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3.S MAX中体视动画生成模块的实现

计算机工程 2002年第4期28卷 178-179,257页

作者：黄心渊陈世红北方工业大学CAD研究中心北京100041 北京联合大学应用文理学院北京100083

介绍了体视动画的生成方法,讨论了如何基于流行的三维动画软件3.S MAX开发体视动画的生成模块。最后给出了建筑动态模拟体视动画中的一帧图像。

关键词： 3.S MAX 三维动画软件体视动画生成模块计算机

Effects of Thinning and Litter Fall Removal on Fine Root Production and Soil Organic Carbon Content in Masson Pine Plantations

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Pedosphere 2010年第4期20卷 486-493页

作者： TIAN Da-Lun PENG Yuan-Ying YAN Wen-De FANG Xi KANG Wen-Xing WANG Guang-Jun CHEN Xiao-Yong Forest Ecology Section Faculty of Life Sciences Central South University of Forestry and Technology Changsha 410006（China） Biology Program Department of Health and Science College of DuPage IL （USA） Biology Program College of Arts and Science Governors State University IL （USA）

Soils play a critical role in the global carbon cycle, and can be major source or sink of CO2 depending upon land use, vegetation type and soil management practices. Fine roots are important component of a forest ecosystem in terms of water and nutrient uptake. In this study the effects of thinning and litter fall removal on fine root production and soil organic carbon content were examined in 20-year-old Masson pine （Pinus resinosa） plantations in Huitong, Hunan Province of china in the growing seasons of 2004 and 2005. The results showed that fine root production was significantly lower in the thinning plots than in the control plots, with a decrease of 58% and 1.% in 2004 and 2005 growing seasons, respectively. Litter fall removal significantly increased fine root production by 1.% in 2004. Soil temperature （Tsoil） and soil moisture （Msoil） were higher in the thinning plots than those in the controls. Litter fall removal had significant effects on Tsoil and Msoil. Soil organic carbon content was higher in the thinning plots but was lower in the plots with litter fall removal compared with that in the controls. Our results also indicated that annual production of fine roots resulted in small carbon accumulation in the upper layers of the soil, and removal of tree by thinning resulted in a significant increase of carbon storage in Masson pine plantations.

关键词： fine roots forest management soil carbon soil moisture soil temperature

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Toll样受体:免疫治疗的新靶位

中国新药与临床杂志 2004年第10期23卷 718-723页

作者：任光圆晏春根谢青绍兴文理学院医学院浙江绍兴312000 上海第二医科大学附属瑞金医院上海200025

Toll样受体 (Toll likereceptors ,TLRs)是新近发现的模式识别受体 ,能识别病原相关分子模式 ,启动炎性应答通路而调节或控制先天与获得性免疫。以TLRs为靶位 ,抑制或激活TLRs表达或调控TLRs信号通路。

关键词：免疫疗法细胞因子类配体信号传导 Toll样受体

Immunohistochemical Studies of the Expression of Matrix Metalloproteinase-2 and Metalloproteinase-9 in Human Prostate Cancer

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Journal of Huazhong university of Science and Technology(Medical {1.) 2003年第4期23卷 373-374,379页

作者：曾汉青肖亚军鲁功成陈勇 Department of Urology

To study the expression of matrix metalloproteinase 2 and 9 in human prostate cancer, matrix metalloproteinase 2 and 9 were immunohistochemically detected in tissues of prostate cancer and benign prostatic hyperplasia (BPH). Our results showed that matrix metalloproteinase 2 and 9 levels in prostate cancer were much higher than those in tissues of BPH, with the cancer invasion being positively correlated with the expression of the metalloproteinases. It is concluded that matrix metalloproteinase 2 and 9 are better molecular markers, which are of help in the diagnosis and prediction of prognosis of prostate cancer.

关键词： prostate cancer matrix metalloproteinase 2 matrix metalloproteinase 9 immunohistochemistry

Screening of GJB2 mutations in Chinese population

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Journal of Otology 2007年第1期2卷 18-22页

作者： HAN Ming-kun1, HAN Dong-yi1, GUO Yu-fen2, LI Qing-zhong3. ZHAO Ya-li1, 4, RAO Shao-qi1, 5, 6, YUAN Hu1, ZONG Liang1, GUAN Jing2, XU Bai-cheng2, WANG Da-yong1, LAN lan1, WANG Qiu-ju1, 7 1 Department of Otorhinolaryngology/ Head and Neck Surgery, and Institute of Otolaryngology, china People Liberation Army General Hospital, Beijing, china 2 Department of Otorhinolaryngology/ Head and Neck Surgery, the Second Affiliated Hospital of LanZhou university, Lanzhou, china 3.Deparment of Otlolaryngology, Eye and ENT Hospital of Fudan university, Shanghai, china 4 Department of Biochemistry and Molecular Biology, Institute of Basic Medical sciences, Chinese Academy of Medical sciences and Peking union Medical college, Beijing, china 5 Departments of Cardiovascular Medicine and Molecular Cardiology, the Cleveland Clinic Foundation, Cleveland, Ohio, USA 6 Department of Bioinformatics, Harbin Medical university, Harbin, china 7 china National Human Genome Center, Beijing, china Department of Otorhinolaryngology/ Head and Neck Surgery and Institute of Otolaryngology China People Liberation Army General Hospital Beijing China Department of Otorhinolaryngology/ Head and Neck Surgery the Second Affiliated Hospital of LanZhou University Lanzhou China Deparment of Otlolaryngology Eye and ENT Hospital of Fudan University Shanghai China Department of Biochemistry and Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Departments of Cardiovascular Medicine and Molecular Cardiology the Cleveland Clinic Foundation Cleveland Ohio USA Department of Bioinformatics Harbin Medical University Harbin China china National Human Genome Center Beijing China

The GJB2 gene(connexin 26) has been shown to be responsible for DFNB1.and DFNA3. We screened the GJB2 gene in 488 patients with prelingual deafness(Group 1., 1.4 with postlingual deafness(Group 2), and 1.7 normal hearing subjects(Group 3.. We found that, in Group 1. 65 patients(1.0}3.%) were homozygotes or compound heterozygotes and 51.patients (1..45%) carried a single pathogenic mutation. The 23.delC mutation was the most frequent mutation, accounting for 73.22% of the known pathogenic alleles in Group 1. No homozygotes or compound heterozygotes were detected in Group 2 or Group 3. Some postlingual deaf patients (2.42%) and normal hearing subjects(4.27%) were 23.delC carriers. Our preliminary data indicate that 23.delC, the most frequent mutation identified in this study, is a major cause for prelingual deafness.

关键词： prelingual deafness postlingual deafness, GJB2 23.delC Chinese

Cu（Ⅱ） attenuates oligomeic and fibrillar A β-induced activation of BV-2 microglia cells

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Cu（Ⅱ） attenuates oligomeic and fibrillar A β-induced act...

Prevention and Treatment of Osteoporosis with Chinese Herbal Medicines

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Han-Chang HANG~(1.*) Xue-Ling DAI~1.Xiao-Hui YANG~2 Wei XU~1.Lin CHEN~2 Zhao-Feng JIANG~(1.*) 1.college of {1. and sciences Beijing {3. university Beijing 1.01.1.china 2 college of Life Science Capital Normal university Beijing 1.003. china

＜正＞Background Amyloid-β peptide（Aβ） is one of the main components of senile plaques,a pathological hallmark of Alzheimer’s disease（AD）.Activated microglia represents a major source of inflammatory factors in Alzheimer’s disease and a possible source of cytotoxic factors.Aβpeptide has been shown to activate microglia and stimulate their production of inflammatory *** evidence has shown that the redox-active biometal Cu（Ⅱ） can modulate the physiochemical properties of Aβ.This article aims to evaluate the effect of oligomeric and fibrillar Aβand Cu（Ⅱ） on microglia activation. Methods Oligomeric and fibrilliar Aβwere prepared by incubation at 4℃for 24h or at 3.℃for 7days,respectively.Aβpeptide assemblies were extensively characterized by CD,TH-T fluorescence and sedimentation *** the Aβ-Cu（Ⅱ） complex preparation,the above oligomeric and fibrillar Aβwere incubated with Cu（Ⅱ） for 1. to form the Aβ-Cu（Ⅱ） complexes, *** immortalized murine BV-2 cells were grown and maintained in Dulbecco’s Modified Eagles Medium （DMEM）（supplemented with 1.%fetal bovine serum and 1.0 mg/mL streptomycin and 1. U/mL penicillin） at 3.℃in a humidified incubator with 5%CO2.20μM concentration of oligomeric or fillbrillar Aβwas chosen,and LPS was chosen as positive control and PBS as vehicle *** viability was quantitively determined using the MTT *** BV-2 cells co-incubated with different forms of Aβor their Aβ-Cu（Ⅱ） complexes for 24 h,real-time PCR（RT-PCR） detected TNFαand iNOS mRNA expression levels of BV-2 *** production of nitric oxide（NO） was quantified by measuring the released NO metabolites（nitrate and nitrite） with Griess *** Cu（Ⅱ） has an important effect on the oligomeric and filbrillar Aβsecondary structure and aggregation,and will disrupts p-sheet structure and convertsβaggregates into non-β*** oligomeric and filbrillar Aβcan induce microglial activation,however the cellular signal ways are different due to t

关键词： Alzheimer’s disease amyloid β-peptide copper nitric oxide(NO) TNFβ

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Chinese Herbal Medicines 2012年第4期4卷 265-270页

作者： ZHAO Xiao-ling1,2,FENG Yu-xiong1,2,3.PENG Yong1,2 1.Institute of Medicinal Plant Development,Chinese Academy of Medical sciences and Peking union Medical college,Beijing 100193.{3. 2.Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicines,Ministry of Education,Beijing 100193.{3. 3.college of Basic Medicine,Guangxi university of Chinese Medicine,Nanning 53.001,{3. [a] Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100193 China [b] Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicines Ministry of Education Beijing 100193 China [c] college of Basic Medicine Guangxi University of Chinese Medicine Nanning 530001 China

In this paper,laboratory reports,medication rules,formulating principles,and research methods are summarized and analyzed,including single herb,compound herbs,and the problems in the prevention and treatment of osteoporosis(OP) within the past *** widely recognized efficacy,satisfying achievements have been achieved in preventing and treating OP with Chinese herbal medicines(CHM).However,due to the complex constituents,the pharmacological activities and mechanism of CHM are not clear yet,and there is no unified standard on the diagnosis and syndrome differentiation of OP and the efficacy evaluation of CHM in the ***,the research in the future should focus on the pharmacology and standardization of CHM in treating OP.

关键词： Chinese herbal medicines efficacy evaluation osteoporosis pharmacological activities prevention and treatment

Metabolism and effect of para-toluene-sulfonamide on rat liver microsomal cytochrome P450 from in vivo and in vitro studies

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Acta Pharmacologica Sinica 2006年第5期27卷 635-640页

作者： Jiang-quan ZHOU~(1.3. Zhi-qiang TANG~1.Jin-nan ZHANG~2 Jing-cheng TANG~2 ~1.epartment of Pharmacy,Cancer Hospital.Chinese Academy of Medical Science and Peking {1. Medical college,Beijing 1.0021.china ~2School of Chemical Biology and Pharmaceutical {3..Capital university of Medical {3..Beijing 1.0069.china DepartmentofPharmacy CancerHospitalChineseAcademyofMedicalScienceandPekingUnionMedicalCollegeBeijing100021China SchoolofChemicalBiologyandPharmaceuticalsciences CapitalUniversityofMedicalSciencesBeijing100069

Aim:To study the in vivo and in vitro metabolism and the effect of para-toluene-sulfonamide （PTS） on cytochrome P450 enzymes （CYP450）.Methods:Total CYP450and microsome protein content were determined after iv pretreatment of rats ***-specific substrates were incubated with rat liver *** isoform activities were determined by using *** chemical inhibitorsadded to the incubation mixture were used to investigate the principal CYP isoformsinvolved in PTS *** effect of PTS on CYP isoforms was investigatedby incubating PTS with specific ***:The groups treated with 3.and 99 mg/kg per d PTS,respectively,had a total CYP content of 0.66±0.1. and0.60±0.1.nmol/*** Kmand Vmaxwere 92.2μmol/L and 0.01.0}nmol/min per ***2C7,CYP2D1.and CYP3.2 might contribute to PTS metabolism in therat *** inhibitory effects of sulfaphenazole and ketoconazole on PTS me-tabolism were shown to have a mixed mechanism,whereas PTS metabolism wasinhibited noncompetitively by *** had little effect on the activities ofthe selected CYP ***:Generally speaking,it is relatively safefor PTS to be co-administered with other ***,care should be takenwhen administering PTS with CYP inhibitors and the substrates of CYP2C,CYP2Dand CYP3..

关键词： cytochrome P450 para-toluene-sulfon amide liver microsomes HPLC inhibitor

心肌特异性新蛋白激酶p93.peroxiredoxin3.相互作用

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生物化学与生物物理进展 2004年第8期31卷 688-692页

作者：冯艳刘冬青王震曹慧青时娜邓仲端丁金凤孟宪敏中国医学科学院中国协和医科大学阜外心血管病医院分子医学中心北京100037 华中科技大学同济医学院药理系武汉430030 华中科技大学同济医学院病理系武汉430030

为了明确p93.心血管系统中的生物学功能及在信号传导通路中的作用 ,采用酵母双杂交技术 ,选择 p93.端第 1. 1. 3.2位氨基酸构建诱饵质粒 ,筛选成人心脏cDNA文库 ,寻找与之相互作用的蛋白质 ,结果得到蛋白peroxiredoxin 3.PRX 3. .采... 详细信息

为了明确p93.心血管系统中的生物学功能及在信号传导通路中的作用 ,采用酵母双杂交技术 ,选择 p93.端第 1. 1. 3.2位氨基酸构建诱饵质粒 ,筛选成人心脏cDNA文库 ,寻找与之相互作用的蛋白质 ,结果得到蛋白peroxiredoxin 3.PRX 3. .采用体外结合实验和免疫共沉淀等方法 ,证实了原核和真核表达的 p93.实可与PRX3.互作用 ,通过双重荧光共定位 ,为二者的相互作用提供了定位依据 .研究提示p93.能参与心肌细胞中与PRX3.关的各种生理病理过程 ,如生长、分化、发育、凋亡。

关键词：心肌特异性新蛋白激酶 p93 酵母双杂交心肌细胞生物学功能信号传导通路