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A mixed blessing for liver transplantation patients—Rapamycin

Hepatobiliary & Pancreatic Diseases International 2023年第1期22卷 14-21页

作者： Guang-Han Fan Chen-Zhi Zhang Feng-Qiang Gao Xu-Yong Wei sun-Bin Ling Kai Wang Jian-Guo Wang Shu-sen Zheng Mehrdad Nikfarjam Xiao Xu Department of Hepatobiliary and Pancreatic Surgery Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China Zhejiang univer.ity School of Medicine Hangzhou 310058China key labor.tor. of Integrated oncology and Intelligent Medicine of Zhejiang Province Hangzhou 310006China Institute of Organ Transplantation Zhejiang UniversityHangzhou 310003China state key labor.tor. of oncology in south china Collaborative Innovation Center for Cancer MedicineSun Yat-sen University CancerGuangzhou 510060China Westlake labor.tor. of Life Sciences and Biomedicine Hangzhou 310024China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalHangzhou 310000China NHC key labor.tor. of Combined Multi-Organ Transplantation Hangzhou 310003China Department of Surgery University of MelbourneAustin HealthHeidelbergVIC 3084Australia

Background:Liver transplantation(LT)is an effective treatment option for end-stage liver *** target of rapamycin(m tor)inhibitors,such as rapamycin,are widely used post *** sources:In this review,we focused on the anti-cancer activities and metabolic side effects of rapamycin after *** literature available on Pub Med for the period of January 1999-September 2022 was *** key words were rapamycin,sirolimus,liver transplantation,hepatocellular carcinoma,diabetes,and lipid metabolism ***:Rapamycin has shown excellent effects and is safer than other immunosuppressive *** has exhibited excellent anti-cancer activity and has the potential in preventing hepatocellular carcinoma(HCC)recurrence post *** is closely related to two long-term complications after LT,diabetes and lipid metabolism ***:Rapamycin prevents HCC recurrence post LT in some patients,but it also induces metabolic *** use of rapamycin benefits the liver recipients.

关键词： Liver transplantation Rapamycin Metabolic disease Hepatocellular carcinoma Tumor recurrence

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Prognostic factors and failure patterns in non-metastatic nasopharyngeal carcinoma after intensity-modulated radiotherapy

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Chinese Journal of cancer 2016年第12期35卷 673-682页

作者： Yan-Ping Mao Ling-Long Tang Lei Chen Ying sun Zhen-Yu Qi Guan-Qun Zhou Li-Zhi Liu Li Li Ai-Hua Lin Jun Ma state key labor.tor. of oncology in south china Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center Department of Radiation oncology Sun Yat-sen University Cancer Center Imaging Diagnosis and Interventional center Sun Yat-sen University Cancer Center Department of Medical Statistics and Epidemiology School of Public HealthSun Yat-sen University

Background: The prognostic values of staging parameters require continual re?assessment amid changes in diag?nostic and therapeutic methods. This study aimed to identify the prognostic factors and failure patterns of non?meta?static nasopharyngeal carcinoma(NPC) in the intensity?modulated radiotherapy(IMRT) ***: We reviewed the data from 749 patients with newly diagnosed, biopsy?proven, non?metastatic NPC in our cancer center(south china. an NPC endemic area) between January 2003 and December 2007. All patients under?went magnetic resonance imaging(MRI) before receiving IMRT. The actuarial survival rates were estimated using the Kaplan–Meier method, and survival curves were compared using the log?rank test. Multivariate analyses with the Cox proportional hazards model were used to test for the independent prognostic factors by backward eliminating insigniicant explanatory ***: The 5?year occurrence rates of local failure, regional failure, locoregional failure, and distant failure were 5.4, 3.0, 7.4, and 17.4%, respectively. The 5?year survival rates were as follows: local relapse?free survival, 94.6%; nodal relapse?free survival, 97.0%; distant metastasis?free survival, 82.6%; disease?free survival, 75.1%; and overall survival, 82.0%. Multivariate Cox regression analysis revealed that orbit involvement was the only signiicant prognostic fac?tor for local failure(P = 0.011). Parapharyngeal tumor extension, retropharyngeal lymph node involvement, and the laterality, longest diameter, and Ho's location of the cervical lymph nodes were signiicant prognostic factors for both distant failure and disease failure(all P key failure pattern for NPC was distant metastasis in the IMRT era. With changes in diagnostic and therapeutic technologies as well as treatment modalities, the signiicant prognostic parameters for local control have also been

关键词： Nasopharyngeal carcinoma Intensity-modulated radiotherapy Prognosis Failure pattern Tumor staging

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