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What Has the COVID-19 Pandemic Taught Us so Far?Addressing the Problem from a Hepatologist's Perspective

Journal of Clinical and Translational Hepatology 2020年第2期8卷 109-112页

作者： Nahum Méndez-sánchez Alejandro Valencia-Rodríguez Xingshun Qi Eric MYoshida Manuel Romero-Gómez Jacob George Mohammed Eslam Ludovico Abenavoli Weifen Xie Rolf Teschke Andres FCarrion Andrew PKeaveny Department of Internal Medicine II Division of Gastroenterology and HepatologyKlinikum HanauHanauAcademic Teaching Hospital of the Medical FacultyGoethe University Frankfurt/MainFrankfurt/MainGermany The Fifth Medical Center General Hospital of PLABeijingChina Department of Gastroenterology General Hospital of Northern Theater Command(Formerly General Hospital of Shenyang Military Area)ShenyangChina Division of Gastroenterology University of British ColumbiaVancouverBCCanada UCM Digestive Diseases and CIBERehd Institute of Biomedicine of Seville(IBiS)SeLiver GroupVirgen del Rocío University HospitalUniversity of SevilleSevilleSpain storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneySydneyNSWAustralia Department of Health sciences University Magna Graecia of CatanzaroItaly Department of Gastroenterology Changzheng Hospital of the Second Military Medical UniversityShanghaiChina Department of Internal Medicine II Division of Gastroenterology and HepatologyKlinikum HanauAcademic Teaching Hospital of the Medical FacultyGoethe University Frankfurt/MainHanauGermany Division of Gastroenterology and Hepatology University of MiamiMiller School of MedicineMiamiFLUSA Department of Transplantation Mayo ClinicJacksonvilleFloridaUSA

As of today, March 30, 2020, when this Editorial is being written, the severe acute respiratory syndrome coronavirus-2 (sARs-CoV-2), causal agent of the coronavirus disease (COVID-19) has been confirmed in more than 745,000 cases worldwide and has claimed the lives of more than 35,000 people.1 In addition to the morbidity and mortality associated with COVID-19, this betacoronavirus has placed several of the world's major economies in strife, mainly in Western Europe and North America, paralyzing travel and regular social interactions, making COVID-19 undoubtedly one of the most important pandemics in human history.

关键词： doubt travel COV

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指南临床适用性评价的问题与需求

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中国循证医学杂志 2020年第3期20卷 249-251页

作者：王强李幼平张伯礼刘瀚旻王杉石炳毅康德英刘关键刘晓清韩英赵荣生姜可伟曾宪涛张宏刘利张伶俐国家卫生健康委医疗管理服务指导中心“指南临床适用性评价体系研究”项目专家组国家卫生健康委医疗管理服务指导中心北京100044 四川大学华西医院中国循证医学中心成都610041 天津中医药大学天津301617 四川大学华西第二医院儿科成都610041 北京大学人民医院胃肠外科北京100044 解放军总医院第八医学中心全军器官移植研究所北京100091 中国医学科学院北京协和医学院北京协和医院感染内科北京100730 空军军医大学西京医院消化内科西安710032 北京大学第三医院药剂科北京100191 武汉大学中南医院循证与转化医学中心武汉430071 北京大学第一医院肾内科北京100034 哈尔滨医科大学附属第一医院神经外科哈尔滨150001 四川大学华西第二医院药学部/循证药学中心成都610041 出生缺陷与相关妇儿疾病教育部重点实验室成都610041 中国药学会循证药学专委会北京100044 不详

临床实践指南是缩小当前最佳证据与临床实践差距的决策工具。指南临床适用性是指临床指南推荐意见能够应用于临床实践的程度。已有研究显示:现有临床指南存在临床适用性差的问题,且仅提高指南质量可能无法解决此问题。国家卫生健康委医... 详细信息

临床实践指南是缩小当前最佳证据与临床实践差距的决策工具。指南临床适用性是指临床指南推荐意见能够应用于临床实践的程度。已有研究显示:现有临床指南存在临床适用性差的问题,且仅提高指南质量可能无法解决此问题。国家卫生健康委医疗管理服务指导中心立项开展临床实践指南临床评价体系建设,拟基于循证方法制订由临床指南目标使用者进行评价的指南临床适用性评价体系,旨在:(1)甄别出临床适用性高的指南;(2)推广临床适用性佳的指南在临床的应用;(3)为指南制/修订者反馈指南的临床适用性结果,以帮助优化指南制订和更新,持续提升指南适用性,真正使临床实现指南可用、好用。

关键词：指南临床适用性评价体系共识

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay shou-shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov serge Bondarenko stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen shanhong Chen shanzhen Chen shao-Long Chen shaomin Chen shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De sio Elisa Del Core shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing beijing Computational science research Center Beijing beijing Conveyi LTD Beijing beijing Glass research institute Co. LtdBeijing beijing institute of Technology Beijing beijing Normal University Beijing Brown University ProvidenceRI Budker institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal University WuhanHubei Central south University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu Kaitengsifang Digital Radio&TV equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced science and Technology Beijing china institute of Atomic Energy Beijing china Jiliang University HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china University of Geosciences Beijing china University of Geosciences WuhanHubei china University of Mining and Technology XuzhouJiangsu china West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRs/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-synchrotron DEsY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint institute for Nuclear research(DLNP JINR) Dubna East china University Of science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential super Proton Proton Collider(sPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(sR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the sR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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