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Hydrogen sulfide ameliorates vascular calcification induced by vitamin D3.plus nicotine in rats

Acta Pharmacologica Sinica 2006年第3期27卷 299-306页

作者： Sheng-ying WU~(2,6) Chun-shui PAN~3.Bin GENG~3.Jing ZHAO~3.Fang YU~3.Yong-zheng PANG~3.Chao-shu TANG~4.Yong-fen QI~(3.4.5) ~2Institute of Cardiovascular Disease,Peking University First Hospital.Beijing 10003. ~3.epartment of Physiology and Pathophysiology,Peking University Health Science center,Beijing 100083.china,~4.ey Laboratory of Molecular Cardiovascular Science,Ministry of Education,Beijing 100083.china 2Institute of Cardiovascular Disease Peking University First Hospital Beijing 100034 China 3.epartment of Physiology and Pathophysiology Peking University Health Science Center Beijing 100083 China 3.epartment of Physiology and Pathophysiology Peking University Health Science Center Beijing 100083 China 3.epartment of Physiology and Pathophysiology Peking University Health Science Center Beijing 100083 China 3.epartment of Physiology and Pathophysiology Peking University Health Science Center Beijing 100083 China 3.epartment of Physiology and Pathophysiology Peking University Health Science Center Beijing 100083 China 4.ey Laboratory of Molecular Cardiovascular Science Ministry of Education Beijing 100083 China 4.ey Laboratory of Molecular Cardiovascular Science Ministry of Education Beijing 100083 China

Aim:To investigate the role of the endogenous cystathionine γ-synthase(CSE)/hydrogen sulfide(H2S)pathway in vascular calcification in ***:A ratvascular calcification model was established by administration of vitamin D3.plusnicotine(VDN).The amount of CSE and osteopontin(OPN)mRNA was deter-mined by using semi-quantitative reverse-transcription polymerase chain *** calcium content,4.Ca2+accumulation and alkaline phosphatase(ALP)activitywere measured.H,S production and CSE activity were ***:yonKossa staining produced strong positive black/brown staining in areas amongthe elastic fibers of the medial layer in the calcified *** calcium content,4.Ca2+accumulation and ALP activity in calcified arteries increased by 6.77-,1.4.-,and 1.87-fold,respectively,compared with *** expression of the OPNgene was upregulated(P4.Ca2+uptake and ALP activity in the VDN plus NaHSgroup was lower than that in the VDN *** content of calcium and4.Ca2+accumulation and activity of ALP in the aorta were 3..8%,4..75% and 63.5% lowerin the low-dosage NariS group than in the VDN group,respectively(P4.Ca2+and activity of ALP was 83.9%,3..8 % and 4..2% lower in the aorta in the high-dosage NariS group than in theVDN group,respectively(P<0.01).The expression of the OPN gene ***:The production of H,S,and CSE activity were de-creased and CSE gene expression was downregulated in rats with vascularcalcification.H2S can ameliorate vascular calcification,suggesting that the H2S/CSE pathway plays a regulatory role in the pathogenesis of vascular calcification.

关键词： hydrogen sulfide cystathionine-lyase vascular calcification mRNA

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A possible mode of the specific recognition of nucleic acids by proteins

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Chinese Science Bulletin 2001年第11期46卷 930-934页

作者： LI Xuqing & LIU CiquanDepartment of Computer Science, Kunming University of Science and Technology, Kunming 65004., china Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223. china Yunnan Observatory, Chinese Academy of Sciences, Kunming 650011, china 4. Modern Biological {3., Yunnan University, Kunming 650091, china Department of Computer Science Kunming University of Science and Technology Kunming China Yunnan Observatory Chinese Academy of Sciences Kunming China Laboratory of Cellular and Molecular Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming China Modern Biological center Yunnan University Kunming China

Seven sets of protein target sites, which occur in several gene promoters, have been analyzed. The results suggest that there is a possible mode of specific recognition of double-helical nucleic acids by proteins. This recognition mode is related to a special topological property of double-helical DNA, which is termed base spatial pattern (BSP) of DNA segment. BSP is the spatial topological property determined only by the spatial arrangement of the bases on double-helical DNA segment.

关键词： protein nucleic acids recognition base spatial pattern (BSP) target sites.

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Nd isotope as the tracer of seawater evolution of early Miocene in the eastern Pacific Ocean

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Chinese Science Bulletin 2003年第B06期48卷 106-110页

作者： LIU Jihua~(1,2,3., CHEN Lirong~1, WANG Yingxi~4.& HAN Jianxiu~5 1. Institute of Oceanology, Chinese Acadcmy of ences, Qingdao 266071. china 2. Key Lab of Marine Sedimentology and Environmental Geology, First Institute of Oceanograpgy, State Oceanic Administration, Qingdao 266061. china 3. Graduate School, Chinese Academy of Sciences, Beijing 10003.. china 4. Modern Analysis {3., Nanjing University. Nanjing 210093. china 5. Guangzhou Marine Investigation Bureau, Guangzhou 510760. china 1. Institute of Oceanology Chinese Academy of Sciences 266071 Qingdao China 2. Key Lab of Marine Sedimentology and Environmental Geology First Institute of Oceanograpgy State Oceanic Administration 266061 Qingdao China 3. Graduate School Chinese Academy of Sciences 100039 Beijing China 4. Modern Analysis center Nanjing University 210093 Nanjing China 5. Guangzhou Marine Investigation Bureau 510760 Guangzhou China

Fifty-six samples of nannofossil ooze were collected from Core PC5794.in the northern equatorial Pacific at 5 cm intervals. With the methods of mass spectrometer (VG3.4. and ICP, the Nd isotopic compositions (εNd(t)), Mn contents and Mg/Sr ratios of carbonate phase have been analyzed. CaCO3.contents of bulk sediments were obtained by dissolution of 0.5 mol/L HCl. Based on these data, the high-resolution εNd(t) profile of seawater in early Miocene with core depth(or time) have been established. The values of εNd(t) range from -6.2 to -2.97 and 4.fluctuation cycles existed during 24.06-22.02 Ma. 4.low εNd(t) values (about -6.4. correspond to high CaCO3.contents, which implicates that there were 4.cold epochs or 4.times of Antarctic Bottom Water activity. They occurred at the time of 24.06 Ma, 23.85 Ma,22.88 Ma and 22.26 Ma, respectively. High εNd(t) values correspond to the high Mn contents and high values of Mg/Sr ratio, which indicates the existence of 4.intense hydrothermal activity periods during 24.06-22 Ma, the durations of them are 4.05-23.98 Ma, 23.69-23.15 Ma, 22.74.22.3. Ma and 22.06-22.02 Ma, respectively.

关键词：同位素钕示踪原子海水演化中新世太平洋微化石分光计持续期海水样品

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Use-wear analysis confirms the use of Palaeolithic bone tools by the Lingjing Xuchang early human

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Chinese Science Bulletin 2010年第21期55卷 2282-2289页

作者： LI ZhanYang 1,4.& SHEN Chen 2,3.4.1 Henan Provincial Institute of Cultural Relics and Archaeology,Zhengzhou 4.0000,china 2 The Joint Laboratory of Human Evolution and Archaeometry,Chinese Academy of Sciences,Beijing 10004.,china 3.The Royal Ontario Museum,Toronto ON M5S2C6,Canada 4.Oriental Archaeology Research {4. of Shandong University,Jinan 250100,china Henan Provincial Institute of Cultural Relics and Archaeology Zhengzhou 450000 China Oriental Archaeology Research center of Shandong University Jinan 250100 China The Joint Laboratory of Human Evolution and Archaeometry Chinese Academy of Sciences Beijing 100044 China The Royal Ontario Museum Toronto ON M5S2C6 Canada

During 2007-2008 excavations at the Lingjing site near Xuchang,Henan Province,dated back to around 100-80 ka ago,a large quantity of mammalian fossil remains were recovered along with a remarkable cluster of Early Modern Human(EMH) skull fragments in *** some of those animal bones were probably modified into tools.A use-wear analysis was carried out to examine the functions of modified bone *** results suggest that Lingjing bone tools were used for drilling,penetrating,and scraping animal substances,and that some might have been hafted during the *** study confirms that early existence ofintentionally-modified bone tools at human occupations of the early Late Pleistocene in northern *** discovery suggests making and use of bone tools were inevitably a part of early human behaviors and cultural development,as such of stone tools.

关键词：早期人类磨损分析旧石器时代工具许昌哺乳动物化石现代人类动物骨头

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High-accuracy topographical information extraction based on fusion of ASTER stereo-data and ICESat/GLAS data in Antarctica

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Science china Earth Sciences 2009年第5期52卷 714-722页

作者： E DongChen1,3.SHEN Qiang2,XU Ying1,3.& CHEN Gang4.1 Chinese Antarctic center of Surveying and Mapping,Wuhan University,Wuhan 4.0}079,{4. 2 Institute of Seismology china Earthquake Administration,Wuhan 4.0}071,{4. 3.Key Laboratory of Polar Surveying and Mapping,State Bureau of Surveying and Mapping,Wuhan University,Wuhan 4.0}079,{4. 4.Department of Geography,University of Calgary,Calgary,Alberta T2N 1N4.Canada Chinese Antarctic center of Surveying and Mapping Wuhan University Wuhan 430079 China Institute of Seismology china Earthquake Administration Wuhan 430071 China Key Laboratory of Polar Surveying and Mapping State Bureau of Surveying an

In order to better support Antarctic inland ice sheet expedition from Zhongshan Station to Dome A,the topographic data are *** present,although the entire Antarctic DEM provided by RAMP(Ra-darsat Antarctic Mapping Project) was estimated at the highest horizontal(spatial) resolution of about 200 m,the real horizontal resolution of the DEM varies from place to place depending on the density and scale of the original source *** ice shelves and the inland ice sheet,the horizontal resolution is about 5 km;the vertical accuracy is estimated to be ±50 m in interior East Antarctic ice sheet and away from the mountain ***,more accurate topographic data are unavailable in *** order to meet the requirements of high-accuracy topographic information for further researches,this paper mainly addresses a fusion study of ASTER stereo pairs and ICESat/GLAS altimetry data for extraction of high-accuracy DEM in East Antarctica,based on the high horizontal resolution(15 m) of ASTER and vertical accuracy(13.8 cm) of ICESat/***,some altimetry data were selected as vertical control points to reduce errors of image correlation matching during the extraction of ASTER-based ***,ice sheet altimetry data derived from ICESat were used to generate DEM ranging from 75° to 81°S because existing ASTER data do not cover this area and high density of the coverage of ICESat altimetry ***,the DEM in coverage of the expedition route was *** analysis of result reveals that the DEM accuracy is improved *** absolute vertical accuracy of DEM is higher than 15 m in some cases and higher than 3. m for all the areas along the expedition route except from the 009-001 scene;the interior accuracy is higher than 15 m and higher than 7 m in some *** can meet the requirements of topographic map at 1:50000 scale,which is an economic and advantageous method to produce the topographic products.

关键词： DEM Antarctica Zhongshan Station Dome A ASTER ICESat GLAS

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Orientation-Singularity Representation and Orientation-Capability Computation of a Special Class of the Gough-Stewart Parallel Mechanisms Using Unit Quaternion

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Chinese Journal of Mechanical Engineering 2012年第6期25卷 1096-1104页

作者： LI Baokun1, 2, CAO Yi1, 3. *, ZHANG Qiuju1, and HUANG Zhen4.1 School of Mechanical Engineering, Jiangnan University, Wuxi 214.22, china 2 School of Mechanical Engineering, Anhui University of Science and Technology, Huainan 23.001, china 3.State Key Laboratory of Fluid Power Transmission and Control, Hangzhou 3.0027, china 4.Robotics Research {3., Yanshan University, Qinhuangdao 066004. china 1. School of Mechanical Engineering Jiangnan University Wuxi 214122 China 2. School of Mechanical Engineering Anhui University of Science and Technology Huainan 232001 China 3. State Key Laboratory of Fluid Power Transmission and Control Hangzhou 310027 China 4. Robotics Research center Yanshan University Qinhuangdao 066004 China

Singular configuration seriously affects the performance of the Gough-Stewart parallel mechanism and has attracted many researchers’ attentions. However, most of existing topics often focus on the position-singularity of the mechanism for a constant-orientation, but few reports research the orientation-singularity for a given position. In order to investigate the orientation-singularity of the Gough-Stewart parallel mechanisms with two dissimilar semi-regular hexagonal platforms for a given position, after constructing the discrimination matrix of the singular configuration of the mechanism and computing the determinant of this matrix by using unit quaternion as the orientation parameters which can avoid the singularities in parameterization, a general symbolic expression representing the three-dimensional orientation-singularity locus for a given position is obtained and the three-dimensional view of the orientation-singularity locus is further described. The orientation-singularity-free void exists inside the orientation-singularity locus, but the shape of the orientation-singularity-free void is irregular and inconvenient for the design of the mechanism. The minimal inscribed sphere of the three-dimensional orientation-singularity locus namely the orientation-singularity-free ball is described. The radius of the ball orientation-capability is used as the measurement for the orientation-singularity-free void size. A new efficient algorithm is proposed for the computation of the orientation-capability. Finally, the influences of the geometry parameters and the different positions of the mechanism on the orientation-capability are discussed. A new method of the singularity analysis of the Gough-Stewart parallel mechanism is advanced based on the unit quaternion, and the research finds have important referential value for the configuration parameters optimization of this class of the parallel mechanisms with the goal of having the maximal singularity-free zone.

关键词： parallel mechanism unit quaternion orientation-singularity orientation-singularity-free void orientation-capability

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Structural characteristics of the Tan-Lu fault zone in Cenozoic basins offshore the Bohai Sea

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Science china Earth Sciences 2008年第S2期51卷 20-31页

作者： QI JiaFu1,2,ZHOU XinHuai3.DENG RongJing4.& ZHANG KeXin2 1 State Key Laboratory of Petroleum Resource and Prospecting,china Petroleum University,Beijing 10224.,china 2 Department of Earth Sciences,china Petroleum University,Beijing 102200,china 3.Tianjin Branch of CNOOC china Limited,Tianjin 3.04.1,china 4.Beijing Research center of CNOOC china Limited,Beijing100027,china china Petr Univ State Key Lab Petr Resource & Prospecting Beijing 102249 Peoples R China china Petr Univ Dept Earth Sci Beijing 102200 Peoples R China CNOOC china Ltd Tianjin Branch Tianjin 300451 Peoples R China CNOOC china Ltd Beijing Res Ctr Beijing 100027 Peoples R China

The Tan-Lu fault zone across the eastern margin of the Cenozoic basins offshore the Bohai Sea is a NNE-trending right-lateral strike-slip fault system developed in the Cenozoic basin cover. It cuts through NE-to NNE-striking major extensional faults that controlled the formation of Paleogene basins. Recent petroleum exploration indicates that Cenozoic structural activities of the Tan-Lu fault system have directly or indirectly affected oil and gas distribution offshore the Bohai Sea. As part of a deep fault zone the Tan-Lu fault zone has been activated since the Oligocene,and obviously affected the tectonic evolution of offshore Bohai basins since then. The formation of Paleogene rift basins offshore the Bohai Sea has utilized the pre-existing structural elements of the Tan-Lu fault zone that developed in the late Mesozoic.

关键词： strike-slip fault extensional structure Tan-Lu fault zone Bohaiwan basin

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Spatial prediction and analysis of Himalayan marmot plague natural epidemic foci in china based on HJ-1 satellite data

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Science china Earth Sciences 2010年第S1期53卷 8-15页

作者： GAO MengXu1,4.LI XiaoWen1,2,CAO ChunXiang1,ZHANG Hao1,LI Qun3.ZHOU Hang3.HE QiSheng1,4.XU Min1,4.ZHAO Jian1,4.ZHENG Sheng1,4.& CHEN Wei1,4.1State Key Laboratory of Remote Sensing Science,Jointly Sponsored by the Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University,Beijing 100101,china 2School of Geography,Beijing Normal University,Beijing 100875,china 3.ffice for Disease Control and Emergency Response,Chinese center for Disease Control and Prevention,Beijing 102206,china 4.raduate University of Chinese Academy of Sciences,Beijing 10004.,china 1. State Key Laboratory of Remote Sensing Science Jointly Sponsored by the Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University Beijing 100101 China4. Graduate University of Chinese Academy of Sciences Beijing 100049 China2. School of Geography Beijing Normal University Beijing 100875 China3. Office for Disease Control and Emergency Response Chinese Center for Disease Control and Prevention Beijing 102206 China

Plague,caused by the gram-negative bacterium Yersinia pestis,is a serious and rapidly progressing illness in humans that can be fatal if not treated *** Qinghai-Tibet Plateau is the largest area of natural Himalayan marmot(Marmota himalayana) plague foci in china and covers more than 63.000 *** County in Gansu Province is a part of this natural focus of plague and was chosen as a study *** study used an ecological niche modeling(ENM) approach to predict the potential distribution of the Himalayan *** and Disaster Monitor Satellite(HJ-1) data was used to investigate environment factors that affect plague host animal *** animal point data from active surveillance was combined with environmental variables from the HJ-1 satellite and other databases,and the models of the potential distribution of Himalayan marmot were produced with the Genetic Algorithm for Rule-Set Production(GARP).The probability of marmot presence was divided into 0-5%,5%-20%,20%-4.%,4.%-80%,and 80%-100% *** with 80%-100% probability exhibited the greatest potential for the presence of Himalayan *** to the predicted potential distribution of Himalayan marmot in the study area,active surveillance of plague hosts and plague control and prevention could be more efficient.

关键词： Himalayan marmot plague spatial prediction GARP HJ-1 satellite

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Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients

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Acta Pharmacologica Sinica 2006年第8期27卷 966-970页

作者： Sheng-nan WU~(2,3.5,6) Rui GAO~(2,3.6) Qing-he XING~(2,3.6) Hua-fang LI~4.Yi-feng SHEN~4.Niu-fan GU~4.Guo-yin FENG~4.Lin HE~(2,3.7)2 Bio-X Life Science Research {4.,Shanghai Jiaotong University,Shanghai 20003.,china 3.Institute of Nutritional Sciences,SIBS,Chinese Academy of Sciences,Shanghai 20003.,china 4.Shanghai Institute of Mental Health,Shanghai 20003.,china 5 Shanghai Institute of Hypertension,Ruijin Hospital,Medical School of Shanghai Jiaotong University,Shanghai 200025,china Bio-X Life Science Research center Shanghai Jiaotong University Shanghai 200030 China

Aim:Extrapyramidal syndrome (EPS) is most commonly affected by typical antip-sychotic drugs that have a high affinity with the D2 ***,manyresearch groups have reported on the positive relationship between the geneticvariations in the DRD2 gene and the therapeutic response in schizophrenia pa-tients as a result of the role of variations in the receptor in modulating *** this study,we evaluate the role DRD2 plays in chlorpromazine-induced EPS in schizophrenic ***:We identified seven SNP(singlenucleotide polymorphism) (-14.Cins>del,TaqIB,TaqID,Ser3.1Cys,rs6275,rs6277and TaqIA) in the DRD2 gene in 14. schizophrenic inpatients (59 with EPS and 87without EPS according to the Simpson-Angus Scale) treated with chlorpromazineafter 8 *** alleles of all loci were determined by PCR (polymerase chainreaction).Results:Polymorphisms TaqlD,Ser3.1Cys and rs6277 were not poly-morphic in the population recruited in the present *** statistical signifi-cance was found in the allele distribution of-14.Cins>del,TaqIB,rs6275 andTaqIA or in the estimated haplotypes (constituted by TaqIB,rs6275 and TaqIA) inlinkage disequilibrium between the two ***:Our results did notlend strong support to the view that the genetic variation of the DRD2 gene playsa major role in the individually variable adverse effect induced by chlorpromazine,at least in Chinese patients with *** results confirmed a previousstudy on the relationship between DRD2 and EPS in Caucasians.

关键词： dopamine receptors basal ganglia disease polymorphism chlorpromazine schizophrenia

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Synthesis of superheavy nuclei with ^(23.)U target

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Science china(Physics,Mechanics & Astronomy) 2009年第10期52卷 1482-1488页

作者： LIU ZuHua1,3.& BAO JingDong2,4.1 Key Laboratory of Beam Technology and Material Modification of Ministry of Education,Beijing Normal University,Beijing 100875,china 2 Department of Physics,Beijing Normal University,Beijing 100875,china 3.2} Institute of Atomic Energy,Beijing 1024.3.china 4.center of Theoretical Nuclear Physics,National Laboratory of Heavy Ion Accelerator of Lanzhou,Lanzhou 73.000,china Key Laboratory of Beam Technology and Material Modification of Ministry of Education Beijing Normal University Beijing 100875 China Department of Physics Beijing Normal University Beijing 100875 China china Institute of Atomic Energy Beijing 102413 China center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator of Lanzhou Lanzhou 730000 China

The production of superheavy nuclei with Z=108-116 via hot fusion reactions of the neutron-rich projectiles with 23.U target is systematically *** results show that the production cross sections of superheavy nuclei do not decrease monotonously as the atomic number Z *** cross sections of the superheavy nuclei at Z = 112 and 115 are enhanced as compared with the whole Z-trend in synthesis of the superheavy nuclei,which clearly illustrates that the reactions with large negative Q-value and shell correction are more favorable to synthesize superheavy nuclei.

关键词： superheavy nuclei fusion reaction cross section 23.U target

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