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chinese Chemical Letters 1993年第10期4卷 871-872页

作者： Guang Dian HAN Guo Feng HUANG institute of materia medica,chinese academy of medical sciences and peking union medical college.beijing 100050

The seleno substituted aromatic compounds were prepared via the Diels-Alder reaction of seleno substituted 3-sulfolenes with dimethyl acetylenedicarboxylate followed by DDQ dehydrogenation.

关键词： TMS HNMR SYNTHESIS OF POLYSUBSTITUTED AROMATIC COMPOUNDS THE DIELS-ALDER REACTION OF SELENO SUBSTITUTED 3-SULFOLENES WITH DIMETHYL ACETYLENEDICARBOXYLATE OCH ppm

A New Bianthraqinonc Glycoside from Eremurus chinensis

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chinese Chemical Letters 2000年第2期11卷 135-138页

作者： Jian Gong SHI1 Chong LI2 Ying Peng ZHANG2 Cheng Zhong ZHANG2 (1institute of materia medica, chinese academy of medical sciences and peking union medical, college, beijing, 100050 2department of Pharmacy, Lanzhou medical college, Lanzhou 730000) institute of materia medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China department of Pharmacy Lanzhou Medical College Lanzhou 730000 China

A new bianthraquinone glycoside, 8-O-β-D-glucopyranosyl-2,7'-bi(1,8-dihydroxy-3- methyl-9, 10-anthraquinonyl)1 was isolated from Eremurus chinensis Fedtch. Its structure was established by spectroscopic techniques in... 详细信息

关键词： Eremurus chinensis Liliaceae bianthraquinone glycoside.

The Synthesis of Some Novel N-[α-(Isoflavone-7-O-) Acetyl]Amino Acid Derivatives

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chinese Chemical Letters 2000年第5期11卷 391-394页

作者： Peng LIU Jun Biao CHANG Rong Feng CHEN Qiang WANG Jing Xi XIE (Henan institute of Chemistry, Henan academy of Science, Zhengzhou 450002 institute of materia medica, chinese academy of medical sciences and peking union medical college, beijing 100050) Henan Acad Sci Henan Inst Chem Zhengzhou 450002 Peoples R China chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China peking union Med Coll Beijing 100050 Peoples R China

A series of novel N-[α-(isoflavone-7-O-)acetyl] amino acid methyl esters were prepared from the efficient and regioselective alkylation of isoflavones with chloroacetyl amino acid derivatives under mild condition.

关键词： Isoflavone analogues N-[α-(isoflavone-7-O-)acetyl] amino acid methyl ester synthesis.

Molecular pharmacognosy

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Science china(Life sciences) 2010年第6期53卷 643-652页

作者： HUANG LuQi1,XIAO PeiGen2,GUO LanPing1 & GAO WenYuan3 1institute of chinese materia medica,china academy of chinese medical sciences,beijing 100700,china 2institute of Medicinal Plant Development,chinese academy of medical sciences,peking union medical college,beijing 100094,china 3School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300072,china institute of chinese materia medica China Academy of Chinese Medical Sciences Beijing China institute of Medicinal Plant Development Chinese Academy of Medical Sciences Peking Union Medical College Beijing China School of Pharmaceutical Science and Technology Tianjin University Tianjin China

This article analyzes the background and significance of molecular pharmacognosy,including the molecular identification of medicinal raw materials,phylogenetic evolution of medicinal plants and animals,evaluation and preservation of germplasm resources for medicinal plants and animals,etiology of endangerment and protection of endangered medicinal plants and animals,biosynthesis and bioregulation of active components in medicinal plants,and characteristics and the molecular bases of top-geoherbs.

关键词： molecular pharmacognosy pharmacognosy borderline subject

Chromosome analysis of esophageal squamous cell carcinoma cell line KYSE 410-4 by repetitive multicolor fluorescence in situ hybridization

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Journal of Genetics and Genomics 2008年第1期35卷 11-16页

作者： Yiling Yang a, b, Jiayou Chu a, Yupeng Wu b, Manli Luo b, Xin Xu b, Yaling Han b, Yan Cai b, Qimin Zhanb, Mingrong Wang b, a department of Genetics, institute of medical Biology, peking union medical college and chinese academy of medical sciences, Kunming 650118, china b State Key Laboratory of Molecular Oncology, Cancer institute (Hospital), peking union medical college and chinese academy of medical sciences, beijing 100021, china department of Genetics Institute of Medical Biology Peking Union Medical College and Chinese Academy of Medical Sciences Kunming 650118 China State Key Laboratory of Molecular Oncology Cancer Institute (Hospital) Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100021 China

Chromosome aberrations are distinctive features of human malignant tumors. Analysis of chromosomal changes can illuminate the molecular mechanisms underlying the development and progression of cancer. To establish the technique of multicolor fluorescence in situ hybridization (M-FISH) for identifying chromosome aberrations in esophageal carcinoma cell line KYSE 410-4, four pools of 6-color whole-chromosome painting probes have been designed and hybridized on the same metaphase spread by four rounds of repetitive FISH. Repetitive 6-color M-FISH was successfully established and the cytogenetic abnormalities in KYSE 410-4 cells were characterized. Chromosome gains occurred at 2q, 3, 8, 17p, and X. An isochromosome 3q was visualized in the cell line, which might be one intermedi- ate mechanism leading to 3p losses and/or 3q gains. Furthermore, 16 structural arrangements were detected, including four derivative chromosomes. The rearrangement of the centromeric regions accounted for approximately 44% of all rearrangements. The results added a more complete and accurate information of the genetic alterations to the classical cytogenetic description of KYSE 410-4 and provided a detailed cytogenetic background data for appropriate use of the cell line. The established 6-color M-FISH was useful for analyzing chro- mosomes in the whole genome of human tumors.

关键词： multicolor fluorescence in situ hybridization KYSE 410-4 karyotype esophageal squamous cell carcinoma

A New Diels-Alder Type Adduct and a New Flavone from the Stem and Root Bark of Morus mongolica

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chinese Chemical Letters 2005年第11期 58-60页

作者： Jie KANG, Ruo Yun CHEN, De Quan YU institute of materia medica, chinese academy of medical sciences and peking union medical college, beijing 100050

A new Diels-Alder type adduct mongolicin G (1) and a new flavone 5′-(1′′, 1′′-dimethyl- allyl)-5,7,2′,4′-tetrahydroxyflavone (2) were isolated from the stem and root bark of Morus mongolica. Their structures we... 详细信息

关键词： Morus mongolica Diels-Alder type adduct mongolicin G flavone 5′-(1′′ 1′′- dimethylallyl)-5 7 2′ 4′-tetrahydroxyflavone

The Induction of Liver Microsomal Cytochrome P450 by Glycyrrhiza uralensis and Glycyrrhetinic acid in Mice

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Biomedical and Environmental sciences 1999年第1期12卷 10-14页

作者： HU WEN-YU LI YA-WEI HOU YAN-NING HE KAN (department of Pharmacology, Instiute of materia medica, chinese academy of medical Scicnces & beijing union medical college, beijing 100050, china) CHEN JIE-FU (Yang-Ming medical University, Taipei) BUT PAUL PU 中国医学科学院药物所北京 100050 中国医学科学院药物所北京 Yang-Ming medical University 台湾香港中文大学中国药物研究中心香港

The effect of Glycyrrhiza uralensis Fisch (GRZ) aqueous extract and one of its active principles Glycyrrhetinic acid (GRT) on hepatic cytochrome P450 in mice were investigated. Oral administration of GRZ at 10g/kg/d or GRT at 50 mg/kg/d for 7 days was foulld to increase the P450 contents up to 4.6 fold compared with the controls. The activities of aryl hydrocarbon hydroxylase (AHH,3. 1 and 3. 3 fold), aminopyrine N-demethylase (ADM, 4. 2 and 3. 2 folds), and 7-ethoxycumarin O-deethylase (ECOD, 2. 8 and 2. 5 fold) were also shown to be increased. Westem blot analysis showed that the subtypes of P450 isoforms induced selectively by GRZ and GRT included CYP1A1 (1. 8 and 1. 5 fold over that of the control, respectively), CYP2B1 (both 1.3 fold), and CYP2C11(3 .2 and 3 .0 fold). Moreover, significant positive correlation between the P450 content or the isoforms and the corresponding enzyme activities mentioned above was observed.

关键词： Glycyrrhetinic acid Clycyrrhiza uralensis hepatic cytochrome P450

Anticancer activity of sodium caffeate and its mechanism

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Acta Pharmacologica Sinica 2005年第10期26卷 1248-1252页

作者： Feng XU~(2,3,4), Sheng-hua ZHANG~3, Rong-guang SHAO~3, Yong-su ZHEN~3 ~2 department of Pharmacology Zhujiang Hospital, Southern medical University Guangzhou 510280 ~3 department of Ontology Medicinal Biotechnology, chinese academy of medical sciences and peking union medical college, beijing 100050, china department of Pharmacology Zhujiang Hospital Southern Medical University Guangzhou China department of Oncology Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

Aim: To study the anticancer activity of sodium caffeate （SC）. Methods: A nucleoside transport assay was used to analyze the inhibitory effects of SC on nucleoside rescue. The MTT assay was used to measure cell proliferation. Flow cytometrywas used to measure the apoptosis of BEC-7402 induced by SC and the cell cycledistribution change. Western blotting analysis was employed to investigate Bcl2, caspase and Bax expression. Intracellular Ca2+and mitochondrial membranepotential were determined by flow cytometry. In vivo anti-tumor activity wasmeasured using a tumor transplantation model in mice. Results: SC inhibited thenucleoside transport of BEL-7402 cells with an IC50of 1.02 mg/mL. SC inhibitedtumor cell proliferation with an IC50between 100 μg/mL and 200μg/mL. SC induced BEL-7402 cell apoptosis in a time-and dose-dependent manner, which wasinduced by arresting cells in S phase. The in vivo study showed that tumorgrowth was inhibited in a dose-dependent manner. Activated caspase-3 and Baxexpression were up-regulated after treatment with SC, while Bcl-2 expression wasdown-regulated. Intracellular Ca2+was increased while mitochondrial membranepotential was decreased by SC. Conclusion: SC is a new anticancer agent withpromising potential.

关键词： caffeic acid anticancer activity cell division cell apoptosis cell cycle phytogenic antineoplastic agent flow cytometry Western blotting

Advances in early diagnosis and therapy of pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2011年第2期10卷 128-135页

作者： Qiang Xu, Tai-Ping Zhang and Yu-Pei Zhaodepartment of General Surgery, peking union medical college Hospital, peking union medical college & chinese academy of Medial sciences, beijing 100730, china department of General Surgery Peking Union Medical College Hospital Peking Union Medical College & Chinese Academy of Medial Sciences Beijing 100730 China

BACKGROUND: Pancreatic cancer remains a devastating disease with a 5-year survival rate of less than 5%. Recent advances in diagnostic methods and therapeutic approaches have increased the possibility of improving the existing poor prognosis. DATA SOURCES: English-language articles reporting early diagnosis and therapy of pancreatic cancer were searched from the MEDLINE and PubMed databases, chinese-language articles were from CHKD (china Hospital Knowledge Database) RESULT: The current literature about pancreatic cancer was reviewed from three aspects: statistics, screening and early detection, and therapy. CONCLUSIONS: Early detection and screening of pancreatic cancer currently should be limited to high risk patients Surgical resection is the only curative approach available, with some recent improvement in outcomes. Gemcitabine has been a standard treatment during the last decade. Gemcitabine based combination treatment, especially combined with newer molecular targeted agents, is promising. The rationale for radiotherapy is controversial, but with the recent development of modern radiation delivery techniques, radiotherapy should be intensified. Patients with borderline pancreatic cancer could benefit from neoadjuvant therapy but more evidence is needed and the best neoadjuvant regimen is still to be determined.

关键词： pancreatic neoplasm early diagnosis biomarkers surgery adjuvant therapy neoadjuvant therapy borderline resectable tumor

THE CHEMISTRY AND DISTRIBUTION OF TAXANE DITERPENOIDS AND ALK

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药学学报 1995年第11期 862-880页

作者： JZ Zhang (institute of materia medica ,Chiese academy of medical sciences and peking union medical college, beijing 100050) present address:National Lab of Natural & Biomimetic Drugs, School of Pharmaceutical sciences, beijing medical Unicersity, B

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关键词： OF TAXANE DITERPENOIDS AND ALK THE CHEMISTRY AND DISTRIBUTION