检索结果-南通市图书馆

Ion channels in neuronal survival

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science china(Life sciences) 2010年第3期53卷 342-347页

作者： WANG YiZheng & XU TianLe institute of Neuroscience and State Key Laboratory of Neuroscience,shanghai institutes for Biological sciences,chinese academy of sciences,shanghai 200031,china 1. institute of Neuroscience and State Key Laboratory of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

The study of ion channels represents one of the most active fields in neuroscience research in *** the last 10 years,active research in various chinese neuroscience institutions has sought to understand the mechanisms responsible for sensory processing,neural development and neurogenesis,neural plasticity,as well as *** addition,extensive studies have been directed to measure ion channel activity,structure-function relationships,as well as many other biophysical and biochemical *** review focuses on the progress achieved in the investigation of ion channels in neuronal survival during the past 10 years in china.

关键词： ion channels neuronal survival and ischemia.

Foliar modifications induced by inhibition of polar transport of auxin

在线全文

学校读者我要写书评

暂无评论

Cell Research 1999年第1期9卷 27-35页

作者： NI DI AN LING JIAN WANG ZHI HONG XU ZHEN Ao XIA(shanghai institute of Plant Physiology, chinese academy of sciences, shanghai 200032, china) 1shanghai institute of Plant Physiology Chinese Academy of Sciences Shanghai 200032 China 1shanghai institute of Plant Physiology Chinese Academy of Sciences Shanghai 200032 China 1shanghai institute of Plant Physiology Chinese Academy of Sciences Shanghai 200032 China 1shanghai institute of Plant Physiology Chinese Academy of Sciences Shanghai 200032 China

The effects of auxin polar transport inhibitors, 9-hydroxy-fluorene-9-carboxylic acid (HFCA); 2, 3, 5-triiodobenzoic acid (TIBA) and trans-cinnamic acid (CA)on leaf pattern formation were investigated with shoots formed from cultured leaf explants of tobacco and cultured pedicel explants of Orychophragmus violaceus, and the seedlings of tobacco and Brassica chinensis. Although the effective concentration varies with the inhibitors used, all of the inhibitors induced the formation of trumpet-shaped and/or fused leaves. The frequency of trumpet-shaped leaf formation was related to the concentration of inhibitors in the *** observation of tobacco seedlings showed that there was only one main vascular bundle and several minor vascular bundles in normal leaves of the control, but there were several vascular bundles of more or less the same size in the trumpet-shaped leaves of treated *** results indicated that auxin polar transport played an important role on bilateral symmetry of leaf growth.

关键词： Brassica Chinensis Orychophragmus violaceus Nicotiana tabacum auxin polar transport foliar modification

Entropy of Dilatonic Black Hole due to Arbitrary Spin Fields

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

chinese Journal of Astronomy and Astrophysics 2001年第4期1卷 357-364页

作者： You-Gen Shen and Chang-Jun Gao (shanghai Astronomical Observatory, chinese academy of sciences, shanghai 200030 National Astronomical Observatories, chinese academy of sciences, Beijing 100012 institute of Theoretical Physics, chinese academy of Scienc institute of Theoretical Physics Chinese Academy of Sciences Beijing 100080

Using the membrane model based on the brick-wall model, we calculate the free energy and entropy of dilatonic black hole due to arbitrary spin fields. The result shows that the entropy of scalar field and the entropy ... 详细信息

关键词： black hole physics - entropy - spin

Ni2+ treatment causes cement gland formation in ectoderm explants of Xenopus laevis embryo

在线全文

学校读者我要写书评

暂无评论

Cell Research 1999年第1期9卷 71-76页

作者： HUANG YONG XIAO YAN DING (shanghai institute of Cell Biology, chinese academy of Science, shanghai 200031, china) 1shanghai institute of Cell Biology Chinese Academy of Science Shanghai 200031 China 1shanghai institute of Cell Biology Chinese Academy of Science Shanghai 200031 China

We found T-type calcium channel blocker Ni2+ can efficiently induce the formation of cement gland in Xenopus laevis animal cap explants. Another T-type specific calcium channel blocker Amiloride can also induce the formation of cement gland, while L-type specific calcium channel blocker Nifedipine has no inductive effect. These results may offer us an new approach to study the differentiation of cement gland through the change of intracelluax calcium concentration.

关键词： Ni2+ cement gland gastrulation T-type calcium channel

Construction of normal human IgE phage antibody library and the screening of the anti-trichosanthin IgE

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Cell Research 1996年第1期6卷 1-9页

作者： ZAN HONG MING YEH (shanghai institute of Cell Biology, chinese academy of sciences, shanghai 200031, china.) shanghai institute of Cell Biology Chinese Academy of Sciences Shanghai 200031 China.Received 3April1996 Revised 11June1996 Accepted 12June1996

Allergen specific IgE response is the major cause of immediate hypersensitivity. However the number of IgEproducing B cells and the amount of IgE, especially the specific IgE, are so low, it greatly impedes the study of the allergic-specifc antibody responses. Here we report the construction of a normal human IgE combinatorial library The repertoire of IgE VH genes and of K genes were separately amplified from normal human peripheral blood lymphocytes through RT-PCR, and were then constructed to form the phage surface display human Fab(IgEVH) library. A plant protein allergen, trichosanthin(TCS), was used to affinity-enrich and to screen the anti-TCS phage HuFab clones from the library. Human IgE(Fab) to TCS were detected.

关键词： Phage antibody library human IgE(Fab) human anti-trichosanthin IgE

Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in chinese schizophrenic patients

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2006年第8期27卷 966-970页

作者： Sheng-nan WU~(2,3,5,6) Rui GAO~(2,3,6) Qing-he XING~(2,3,6) Hua-fang LI~4 Yi-feng SHEN~4 Niu-fan GU~4 Guo-yin FENG~4 Lin HE~(2,3,7)2 Bio-X Life Science Research Center,shanghai Jiaotong University,shanghai 200030,china 3 institute of Nutritional sciences,SIBS,chinese academy of sciences,shanghai 200031,china 4 shanghai institute of Mental Health,shanghai 200030,china 5 shanghai institute of Hypertension,Ruijin Hospital,Medical School of shanghai Jiaotong University,shanghai 200025,china Bio-X Life Science Research Center Shanghai Jiaotong University Shanghai 200030 China

Aim:Extrapyramidal syndrome (EPS) is most commonly affected by typical antip-sychotic drugs that have a high affinity with the D2 ***,manyresearch groups have reported on the positive relationship between the geneticvariations in the DRD2 gene and the therapeutic response in schizophrenia pa-tients as a result of the role of variations in the receptor in modulating *** this study,we evaluate the role DRD2 plays in chlorpromazine-induced EPS in schizophrenic ***:We identified seven SNP(singlenucleotide polymorphism) (-141Cins>del,TaqIB,TaqID,Ser311Cys,rs6275,rs6277and TaqIA) in the DRD2 gene in 146 schizophrenic inpatients (59 with EPS and 87without EPS according to the Simpson-Angus Scale) treated with chlorpromazineafter 8 *** alleles of all loci were determined by PCR (polymerase chainreaction).Results:Polymorphisms TaqlD,Ser311Cys and rs6277 were not poly-morphic in the population recruited in the present *** statistical signifi-cance was found in the allele distribution of-141Cins>del,TaqIB,rs6275 andTaqIA or in the estimated haplotypes (constituted by TaqIB,rs6275 and TaqIA) inlinkage disequilibrium between the two ***:Our results did notlend strong support to the view that the genetic variation of the DRD2 gene playsa major role in the individually variable adverse effect induced by chlorpromazine,at least in chinese patients with *** results confirmed a previousstudy on the relationship between DRD2 and EPS in Caucasians.

关键词： dopamine receptors basal ganglia disease polymorphism chlorpromazine schizophrenia

Bcl-2 over-expression and activation of protein kinase C suppress the Trail-induced apoptosis in Jurkat T cells

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Cell Research 2001年第2期11卷 101-106页

作者： GUO BEN CHANG, YONG HUA XU institute of Biochemistry and Cell Biology, shanghai institutes for Biological sciences, chinese academy of sciences, 320 Yue-yang Road, shanghai 200031, china 1institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yue-yang Road Shanghai 200031 China 1institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yue-yang Road Shanghai 200031 China

Trail, a tumor necrosis factor-related apoptosis-inducing ligand, is a novel potent endogenous activator of the cell death pathway through the activation of cell surface death receptors Trail-R1 and Trail-R2. Its role, like FasL in activation-induced cell death (AICD), has been demonstrated in immune system. However the mechanism of Trail induced apoptosis remains nuclear. In this report, the recombinant Trail protein was expressed and purified. The apoptosis-inducing activity and the regulation mechanism of recombinant Trail on Jurkat T cells were explored in vitro. Trypan blue exclusion assay demonstrated that the recombinant Trail protein actively killed Jurkat T cells in a dose-dependent manner. Trail-induced apoptosis in Jurkat T cells were remarkably reduced by Bcl-2 over expression in BcL-2 gene transfected cells. Treatment with PMA (phorbol 12-myristate 13-acetate), a PKC activator, suppressed nail-induced apoptosis in Jurkat T cells. The inhibition of apoptosis by PMA was abolished by pretreatment with Bis, a PKC inhibitor. Taken together, it was suggested that Bcl-2 over-expression and PMA activated PKC actively down-regulated the Trail-mediated apoptosis in Jurkat T cell.

关键词： trail Jurkat T cells apoptosis Bcl-2 PEA PKC Bis.

Regular behaviors in SU(2) Yang-Mills classical mechanics

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 1997年第3期8卷 139-143页

作者： Xu Xiao Ming (shanghai institute of Nuclear Research, the chinese academy of sciences, shanghai 201800) shanghaiinstituteofNuclearResearch theChineseAcademyofSciencesShanghai201800

ＲｅｇｕｌａｒｂｅｈａｖｉｏｒｓｉｎＳＵ（２）ＹａｎｇＭｉｌｓｃｌａｓｉｃａｌｍｅｃｈａｎｉｃｓＸｕＸｉａｏＭｉｎｇ（ＳｈａｎｇｈａｉＩｎｓｔｉｔｕｔｅｏｆＮｕｃｌｅａｒＲｅｓｅａｒｃｈ，ｔｈｅＣｈｉｎｅｓｅＡ... 详细信息

ＲｅｇｕｌａｒｂｅｈａｖｉｏｒｓｉｎＳＵ（２）ＹａｎｇＭｉｌｓｃｌａｓｉｃａｌｍｅｃｈａｎｉｃｓＸｕＸｉａｏＭｉｎｇ（ＳｈａｎｇｈａｉＩｎｓｔｉｔｕｔｅｏｆＮｕｃｌｅａｒＲｅｓｅａｒｃｈ，ｔｈｅＣｈｉｎｅｓｅＡｃａｄｅｍｙｏｆＳｃｉｅｎｃｅｓ，...

关键词： SU(2) 杨-Mills经典力学正则行为

Total Synthesis of Przewaquinone A

在线全文

学校读者我要写书评

暂无评论

chinese Chemical Letters 1997年第3期8卷 205-206页

作者： Wen Hu DUAN Jun Chao CAI (shanghai institute of Materia Medica, chinese academy of sciences, shanghai 200031) chinese ACAD SCI SHANGHAI INST MAT MEDSHANGHAI 200031PEOPLES R CHINA

Przewaquinone A, a natural orthoquinone was synthesized through several steps, the analytic data of the synthetic target compound was identical with that of przewaquinone A.

关键词： HRMS HNMR Total Synthesis of Przewaquinone A