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Magnetostratigraphy of Late Cenozoic fossil mammals in the northeastern margin of the Tibetan Plateau

Science Bulletin 2003年第2期48卷 188-193页

作者： SONG Chunhui1,2,FANG Xiaomin 1,2,GAO Junping1, NIE Junsheng1,YAN Maodu1,3.XU Xianhai1 & SUN Dong1 1. MOE National Laboratory of Western China抯 Environmental Systems & College of Resource and Environment,Lanzhou university,Lanzhou 73.000,China 2. State Key Laboratory of Loess and Quaternary Geology ,Institute of Earth Environment,Chinese Academy of sciences,Xi抋n 710075, China 3. department of geological sciences,{3.,annarbor,mi 48109,usa MOE National Laboratory of Western China’s Environmental Systems & College of Resource and Environment Lanzhou University Lanzhou China State Key Laboratory of Loess and Quaternary Geology Institute of Earth Environment Chinese Academy of Sciences Xi’an China department of geological sciences University of Michigan Ann Arbor USA

A number of fossil mammals have been found in the very thick Cenozoic stratigraphy of the Guide Basin in the northeastern margin of the Tibetan *** of these are of great significance in mammal evolution and stratigraphic correla-tion on and around the Tibetan Plateau and North ***,the chronology of these mamals is poorly *** of the mammals will not only place precise age constraints on the mammals,but also provide much inlormation on the related stratigraphy that records the uplift process of the Tibetan *** paleomagnetism of the upper part of the Cenozoic stratigraphy at He'erjia and Lajigai north of Guide County has revealed magnetic chrons that can be correlated to Ganss and 3.n *** the section spanning about 3.16.5 Ma and the *** and third layers of fossil mammals at about 5.25,5.1 and 4.4 Ma,*** of the significant genus Gazella kueitensis and the Chinese elephant Anancus sinensis are firstly constrained at about 5.25 MaBP and 4.4 Ma,*** mammalian evolution and the associated increase in coarse sediments and sedimentation rate may suggest that the northeastern Tibetan Plateau was uplifted rapidly at that time,and the eastern Tibetan Plateau with its neighboring regions was not high enough to stop mammal exchange between the northern and southern sides of the Tibetan Piateau.

关键词： Tibetan Plateau Guide Basin Late Cenozoic stratigra-phy fossil mammals paleomagnetism.

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Multi-wavelength nanowire micro-LEDs for future high speed optical communication

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Opto-Electronic Advances 2024年第3期7卷 1-3页

作者： Ayush Pandey Zetian mi department of Electrical Engineering and Computer Science University of MichiganAnn ArborMI 48109USA

The future of optoelectronics is directed towards small-area light sources,foremost being ***,their use has been inhibited so far primarily due to fabrication and integration challenges,which impair efficiency and ***,bottom-up nanostructures grown using selective area epitaxy have garnered attention as a solution to the aforementioned *** Fu *** used this technique to demonstrate uniform p-i-n core-shell InGaAs/InP nanowire array light emitting *** devices are capable of voltage and geometry-controlled multi-wavelength and high-speed *** publication accentuates the wide capabilities of bottom-up nanostructures to resolve the difficulties of nanoscale optoelectronics.

关键词： communication high operations

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Topological Dirac-vortex microcavity laser for robust on-chip optoelectronics

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Light(Science & Applications) 2024年第4期13卷 591-592页

作者： Yuanpeng Wu Zetian mi department of Electrical Engineering and Computer Science University of Michigan1301 Beal AvenueAnn ArborMI 48109USA

Dirac-vortex microcavity laser based on InAs/InGaAs quantum dots have been experimentally realized on silicon *** topological laser features a large spectral range and high robustness against variations such as cavity... 详细信息

关键词： laser optoelectronics cavity

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A low-noise,high-gain,and large-dynamic-range photodetector based on a JFET and a charge amplifier

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Frontiers of Information Technology & Electronic Engineering 2024年第2期25卷 316-322页

作者： Jinrong WANG Shuang'e WU Chengdong mi Yaner QIU Xin'ai BAI department of Physics Lyuliang UniversityLvliang033001China Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques South China University of TechnologyGuangzhou510640China

We demonstrate a low-noise,high-gain,and large-dynamic-range photodetector(PD)based on a junction field-effect transistor(JFET)and a charge amplifier for the measurement of quantum noise in Bell-state detection(BSD).Particular photodiode junction capacitance allows the silicon N-channel JFET 2sk152 to be matched to the noise requirement for charge amplifier *** electronic noise of the PD is effectively suppressed and the signal-to-noise ratio(SNR)is up to 15 dB at the analysis frequency of 2.75 MHz for a coherent laser power of 50.08µ*** combining of the inductor and capacitance,the alternating current(AC)and direct current(DC)branches of the PD can operate linearly in a dynamic range from 25.06µW to 17.50 *** PD can completely meet the requirements of SNR and dynamic range for BSD in quantum optics experiments.

关键词： Quantum noise Bell-state detection(BSD) Photodetector(PD) Junction field-effect transistor(JFET) Charge amplifier

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Systemic lupus erythematosus in a 15-year-old female with multiple splenic nodules:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2128-2133页

作者： mi Il Kang Hyeok Chan Kwon Division of Rheumatology Department of Internal MedicineDankook University College of MedicineCheonan-si 31116South Korea Division of Rheumatology Department of Internal MedicineDankook University HospitalDankook University College of MedicineCheonan-si 31116South Korea

BACKGROUND Systemic lupus erythematosus(SLE)is a chronic inflammatory disease primarily affecting young *** can invade any organ,and various forms of splenic invasion have been *** include splenomegaly and splenic infarction,rupture,and *** study encountered a rare case of splenic involvement,with nodules of various sizes without calcifications or *** SUMMARY A 15-year-old girl presented with arthralgia,weight loss,fever,increased levels of inflammatory markers,and positive antinuclear antibody test *** patient was diagnosed with *** was asymptomatic while taking steroids and *** months after discharge,the patient developed a fever and abdominal *** enteritis was suspected,and abdominopelvic computed tomography(AP-CT)was *** were no specific findings in the gastrointestinal tract,but multiple splenic nodules were *** or hemangioma was considered;however,no specific radiological findings were observed.A biopsy of the spleen was performed to determine the possibility of *** histological findings of the spleen included extensive periarteriolar necrosis with hematoxylin bodies and numerous karyorrhectic *** on the biopsy results,the patient was diagnosed with an SLE flare-up and was maintained on high-dose steroids and *** As disease activity increased,multiple nodules in the spleen that were previously unseen were observed using AP-CT and histologically *** invasion by SLE can appear in multiple nodular forms and ***,physicians should consider these findings when differentiating these nodules from infections and malignancies.

关键词： Multiple nodules Spleen Splenectomy Systemic lupus erythematosus Differential diagnosis Case report

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Imprinting at the KBTBD6 locus involves species-specific m ternal methylation and monoallelic expression in livestock animals

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Journal of Animal Science and Biotechnology 2024年第1期15卷 127-145页

作者： Jinsoo Ahn In-Sul Hwang mi-Ryung Park Seongsoo Hwang Kichoon Lee department of Animal sciences The Ohio State UniversityColumbusOH 43210USA Animal Biotechnology Division Rural Development AdministrationNational Institute of Animal ScienceJeonbuk 55365Republic of Korea Columbia Center for Translational Immunology Columbia University Irving Medical CenterColumbia UniversityNew YorkNY 10032USA Animal Welfare Research Team National Institute of Animal ScienceRDA1500Kongjwipatjwi‑roJeollabuk‑do 55365Republic of Korea

Background The primary differentially methylated regions(DMRs) which are maternally hypermethylated serve as imprinting control regions(ICRs) that drive monoallelic gene expression, and these ICRs have been investigated due to their implications in mammalian development. Although a subset of genes has been identified as imprinted, in-depth comparative approach needs to be developed for identification of species-specific imprinted genes. Here, we examined DNA methylation status and allelic expression at the KBTBD6 locus across species and tissues and explored potential mechanisms of *** Using whole-genome bisulfite sequencing and RNA-sequencing on parthenogenetic and normal porcine embryos, we identified a maternally hypermethylated DMR between the embryos at the KBTBD6 promoter Cp G island and paternal monoallelic expression of KBTBD6. Also, in analyzed domesticated mammals but not in humans, non-human primates and mice, the KBTBD6 promoter Cp G islands were methylated in oocytes and/or allelically methyl-ated in tissues, and monoallelic KBTBD6 expression was observed, indicating livestock-specific imprinting. Further analysis revealed that these Cp G islands were embedded within transcripts in porcine and bovine oocytes which coexisted with an active transcription mark and DNA methylation, implying the presence of transcription-dependent *** In this study, our comparative approach revealed an imprinted expression of the KBTBD6 gene in domesticated mammals, but not in humans, non-human primates, and mice which implicates species-specific evolution of genomic imprinting.

关键词： Differentially methylated region Domesticated mammal Imprinting KBTBD6 Parthenogenetic

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Factors affecting length of stay according to bronchopulmonary dysplasia severity:a nationwide cohort study in Korea

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World Journal of Pediatrics 2024年第5期20卷 470-480页

作者： Hye mi Lee Jeongmin Shin Sae Yun Kim So Young Kim department of Pediatrics College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea department of Pediatrics Yeouido St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea1063-roYeongdeungpo-guSeoul07345Republic of Korea

Background Longer hospitalizations for preterm infants with bronchopulmonary dysplasia(BPD)delay developmental outcomes,increase the risk for hospital-acquired complications,and exert a substantial socioeconomic *** study aimed to identify factors associated with an extended length of stay(LOS)at different levels of severity of *** A cohort study was conducted using the Korean Neonatal Network registry of very low birth weight infants with BPD between 2013.and 2017 through retrospective *** A total of 4263.infants were diagnosed with *** mild BPD,infants requiring surgical treatment for patent ductus arteriosus needed a longer LOS[eadjustedβcoefficients(adjβ)1.041;95%confidence interval(CI):0.01–0.08]and hydrocephalus(eadjβ1.094;95%CI 0.01–0.17).In moderate BPD,infants administered steroids or with intraventricular hemorrhage required a longer LOS(eadjβ1.041;95%CI 0.00–0.07 and eadjβ1.271;95%CI 0.11–0.3.,respectively).In severe BPD,infants with comorbidities required a longer LOS:pulmonary hypertension(eadjβ1.174;95%CI 0.09–0.23.,administrated steroid for BPD(eadjβ1.116;95%CI 0.07–0.14),sepsis(eadjβ1.062;95%CI 0.01–0.11),patent ductus arteriosus requiring surgical ligation(eadjβ1.041;95%CI 0.00–0.08),and intraventricular hemorrhage(eadjβ1.016;95%CI 0.05–0.26).Additionally,the higher the clinical risk index score,the longer the LOS needed for infants in all *** The factors affecting LOS differed according to the severity of *** approaches to reducing LOS may be devised using knowledge of the various risk factors affecting LOS by BPD severity.

关键词： Bronchopulmonary dysplasia Length of stay Very low birth weight

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Uncovering hidden nodes and hidden links in complex dynamic networks

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 51-63页

作者： Zhaoyang Zhang Xinyu Wang Haihong Li Yang Chen Zhilin Qu Yuanyuan mi Gang Hu department of Physics School of Physical Science and TechnologyNingbo UniversityNingbo 315211China School of Science Beijing University of Posts and TelecommunicationsBeijing 100876China department of Medicine David Geffen School of MedicineUniversity of CaliforniaLos Angeles 90095USA Brainnetome Center and National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China department of Psychology Tsinghua UniversityBeijing 100084China department of Physics Beijing Normal UniversityBeijing 100875China

Inferring network structures from available data has attracted much interest in network science;however,in many realistic networks,only some of the nodes are perceptible while others are hidden,making it a challenging *** this work,we develop a method for reconstructing the network with hidden nodes and links,taking account of fast-varying noise and time-delay *** calculating the correlations of available data with different derivative orders for multiple pairs of accessible nodes,analyzing and integrating the relationships between different correlations,and defining diverse hidden-node-related reconstruction motifs,we can effectively identify the hidden nodes and hidden links in the network.

关键词： networks and genealogical trees stochastic analysis methods time series analysis

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Low-molecular-weight fucoidan inhibits the proliferation of melanoma via Bcl-2 phosphorylation and PTEN/AKT pathway

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Oncology Research 2024年第2期32卷 273-282页

作者： miNJI PARK CHULHWAN BANG WON-SOO YUN YUN-mi JEONG T&R Biofab Co. Ltd.Seongnam-si13487Korea department of Dermatology Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul02706Korea department of Mechanical Engineering Tech University of KoreaSi-heung City15073Korea

Fucoidan,a sulfate polysaccharide obtained from brown seaweed,has various bioactive properties,including anti-inflammatory,anti-cancer,anti-viral,anti-oxidant,anti-coagulant,anti-thrombotic,anti-angiogenic,and anti-Helicobacter pylori ***,the effects of low-molecular-weight fucoidan(LMW-F)on melanoma cell lines and three dimensional(3.)cell culture models are not well *** study aimed to investigate the effects of LMW-F on A3.5 human melanoma cells and cryopreserved biospecimens derived from patients with advanced *** wave was used to fragment fucoidan derived from Fucus vesiculosus into smaller *** and live/dead assays showed that LMW-F inhibited cell proliferation in both A3.5 cells and patientderived melanoma explants in a 3.-printed collagen *** PTEN/AKT pathway was found to be involved in the anti-melanoma effects of *** blot analysis revealed that LMW-F reduced the phosphorylation of Bcl-2 at Thr 56,which was associated with the prevention of anti-apoptotic activity of cancer *** findings suggested that LMW-F could enhance anti-melanoma chemotherapy and improve the outcomes of patients with melanoma resistance.

关键词： Low-molecular-weight fucoidan Melanoma Patient-derived melanoma explants in a 3.-printed collagen scaffold Anti-melanoma effect PTEN-AKT-Bcl-2 network

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Accelerated design of high-performance Mg-Mn-based magnesium alloys based on novel bayesian optimization

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Journal of Magnesium and Alloys 2024年第2期12卷 750-766页

作者： Xiaoxi mi Lili Dai Xuerui Jing Jia She Bjørn Holmedal Aitao Tang Fusheng Pan College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Southwest Technology and Engineering Research Institute Chongqing 400039China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China department of Materials Science and Engineering Norwegian University of Science and Technology(NTNU)Trondheim 7051Norway

Magnesium(Mg),being the lightest structural metal,holds immense potential for widespread applications in various *** development of high-performance and cost-effective Mg alloys is crucial to further advancing their commercial *** the rapid advancement of machine learning(ML)technology in recent years,the“data-driven''approach for alloy design has provided new perspectives and opportunities for enhancing the performance of Mg *** paper introduces a novel regression-based Bayesian optimization active learning model(RBOALM)for the development of high-performance Mg-Mn-based wrought *** employs active learning to automatically explore optimal alloy compositions and process parameters within predefined ranges,facilitating the discovery of superior alloy *** model further integrates pre-established regression models as surrogate functions in Bayesian optimization,significantly enhancing the precision of the design *** RBOALM,several new high-performance alloys have been successfully designed and ***,after mechanical property testing of the designed alloys,the Mg-2.1Zn-2.0Mn-0.5Sn-0.1Ca alloy demonstrates exceptional mechanical properties,including an ultimate tensile strength of 406 MPa,a yield strength of 287 MPa,and a 23.fracture ***,the Mg-2.7Mn-0.5Al-0.1Ca alloy exhibits an ultimate tensile strength of 211 MPa,coupled with a remarkable 41%fracture elongation.

关键词： Mg-Mn-based alloys High-performance Alloy design Machine learning Bayesian optimization

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