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Probability parametric imaging with DCE-MRI data to identify prostate cancer in the peripheral zone

Progress in Natural Science:Materials International 2006年第9期16卷 948-953页

作者： HUANG Xinrui, WANG Qiang, XU Yufeng, WANG Xiaoying and BAO Shanglian ( The Key Laboratory of Medical physics and Engineering, peking university, beijing 100871,{3. The Medical School of peking university, beijing 100083.{3. 3. The First Hospital of peking university, beijing 10003.,{3.) [a]The key Laboratory of Medical physics and Engineering Peking University Beijing China [b]The Medical School of peking university Beijing China [c]The First Hospital of peking university Beijing China

To quantitatively analyze prostate dynamic contrast-enhanced magnetic resonance images (DCE-MRI), a retrospective study was carried out to construct a mathematical model to predict whether a lesion is cancerous or not. With known diagnosis of 52 re-gions-of-interest (10 malignant, 26 benign and 16 normal) in peripheral zone (PZ) of prostate from 18 patients undergoing needle biopsy and 8 normal volunteers, we combined feature parameters (k1, k2 and tp) from the linear-slope model with logistic regression to determine the statistical probability model. Prostate cancerous probability maps were derived using the model on each subject to examine the correlation between the model-based prediction and the known diagnosis. Compared the model prediction results of 52 regions-of-interest with the histopathologic results, the total agreement rate was 90.4 % ; the agreement rate was 60 % for the malignant and 97. 6 % for the nonmalignant. The diagnostic results only referencing the probability maps by two radiologists showed a high agreement in tissue characteristics and lesion location with the combining results from other diagnostic techniques such as PSA (prostate specific antigen) level and MRS (magnetic resonance spectroscopy) .

关键词： time-intensity curve prostate DCE-MRI logistic regression probability parametric image.

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A general information theoretical proof for the second law of thermodynamics

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Science china(physics,Mechanics & Astronomy) 2008年第7期51卷 813-816页

作者： ZHANG QiRen Department of technical physics, peking university,{3., china 1. Department of technical physics Peking University Beijing 100871 China

It is shown that the conservation and the non-additivity of the information, together with the additivity of the entropy, make the entropy increase in an isolated system. The collapse of the entangled quantum state offers an example of the information non-additivity. Nevertheless, the non-additivity of information is also true in other fields in which the interaction information is important. Examples are classical statistical mechanics, social statistics and financial processes. The second law of thermodynamics is thus proven in its most general form. It is exactly true not only in quantum and classical physics but also in other processes in which the information is conservative and non-additive.

关键词： information conservation non-additivity of information entropy increase

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Kinetic characteristics of continuous flow polymerase chain reaction chip: A numerical investigation

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Science china(Technological Sciences) 2010年第7期53卷 1967-1972页

作者： WANG ShiYing1 & WANG Wei2,3.1 School of physics, peking university, beijing 100871,{3. 2 Institute of Microelectronics, peking university, beijing 100871,{3. 3.National Key Laboratory of Science and Technology on Micro/Nano Fabrication, beijing 100871,{3. 1. School of physics Peking University Beijing 100871 China2. Institute of Microelectronics Peking University Beijing 100871 China3. National Key Laboratory of Science and Technology on Micro/Nano Fabrication Beijing 100871 China

Continuous flow PCR (polymerase chain reaction) chip holds impressive advantages compared to micro chamber PCR chip. In order to have better understanding of kinetic characteristics of continuous flow PCR chip, a comprehensive mathematical model is presented in this paper, including melting, annealing and extension phases of a typical PCR process which has the essence of a convection-diffusion-reaction system. Using this model, we can simulate the PCR process in series of reaction cycles. Numerical results show that the average sample velocity plays a significant role in affecting the amplification efficiency. Also, appropriate combination of the PCR mixture is important for high-quality DNA amplification. Giving a large initial DNA concentration range, the continuous flow PCR scheme holds excellent real-time detection ability theoretically. The present numerical model bridges the temperature distribution to the real DNA amplification, and thereby is able to successfully predict continuous flow PCR properties which are important for the chip design.

关键词： continuous flow PCR chip numerical simulation convection-diffusion-reaction system

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Electronic structure and magnetism of R(Fe,Si)_(12) (R=Y,Nd)

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Science china(physics,Mechanics & Astronomy) 2006年第2期49卷 195-202页

作者： SUN Guang’ai1, CHEN Bo1, DU Honglin2, FAN Zhijian1, GAO Tao3.& QI Xinhua3.. Institute of Nuclear physics and Chemistry, china Academy of Engineering physics, Mianyang 621900, china 2. Department of physics, peking university, beijing 100871, china 3. Institute of Atomic and Molecular physics, Sichuan university, Chengdu 610065, china 1. Institute of Nuclear physics and Chemistry China Academy of Engineering Physics Mianyang 621900 China 2. Department of physics Peking university Beijing 100871 China 3. Institute of Atomic and Molecular physics Sichuan University Chengdu 610065 China

The newly developed full-potential linearized augmented plane wave (LAPW) and local orbitals (lo) based on standard APW methods are briefly introduced, and the structure and magnetic properties of R(Fe, Si)12 compounds (R = Y, Nd) are calculated using the method. The distribution of Si at different sites is analyzed based on total energy of one crystal unit with structure having been optimized. The characters of magnetic mo-ments, total density of states (TDOS) and partial density of states (PDOS) for different crystal sites Si occupies are obtained and analyzed. The results show that the total mag-netic moments of RFe10Si2 (R = Y, Nd) are larger than those of RFe10M2 (M = Ti, V, Cr, Mn, Mo and W) and the hybridization mechanism is seen as follows. Si(8j) reduce the mag-netic moments of Fe at three sites, however, Si(8f) mainly reduce the magnetic moments of Fe(8i) and Fe(8j) atoms. The Curie temperature is markedly enhanced by the introduc-tion of Si atoms according to spin fluctuation of DOS at Fermi level.

关键词： (L)APW+lo method R(Fe Si)12(R = Y Nd) magnetic moment Density of state.

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A novel endorectal RF coil for high resolution MRI and spectroscopy of the prostate

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Progress in Natural Science:Materials International 2005年第5期15卷 472-476页

作者： ZHANG Hongjie 1,2, SONG Xiaoyu1, WANG Xiaoying3. XU Pingfang1 and BAO Shanglian1*(1. beijing Key Laboratory of Medical physics & Engineering, peking university,{3., china 2. Navy General Hospital, beijing 10003., china 3. peking university First Hospital, beijing 10003., china) beijing Key Laboratory of Medical physics & Engineering Peking University Beijing 100871 China Navy General Hospital Beijing 100037 China peking university First Hospital Beijing 100034 China

The diagnosis of prostate diseases by magnetic resonance imaging (MRI) in vivo is sometimes difficult for the lower signal to noise ratio (SNR). To increase the SNR of the prostate image, we designed a RF coil that can be inserted into rectum and was named endorectal coil. The properties of RF coil were evaluated using a network analyzer. Moreover the images and spectroscopy of a special phantom were acquired and the results were compared to those of the commercial TORSO coil (G.E. Medical Systems, USA). Our coil gave a significantly higher SNR at the region of interest (ROI). The achieved high local SNR and resulting high spatial resolution would add more anatomic and biochemical information to the diagnosis of prostate diseases.

关键词： MRI RF coil endorectal coil.

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THE PHYSICAL ENTROPY OF SINGLE CONSERVATION LAWS

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Journal of Computational Mathematics 1998年第5期16卷 437-444页

作者： (Department of Mathematics, peking university, beijing 100871, china) beijing Univ Dept Math Beijing 100871 Peoples R China

By means of the comparisons with the formulas in statistical mechanics and thermodynamics, in this paper it is demonstrated that for the single conservation law partial derivative(t)u + partial derivative(x)f(u) = 0, if the flux function f(u) is convex (or concave), then, the physical entropy is S = -f(u); Furthermore, if we assume this result can be generalized to any f(u) with two order continuous derivative, from the thermodynamical principle that the local entropy production must be non-negative, one entropy inequality is derived, by which the O.A. Olejnik's famous E- condition can be explained successfully in physics.

关键词： conservation laws entropy entropy production

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Experimental measurement of growth patterns on fossil corals:Secular variation in ancient Earth-Sun distances

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Chinese Science Bulletin 2010年第35期55卷 4010-4017页

作者： ZHANG WeiJia1,3.4,LI ZhengBin2,3.& LEI Yang1 1 Department of physics,peking university,{3. 100871,china 2 Department of Electrical Engineering and Computer Science,peking university,{3. 100871,china 3.State Key Laboratory of Advanced Optical Communication Systems & Networks,peking university,{3. 100871,china 4 Committee of Yuanpei Honors Program,peking university,{3. 100871,china Department of physics Peking University Beijing 100871 China State Key Laboratory of Advanced Optical Communication Systems & Networks Peking University Beijing 100871 China Committee of Yuanpei Honors Program Peking University Beijing 100871 China Department of Electrical Engineering and Computer Science Peking University Beijing 100871 China

In recent years,much attention has been given to the increase in the Earth-Sun distance,with the modern rate reported as 5-15 m/cy on the basis of astronomical ***,traditional methods cannot measure the ancient leaving rates,so a myriad of research attempting to provide explanations were met with unmatched *** this paper we consider that the growth patterns on fossils could reflect the ancient Earth-Sun *** mechanical analysis of both the Earth-Sun and Earth-Moon systems,these patterns confirmed an increase in the Earth-Sun *** a large number of well-preserved specimens and new technology available,both the modern and ancient leaving rates could be measured with high precision,and it was found that the Earth has been leaving the Sun over the past 0.53.billion *** Earth's semi-major axis was 146 million kilometers at the beginning of the Phanerozoic Eon,equating to 97.6% of its current *** modern leaving rates are 5-14 m/cy,whereas the ancient rates were much *** results indicate a special expansion with an average expansion coefficient of 0.57H0 and deceleration in the form of Hubble *** the basis of experimental results,the Earth's semi-major axis could be represented by a simple formula that matches fossil measurements.

关键词：地球太阳古代距离生长模式实验石珊瑚量化

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β-delayed proton decays near the proton drip line

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Science china(physics,Mechanics & Astronomy) 2005年第3期48卷 257-267页

作者： XU Shuwei 1 , LI Zhankui 1 , XIE Yuanxiang 1 , HUANG Wenxue 1 , SHU Nengchuan 2 , CHEN Yongshou 2 , XU Furong 3., WANG Kun 4 , PAN Qiangyan 1 , WANG Xudong 1 , YU Yong 1 & XING Yebing 1 1. Institute of Modern physics, Chinese Academy of Sciences, Lanzhou 73.000, china 2. Nuclear physics Department, china Institute of Atomic Energy, beijing 102413. china 3. Department of technical physics, peking university, beijing 100871, china 4. Shanghai Institute for Nuclear Research, Shanghai 201800, china 1. Institute of Modern physics Chinese Academy of Sciences 730000 Lanzhou China 2. Nuclear physics Department China Institute of Atomic Energy 102413 Beijing China 3. Department of technical physics Peking University 100871 Beijing China 4. Shanghai Institute for Nuclear Research 201800 Shanghai China

We briefly reviewed the experimental study on a-delayed proton decays near the proton drip line published by our group during the period of 1996―2004, namely the first observation of the a-delayed proton decays of 9 new nuclides in the rare-earth region and the new measurements of a-delayed proton decays of 5 nuclides in the mass ～90 region near the N = Z line with the aid of the “p-?” coincidence in combination with a He-jet tape transport system. In the meantime some important experimental technique details were supplemented. The experimental results, including the half -lives, spins, parities, deformations and production reaction cross sections for the 14 nuclei were summarized and compared with the current nuclear-model predictions, and then the following points were represented. (1) The experimental half-lives for 85Mo and 92Rh as well as the predicted “waiting point” nuclei 89Ru and 93.d are 5―10 times longer than the theoretical predictions given by M?ller et al. using a macroscopic-microscopic model. It considerably influences the predictions of the abundances of the nuclides produced in the rp-process. (2) The current-model predictions are not consistent with the experimental assignments of the spins and parities for the proton drip-line nuclei 142Ho and 128Pm. However, the nuclear potential energy surface (PES) calculated by using a Woods- Saxon-Strutinsky method reproduced the experimental results. (3. The Alice code overestimated the production reaction cross sections of the studied 9 rare-earth nuclei by one order of magnitude or two, while HIVAP code overestimated them by one order of magnitude approximately.

关键词： proton drip line, β-delayed proton decay, He-jet tape transport system, "p-γ" coincidence, spin, parity, deformation, production reaction cross section.

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Modeling the intracellular dynamics for Vif-APO mediated HIV-1 virus infection

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Chinese Science Bulletin 2010年第22期55卷 2329-2340页

作者： WANG Yi1,2 & LAI LuHua1,3.1 Center for Theoretical Biology, peking university, beijing 100871, china 2 School of {3., peking university, beijing 100871, china 3.BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, peking university, beijing 100871, china Center for Theoretical Biology Peking University Beijing 100871 China School of physics Peking University Beijing 100871 China BNLMS State Key Laboratory for Structural Chemistry of Unstable and Stable Species College of Chemistry and Molecular Engineering Peking University Beijing 100871 China

The viral infectivity factor (Vif) was found to be essential for controlling HIV-1 virus infectivity. It targets cellular antiviral proteins in APOBEC family (APO) to trigger its fast degradation and inhibits APO packaging into nascent virion. In the present study, we propose a mathematical model to quantitatively study the intracellular dynamics of these typical virus-host interactions. Four sets of published experimental data were compared with simulation results to justify the model. Systematic parameter sensitivity and perturbation analysis showed that parameters related to APO are crucial to the infectivity of newly synthesized HIV-1 virus. Interestingly, we discovered that the synthesis rate of the viral structure protein Gag and the required number per nascent virion are optimized to achieve high virion production with minimal level of packaged APO, and large portion of model parameters are beneficial to virus only within a relatively small range. Furthermore, minor variations in several parameters related to viral protein Tat, the activator of viral RNA synthesis, were found to induce switch-like behaviors on both incorporated Vif and APO. These findings may provide new insights for understanding the high mutation rate of HIV-1 virus and its latency, as well as help identify key targets for therapeutic design.

关键词：病毒感染载脂蛋白 HIV 细胞内动力学抗病毒蛋白建模介导

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|m| Partial wave treatment for two-dimensional Coulomb-scattering and Regge pole

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Science china(physics,Mechanics & Astronomy) 2004年第6期47卷 676-684页

作者： WANG Jing & ZENG Jinyan Department of physics,Tsinghua university,beijing 100084,{3. School of physics,peking university,beijing 100871,{3. Department of physics Tsinghua University Beijing 100084 China School of physics Peking University Beijing 100871 China

The symmetry and |m| partial-wave analysis for two-dimensional (2D) Coulomb-scattering is investigated. As a function of energyE, the |m| partial-wave scattering amplitudef |m|(θ) is analytically continuated to the, negativeE (complexk) plane, and it is found that the bound state energy eigenvalues (E<0) are just located at the poles off |m|(θ) on the positive imaginaryk axis as is expected. In addition, as a function of |m|,f |m|(θ) is analytically continuated to the complex |m| plane, the bound state energy eigenvalues are just located at the poles off |m|(θ) on the positive real |m| axis.

关键词： two-dimensional Coulomb scattering, |m| partial-wave, Regge pole.

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