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LOD score exclusion analyses for candidate disease susceptibility genes using case-parents design

Progress in Natural Science:Materials International 2006年第1期16卷 30-38页

作者： DENG Hongwen1,2,3 and GAO Guimin2,4.(1.Laboratory of Molecular and Statistical Genetics, college of Life Sciences, Hunan Normal university, Changsha 4.0081, china 2.Osteoporosis Research Center, Creighton university Medical Center, Omaha NE 68131, USA 3. Department of Biomedical Sciences, Creighton university, Omaha NE 68131, USA 4. Virginia Bioin format ics Institute and Department of statistics, Virginia Polytechnic Institute and State university, Blacksburg VA 24.61-0315, USA) [a]Laboratory of Molecular and Statistical Genetics College of Life Sciences Human National University Changsha China [b]Osteoporosis Research Center Creighton University Medical Center Omaha NE USA [c]Department of Biomedical Sciences Creighton University Omaha NE USA [d]Virginia Bioinformatics Institute and Department of statistics Virginia Polytechnic Institute and State University Blacksburg VA USA

The focus of almost all the association studies of candidate genes is to test for their importance. We recently developed a LOD score approach that can be used to test against the importance of candidate genes for complex diseases and quantitative traits in random samples. As a complementary method to regular association analyses, our LOD score approach is powerful but still affected by the population admixture, though it is more conservative. To control the confounding effect of population heterogeneity, we develop here a LOD score exclusion analysis using case-parents design, the basic design of the transmission disequilibrium test (TDT) approach that is immune to population admixture. In the analysis, specific genetic effects and inheritance models at candidate genes can be analyzed and if a LOD score is ≤ - 2. 0, the locus can be excluded from having an effect larger than that specified. Simulations show that this approach has reasonable power to exclude a candidate gene having small genetic effects if it is not a disease susceptibility locus (DSL) with sample size often employed in TDT studies. Similar to association analyses with the TDT in nuclear families, our exclusion analyses are generally not affected by population admixture. The exclusion analyses may be implemented to rule out candidate genes with no or minor genetic effects as supplemental analyses for the TDT. The utility of the approach is illustrated with an application to test the importance of vitamin D receptor (VDR) gene underlying the differential risk to osteoporosis.

关键词： association studies candidate genes case-parents design disease susceptibility locus exclusion mapping LOD score.

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TESTING SERIAL CORRELATION IN SEMIPARAMETRIC VARYING COEFFICIENT PARTIALLY LINEAR ERRORS-IN-VARIABLES MODEL

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Journal of Systems Science & Complexity 2009年第3期22卷 483-494页

作者： Xuemei HU Feng LIU Zhizhong WANG mathematics and statistics college Chongqing Technology and Business University Chongqing 400067 China. School of mathematics and Physics Chongqing InsLitu$e of Technology Chongqing 400050 China. School of mathematics and Computing Technology Central South University Changsha 410075 China.

The authors propose a V_(N,p) test statistic for testing finite-order serial correlation in asemiparametric varying coefficient partially linear errors-in-variables *** test statistic is shownto have asymptotic normal distribution under the null hypothesis of no serial *** MonteCarlo experiments are conducted to examine the finite sample performance of the proposed V_(N,p) *** results confirm that the proposed test performs satisfactorily in estimated sizeand power.

关键词： Asymptotic normality local linear regression measurement error modified profile leastsquares estimation partial linear model testing serial correlation varying coefficient model.

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THE ASYMPTOTICALLY OPTIMAL EMPIRICALBAYES ESTIMATION IN ONE WAY ANOVA MODEL

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Systems Science and Mathematical Sciences 1999年第1期12卷 13-22页

作者： WEI Laisheng (Department of statistics and finance, university of Science and Technology of china, Hefei 230026, china) 中国科学技术大学统计系安徽合肥

Consider the one-way analysis of variance (ANOVA) model Yij=μ+αi+∈ij,i=1,…,a; j = 1,…,b, ∈ij～N(0, σ2). By using the kernel estimation of multivariate density function and its partial derivatives and making use of the estimators of nuisance parameters μ and σ2, we construct the empirical Bayes (EB) estimators of parameter vector α = (α1,…，αa)T. Under the existence condition of the second order moment on prior distribution, we obtain their asymptotic optimality.

关键词： Asymptotic optimality empirical Bayes estimation one way ANOVA model.

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Group sparse representation for image categorization and semantic video retrieval

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Science china(Information Sciences) 2011年第10期54卷 2051-2063页

作者： LIU YaNan 1,2 ,WU Fei 2 & ZHUANG YueTing 2 1 School of Information,Zhejiang university of finance & economics,Hangzhou,310018,china 2 {4. of Computer Science and Technology,Zhejiang university,Hangzhou,310012,china 1. School of Information Zhejiang University of Finance & Economics Hangzhou 310018 China2. College of Computer Science and Technology Zhejiang University Hangzhou 310012 China

Multimedia content analysis and management are a promising and challenging *** this paper we develop a novel approach to image representation,which we call group sparse representation (GSR),for image classification and video *** basic idea is to represent a test image as a weighted combination of all the training *** particular,we introduce two sets of weight coefficients,one for each training image and the other for each ***,we formulate our concern as a group nonnegative garrote *** resulting representations are sparse,and they are appropriate for discriminant *** on Caltech101 and PASCAL VOC2008 image dataset and TRECVID2005 video corpus testify that our proposed approach is efficient and effective.

关键词： compressive sensing group sparse representation bag-of-SIFT-words nonnegative garrote l1-minimization apcluster

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THE EQUIVALENT MECHANICAL MODELS OF LIQUID SLOSHING IN A SPHERICAL TANK WITH SPACER UNDER LOW GRAVITY

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Journal of Hydrodynamics 2005年第1期17卷 110-116页

作者： CHENGXu-duo HUMei-zhu WENJi-hua SchoolofFoodScienceandEngineering NanjingUniversityofFinanceandEconomics.Nanjing210003China／／DepartmentofPhysicsAnqingTeachersCollegeAnqing246011China SchoolofFoodScienceandEngineering NanjingUniversityofFinanceandEconomicsNanjing210003China

The dynamics of liquid sloshing in a spherical tank with spacer under low gravity was investigated. By extending the characteristic functions, the frequencies of liquid free sloshing, reaction force and moments on the wall of tank were obtained. By mechanical equivalent principle, the equivalent models of spring vibrator damper of liquid sloshing were given. The numerical results obtained show when a spacer is inserted in the tank, the sloshing frequency of liquid and the sloshing mass of liquid will decrease.

关键词： low gravity liquid sloshing equivalent mechanical models

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BOUNDEDNESS OF DYADIC DERIVATIVE AND CESARO MEAN OPERATOR ON SOME B-VALUED MARTINGALE SPACES

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Acta Mathematica Scientia 2011年第1期31卷 268-280页

作者：陈丽红刘培德 college of Science Wuhan Textile University School of mathematics and statistics Wuhan University

In this article, it is proved that the maximal operator of one-dimensional dyadic derivative of dyadic integral I＊ and Cesàro mean operator σ＊ are bounded from the B-valued martingale Hardy spaces pΣα, Dα, pLα, p H#α, pKr to Lα （0 α ∞）, respectively. The facts show that it depends on the geometrical properties of the Banach space.

关键词： B-valued martingale martingale space dyadic derivative dyadic integral

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Relationship Between Vegetation Restoration and Soil Microbial Characteristics in Degraded Karst Regions: A Case Study

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Pedosphere 2011年第1期21卷 132-138页

作者： WEI Yuan YU Li-Fei ZHANG Jin-Chi YU Yuan-Chun D. L. DEANGELIS School of Resources and Environmental Management Guizhou College of Finance and Economics Guiyang 550004 (China) college of Forestry Guizhou University Guiyang 550025 (China) college of Forest and Environment Nanjing Forestry University Nanjing 210037 (China) Department of Biology University of Maimi P. O. Box 249118 Coral Gables FL 33124 (USA)

The mechanism of vegetation restoration on degraded karst regions has been a research focus of soil science and ecology for the last *** an attempt to preferably interpret the soil microbiological characteristic variation associated with vegetation restoration and further to explore the role of soil microbiology in vegetation restoration mechanism of degraded karst regions,we measured microbial biomass C and basal respiration in soils during vegetation restoration in Zhenfeng County of southwestern Guizhou Province,*** community level physiological profiles(CLPP) of the soil microbial community to were estimated determine if vegetation changes were accompanied by changes in functioning of soil microbial *** results showed that soil microbial biomass C and microbial quotient(microbial biomass C/organic C) tended to increase with vegetation restoration,being in the order arboreal community stage > shrubby community stage > herbaceous community stage > bare land *** trend was found in the change of basal respiration(BR).The metabolic quotient(the ratio of basal respiration to microbial biomass,qCO 2) decreased with vegetation restoration,and remained at a constantly low level in the arboreal community *** of the CLPP data indicated that vegetation restoration tended to result in higher average well color development,substrate richness,and functional *** utilization of specific substrate guilds was highest in the arboreal community *** component analysis of the CLPP data further indicated that the arboreal community stage was distinctly different from the other three *** conclusion,vegetation restoration improved soil microbial biomass C,respiration,and utilization of carbon sources,and decreased qCO 2,thus creating better soil conditions,which in turn could promote the restoration of vegetation on degraded karst regions.

关键词： basal respiratory community level physiological profile functional diversity metabolic quotient microbial biomass C

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Extension of Some Classical Results on Ruin Probability to Delayed Renewal Model

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Acta Mathematicae Applicatae Sinica 2002年第4期18卷 675-680页

作者： Chun Su, Tao Jiang, Qi-he TangDepartment of statistics and finance, university of Science and Technology of china, Hefei 230026 Department of statistics and finance University of Science and Technology of China Hefei 230026 China

Embrechts and Veraverbeke investigated the renewal risk model and gave a tail equivalence relationship of the ruin probabilities (?)(x) under the assumption that the claim size is heavy-tailed, which is regarded as a classical result in the context of extremal value theory. In this note we extend this result to the delayed renewal risk model.

关键词： Delayed renewal risk model heavy-tails ruin probability

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酵母内含子在基因序列中的分布对基因转录效率的影响

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生物化学与生物物理进展 2003年第6期30卷 945-949页

作者：张静石秀凡杨恒芬云南大学应用统计中心中国科学院昆明动物研究所

对酵母中高效转录和低效转录基因内含子序列寡核苷酸使用情况的对照分析 ,显示两类内含子的序列结构有差异 ,并且高效转录基因内含子序列含有较多潜在的转录因子结合位点 ,由此推测内含子可能参与基因转录的调控 .这个结论有待更多的数... 详细信息

对酵母中高效转录和低效转录基因内含子序列寡核苷酸使用情况的对照分析 ,显示两类内含子的序列结构有差异 ,并且高效转录基因内含子序列含有较多潜在的转录因子结合位点 ,由此推测内含子可能参与基因转录的调控 .这个结论有待更多的数据证实 .对内含子和外显子在两组基因序列中的分布 (长度、位置等 )进行详细比较分析后显示 ,高效转录基因内含子和低效转录基因内含子的长度有比较明显的界限 .两组基因中外显子长度的均值虽然有些差异 ,却没有明显的界限 .基因序列长度与外显子长度的情况相似 .虽然内含子的相对位置在两类基因中都很靠近 5′端 ,但是从实际位置看 ,高效转录基因中比较多的内含子很靠近基因的 5′端 ,有些则位于 5′ UTR区域 .这些结果提示 ,基因的转录效率与内含子的长度有关 ,与外显子及基因序列的长度无关 ,内含子的位置也可能影响转录效率 ,内含子对基因转录的调控可能与基因上游的转录调控有关联。

关键词：酵母基因转录频率内含子长度内含子位置基因序列基因转录

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POLAR SETS OF MULTIPARAMETER BIFRACTIONAL BROWNIAN SHEETS

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Acta Mathematica Scientia 2010年第3期30卷 857-872页

作者：陈振龙李慧琼 college of statistics and mathematics Zhejiang Gongshang University

Let B^H＇K={B^H＇K（t）, t∈R＋^N} be an （N,d）-bifractional Brownian sheet with Hurst indices H = （H1,…,HN） C∈0,1）^N and K = （K1,…,KN） ∈ （0,1]^N. The properties of the polar sets of B^H＇K are discussed. The sufficient conditions and necessary conditions for a compact set to be polar for B^H＇K are proved. The infimum of Hausdorff dimensions of its non-polar sets are obtained by means of constructing a Cantor-type set to connect its Hausdorff dimension and capacity.

关键词： Bifractional Brownian sheet polar set Hausdorff dimension packing dimen- sion capacity

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