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藏羊血红蛋白抗氧化肽模拟酶解筛选及活性验证

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食品与发酵工业 2024年

作者：刘鑫罗唐君韩丽娟桂林生侯生珍孙胜男赵成周 1.青海大学医学部药学系 2.青海大学农牧学院 3.青海大学藏医学院青海大学藏医学院青海大学农牧学院青海大学医学部药学系

Based on the theoretical basis of bioinformatics， this paper used the computer to simulate the enzymatic digestion of Tibetan sheep hemoglobin， using online activity scoring， activity prediction， and molecular docking techniques to screen their antioxidant peptides and verify their antioxidant properties by DPPH free radical and ABTS cationic radical scavenging rate experiments. The amino acid sequences of Tibetan sheep hemoglobin were screened using the Uni Prot database to evaluate its potential bioactivities， ExPASy Peptide cutter online tool was {3. to enzymatically digest the screened peptide chains， Peptide Ranker was {3. to score the bioactivity prediction， and the online tools Innovagen， ToxinPred， iBitter-ScM， A1.erTOP， and AdmetSAR for solubility， toxicity， bitterness， sensitization and ADMET， molecular docking using Keap1.receptor for activity prediction， and finally validation of the screened antioxidant peptides of Tibetan sheep hemoglobin using DPPH free radical and ABTS cationic radical scavenging rate assay. Results showed that five Tibetan sheep hemoglobin chains contained 20 amino acids， and a total of 258 peptides （485 peptides） were obtained by enzymatic digestion， and 1.0 peptides （1.4 peptides） with ratings greater than 0.5 were screened out by the bioactivity scoring system， and 1. peptides with good solubility， non-toxicity， non-bitterness， and non-allergenicity were obtained through the prediction of their activities， and the molecular docking was carried out for the 1. peptides that had a better intestinal absorption， and the top three peptides with molecular docking scores， KRM， FPL， and FL， were subjected to in vitro antioxidant activity assay， and the results showed that the free radical scavenging ability of FPL and KRM exceeded that of the positive control， with Ic50of 0.1.5 0±0.01. 3. 0.3.9 1.0.03. 4， 0.256 5±0.01. 1. （0.3.4 6±0.047 1. mg/mL， respectively， and the free radical scavenging ability of FL reached 88.90% and 94.40%

关键词：藏羊血红蛋白虚拟酶解模拟筛选抗氧化肽分子对接

Parabolic equation of the m-Laplacian with nonlinear boundary condition

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chinese Science Bulletin 1998年第11期43卷 905-908页

作者： WANG Shu+ 1. 2, WANG Mingxin 3. XIE{1.hunhong 1.1. Department of mathematics, Nanjing University, Nanjing 21.093.{1.hina 2. Department of mathematics, Henan University, Kaifeng 475001.{1.hina 3. Department of applied mathematics, Southeast University, Department of Mathernntics Nanjing University Nanjing China Department of mathematics Henan University Kaifeng China Department of applied {1. Southeast University Nanjing China

The existence and nonexistence of global positive weak solutions of parabolic equation of the m-Laplician with nonlinear boundary condition are dealt with. The necessary and sufficient conditions on the existence of a... 详细信息

关键词： nonlinear boundary condition parabolic equation of m-Laplacian global solution blow-up.

A trust region algorithm for bilevel programing problems

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chinese Science Bulletin 1998年第10期43卷 820-824页

作者： LIU Guoshan 1. HAN Jiye 2 and WANG Shouyang 3.1. Department of {1., Beijing Normal University, Beijing 1.0875, china 2. Institute of applied {1., chinese Academy of Sciences, Beijing 1.0080, china 3. Institute of Systems Science, chi Department of mathematics Beijing Normal University Beijing China Institute of applied {1. Chinese Academy of Sciences Beijing China Institute of Systems Science Chinese Academy of Sciences Beijing China

A trust region algorithm is proposed for solving bilevel programming problems where the lower level programming problem is a strongly convex programming problem with linear constraints. This algorithm is based on a tr... 详细信息

关键词： bilevel programming problem trust region algorithm global convergence.

Approximation of dense-n/2-subgraph and table compression problems

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Science china {1. 2005年第9期48卷 1223-1233页

作者： XU Dachuan~1.HAN Jiye~2 & DU Dongle~3.1.{1.ollege of applied Sciences,Beijing University of Technology,Beijing 1.0022,china 2. Institute of applied {3.,Academy of {3. and Systems Science,chinese Academy of Sciences,Beijing 1.0080,china 3. Faculty of Administration,University of New Brunswick,P.O.Box 4400,Fredericton,NB E3. 5A3.canada college of applied Sciences Beijing University of Technology Beijing 100022 China Institute of applied {1. Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 China Faculty of Administration University of New Brunswick P.O. Box 4400 Fredericton NB E3B 5A3 Canada

We develop improved approximation algorithms for two NP-hard problems: the dense-n/2-subgraph and table *** on SDP relaxation and advanced rounding techniques,we first propose 0. 5982 and 0. 5970-approximation algorithms respec- tively for the dense-n/2-subgraph problem (DSP) and the table compression problem (TcP). Then we improve these bounds to 0. 624{1.and 0. 6708 respectively for DSP and TcP by adding triangle inequalities to strengthen the SDP *** results for TcP beat the 0. 5 bound of a simple greedy algorithm on this problem,and hence answer an open question of Anderson in an affirmative way.

关键词： dense-n/2-subgraph problem(DSP) table compression problem(TcP) SDP approximation ratio

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归一化模型在人类认知活动中的应用

应用心理学 2024年

作者：孙阳阳罗鑫宇周柳芳李海燕孙彦良 1.山东师范大学心理学院 2.上海外国语大学国际工商管理学院 3.山东大学齐鲁医院神经外科山东师范大学心理学院上海外国语大学国际工商管理学院山东大学齐鲁医院神经外科

神经计算模型是深入解析神经元信息编码过程的重要方法。近年来，归一化模型(normalization model)作为一种新兴神经计算方法，在人类认知活动中广泛应用。此模型基于当前反应神经元的活动与神经元池活动总和的比率，来揭示神经元的实... 详细信息

神经计算模型是深入解析神经元信息编码过程的重要方法。近年来，归一化模型(normalization model)作为一种新兴神经计算方法，在人类认知活动中广泛应用。此模型基于当前反应神经元的活动与神经元池活动总和的比率，来揭示神经元的实际响应。最初用于解析初级视觉皮层中的神经元活动，随后在感知觉和注意机制研究中得到了充分的验证和应用，但在高级认知活动研究中的应用仍显不足。展望未来，归一化模型在高级认知活动研究中的应用值得进一步拓展。

关键词：归一化模型感觉注意决策工作记忆

Two-dimensional Riemann problems of simplified Euler equation

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chinese Science Bulletin 1998年第6期43卷 441-444页

作者： YANG Xiaozhou 1.2 and HUANG Feimin+1.1. Institute of applied {1., chinese Academy of Sciences, Beijing 1.0080, china 2. Department of {1., Shantou University, Guangdong 51.063. china Institute of applied {1. Chinese Academy of Sciences Beijing China Department of mathematics Shantou University Guangdong China

The two-dimensional Riemann problem of simplifed Euler equation is discussed, in which initial value contains two different constant states that are separated by a smooth curve. This problem is a natural description of realistic phenomena, but it is hard to study by conventional idea. So a new approach is proposed. Some new properties about two-dimensional rarefaction wave, shock wave and intermediate state of solutions are disclosed.

关键词： D Riemann problem implicit functions cylindrical surface pencil of cylindrical surface.

Mathematical stencil and its application in finite difference approximation to the Poisson equation

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Science china {1. 2005年第10期48卷 1421-1429页

作者： FENG Hui~1.ZHANG Baolin~(1.2) & LIU Yang~1.1. Department of mathematics,Wuhan University,Wuhan 4{1.072,china 2. Laboratory of computational Physics,Institute of applied Physics and computational mathematics,Beijing 1.0088. china 1. Department of mathematics Wuhan University 430072 Wuhan China 2. Laboratory of computational Physics Institute of Applied Physics and Computational Mathematics 100088 Beijing China

The concept of mathematical stencil and the strategy of stencil elimination for solving the finite difference equation is presented, and then a new type of the iteration algorithm is established for the Poisson equation. The new algorithm has not only the obvious property of parallelism, but also faster convergence rate than that of the classical Jacobi iteration. Numerical experiments show that the time for the new algorithm is less than that of Jacobi and Gauss-Seidel methods to obtain the same precision, and the computational velocity increases obviously when the new iterative method, instead of Jacobi method, is applied to polish operation in multi-grid method, furthermore, the polynomial acceleration method is still applicable to the new iterative method.

关键词： mathematical stencil, stencil elimination, Poisson equation, finite difference, iterative algorithm,parallelism.

Existence of the solutions and the attractors for the large-scale atmospheric equations

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Science china Earth Sciences 2006年第6期49卷 650-660页

作者： HUANG Haiyang1.& GUO Boling2 1. Department of mathematics, Beijing Normal University, Beijing 1.0875,{1.hina 2. Institute of applied Physics and{1.omputational mathematics, Beijing 1.0080,{1.hina 1. Department of mathematics Beijing Normal University Beijing 100875 China 2. Institute of applied Physics and{1.omputational mathematics Beijing 100080 China

In this paper, firstly, the proper function space is chosen, and the proper expression of the operators is introduced such that the complex large-scale atmospheric motion equations can be described by a simple and abstract equation, by which the definition of the weak solution of the atmospheric equations is made. Secondly, the existence of the weak solution for the atmospheric equations and the steady state equations is proved by using the Galerkin method. The existence of the non-empty global attractors for the atmospheric equations in the sense of the chepyzhov-Vishik’s definition is obtained by constructing a trajectory attractor set of the atmospheric motion equations. The result obtained here is the foundation for studying the topological structure and the dynamical behavior of the atmosphere attractors. Moreover, the methods used here are also valid for studying the other atmospheric motion models.

关键词： atmosphere equations, weak solution, trajectory attractor, global attractor, equilibrium.

On some tests-based projection pursuit for elliptical symmetry of a high-dimensional distribution

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chinese Science Bulletin 1998年第6期43卷 450-458页

作者： JING Ping 1.and ZHU Lixing 2 1. mathematics Lab,{1.hina University of Mining & Technology, Beijing 1.0083.{1.hina 2. Probability Lab, Institute of {3. mathematics,{1.hinese Academy of Sciences, Beijing 1.0080,{1.hina mathematics Lab China University of Mining & Technology Beijing China Probability Lab Institute of Applied Mathematics Chinese Academy of Sciences Beijing China

Some test statistics of Kolmogorov type and cramér-von Mises type based on projection pursuit technique are proposed for the testing problem of sphericity of a high-dimensional distribution. The limiting distributions of the test statistics are derived under the null hypothesis and under any fixed alternative. The asymptotic properties of bootstrap approximation are investigated. Furthermore, for computational reasons, an approximation for the statistics, based on the number theoretic method, is suggested.

关键词： bootstrap approximation projection pursuit type statistic elliptical symmetry.