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Surface electrocardiogram and action potential in mice lacking urea transporter UT-B

Science China(Life Sciences) 2009年第5期52卷 474-478页

作者： MENG Yan1, ZHAO ChunYan2, ZHANG XueXin2, ZHAO HuaShan1, GUO LiRong1, Lü Bin1, ZHAO XueJian1& YANG BaoXue1,3 1 department of Pathophysiology, School of Basic medicine, Jilin university, Changchun 130021, China 2 department of Physiology, School of Basic medicine, Jilin university, Changchun 130021, China 3 department of medicine, university of california, san francisco ca 94143, usa department of Pathophysiology School of Basic Medicine Jilin University Changchun 130021 China department of Physiology School of Basic Medicine Jilin University Changchun 130021 China department of medicine University of California San Francisco CA 94143 USA

UT-B is a urea transporter protein expressed in the kidney and in many non-renal tissues including erythrocytes, brain, heart, bladder and the testis. The objective of this study was to determine the phenotype of UT-B deletion in the heart. UT-B expression in the heart was studied in wild-type mice vs UT-B null mice by utilizing RT-PCR and Western blot. A surface electrocardiogram (ECG) recording (lead II) was measured in wild-type mice and UT-B null mice at the ages of 6, 16 and 52 weeks. For the action potential recording, the ventricular myocytes of 16 w mice were isolated and recorded by floating microelectrode method. The sodium current was recorded by the patch clamp technique. RT-PCR and Western blot showed the UT-B expression in the heart of wild-type mice. No UT-B transcript and protein was found in UT-B null mice. The ECG recording showed that the P-R interval was significantly prolonged in UT-B null mice ((43.5 ± 4.2), (45.5 ± 6.9) and (43.8 ± 7.6) ms at ages of 6, 16 and 52 weeks) vs wild-type mice ((38.6 ± 2.9), (38.7 ± 5.6) and (38.2 ± 7.3) ms, Pcantly in UT-B null mice ((92.17 ± 10.56) and (101.89 ± 9.54) mV/s) vs those in wild-type mice (vs (110.51 ± 10.38) and (109.53 ± 10.64) mV/s, Pcantly prolonged in UT-B null mice ((123.83 ± 11.17) and (195.43 ± 16.41) ms) vs that in wild-type mice ((108.27 ± 10.85) and (171.00 ± 15.53) ms, Pcantly in UT-B null mice (-8.80 ± 0.92) nA vs that in wild-type mice ((-5.98 ± 1.07) nA, Pcauses progressive heart block in mice.

关键词： urea transporter heart block electrocardiogram

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Matrix metalloproteinases and their expression in mammary gland

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Cell Research 1998年第3期8卷 187-194页

作者： URIA JOSE A ZENA WERB(department of Anatomy, university of california san francisco, ca 94143-0452, usa) department of Anatomy University of California San Francisco CA USA

The matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that play a key role in both normal and pathological processes involving tissue remodeling events. The expression of these proteolytic enzymes is highly regulated by a balance between extracellular matrix (ECM) deposition and its degradation, and is controlled by growth factors, cytokines, hormones, as well as interactions with the ECM macromolecules. Furthermore, the activity of the MMPs is regulated by their natural endogenous inhibitors, which are members of the tissue inhibitor of metalloproteinases (TIMP) family. In the normal mammary gland, MMPs are expressed during ductal development, lobulo-alveolar development in pregnancy and involution after lactation. Under pathological conditions, such as tumorigenesis, the dysregulated expression of MMPs play a role in tumor initiation, progression and malignant conversion as well as facilitating invasion and motastasis of malignant cells through degradation of the ECM and basement membranes. Matrix metalloproteinases and their expression in mammary gland

关键词： Matrix metalloproteinases ECM cancer progression mammary gland

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POLES OF ZETA FUNCTIONS OF COMPLETE INTERSECTIONS

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Chinese Annals of Mathematics,Series B 2000年第2期21卷 187-200页

作者： WAN DAQING(department of Mathematics, university of california, Irvine, ca 92697-3875, usa.) department of Mathematics University of California Irvine CA 92697-3875 USA

A vanishing theorem is proved for e-adic cohomology with compact support on an affine (singular) complete intersection. As an application, it is shown that for an affine complete intersection defined over a finite field of q elements, the reciprocal "poles" of the zeta function are always divisible by q as algebraic integers. A p-adic proof is also given, which leads to further q-divisibiliy of the poles or equivalently an improvement of the polar part of the AxKatz theorem for an affine complete intersection. Similar results hold for a projective complete intersection.

关键词： Pole Zeta function Complete intersection

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ON THE KINEMATIC GEOMETRY OF MANY BODY SYSTEMS

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Chinese Annals of Mathematics,Series B 1999年第1期20卷 11-28页

作者： WU-YI HSIANG(department of Mathematics,university of california,berkeley,ca 94720-3840,usa) Univ calif Berkeley Dept Math Berkeley CA 94720 USA

In mechanics, both classical and quantum, one studies the profound interaction betweentwo types of energy, namely, the kinetic energy and the potential energy. The former can beorganized as the kinematic metric on the configuration space while the latter can be representedby a suitable potential function, such as the Newtonian potential in celestial mechanics andthe Coulomb potential in quantum mechanics of atomic and molecular physics. In this paper,the author studies the kinematic geometry of n-body systems. The main results are (i) theintroduction of a canonical coordinate svstem which reveals the total amount of kinematicsymmetry by an SO(3) x O(n-1) action in such a canonical coordinate representationt (ii) anin depth analysis of the above kinematic system both in the setting of classical invariant theoryand by the technique of equivariant Riemannian geometry; (iii) a remarkably simple formulafor the potential function in such a canonical coordinate system which reveals the well-fittingbetween the kinematic symmetry and the Potential energy.

关键词： Kinematic geometry Many body system Configuration space

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Representations of Knot Groups and Twisted Alexander Polynomials

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Acta Mathematica Sinica,English Series 2001年第3期17卷 5+362-380页

作者： Xiao Song LIN department of Mathematics,university of california,Riversides,ca 92521.usa department of Mathematics University of California Riverside USA

We present a twisted version of the Alexander polynomial associated with a matrix rep- resentation of the knot *** of two knots with the same Alexander module but different twisted Alexander polynomials are given.

关键词： Twisted Alexander polynomial Representation space Knot group

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A Formula for the Non-integer Powers of the Laplacian

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Acta Mathematica Sinica,English Series 1999年第1期15卷 21-24页

作者： Zhengxu Hedepartment of Mathematics,university of california,san Diego,La Jolla,ca 92093-0112,usa department of Mathematics University of California San Diego La Jolla USA

We provide an elementary formula for the non-integer powers of the Laplace operator in the Euclidean *** formulas are helpful in establishing the elliptic nature of some pseudo- differential operators arising from the... 详细信息

关键词： Laplacian Power of Laplacian

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Total synthesis of(+)-lentiginosine via a key Au catalysis

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Science China Chemistry 2010年第1期53卷 113-118页

作者： CUI Li & ZHANG LiMing department of Chemistry & Biochemistry,university of california,santa Barbara,ca 93106,usa 1. department of Chemistry & Biochemistry University of California Santa Barbara CA 93106 USA

Total syntheses of(+)-lentiginosine and its 8a-epimer using a gold-catalyzed oxidative cyclization as the key step were *** gold chemistry,reported previously in a 4+2 synthesis of piperidin-4-ones,tolerates functiona... 详细信息

关键词： gold total synthesis cyclization oxidation alkaloid

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Personality Trait Detection via Transfer Learning

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Computers, Materials & Continua 2024年第2期78卷 1933-1956页

作者： Bashar Alshouha Jesus Serrano-Guerrero francisco Chiclana francisco P.Romero Jose A.Olivas department of Information Technologies and Systems University of Castilla-La ManchaCiudad Real13071Spain Institute of Artificial Intelligence School of Computer Science and InformaticsDe Montfort UniversityThe GatewayLeicesterLE19BHUK

Personality recognition plays a pivotal role when developing user-centric solutions such as recommender systems or decision support systems across various domains,including education,e-commerce,or human ***-ditional machine learning techniques have been broadly employed for personality trait identification;nevertheless,the development of new technologies based on deep learning has led to new opportunities to improve their *** study focuses on the capabilities of pre-trained language models such as BERT,RoBERTa,ALBERT,ELECTRA,ERNIE,or XLNet,to deal with the task of personality *** models are able to capture structural features from textual content and comprehend a multitude of language facets and complex features such as hierarchical relationships or long-term *** makes them suitable to classify multi-label personality traits from reviews while mitigating computational *** focus of this approach centers on developing an architecture based on different layers able to capture the semantic context and structural features from ***,it is able to fine-tune the previous models using the MyPersonality dataset,which comprises 9,917 status updates contributed by 250 Facebook *** status updates are categorized according to the well-known Big Five personality model,setting the stage for a comprehensive exploration of personality *** test the proposal,a set of experiments have been performed using different metrics such as the exact match ratio,hamming loss,zero-one-loss,precision,recall,F1-score,and weighted *** results reveal ERNIE is the top-performing model,achieving an exact match ratio of 72.32%,an accuracy rate of 87.17%,and 84.41%of *** findings demonstrate that the tested models substantially outperform other state-of-the-art studies,enhancing the accuracy by at least 3%and confirming them as powerful tools for personality *** findings represent substantial a

关键词： Personality trait detection pre-trained language model big five model transfer learning

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Endoscopic submucosal dissection for early gastric cancer:A major challenge for the west

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 1965-1968页

作者： francisco Schlottmann department of Surgery University of Illinois at ChicagoChicagoIL 60612United States department of Surgery Hospital Alemán of Buenos AiresBuenos Aires 1640-C1118AATArgentina

Gastric cancer(GC)is the 5th most common cancer and the 3rd most common cause of cancer mortality *** main endoscopic resective techniques exist for early GC(EGC):Endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD).ESD has been widely embraced in the last decade because it allows radical en bloc resections and is associated with better outcomes,as compared to ***,the lack of training opportunities and flat learning curve due to low volume of EGC cases represent major obstacles to obtain proficiency on ESD in the *** this procedure is highly efficient for the treatment of EGC,dedicated training programs with a stepwise approach and updated guidelines for ESD embracement are needed in Western countries.

关键词： Gastric cancer Early gastric cancer Endoscopy West Training

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Classification of rational holomorphic maps from B^2 into B^N with degree 2

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Science China Mathematics 2009年第12期52卷 2647-2667页

作者： JI ShanYu 1 & ZHANG Yuan 2 1 department of Mathematics, university of Houston, Houston, TX 77204, usa 2 department of Mathematics, university of california at san Diego, La Jolla, ca 92093, usa department of Mathematics University of Houston Houston USA department of Mathematics Rutgers University New Brunswick USA

Rational proper holomorphic maps from the unit ball in C 2 into the unit ball C N with degree 2 are classified, up to automorphisms of balls.

关键词： rational holomorphic maps between balls classification maps with degree 2

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