检索结果-南通市图书馆

Engagement of PSGL-1 enhances β2-integrin-involved adhesion of neutrophils to recombinant ICAM-1

Acta Pharmacologica Sinica 2006年第5期27卷 617-622页

作者： Xiao-guang WANG~(2,3. Yan-ping CHENG~4 Xue-qing BA~(2,5) ~2Institute of Genetics and Cytology Northeast normal university,Changchun 13.024,china:~3.epartment of Biology,Changchun normal college,Changchun 13.03.,china ~4college of life science.Jilin normal university,Siping 13.001,china Institute of Genetics and Cytology Northeast Normal University Changchun China Department of Biology Changchun Normal College Changchun China college of life science Jilin Normal University Siping China

Aim:The interactions of selectins and their ligands initiate the process of leuko-cyte migrating into inflamed tissue.P-selectin glycoprotein ligand 1 （PSGL-1） isthe best characterized ligand of selectins,and has been demonstrated to mediatethe adhesion of leukocytes to all three selectins in ***-1 not only func-tions as an anchor molecule to capture the leukocytes to the activated endothelialcells by its interaction with selectins,but also transduces the signals to *** present work aimed to investigate the mechanism by whichPSGL-1-mediated signal activates neutrophils and enhances the adhesion to theendothelial ***:We detected the effects of the engagement of PSGL-1with monoclonal antibodies （mAb） or P-selectin on the adhesion of neutrophils tothe recombinant intercellular adhesion molecule-1 （ICAM-1）,and on the expres-sion of β***,the role of cytoskeleton in these process wasstudied by using inhibitor cytochalasin ***:The engagement of PSGL-Iincreased the expression of β2-integrin on the surface of neutrophils and en-hanced the adhesion of neutrophils to the recombinant *** againstCD18 impaired the adhesion of PSGL-1-engaged neutrophils to ***,the inhibitor cytochalasin B largely blocked the increase of CD 18 expression aswell as the adhesion of PSGL-1-engaged neutrophils to ***:The PSGL-1-transduced signals can enhance β2-integrin-involved adhesion ofneutrophils to the recombinant ICAM-1,and this process depends on the dynam-ics of cytoskeleton.

关键词： P-selectin ligand protein intercellular signaling peptides and proteins intercellular adhesion molecule-1 CD 18 antigens

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Peak structure in the interlayer conductance of Moirésuperlattices

引用

Chinese Physics B 2024年第10期33卷 376-380页

作者： Yizhou Tao Chao Liu Mingwen Xiao henan Fang college of Electronic and Optical Engineering&college of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China Department of Physics Nanjing UniversityNanjing 210093China

We investigate the peak structure in the interlayer conductance of Moirésuperlattices using a tunneling theory wedeveloped *** theoretical results predict that,due to the resonance of two different partial waves,the doublepeakstructure can appear in the curve of the interlayer conductance versus twist ***,we study the influencesof the model parameters,i.e.,the chemical potential of electrodes,the thickness of Moirésuperlattice,and the strength ofinterface potential,on the peak structure of the interlayer *** particular,the parameter dependence of the peakstructure is concluded via a phase diagram,and the physical meanings of the phase diagram is ***,thepotential applications of the present work is discussed.

关键词： Moirésuperlattice interlayer conductance electronic transport twistronics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A new fossil genus of Mesosciophilidae(Diptera,Nematocera) with two new species from the Middle Jurassic of Inner Mongolia,china

引用

Progress in Natural science:Materials International 2009年第12期19卷 1837-1841页

作者： Tingting Li,Dong Ren~* college of life science,Capital {3. university,Beijing 100048,china college of life science Capital Normal University Beijing 100048 China

A new genus within the family Mesosciophilidae,Jurasciophila ***.,with two new species,J,curvula *** *** *** *** ***.,are described and *** are established based on fossil specimens with bodies and complete *** of them were collected from the late Middle Jurassic Jiulongshan Formation of Daohugou in southeastern Inner Mongolia,*** with two known genera,Mesosciophilina(Kovalev,1985) and Mesosciophilopsis(Blagoderov,1994),the new genus has transitional characters. The distribution pattern of Mesosciophilidae is briefly discussed.

关键词： Mesosciophilidae Middle Jurassic Jiulongshan Formation

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Non-universal Gauge Bosons Z'and the Process e~+e~- →f

引用

Communications in Theoretical Physics 2004年第3期41卷 419-424页

作者： YUE Chong-Xing~1 WANG Shun-Zhi~2 1 Department of Physics,Liaoning normal university,Dalian 116029,china 2 {3. of Physics and Information Engineering,henan normal university,xinxiang 453.02,china Department of Physics Liaoning Normal University Dalian 116029 college of Physics and Information Engineering Henan Normal University Xinxiang 453002

Introduetion Altl、ough the standard model(SM)that bases on thega、lge gro、ip SU:(2)xU(1)has been sueeessful in de-seribing the Physies of eleetroweak interaetions,the meeh-anisn,of the eleetroweak symmetry breaking(... 详细信息

关键词： non-universal gauge bosons cross section TC2 models

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Landscape Change and its effect on the environment of Daqing City

引用

Progress in Natural science:Materials International 2005年第7期15卷 641-649页

作者： ZANG Shuying, ZHANG Jing and JIA Li ( college of life and Environment science, Harbin {3. university, Harbin 150080, china college of Resources Environment & Tourism, Capital {3. university, Beijing 10003., china college of Economics and Management, Northeast Agricultural university, Harbin 15003., china) college of life and Environment science Harbin Normal University Harbin 150080 China college of Resources Environment and Tourism Capital Normal University Beijing 100037 China college of Economics and Management Northeast Agricultural University Harbin 150030 China

In this paper, we will study the temporal-spatial landscape change from 1978 to 2001 in Daqing City, based on the mul- ti spectral scanner (MSS) and thematic mapper (TM) images of remote sensing (RS) of 1978, 1988, 1992, 1996 and 2001. In order to explain the effects of the component change on the whole landscape, we make a statistic analysis about the transfer probability matrix of the component types of the landscape by using the ARCGIS platform through the overlay analysis of different landscape components. Based on the transfer probability matrix, we calculate the in-transfer ratio, the out-transfer ratio and the contributor ratio of the special transfer process of the main landscape components. The results illustrate that the cultivated-land, grassland, swamp, and alkaline land are the main contributors resulting in the landscape change: the out-transfer ratios of grassland and swamp are much higher than the in-transfer ones; the in-transfer ratio of alkaline land is much higher than the out-transfer one; the in-transfer ratio of the land-lot is always higher than its out-transfer with the highest rate per year, although there is a small difference among the in-transfers and the out-transfers per year. The main landscape changing processes are the salination of cultivated-land, salination or desertification of grassland, salination and degeneration of swamp. Results in this paper can provide scientific basis for investigating the landscape change mechanism of resources-based city.

关键词： landscape change environmental effect transfer probability resources-based city.

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Knockdown of CD146 reduces the migration and proliferation of human endothelial cells

引用

Cell Research 2006年第3期16卷 313-318页

作者： Yanyong Kang~(1,3. Fengcai Wang~(1,2) Jing Feng~1 Dongling Yang~1 Xu Yang~3.Xiyun Yan~11 National Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of science Beijing 100101,china 2 Chemistry Department,Anyang teacher's college,Anyang 455000,china 3.college of life science,Central china normal university,Wuhan 43.079,china National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Science Beijing China college of life science Central China Normal University Wuhan China Chemistry Department Anyang teacher's College Anyang China

Our previous study has demonstrated that CD 146 molecule is a biomarker on vascular endothelium,which is involvedin angiogenesis and tumor *** the mechanism behind is not *** we have for the first time devel-oped a novel CD146 blockade system using CD146 siRNA to study its function on endothelial *** data showedthat CD146 siRNA specifically blocked the expression of CD146 on both mRNA and protein levels,leading to thesignificant suppression of HUVEC proliferation,adhesion and *** results demonstrate that CD146 playsa key role in vascular endothelial cell activity and angiogenesis,and CD146 siRNA can be used as a new inhibitor foranti-angiogenesis therapy.

关键词： small interfering RNA adhesion molecule CD 146 vascular endothelial cell

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Characteristics of fMRI BOLD signal and its neurophysiological mechanism

引用

Progress in Natural science:Materials International 2007年第6期17卷 630-638页

作者： Zhao Xiaohu1,2, Wu Yigen3.and Guo Shengli3.1. college of life sciences, Zhejiang {3., Hangzhou 3.0058, china 2. Imaging Department of Tongji Hospital of Tongji {3., Shanghai 200065, china 3. college of Mathematics and Physics, Nanjing {3. of Information science and Technology, Nanjing 210044, china) college of life sciences Zhejiang University Hangzhou 310058 China Imaging Department Tongji Hospital Tongji University Shanghai 200065 China college of Mathematics and Physics Nanjing University of Information Science and Technology Nanjing 210044 China

The functional magnetic resonance imaging (fMRI) based on blood oxygen level dependent (BOLD) contrast has emerged as one of the most potent noninvasive tools for mapping brain function and has been widely used to explore physiological, pathological changes and mental activity in the brain. Exploring the nature and property of BOLD signal has recently attracted more attentions. Despite that great progress has been made in investigation of the characteristics and neurophysiological basis, the exact nature of BOLD signal remains unclear. In this paper we discuss the characteristics of BOLD signals, the nonlinear BOLD response to external stimuli and the relation between BOLD signals and neural electrophysiological recordings. Furthermore, we develop our new opinions regarding nonlinear BOLD response and make some perspectives on future study.

关键词： functional magnetic resonance imaging blood oxygen level dependent nonlinear response neural electrophysiological activity.

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Two new Jurassic stoneflies (Insecta: Plecoptera) from Daohugou, Inner Mongolia, china

引用

Progress in Natural science:Materials International 2008年第8期18卷 1039-1042页

作者： Yushuang Liu, Dong Ren * college of life science, Capital {3. university, 105 Xisanhuanbeilu, Haidian District, Beijing 10003., china college of life science Capital Normal University 105 Xisanhuanbeilu Haidian District Beijing 100037 China

Two new genera and two new species of family Taeniopterygidae, Mengitaenioptera multiramis gen. et sp. nov. and Noviramonemoura trinervis gen. et sp. nov. are described. These fossils were collected from Daohugou Village (the Middle Jurassic), Inner Mongolia, china. Hitherto, these fossil species from Daohugou are the oldest taeniopterygids. Both simple and complex venations simultaneously occurred in this group, which reveals that the early diversification of taeniopterids was well underway by the Middle Jurassic. Therefore, we prefer to adopt the Comstock’s opinion that the venation of taeniopterids was derived from the simple venation of the older group (such as Palaeonemouridae) at much ancient geological time ago. Some of the descendants carried this simple venation; others evolved into complex venation with many additional crossveins and branches.

关键词： Plecoptera Taeniopterygidae Daohugou Inner Mongolia Middle Jurassic

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Atomic Force Microscopy-based Cell Nanostructure for Ligand-conjugated Quantum Dot Endocytosis

引用

Acta Biochimica et Biophysica Sinica 2006年第9期38卷 646-652页

作者： Yun-Long PAN~1* Ji-Ye CAI~2 Li QIN~3.Hao WANG~4 1 The First Affiliated Hospital of Jinan university,Guangzhou 51063.,china 2 college of {3. science and Technology,Jinan university,Guangzhou 51063.,china 3.Department of Histology and Embryology,Medical college of Jinan university,Guangzhou 51063.,china 4 Information and Optoelectronic science and Engineering.South china normal university,Guangzhou 51063.,china The First Affiliated Hospital of Jinan universityGuangzhou 51063. China college of life science and Technology Jinan UniversityGuangzhou 510632 China Department of Histology and Embryology Medical College of Jinan UniversityGuangzhou 510632 China School for Information and Optoelectronic science and Engineering South China Normal UniversityGuangzhou 510631 China

While it has been well demonstrated that quantum dots (QDs) play an important role inbiological labeling both in vitro and in vivo,there is no report describing the cellular nanostructure basis ofreceptor-mediated ***,nanostructure evolution responses to the endocytosis of transferrin(Tf)-conjugated QDs were characterized by atomic force microscopy (AFM).AFM-based nanostructureanalysis demonstrated that the Tf-conjugated QDs were specifically and tightly bound to the cell receptorsand the nanostructure evolution is highly correlated with the cell membrane receptor-mediated ***,confocal microscopic and flow cytometry results have demonstrated the specificity anddynamic property of Tf-QD binding and *** found that the internalization of Tf-QD is linearlyrelated to ***,while the nanoparticles on the cell membrane increased,the endocytosis was stillvery active,suggesting that QD nanoparticles did not interfere sterically with the binding and function ***,ligand-conjugated QDs are potentially useful in biological labeling of cells at a nanometerscale.

关键词： quantum dot endocytosis nanostructure atomic force microscopy

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Construction and characterization of the transformation-competent artificial chromosome (TAC) libraries of Leymus multicaulis

引用

science china(life sciences) 2008年第7期51卷 604-613页

作者： XU YueYu 1,2,3.ZHOU YuLei 4,5 ,SONG LinLin 6 ,ZHANG Yan 3.&ZHAO MaoLin 1 1 Beijing Agro-Biotechnology Research Center,Beijing Academy of Agriculture and Forestry science,Beijing 100097,china 2 Department of Chemistry and Chemical Engineering,Hunan Institute of Engineering,Xiangtan 411104,china 3.{3. of life science,Capital normal university,Beijing 10003.,china 4 {3. of life science,Zhongkai university of Agriculture and Technology,Guangzhou 510225,china 5 {3. of Grassland science,Gansu Agricultural university,Lanzhou 73.070,china 6 Department of Biology,henan Institute of science and Technology,xinxiang 453.03.china Beijing Agro-Biotechnology Research Center Beijing Academy of Agriculture and Forestry Science Beijing China Department of Chemistry and Chemical Engineering Hunan Institute of Engineering Xiangtan China college of life science Capital Normal University Beijing China college of life science Zhongkai University of Agriculture and Technology Guangzhou China college of Grassland science Gansu Agricultural University Lanzhou China Department of Biology Henan Institute of Science and Technology Xinxiang China

Transformation-competent artificial chromosome system is able to clone and transfer genes efficiently in *** order to clone genes highly tolerant to barley yellow dwarf virus(BYDV),Aphids,drought and salt from Leymus multicaulis,the two TAC genomic libraries I and II were constructed in vector pYLTAC17 and pYLTAC747H/sacB,which contain about 165000 and 23.000 recombinant clones *** genome coverage of the two libraries was totally estimated to be about 3.5 haploid genome equivalents,as size selection of genomic DNA fragments was approximately from 9 to 3.0 *** of the genomic libraries were collected as bulked pools each containing 500 clones or so,stored in twelve 96-deep-well plates and then were gridding in triplicate onto a high-density colony hybridization filter with a 3.3.pattern using a GeneTAC?G3.arraying robot after being transferred manually into three 3.4-well *** 2501 and 2890 clones of Library in pYLTAC17 and in pYLTAC747H/sacB were stored individually in fourteen 3.4-well plates and then were automatically gridding in duplicate onto a high-density colony hybridization filter with a 6×6 pattern after a replication of *** positive clones were detected by using the probe glutahione reductase gene of *** libraries constructed here can be used to isolate genomic clones containing target genes,and to carry out genome walking for positional *** the target TAC clones were isolated,they could be immediately transferred into plant genomes with the Agrobacterium system.

关键词： Leymus multicaulis megabase-size DNA transformation-competent artificial chromosome(TAC) genomic library

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：