSCs) and the adipogenic trans-differentiation of primary mouse osteoblasts. The results indicated that daidzein, genistein and glycitein at concentrations from 1×10-8 mol/L to 1×10-5mol/L promoted the proliferation of MSCs and osteoblasts; genistein, daidzein and glycitein promoted osteogenic differentiation and inhibited adipogenic differentiation of MSCs, and inhibited adipocytic transdifferentiation of osteoblasts at appropriate concentrations as 17β-estradiol. It suggests that genistein, daidzein and glycitein regulate a dual differentiational process of MSCs into the osteogenic and adipogenic lineages, and trans-differentiational process of primary osteoblasts into the adipocyte lineages, causing a lineage shift toward osteoblast. Protective effects of them on bone may be mediated by a reversal of adipogenesis which may promote the proliferation, differentiation and mineralization of osteoblasts, and make adipocytes secrete less cytokines which may promote osteoclast formation and activation. In addition, the results also indicated that genistein, daidzein and glycitein may be helpful in preventing the development of steroid induced osteonecrosis.

关键词： genistein daidzein glycitein bone marrow stromal cells osteoblasts osteogenic differentiation adipogenic differentiation adipogenic trans-differentiation.

重铬酸钾和氧化还原物质反应致质粒DNA断链

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中华预防医学杂志 1999年第6期33卷 354-356页

作者：刘翔刘世杰北京医科大学公共卫生学院劳动卫生教研室 100083

目的　在体外研究六价铬化合物诱导质粒ＤＮＡ链断裂的作用。方法　采用质粒松弛法。结果　重铬酸钾（０．５ｍｍｏｌ／Ｌ）、抗坏血酸（１ｍｍｏｌ／Ｌ）、谷胱甘肽（５ｍｍｏｌ／Ｌ）或过氧化氢（１７ｍｍｏｌ／Ｌ）单独作... 详细信息

目的　在体外研究六价铬化合物诱导质粒ＤＮＡ链断裂的作用。方法　采用质粒松弛法。结果　重铬酸钾（０．５ｍｍｏｌ／Ｌ）、抗坏血酸（１ｍｍｏｌ／Ｌ）、谷胱甘肽（５ｍｍｏｌ／Ｌ）或过氧化氢（１７ｍｍｏｌ／Ｌ）单独作用都不能诱导明显的ＤＮＡ单链断裂。然而，将重铬酸钾和具有氧化还原功能的物质与ＤＮＡ共同温浴，发现重铬酸钾和抗坏血酸、谷胱甘肽或过氧化氢反应后可明显诱导质粒ＤＮＡ单链断裂。重铬酸钾和过氧化氢（１７ｍｍｏｌ／Ｌ）还诱导质粒ＤＮＡ双链断裂。结论　抗坏血酸、谷胱甘肽和过氧化氢可能在重铬酸钾的致癌过程中起重要作用。

关键词：重铬酸钾质粒 DNA损伤氧化还原反应癌

Human impacts on the terrestrial ecosystem of Fildes Peninsula of King George Island, Antarctica

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Journal of environmental sciences 2000年第1期12卷 14-19页

作者： ZHAO Ye\+1, XU Cui\|hua\+2 (1. Institute of Resource and environmental sciences, beijing Normal {3., beijing 100875, china 2. Laboratory of Industrial Hygiene, Ministry of public health, beijing 100088, china) Foundation item: National Natur

Antarctic environment has valuable baseline information for understanding the global change. The objectives of this study were to investigate the impacts of human activities on Antarctic terrestrial ecosystem. Based on the investigation results and the sampling analysis of the environment of Fildes Peninsula, King George Island, Antarctica, it was shown that there are some artificial radioactive elements—? ? 13. Cs in Antarctic environment: the radioactivity of 13. Cs in the surface soil, the surface moss, the fruticose lichen and the crustaceous lichen are 6 00—14 80, 25 07, 29 04 and 58 07 Bq/kg separately; i.e. the sequence of 13. Cs specific activity is as follows: crustaceous lichen>fruticose lichen>surface moss>surface soil, which demonstrates that the crustaceous lichen is one of the most sensitive monitor ways for the effect of the long term diffusion of 13. Cs. The impacts of the scientific research activities on the partial ecosystem of Fildes Peninsula include: the changes of the landscape and the soil material have made a strong freezing thawing process, which decreases the stability of the ground surface, causes the degradation of the vegetation in the some small areas; some small lakes, runoff and lichens in middle areas of Fildes Peninsula have been affected by the wastes of the stations, in the surrounding areas of the expedition stations, the concentration of Cr, Cu, Ni, Pb and Zn in the lichen and the water are higher than that of the contrasting area. Fildes Peninsula is one of the most crowded areas of expedition stations, at some extent, the environment and terrestrial ecosystem have been affected by the human activities. The conservation of the environment and ecosystem should be an important aspect of Antarctic environmental sciences.

关键词： Antarctica Fildes Peninsula terrestrial ecosystem human impacts CLC number: X21 Document code: A