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中国植物病理学会第九届全国会员代表大会暨2010年学术年会

作者： Wei Guan,Tingchang Zhao (state key laboratory for biology of Plant Diseases and Insect Pests,institute of Plant Protection,chinese academy of Agricultural sciences,beijing,100093)

Xylella fastidiosa is the causative agent of many economically important plant *** diversity of *** provided a framework to detect,diagnose and control the disease caused by X. *** of the representative works done by using molecular biological methods were discussed in this paper,in order to review the progress of the researches in this field and provide guiding significances for further works.

关键词： Xylella fastidiosa genetic diversity Detection Review

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molecular Design of Plant Cultivars and molecular Breeding

Molecular Design of Plant Cultivars and Molecular Breeding

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中国遗传学会植物遗传与基因组学专业委员会2005年学术研讨会

作者： Zhang Aimin Wang Daowen Zhang Xiangqi institute of genetics and Developmental biology, chinese academy of sciences state key lab of Plant Cell and Chromosome engineering, beijing, 100101

Plant genetic improvement is the important driving force of agricultural progress and development. molecular design of plant cultivars and molecular breeding is the new generation technology of plant breeding based on transgenic technology and molecular marker assisted selection technology. By intensively using the results achieved in functional genomics, metabolomics, Plant cultivars molecular design will achieved by optimum regu-

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More active glycolytic pathway in esophageal squamous cell carcinoma

More active glycolytic pathway in esophageal squamous cell c...

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全国肿瘤流行病学和肿瘤病因学学术会议

作者： Zhao Xiaohang~1,Liu Fei~1,Wang Lishun~2,Liu Siqi~2,Wang Rong~3, Xu Ningzhi~1,Xu Yang~1,Sun Yulin~1 1 state key laboratory of molecular Oncology,Cancer institute & Hospital,chinese academy of medical sciences & Peking Union medical College,beijing 100021,china 2 beijing institute of Genomics,chinese academy of sciences,beijing,101300,china. 3 Department of genetic and Genomic Science,Department of Structural and Chemical biology, Mount Sinai,School of Medicine,New York City,NY,USA

Cancer cells are resistant to apoptosis and show a shift in energy production from mitochondrial oxidative phosphorylation to cytosolic *** observe the metabolic reprogramming of esophageal cancer,8 pairs of tissue specimens of esophageal squamous cell carcinoma(ESCC) were separated and identified via 2-DE-MALDI-TOF-MS strategy.A total of 37 differentially expressed proteins were recognized as an exclusive profile that could distinguish ESCC from normal esophagus tissues,including 23 up-regulated and 14 down-regulated proteins. In which,five key proteins of glycolytic pathway were identified overexpressed in ESCC with lymph node *** glucose metabolism and lactate production of ESCC cells were found more active than that of the normal epithelia *** migration of esophageal cancer cells KYSE410 was found more effective than that of KYSE30 ***,it was also found KYSE410 with higher aerobic glycolysis and invasion capability than that of KYSE30 ***,the oligomycin,a respiration suppressor through suppressing the ATPase-F1 subunit, was enhanced glycolysis of KYSE30 cells,whereas it was no effect on KYSE410 *** may be energy supportment of KYSE30 partially depended on oxygen respiration and KYSE410 was more depending on *** data suggested that the Warburg effect may also exist in esophageal cancer and cancer cell movement was correlated with aerobic glycolysis.

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genetic polymorphisms of milk epithelial mucin of yaks

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Progress in Natural Science:Materials International 2006年第11期16卷 1222-1226页

作者： ZHENG Yucai~1, ZHAO Xingbo~2**, JIN Suyu~1, PENG Xianwen~1 and BAI Wenlin~1 (1. College of Life Science and Technology, Southwest University for Nationalities, Chengdu 610041, china 2. state key laboratory for Agrobiotechnology and Ministry of Agriculture key laboratory of Animal genetics, Breeding and Reproduction, china Agricultural University, beijing 100094, china) College of Life Science and Technology Southwest University for Nationalities Chengdu 610041 China state key laboratory for Agrobiotechnology Ministry of Agriculture Key Laboratory of Animal Genetics Breeding and Reproduction China Agricultural University Beijing 100094 China

Milk epithelial mucin (MUC1) of yaks was separated by SDS-polyacrylamide gel electrophoresis. A total of nine types of MUC1 were revealed in 427 yaks from five yak breeds including Maiwa yak, Jiulong yak, Tianzhu white yak, Qinghai yak and Tibetan yak. The molecular weights of MUC1 are from 163 kD to 208 kD, most of which are larger than those of bovine. Population genetic analysis shows that the gene frequency and genotype frequency of yak MUC1 differ among breeds, with relatively high gene heterozygosity. The five yak breeds studied fall into two groups according to their milk MUC1 gene frequency, suggesting that milk MUC1 exhibits specificities for local yak groups.

关键词： yak milk genetic polymorphism MUC1.

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Risk of Genome-Wide Association Study-Identified genetic Variants for Non-Hodgkin lymphoma in a chinese Population

Risk of Genome-Wide Association Study-Identified Genetic Var...

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全国肿瘤流行病学和肿瘤病因学学术会议

作者： Yan Qiao,Chen Wu,Yuling Zhou,Kan Zhai,Jiang Chang,Dianke Yu,Wen Tan,Dongxin Lin state key laboratory of molecular Oncology,Department of Etiology and Carcinogenesis,beijing key laboratory for Carcinogenesis and Cancer Prevention,Cancer institute and Hospital,chinese academy of medical sciences and Peking Union medical College, beijing,china

Background Recent genome-wide association studies have identified 12 single nucleotide polymorphisms(SNP) associated with the Non-Hodgkin lymphoma subtypes in *** are different incidence rate of NHL and different proportion of NHL subtypes in chinese compared with those in *** study evaluated the effects of these identified SNPs on susceptibility to NHL in a chinese *** We assessed the associations of these 12 SNPs with NHL in a case-control study that consisted of 810 cases and 1,543 *** ratios(OR) and 95%confidence intervals(CI) were computed by logistic regression,and cumulative effect of risk alleles were also *** We found that the allele frequencies of these SNPs in our study population are significantly different from those in Caucasian populations,with the 5 SNPs(rs17483466,rs757978,rs13397985,rs735665 and rs11083846) being extremely rare in *** SNPs(rs872071 in the 3’-UTR of IRF4 and rs10484561 in the human leukocyte antigen(HLA) classⅡ) were significantly associated with NHL risk in our study population,with the OR of 1.20,(95%CI, 1.04-1.38;P=0.011) for rs872071 and OR of 1.97 for rsl0484561(95%CI, 1.61-2.42;P=1.05×10) calculated using additive *** associations of these two SNPs with the risk were seen in both T-cell NHL and B-cell *** increasing number of risk genotypes,a cumulative effect was observed with the ORs being gradually elevated(P=3.52×10).Compared with carrying no risk genotype,individuals carrying 1 or 2 risk genotypes had an adjusted OR of 1.41 (95%CI,1.17-1.71;P=0.004) or 2.52(95%CI,1.85-3.44;P=5.98×10), *** other SNPs had no significant associations with NHL risk in the chinese *** These results suggest that the SNPs rs872071 and rs10484561 contribute to the risk of developing NHL in the chinese population individually and jointly

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史氏鲟和达氏鳇养殖亲鱼群体遗传多样性分析

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水产学报 2010年第12期34卷 1795-1799页

作者：牛翠娟胡红霞罗静李陈中国科学院昆明动物研究所遗传资源与进化国家重点实验室北京师范大学生命科学学院教育部生物多样性与生态工程重点实验室北京市水产科学研究所

利用线粒体控制区序列片段(史氏鲟,425bp,达氏鳇,434bp)分析检测了两个养殖场留做后备亲鱼的史氏鲟和达氏鳇的遗传多样性。在所检测的养殖史氏鲟后备亲鱼4个年龄群体共34个体中,发现5个单倍型,共有11个多态位点,占碱基总数的2.6%,无简... 详细信息

利用线粒体控制区序列片段(史氏鲟,425bp,达氏鳇,434bp)分析检测了两个养殖场留做后备亲鱼的史氏鲟和达氏鳇的遗传多样性。在所检测的养殖史氏鲟后备亲鱼4个年龄群体共34个体中,发现5个单倍型,共有11个多态位点,占碱基总数的2.6%,无简约信息位点。不同单倍型之间有1～10个变异位点,占碱基总数的0.2%～2.4%。各单倍型之间的遗传距离为0.002～0.024。单倍型多样性Hd=0.768,平均核苷酸差异数k=4.367,核苷酸多样性Pi=0.011。而分别来自2个养殖场的2个达氏鳇养殖群体都是1个群体仅1个单倍型,2个单倍型之间仅有2个碱基差异,遗传距离为0.005,遗传变异极度缺乏。结果提示在利用史氏鲟和达氏鳇后备亲鱼进行繁殖育苗时要充分注意近交的影响。

关键词：史氏鲟达氏鳇后备亲鱼线粒体控制区遗传多样性

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genetic Diversity and Geographical Differentiation of Cultivated Six-Rowed Naked Barley Landraces from the Qinghai-Tibet Plateau of china Detected by SSR Analysis

Genetic Diversity and Geographical Differentiation of Cultiv...

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中国遗传学会植物遗传与基因组学专业委员会2005年学术研讨会

作者： Feng Zong-Yun, Zhang Li-Li, Zhang Yi-Zheng, Ling Hong-Qing key laboratory of molecular biology & Biotechnology, College of Life sciences, Sichuan University, Chengdu 610065, china The state key laboratory of Plant Cell & Chromosome engineering, institute of genetics & Developmental biology, chinese academy of sciences, Datun Road, Chaoyang District, beijing 100101, china College of Agronomy, Sichuan Agricultural University, Yuan 625014, china

Cultivated six-rowed naked barley (Hordeum vulgare ssp. hexastichon var. nudum Hsu) is the oldest cultivated barley in china. To study genetic diversity, geographical differentiation and evolutionary relationships, 65 accessions of cultivated six-rowed naked barley landraces collected from the Qinghai-Tibet plateau of china (25 accessions from Tibet (XZ), 20 from Qinghai (QH) and 20 from Ganzi prefecture in Sichuan province

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molecular Cytogenetic Characterization of a New T2BL·1RS Wheat-Rye Chromosome Translocation Line Resistant to Stripe Rust and Powdery Mildew

Molecular Cytogenetic Characterization of a New T2BL·1RS Wh...

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中国遗传学会植物遗传和基因组学专业委员会2009年学术研讨会

作者： Chunmei Wang~(1*),Qi Zheng~(2*),Lihui Li~3,Yongchun Niu~4,Haibo Wang~5,Bin Li~2,Xiaotian Zhang~1,Yunfeng Xu~1,and Diaoguo An~(1**) 1 Center for Agricultural Resources Research,institute of genetics and Developmental biology(IGDB), chinese academy of sciences(CAS),Shijiazhuang 050021 2 The state key laboratory of Plant Cell and Chromosome engineering,IGDB,CAS,beijing 100101 College of Life sciences,china genetic and molecular Breeding University,beijing 100000 3 The National key Facility for Crop Gene Resources and genetic Improvement,institute of Crop Science, chinese academy of Agricultural sciences(CAAS),beijing 100081 4 institute of Plant Protection,CAAS,beijing 100193 5 institute of genetics and Physiology,Hebei academy of Agriculture and Forestry sciences,Shijiazhuang, 050051

Wheat(Triticum aestivum) genotypes with rye(Secale cereale) 1RS chromosomal translocations are widely used in wheat breeding programs because 1RS carries genes for resistance to several ***,some of the pathogens have ... 详细信息

关键词： Wheat rye translocation line GISH and FISH wheat stripe rust and powdery mildew

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molecular characterization of the Mg2+-responsive PhoP regulator in control of the intracellular growth of Yersinia pestis

Molecular characterization of the Mg2+-responsive PhoP regul...

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首届全国微生物基因组学学术研讨会

作者： Dongsheng Zhou, Long Qin, Yingli Li, He Gao, Yu Wang, Yajun Song, and Ruifu Yang state key laboratory of pathogen and Biosecurity, institute of Microbiology and Epidemiology, academy of Military medical sciences, beijing 100071, china

Yersinia pestis is considered as a facultative intracellular pathogen capable of surviving and growing within macrophages. The Mg2+-responsive PhoP regulator was previously shown to be important for Y. pestis survival in macrophage and under macrophage-induced stresses of low pH, oxidative stress, high osmolarity and antimicrobial peptides. In this work, a phoP mutan of Y. pestis is generated using the Red cloning procedure. Microarray transcriptional profiling of the phoP mutant in response to low Mg2+ stimulus reveals at least 706 genes whose expression is dependent on PhoP, representing approximately 16% of the total protein-coding capacity of the Y. pestis genome. The microarray data provides a framework of candidate PhoP targets for further biochemical investigation. A total of 45 putative operons are subsequently shown to be under the direct control of PhoP by using electrophoretic

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A feature ensemble technology to identify molecular mechanisms for distinction between multiple subtypes of lymphoma

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Progress in Natural Science:Materials International 2008年第12期18卷 1491-1500页

作者： Yueying Yang~(a,1) Haiyun Wang~(a,b,1) Xia Li~(a,b,c) Xue Xiao~c Su Fei~a Chuanxing Li~a Hongzhi Wang~d Shaoqi Rao~(a,c,e) Yadong Wang~d a College of Bioinformatics Science and Technology,Bio-pharmaceutical key laboratory of Heilongjiang Province and state,Harbin medical University,Harbin 150081,china b College of Life Science and Technology,Tongji University,Shanghai 200092,china c The Biomedical engineering institute,Capital Medieal University,beijing 100054,china d Department of Computer Science,Harbin institute of Technology,Harbin 150080,china e Department of molecular Cardiology,Cheveland Clinic Foundation,Cleveland,OH 44195,USA College of Bioinformatics Science and Technology Bio-pharmaceutical Key Laboratory of Heilongjiang Province and State Harbin Medical University Harbin 150081 China College of Life Science and Technology Tongji University Shanghai 200092 China The Biomedical engineering institute Capital Medical University Beijing 100054 China Department of Computer Science Harbin Institute of Technology Harbin 150080 China Department of molecular Cardiology Cleveland Clinic Foundation Cleveland OH 44195 USA

Due to complexities and genetic heterogeneities of biological phenotypes,robust computational approaches are desirable to achieve high generalization performance with multiple classifiers,perturbations of the data structures,and biological *** purpose of this study is to extend our developed ensemble decision approach to distinguish multiple heterogeneous phenotypes and to elucidate the underlying molecular bridges that intertwine the *** work identifies the significant molecular mechanisms (disease-relevant genes and functions) that underpin the complex molecular mechanisms for distinction between multiple phenotypes. Feature genes and hierarchical gene cores identified by our method have achieved high accuracy in the classification of multiple pheno- *** results show that the proposed analysis strategy is feasible and powerful in the classification of biological subtypes and in the explanation of the molecular connections between clinical *** interpretations with Gene Ontology revealed concerted genetic pathways for some lymphoma subtypes.

关键词： Ensemble decision approach molecular mechanisms Lymphoma Microarray

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