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可降解个性化接骨板的增材制造及临床试验流程

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骨科 2021年第4期12卷 293-299页

作者：中国装备协会医用增材制造专家委员会齐大虎李慈朱皓董献振苏瑾景明张焙智胡斌石志良田静静戴红莲周钢方忠罗政强胡懿郃张培训赵宇肖骏不详华中科技大学同济医学院附属同济医院骨科武汉430030 北京大学人民医院创伤骨科北京100044 武汉理工大学材料复合新技术国家重点实验室武汉430070 华中科技大学材料成形与模具技术国家重点实验室武汉430074 天津市医疗器械质量监督检验中心天津300384 湖北嘉一三维高科股份有限公司湖北咸宁437000 武汉理工大学机电工程学院武汉430070 中国医学科学院北京协和医学院北京协和医院骨科北京100730 中南大学湘雅医院骨科长沙410008

骨折复位内固定术是骨科的常规手术,内固定作为该手术的关键步骤之一,目的是维持骨折断端的复位。现阶段临床上使用的接骨板和螺钉系统大多数采用金属材料通过传统工艺制备而成,因其缺乏个性化外形且不具备降解性能,常常难以匹配特殊形... 详细信息

骨折复位内固定术是骨科的常规手术,内固定作为该手术的关键步骤之一,目的是维持骨折断端的复位。现阶段临床上使用的接骨板和螺钉系统大多数采用金属材料通过传统工艺制备而成,因其缺乏个性化外形且不具备降解性能,常常难以匹配特殊形态的骨折部位且需要二次手术取出。可降解材料结合增材制造技术有望解决以上问题,其可赋予接骨板个性化外形和降解性能,达到更好的治疗效果。但目前可降解个性化接骨板的制备和临床试验流程在国内外均缺乏统一认识和标准。因此,本共识专家组经过多轮讨论,以有机/无机复合材料接骨板为例,从可降解个性化接骨板的“增材制造流程”和“临床试验流程”两方面出发形成本共识,为国内外各中心可降解个性化接骨板的制备和临床试验提供参考。

关键词：骨折内固定术接骨板可降解个性化增材制造临床试验

Diagnosis and Treatment of Acne Inversa/Hidradenitis Suppurativa in china: An Expert Consensus Statement (2021 Version)

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International Journal of Dermatology and Venereology 2021年第2期4卷 100-108页

作者： Hong Fang Xing-Hua Gao Song-Mei Geng Heng Gu Jun Gu Li He Xian Jiang Hong-Zhong Jin Qiang Ju Xiao-Jing Kang Wei Lai Cheng-Xin Li Hang Li Heng-Jin Li Shan-Shan Li Yu-Zhen Li Qing Sun Juan Tao Baoxi Wang Gang Wang Xin-Feng Wu Lei-Hong Xiang Hong-Fu Xie Hao-Xiang Xu Jin-Hua Xu Yan Yan Zhi-Zhong Zheng Department of Dermatology The First Affiliated Hospital of Zhejiang UniversityHangzhouZhejiang 310003China Department of Dermatology No.1 Hospital of China Medical UniversityShenyangLiaoning 110001China Department of Dermatology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Hospital for Skin Diseases(Institute of Dermatology) Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China Department of Dermatology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China Department of Dermatology First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Department of Dermatology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Dermatology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Dermatology Renji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200025China Department of Dermatology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang 830001China Department of Dermatology and Venereology The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510630China Department of Dermatology First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Dermatology and Venerology Peking University First HospitalBeijing 100034China Department of Dermatology Hainan Hospital of PLA General HospitalSanyaHainan 572013China Department of Dermatology and Venereology The First Hospital of Jilin UniversityChangchunJilin 130021China Department of Dermatology Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150086China Department of Dermatology Qilu Hospital of Shandong UniversityJinanShandong 250012China Department of Dermatology Affiliated Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China De

Acne inversa/hidradenitis suppurativa is a chronic,recurrent,inflammatory skin disease that affects the pilosebaceous units,causinfollicular *** etiology and pathogenesis of acne inversa/hidradenitis suppurativa involves internal and external factors such as genetic susceptibility,inflammation and immunity,microorganisms,obesity,and *** inversa/hidradenitis suppurativa is difficult to treat,and the current aim of treatment is to control the frequency and duration of disease flares and improve the quality of *** protocols for acne inversa/hidradenitis suppurativa should be selected based on the disease severity *** treatments include antibiotics,retinoids,biologics,immunosuppressive agents,and antiandrogen *** treatments include surgery and laser/light *** consensus aims to further standardize the diagnosis and treatment procedures of acne inversa/hidradenitis suppurativa in china to facilitate its diagnosis and treatment.

关键词： acne inversa consensus diagnosis hidradenitis suppurativa therapy

Search for the weak decayψ(3.86)→■+c.c.

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Chinese Physics C 2023年第1期47卷 19-27页

作者：麦迪娜 M.N.Achasov P.Adlarson M.Albrecht R.Aliberti A.Amoroso 安美儒安琪白旭红白羽 O.Bakina R.Baldini Ferroli I.Balossino 班勇 V.Batozskaya D.Becker K.Begzsuren N.Berger M.Bertani D.Bettoni F.Bianchi J.Bloms A.Bortone I.Boyko R.A.Briere A.Brueggemann 蔡浩蔡啸 A.Calcaterra 曹国富曹宁 S.A.Cetin 常劲帆常万玲 G.Chelkov 陈琛陈超陈刚陈和生陈玛丽陈申见陈少敏 T.Chen 陈旭荣 X.T.Chen 陈元柏陈卓俊成伟帅初晓 G.Cibinetto F.Cossio 崔佳佳代洪亮代建平 A.Dbeyssi R.E.de Boer D.Dedovich 邓子艳 A.Denig I.Denysenko M.Destefanis F.De Mori 丁勇董静董燎原董明义董翔杜书先 P.Egorov 范玉兰方建房双世方文兴方易 R.Farinelli L.Fava F.Feldbauer G.Felici 封常青冯俊华 K Fischer M.Fritsch C.Fritzsch 傅成栋高涵高原宁高扬 S.Garbolino I.Garzia 葛潘婷葛振武耿聪 E.M.Gersabeck A Gilman K.Goetzen 龚丽龚文煊 W.Gradl M.Greco 谷立民顾旻皓顾运厅关春懿郭爱强郭立波郭如盼郭玉萍 A.Guskov 韩婷婷韩文颖郝喜庆 F.A.Harris 何凯凯何康林 F.H.Heinsius C.H.Heinz 衡月昆 C.Herold M.Himmelreich 侯国一侯颖锐侯治龙胡海明 J.F.Hu 胡涛胡誉黄光顺黄凯旋黄麟钦黄麟钦黄性涛黄燕萍黄震 T.Hussain N Hüsken W.Imoehl M.Irshad J.Jackson S.Jaeger S.Janchiv 纪全姬清平季晓斌季筱璐吉钰瑶贾泽坤姜侯兵姜赛赛江晓山 Y.Jiang 焦健斌焦铮金山金毅荆茂强 T.Johansson N.Kalantar-Nayestanaki 康晓珅 R.Kappert 柯百谦 I.K.Keshk A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc W.Kühn J.J.Lane J.S.Lange P.Larin A.Lavania L.Lavezzi 雷祚弘 H.Leithoff M.Lellmann T.Lenz 李翠李聪李春花李澄李德民李飞李刚李慧李贺李海波李惠静 H.N.Li J.Q.Li 李静舒李井文李科 L.J.Li 李龙科李蕾李明浩李培荣李素娴栗帅迎李腾李卫东李卫国李旭红李晓玲李晓宇梁昊梁浩梁浩梁勇飞梁羽铁廖广睿廖龙洲 J.Libby A.Limphirat 林创新林德旭 T.Lin 刘北江刘春秀 D.Liu 刘福虎刘芳刘峰 G.M.Liu H.Liu 刘宏邦刘怀民刘欢欢刘汇慧刘建北刘佳俊刘晶译刘凯刘魁勇刘珂刘亮刘露刘美宏刘佩莲刘倩刘树彬刘桐刘维克刘卫民刘翔刘英刘玉斌刘振安刘智青娄辛丑卢飞翔吕海江吕军光陆小玲卢宇卢云鹏 Z.H.Lu 罗成林罗民兴罗涛罗小兰吕晓睿吕翌丰马凤才马海龙马连良马明明马秋梅马润秋马瑞廷马骁妍马尧 F.E.Maas M.Maggiora S.Maldaner S.Malde Q.A.Malik A.Mangoni 冒亚军毛泽普 S.Marcello 孟召霞 J.G.Messchendorp G.Mezzadri H.Miao 闵天觉 R.E.Mitchell 莫晓虎 N.Yu.Muchnoi Y.Nefedov F.Nerling I.B.Nikolaev 宁哲 S.Nisar 牛艳 S.L.Olsen 欧阳群 S.Pacetti 潘祥潘越 A.Pathak M.Pelizaeus 彭海平 K.Peters 平加伦平荣刚 S.Plura S.Pogodin V.Prasad 齐法制齐航漆红荣祁鸣齐天钰钱森钱文斌钱圳乔从丰秦佳佳秦丽清覃潇平秦小帅秦中华邱进发屈三强 K.H.Rashid C.F.Redmer 任旷洁 A.Rivetti V.Rodin M.Rolo 荣刚 Ch.Rosn Institute of High Energy Physics Beijing 100049China Beihang university Beijing 100191China beijing Institute of Petrochemical Technology Beijing 102617China Bochum Ruhr-university D-44780 BochumGermany Carnegie Mellon university PittsburghPennsylvania 15213USA Central china Normal university Wuhan 430079China Central South university Changsha 410083China china center of Advanced science and Technology Beijing 100190China COMSATS university Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan university Shanghai 200433China G.I.Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal university Guilin 541004China Guangxi university Nanning 530004China Hangzhou Normal university Hangzhou 310036China Hebei university Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal university Xinxiang 453007China Henan university of science and Technology Luoyang 471003China Henan university of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal university Changsha 410081China Hunan university Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana university BloomingtonIndiana 47405USA AINFN Laboratori Nazionali di Frascati I-00044FrascatiItaly INFN Sezione di Perugia I-06100PerugiaItaly university of Perugia I-06100PerugiaItaly INFN Sezione di Ferrara I-44122FerraraItaly university of Ferrara I-44122FerraraItaly Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Jilin university Changchun 130012China Johannes Gutenberg university of Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany Joint Institute for Nuclear Research 141980 DubnaMoscow regionRussia Justus-Liebig-Universitaet Giessen II.Physikalisches InstitutHeinrich-Buff-Ring 16D-35392 GiessenGermany Lanzhou U

Using(448.1±2.9)×10^(6)ψ(3.86)for the weak baryonic decayψ(3.86)→Λc+∑-+c.c..The analysis procedure is optimized using a blinded *** significant signal is observed,and the upper limit on the branching fraction(B... 详细信息

关键词： weak decay upper limit BESIII detector