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Correlation of Behavior Changes and BOLD Signal in Alzheimer-like Rat Model

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Acta Biochimica et Biophysica Sinica 2004年第12期36卷 803-810页

作者： Zheng-Hui HU#, Xiao-Chuan WANG1#, Li-Yun LI3. Mai-Li LIU3. Rong LIU1, Zhiqun LING1, Qing TIAN1, Xiao-Wei TANG, Yi-Gen WU2*, and Jian-Zhi WANG1* Department of physics and Bio-X disciplinary Laboratory, Zhejiang University, Hangzhou 3.0027,china 1 Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 43.03., china 2{3. of high energy physics and Key Laboratory of Nuclear Analysis Techniques, chinese academy of sciences, P.O. Box 918, beijing 10003., china 3.uhan {3. of physics and Mathematics, State Key Laboratory of Magnetic Resonance and Atomic and Molecular physics, chinese academy of sciences, Wuhan 43.071, china Department of physics and Bio-X disciplinary Laboratory Zhejiang UniversityHangzhou 310027China Department of Pathophysiology Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030 China Wuhan institute of physics and Mathematics State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Chinese Academy of SciencesWuhan 430071 China institute of high energy {3. and Key Laboratory of Nuclear Analysis Techniques Chinese Academy of SciencesP.O. Box 918 Beijing 100039 China

To explore a potential means for the early diagnosis of Alzheimer disease, we studied the relationship of resting T2* signal and tau hyperphosphorylation/spatial memory deficit. The rat model with tau hyperphosphorylation and spatial memory deficit was established by bilateral hippocampi injection of isoproterenol (IP). Then, the correlative alteration between resting T2* signal and spatial memory retention was assessed with blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) study and Morris Water Maze test, and Western blot was employed to confirm tau hyperphosphorylation. The analysis showed following results. (1) Tau phosphorylation at Ser3.6/Ser404 and Ser199/Ser202 was signifi- cantly increased in IP-injected rats as detected by PHF-1 and tau-1, respectively. (2) An AD-like spatial memory retention disturbance was induced at 24 h after isoproterenol injection. (3. A sensitivity threshold of resting T2* signal intensity, which separated the IP-treated rats from vehicle control, was obtained by applying linear regression analysis, and an estimated sensitivity statistical threshold was at 3..62. These results suggest that resting T2* signal may serve as a noninvasive quantitative marker in predicting AD-like spatial memory deficits and tau hyperphosphorylation.

关键词： Alzheimer disease (AD) functional magnetic resonance imaging (fMRI) isoproterenol (IP) Morris Water Maze diagnosis

Simulation of the in-flight calibration of the collimator alignment and PSF for HXMT

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Science china(physics,Mechanics & Astronomy) 2010年第S1期53卷 47-50页

作者： XIONG ShaoLin,LI XinQiao,QU JinLu & LU FangJun Key Laboratory for Particle Astrophysics,institute of high {3. physics,chinese academy of sciences(CAS),beijing 100049,china 1. Key Laboratory for Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences (CAS) Beijing 100049 China

The Hard X-ray Modulation Telescope(HXMT) is an X-ray astronomical satellite in 1-250 keV,consisting of three collimated *** present the in-flight calibration approach of the collimator alignment and Point Spread Function(PSF) for HXMT,using both the direct fitting method and the imaging *** to observational simulations of the Crab Nebula,we find that these two methods produce almost the same calibration accuracy of the alignment,and with a one-day scanning observation,the alignment can be calibrated to better than 0.45' and 0.1' along the wide and narrow directions of the Field of View(FOV) for a detector module,which corresponds to a localization accuracy of better than 0.1' and meets the scientific requirement.

关键词： HXMT alignment PSF calibration

Potential land for plantation of Jatropha curcas as feedstocks for biodiesel in china

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Science china Earth sciences 2010年第1期53卷 120-127页

作者： WU WeiGuang 1,2,3.HUANG JiKun 1,3.& DENG XiangZheng 1,3.1 institute of Geographic sciences and Natural Resources Research,chinese {3. of sciences,beijing 100101,china 2 Department of Economics and Management,Zhejiang Forestry University,Linan 3.13.0,china 3.Center for chinese Agricultural Policy,chinese {3. of sciences,beijing 100101,china 1. institute of Geographic sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China2. Department of Economics and Management Zhejiang Forestry University Linan 311300 China3. Center for Chinese Agricultural Policy Chinese Academy of Sciences Beijing 100101 China

As a renewable energy,biofuel has attracted great attention in china and the rest of *** with the national food security,china recently has shifted its biofuel development priority from grain-based to non-grain-based biofuels,including forest-based biodiesel,since *** curcas is one of major biodiesel ***,there is rising debate on availability of land for expanding Jatropha curcas *** overall goal of this paper is to evaluate potential land for Jatropha curcas used as feedstock for biodiesel in *** on remote sensing data on land use,data on meteorological,soil and land slope,and suitable environment for Jatropha curcas plantation,this study uses Agro Ecological Zone method and considers social-economic constraints to evaluate potential suitable land for Jatropha curcas plantation in china's major Jatropha curcas production region,Southwest *** results show that while there are some potential lands to expand Jatropha curcas areas,amount of these lands will hardly meet the government's target for Jatropha curcas-based biodiesels development in the *** may need to reconsider its long-term targets on the development of Jatropha curcas-based biodiesels.

关键词： biodiesel Jatropha curcas potential land suitability evaluation Southwest china

Comparison of dark energy models:A perspective from the latest observational data

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中国科学：物理学、力学、天文学英文版 2010年第9期53卷 1631-1645页

作者： LI Miao1,2,LI XiaoDong2,3.& ZHANG Xin1,4 1Kavli institute for Theoretical physics china,{3. academy of sciences,beijing 100190,china 2Key Laboratory of Frontiers in Theoretical physics,institute of Theoretical physics,{3. academy of sciences,beijing 100190,china 3.nterdisciplinary Center for Theoretical Study,University of Science and Technology of china,Hefei 23.026,china 4Department of physics,College of sciences,Northeastern University,Shenyang 110004,china 1. Kavli institute for Theoretical physics china Chinese Academy of Sciences Beijing 100190 China2. Key Laboratory of Frontiers in Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences Beijing 100190 China3. Interdisciplinary Center for Theoretical Study University of Science and Technology of China Hefei 230026 China4. Department of Physics College of Sciences Northeastern University Shenyang 110004 China

We compare some popular dark energy models under the assumption of a flat universe by using the latest observational data including the type Ia supernovae Constitution compilation,the baryon acoustic oscillation measurement from the Sloan Digital Sky Survey,the cosmic microwave background measurement given by the seven-year Wilkinson Microwave Anisotropy Probe observations and the determination of H0 from the Hubble Space *** comparison statistics such as the Bayesian and Akaike information criteria are applied to assess the worth of the *** statistics favor models that give a good fit with fewer *** on this analysis,we find that the simplest cosmological constant model that has only one free parameter is still preferred by the current *** other dynamical dark energy models,we find that some of them,such as the αdark energy,constant w,generalized Chaplygin gas,Chevalliear-Polarski-Linder parametrization,and holographic dark energy models,can provide good fits to the current data,and three of them,namely,the Ricci dark energy,agegraphic dark energy,and Dvali-Gabadadze-Porrati models,are clearly disfavored by the data.

关键词： dark energy models observational constraints model comparison information criteria

An SGS Model and Its Application

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Communications in Nonlinear Science and Numerical Simulation 1999年第2期4卷 87-90页

作者： Zhengtong XIE Jiachun LI (institute of Mechanics, chinese academy of sciences, beijing 100080,{3.) institute of Mechanics Chinese Academy of Sciences Beijing 100080 China

Based on the turbulent energy and structure function model, a subgridstress model named transitional structure function (TSF) is proposed, which exhibitsmore satisfactory performance than the previous one when applied in turbulent flow withinand above forest *** time and horizontal averaged statistics such as mean verticalprofiles of wind velocity, Reynolds stress, turbulent kinetic energy etc., and instantaneousfields as well are in general agreement with earlier observations, at least in a qualitativesense.

关键词： Large-Eddy simulation SGS model turbulent flow canopy

Chemical and mineralogical characterizations of a copper converter slag

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Rare Metals 2002年第3期21卷 175-181页

作者： DENG Tong and LING Yunhaninstitute of Chemical Metallurgy, chinese academy of sciences, beijing 00080,{3. institute of Chemical Metallurgy Chinese Academy of Sciences 北京 100080

A copper converter slag was examined chemically and mineralogically to determine its existing phases, in particular those containing Co and Cu. The slag consists predominantly of fayalite and magnetite, together with some glass, chalcocite, and metallic copper. Copper is entrapped in the slag mostly as chalcocite and metallic copper, as well as trace copper oxide. There was no indication of any independent Co mineral in the slag, but Co was found to be enriched in fayalite and megnetite as solid solution, although Co was detected in all the phases of the slag by SEM-EDX (scanning electron microscopy equipped with model EDAX-9100 energy dispersive spectrometer) and WDS (model WDX-2A X-ray wave-length dispersive spectrometer).

关键词： Cu Co converter slag characterization

Virtualities of quark and gluon in QCD vacuum

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Science china(physics,Mechanics & Astronomy) 2008年第10期51卷 1439-1447页

作者： ZHOU LiJuan1, QIN SongMei2, WU Qing3.& MA WeiXing4 1 Collaboration Group of Hadron physics and Non-perturbative QCD Study, Guangxi University of Tech- nology, Liuzhou 545006, china 2 Department of physics, Guangxi University, Nanning 540003. china 3.Department of physics, Qingdao University, Qingdao 266071, china 4 institute of high energy physics, chinese academy of sciences, beijing 100049, china 1. Collaboration Group of Hadron physics and Non-perturbative QCD Study Guangxi University of Technology Liuzhou 545006 China 2. Department of physics Guangxi University Nanning 540003 China 3. Department of physics Qingdao University Qingdao 266071 China 4. institute of high energy physics Chinese Academy of Sciences Beijing 100049 China

The non-local vacuum condensates of quantum chromodynamics (QCD) describe the distributions of quarks and gluons in the non-perturbative QCD vacuum state. Physically, this means that vacuum quarks and gluons have a nonzero mean-squared momentum in the vacuum, called virtuality. The quark virtuality is given by the ratio of the local quark-gluon mixed vacuum condensate to the quark local vacuum condensate. The gluon virtuality is expressed by gluon vacuum condensates and four-quark vacuum condensates. We study the two virtualities by solving Dyson-Schwinger Equations and calculating quark and gluon vacuum condensates. Our theoretical results for quark virtuality are in good agreement with many other theoretical model predictions such as QCD sum rules and lattice QCD calculations. Our calculation on gluon virtuality is initial and the results are quite interesting.

关键词： quark gluon virtuality QCD vacuum condensate non-perturbative QCD

Hard X-ray lags of Cygnus X-1 on short timescales

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Science china(physics,Mechanics & Astronomy) 2010年第S1期53卷 150-152页

作者： JIN Jing1,LU Yu2,3.QU JinLu2 & LI TiPei1,2 1 Department of Engineering physics & Center for Astrophysics,Tsinghua University,beijing 100084,{3. 2 Key Laboratory of Particle Astrophysics,institute of high energy physics,chinese academy of sciences,beijing 100049,{3. 3.Graduate University of chinese academy of sciences,beijing 100049,{3. 1. Department of Engineering physics & Center for Astrophysics Tsinghua University Beijing 100084 China2. Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China3. Graduate University of Chinese Academy of Sciences Beijing 100049 China

Calculating the time lags over different timescales using the cross-correlation technique may lead to a biased estimate of small *** a timescale for lightcurve binning,we propose to subtract the local average instead of the global average during the cross-correlation,in order to filter variations on timescales larger than the bin *** new method allows us to make an unbiased estimate of the time lags using RXTE/PCA data on timescales as small as-5 ms,where the Fourier technique becomes *** calculate the time lag spectra of Cygnus X-1 at different spectral states with the new method,and find that the source appears to have similar X-ray lags on small timescales independent of its spectral states.

关键词： spectral lags Cygnus X-1 data analysis

Light collection of the POLAR detector

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Science china(physics,Mechanics & Astronomy) 2010年第S1期53卷 43-46页

作者： DONG YongWei,LI YanGuo,WU BoBing,ZHANG YongJie & ZHANG ShuangNan Key Laboratory of Particle Astrophysics,institute of high {3. physics,chinese academy of sciences,beijing 100049,china 1. Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China

POLAR is a compact polarimeter dedicated to measuring the polarization of GRBs between 50-3.0 *** light collection of 200 mm×6 mm×6 mm plastic bars has been simulated and optimized in order to get uniform response to X-rays at different points along one single *** to the Monte Carlo results,the amplitude uniformity strongly depends on the level of polishing of the scintillator surface and the covering.A uniformity of 89% is achieved with a prototype constructed by a non position-sensitive PMT and an array of 4×4 bars.

关键词： plastic scintillator light collection gamma-ray burst polarimeter