检索结果-南通市图书馆

chinese Chemical Letters 1997年第12期8卷 0-0页

作者： Wen Qian YANG Xiao Ming YU Shi Zhi CHEN Liang HUANG(institute of materia medica, chinese academy of medical sciences & peking union medical college,beijing, 100050)

Tricyclic compound 6 was synthesized form compound 1 through sis steps, thus preblem of the stereochemistry of C2α-H being solved. The stereochemistry for introducing hydroxy groups at C3β and C4α positions in com... 详细信息

关键词： Studies on the Total Synthesis of Hainanolide Positions Revising the Stereochemistry of C H and Introducing the Two Hydroxy Groups at C

Aqueous Diels-Alder Reactions of Cyclopentadicnc with Symmetric Diester of Fumarate or Maleate

在线全文

学校读者我要写书评

暂无评论

chinese Chemical Letters 2000年第2期11卷 99-100页

作者： Guang Dian HAN1 Zhao Yang MA2 Guo Sen HE2 (1 institute of materia medica, peking union medical college, chinese academy of medical sciences, beijing 100050 2institute of Occupational Health, chinese academy of preventive Medicine, beijing 100050) institute of materia medica Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100050 China institute of Occupational Health Chinese Acad. of Preventive Medicine Beijing 100050 China

Symmetric, diesters of cis- or trans- bicyclo[2,2,1]hept-5-ene-2,3-dicarboxylate were prepared by aqueous Diels-Alder reaction of cyclopentadiene with symmetric diester of fumarate or maleate.

关键词： Aqueous Diels-Alder reaction diester of bicyclohept-5-ene-2,3-dicarboxylate diester of fumarate and maleate cyclopentadiene.

HIV-specific CD8^+ T cell responses to HXB2 Gag and Nef peptide pools in chinese HIV/AIDS patients

在线全文

学校读者我要写书评

暂无评论

Science china(Life sciences) 2009年第9期52卷 841-846页

作者： ZHANG HongWei,QIU ZhiFeng,JIAO Yang,WANG AiXia & LI TaiSheng department of Infectious Diseases,peking union medical college Hospital,chinese academy of medical sciences,beijing 100730,china department of Infectious Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing China

HXB2 is primarily used as a template strain in developing HIV vaccines in Europe and the US. However,it is not yet known whether the strain can induce strong HIV-specific CD8+ T cell responses in chinese HIV/AIDS patients. In the present study,two groups of subjects were investigated:9 AIDS patients and 7 long-term nonprogressors (LTNPs). HIV-specific CD8+ T cell responses were examined in all patients through the ELISPOT assay. CD4+ T cell counts,CD8+ T cell counts,viral load and HIV subtype of each patient were also measured. Thailand B virus strain was identified among all the patients. The breadth and magnitude of HIV-specific CD8+ T cell responses in the LTNPs group are greater than those in the AIDS group (Pchinese HIV/AIDS patients infected with Thailand B virus strain. HIV-1 vaccines based on HXB2 strain that can induce extensive immunity may be helpful for chinese.

关键词： HIV/AIDS CD8+ T cells ELISPOT assay

Synthesis of the Natural Products Resveratrol (Ⅰ) and Isorhapotogenin (Ⅱ)

在线全文

学校读者我要写书评

暂无评论

chinese Chemical Letters 1998年第11期9卷 0-0页

作者： Ya Bing FENG Lin WANG Zhi Zhong ZHAO (institute of materia medica, chinese academy of medical sciences peking union medical Collage, beijing, 100050)

We have synthesized two natural products, resveratrol Ⅰ and isorhapotigenin Ⅱ by 8 and 7 step reaction sequence, respectively. The synthetic products Ⅰ and Ⅱ were characterized by ***, 1H-NMR in comparison with th... 详细信息

关键词： Total synthesis, resveratrol isorhapotigenin

Beneficial effects of melatonin in experimental models of Alzheimer disease

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2006年第2期27卷 129-139页

作者： Yong CHENG~2 Zheng FENG~3 Qing-zhu ZHANG~4 Jun-tian ZHANG~(2.5) ~2department of Pharmacology,institute of materia medica,chinese academy of medical sciences and peking union medical college,beijing 100050,china:~3department of Anesthesiology,University of California,San Diego,and Veterans Affairs medical Center,3350 La Jolla Village Drive,San Diego,CA 92161,USA:~4department of Pharmacology,college of Pharmacy,Shandong University,Jinan 250012,china department of Pharmacology Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China department of Anesthesiology University of California San Diego Veterans Affairs medical Center San Diego USA department of Pharmacology College of Pharmacy Shandong University Jinan China

Alzheimer’s disease(AD),a progressive degenerative disorder,is characterizedby the presence of amyloid deposits,neurofibrillary tangles and neuron *** evidence indicates that antioxidants could be useful either for the pre-vention or treatment of *** has been shown that melatonin is a potent antioxi-dant and free radical ***,melatonin stimulates severalantioxidative enzymes and improves mitochondrial energy *** find-ings led us to study amyloid precursor protein transgenic mice,ovariectomizedrats,and pheochromocytoma and astroglioma cell lines,to observe whether mela-tonin had any effect on Alzheimer’s symptoms or pathological *** foundthat melatonin had many beneficial effects in experimental models of AD,includ-ing improvement of cognitive function,anti-oxidative injury,anti-apoptosis,inhi-bition of β-amyloid(Aβ)deposition and Aβ fiber *** groups haveshown that melatonin has an inhibitory effect on tau protein *** actions may potentially slow down or stop the progression of dementia.

关键词： melatonin Alzheimer disease beta-amyloid protein calcium overload APP transgenic mice ovariectomized rats tau protein hyperphosphorylation

Full-length genome of wild-type hepatitis A virus (DL3) isolated in china

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2003年第3期9卷 499-504页

作者： Guo-Dong Liu Ning-Zhu Hu Yun-Zhang Hu department of Vaccine Research, institute of medical Biology, chinese academy of medical sciences, peking union of medical college, Kunming 650118, Yunnan Province, china department of Vaccine Research Institute of Medical Biology Chinese Academy of Medical Sciences. 379 Jiaoling Road Kunming 650118 Yunnan Province China.

AIM: To characterize the genome of an wild-type HAV isolate (DL3) in ***: A stool specimen was collected from hepatitis A patient from Dalian, china. HAV (DL3) was isolated and viral RNA was extracted. The genome of DL3 was amplified by reverse transcription and polymerase chain reaction (RT-PCR),followed by cloning into pGEM-T vector. The positive colonies were selected and sequenced. The full-length genome of DL3 was analyzed and compared with other wild-type HAV ***: The genome of DL3 was 7 476 nucleotides (nt)in size, containing 732-nt 5'untranslated region (UTR), 6 681-nt open reading frame (ORF) which encoded a polyprotein of 2 227 amino acids (aa), and 63-nt 3'UTR. The base composition was 28.96 % A (2 165), 16.08 % C (1 202), 22.11% G(1 653)and 32.85% U (2 456). Genomic comparisons with wildtype HAV isolates revealed that DL3 had the highest identity of 97.5 % for nt (185 differences) with AH1, the lowest identity of 85.7 % (1 066 differences) with SLF88. The highest identity of 99.2 % for amino acid (18 differences)appeared among DL3, AH2 and FH3, and the lowest identity of 96.8 % (72 differences) between DL3 and SLF88. Based upon comparisons of the VP1/2A junction and the VP1 amino terminus, DL3 was classified as subgenotype IA. Phylogenetic analysis showed that DL3 was closest to the isolates in ***: The sequence comparison and phylogenetic analysis revealed that DL3 is most similar to the isolates in Japan, suggesting the epidemiological link of hepatitis A happened in china and Japan.

关键词：全片断基因组野生型甲型肝炎病毒粪便标本 RT-PCR 克隆

TAXAYUNTIN A,B,C AND D----FOUR NEW TETRACYCLIC TAXANES FROM TAXUS YUNNANENSIS

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

chinese Chemical Letters 1993年第8期4卷 695-698页

作者： Wei Ming CHEN Jin Yun ZHOU Pei Ling ZHANG Qi Cheng FANG institute of materia medica,chinese academy of medical sciences and peking union medical college beijing 100050,

Four new taxane diterpenoids were isolated from the bark of Taxus *** structures were elucidated as the new skeleton with 5/7/6/4 membered rings by spectral analysis and 2D NMR shift correlation experiments.

关键词： FOUR NEW TETRACYCLIC TAXANES FROM TAXUS YUNNANENSIS TAXAYUNTIN A,B,C AND D Chen FAB ppm

Immunobiology of Facial Nerve Repair and Regeneration

在线全文

学校读者我要写书评

暂无评论

Journal of Otology 2006年第2期1卷 107-115页

作者： QUAN Shi-ming, GAO Zhi-qiang department of Otorhinolaryngology, peking union medical college Hospital, chinese academy of medical sciences and peking union medical college, beijing People’s Republic, china department of Otorhinolaryngology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing People’s Republic China

Immunobiological study is a key to revealing the important basis of facial nerve repair and regeneration for both research and development of clinic treatments. The microenvironmental changes around an injuried facial motoneuron, i.e., the aggregation and expression of various types of immune cells and molecules in a dynamic equilibrium, impenetrate from the start to the end of the repair of an injured facial nerve. The concept of 'immune microenvironment for facial nerve repair and regeneration', mainly concerns with the dynamic exchange between expression and regulation networks and a variaty of immune cells and immune molecules in the process of facial nerve repair and regeneration for the maintenance of a immune microenvironment favorable for nerve repair. Investigation on microglial activation and recruitment, T cell behavior, cytokine networks, and immunological cellular and molecular signaling pathways in facial nerve repair and regeneration are the current hot spots in the research on immunobiology of facial nerve injury. The current paper provides a comprehensive review of the above mentioned issues. Research of these issues will eventually make immunological interventions practicable treatments for facial nerve injury in the clinic.

关键词： microglia T cell cytokine network microenviroment signaling pathway repair and regeneration facial nerve

A SYNTHESIS OF TETRAMETHYL ETHER OFROSMARINIC ACID BENZYL ESTER

在线全文

学校读者我要写书评

暂无评论

chinese Chemical Letters 1996年第6期7卷 507-508页

作者： Yan ZHUANG Zong Ru GUO Guang Zhong YANG Xiao Tian LIANG(institute of materia Medial chinese academy of medical sciencespeking union medical college, Xian Nong Tan Street,beijing 100050) Inst. of Materià medica Chinese Academy of Medical Sciences Peking Union Medical College 1 Xian Nong Tan Street Beijing 100050

A rosmarinic acid derivative, tetramethyl ether of rosmarinic acid benzyl ester, was synthesized. This is the first report of building this structural skeleton.

关键词： ACID A SYNTHESIS OF TETRAMETHYL ETHER OFROSMARINIC ACID BENZYL ESTER

THE STRUCTURE OF TRIPTOPHENOLIDE

在线全文

学校读者我要写书评

暂无评论

chinese Chemical Letters 1994年第3期5卷 217-220页

作者： Shi Shan YU Dong Ming ZHANG De Quan YU Xiao Tian LIANG(institute of materia medica,chinese academy of medical sciences and peking union medical college,beijing 100050)

Triptophenolide methyl ether and iso-triptophenolidemethl ether were synthesized from triptophenolide .It is comfirmed that the triptophenolide structure which DFYu reported in 1990 is not corect by analysis of 1HNMR...

关键词：