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A preliminary molecular historical biogeography of Caragana (Leguminosae) based on ITS and trnL-F DNA sequence data

Journal of Arid Land 2009年第1期1卷 64-73页

作者： MingLi ZHANG1,2, Yun KANG3 , JunBo YANG4 1 laboratory of Evolution and Biodiversity Conservation in Arid Region, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, china 2 Institute of Botany, Chinese Academy of Sciences, Beijing 100093, china 3 school of pharmacy, fudan university, shanghai 200032, china 4 Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, china laboratory of Evolution and Biodiversity Conservation in Arid Region Xinjiang Institute of Ecology and Geography Chinese Academy of Sciences Urumqi 830011 China Institute of Botany Chinese Academy of Sciences Beijing 100093 China school of pharmacy Fudan University Shanghai 200032 China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China

The nrDNA internal transcribed spacer (ITS) and cpDNA trnL-F internal spacer (IGS) sequence data of Caragana eight species and one outgroup Halimodendron halodendron, was employed to reconstruct a phylogenetic tree, then the area relationship was analyzed by means of component analysis (CA), Brooks parsimony analysis (BPA), and dispersal-vicariance analysis (DIVA), six areas were selected from two divided distributions of East Asia and Tethys in Caragana. The phylogenetic tree indicated that there were three distinctive groups, which were attributed to some morphological characters, first with pinnate foliage and deciduous rachis, second with palmate foliage and persistent sclerotic stick rachis, and third with pinnate foliage and persistent sclerotic stick rachis. The results of CA and BPA illustrated general area relationships. An explicit area relationship should be Altai-Sayan, Far East NE china and North china (Hengduan Mountains). DIVA recognized several explanatory vicariance and dispersal events. As the scenario of Caragana distribution pattern, it looks like the vicariance versus dispersal plays more important role. In vicaraince, there are not only the isolated far-distance vicariance, but also the adjacent vicariance especially a vicariance between Hengduan Mountains and North china.

关键词： Caragana ITS trnL-F phylogeny cladistic biogeography DIVA distribution pattern

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Lymphangiogenic and angiogenic microvessel density in human primary sporadic colorectal carcinoma

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World Journal of Gastroenterology 2008年第1期14卷 101-107页

作者： Ge Yan, Xiao-Yan Zhou, San-Jun Cai, Gui-Hong Zhang, Jun-Jie Peng, Xiang Du, Department of Pathology, Cancer Hospital of fudan university Department of Oncology, shanghai Medical College, fudan university Colorectal Cancer Center, fudan university, 270 Dong’an Road, shanghai 200032, china Department of Pathology Cancer Hospital of Fudan University Shanghai 200032 China.

AIM： To investigate the distribution pattern of lymphatic vessels and microvessels in sporadic colorectal carcinoma （SCRC） and their relationship to metastasis and prognosis. METHODS： The lymphatic vessel density （LVD） and microvessel density （MVD） in tumor tissue obtained from 132 patients with primary SCRC, including 74 with metastases and 58 without metastases, were evaluated by immunohistochemistry using antibodies directed against D2-40 and yon Willebrand factor （vWF）. RESULTS：（1） The lymphatic vessels and microvessels at central portions of SCRC often had a reticular architecture with numerous tiny and ill-defined lumina, while those at tumor borders had large and open lumina. The LVD and MVD were both obviously higher in colorectal cancer patients with metastases than in those without （P 〈 0.001）. （2） For each one lymphatic vessel increased, there was a 1.45-fold increase in the risk of metastasis in SCRC. The specificity and sensitivity of LVD in predicting metastasis or non-metastasis in SCRC were 71.62% and 56.90%, respectively, and the corresponding LVD was 5. For each one microvessel increased, there was a 1.11-fold increase in the risk of metastasis in SCRC. The specificity and sensitivity of MVD were 66.22% and 51.72%, respectively. （3） Double labeling immunohistochemistry showed D2-40 immunoreactivity to be specific for lymphatic vessels. （4） Univariate analysis indicated that high LVD, high MVD, as well as co-accounting of high LVD and high MVD were associated with patient＇s poor disease-free survival （Puni 〈 0.05）; multivariate analysis indicated that co-accounting of LVD and MVD was an independent prognostic factor of colorectal cancer, CONCLUSION： D2-40 is a new specific antibody for lymphatic endothelial cells. Lymphogenesis and angiogenesis are commonly seen in SCRC, especially at tumor borders. The detection of LVD and MVD at tumor borders may be useful in predicting metastasis and prognosis in patients with SCRC, and, in particular, coaccount

关键词： Lymphangiogenesis Angiogenesis Lymphaticvessel density Microvessel density Sporadic colorectalcarcinoma Metastasis

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SOME RESULTS OF A NEHARI FAMILY

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Chinese Annals of Mathematics,Series B 2005年第1期26卷 57-66页

作者： ZHUHUACHENG YANGZONGXIN CHENJIXIU InstituteofMathematics LaboratoryofMathematicsforNonlinearSciencesFudanUniversityShanghai200433China InstituteofMathematics，laboratoryofMathematicsforNonlinearSciences，fudanuniversity Shanghai200433China

The authors study the Nehari family Nb and obtain some important properties for this family.

关键词： Schwarzian derivative Nehari family

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GROUP ACTIONS ON VON NEUMANN REGULAR RINGS

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Chinese Annals of Mathematics,Series B 1994年第2期15卷 235-240页

作者： ZHANG YINHUO(Institute of Mathematics,fudan university, shanghai 200433, china) 复旦大学数学所上海 200433

Let A be a ring with indentity, G a finite group of automorphisms of A. The main result of this paper is that A/AG is Galois if and only if it is Frobenius and the module AGA (or AAG)is faithful. Moreover if |G| is in... 详细信息

关键词： Von Neumann regular ring Extension Group Automorphism.

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Phylogeographic analysis of human papillomavirus 58

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Science china(Life Sciences) 2009年第12期52卷 1164-1172页

作者： LI YanYun1, LI ZuoFeng2, HE YiFeng1, KANG Yu1, ZHANG XiaoYan1, CHENG MingJun1, ZHONG Yang2, 3· & XU CongJian1· 1 Obstetrics and Gynecology Hospital of fudan university, shanghai 200011, china 2 shanghai Bioinformation Research Center, shanghai 200235, china 3 school of Life Sciences, fudan university, shanghai 200433, china Obstetrics and Gynecology Hospital of fudan university Shanghai China shanghai Bio-information Research Center Shanghai China school of Life Sciences Fudan University Shanghai China

Human papillomavirus 58 (HPV58) is one type of HPV with high risk of causing cervical cancer. Unusually high prevalence of HPV58 has been reported in Asia, Africa and some other areas. However, due to the scattered distribution of global data, in addition to the lack of data of some HPV58 high-incidence nations and regions, like china's Mainland, a comprehensive analysis of the global geographical distribution of HPV58 remains blank so far. In this study, HPV58 from the human cervical cancer tissue was detected in china's Mainland, and 14 new HPV58-E6/L1 gene sequences were obtained. Moreover, phylogeographic analysis has been conducted combining the HPV58 sequences that have been deposited in GenBank since 1985. The study result shows that the sequences detected from the shanghai, Jiangsu and Sichuan areas are homologous with those found in the past from Hong Kong and Xi'an, china, as well as Japan and other Southeast Asian areas. Furthermore, Western Africa is considered to be the "root" source of the HPV58 variant, while china's Mainland and Southeast Asia are "transit points" and the new sources of HPV58 after receiving the isolates from the "root" source; like HPV16 and HPV18, the HPV58 might also be one of the major HPV types associated with the development and spread of cervical cancer.

关键词： human papillomavirus 58 (HPV58) cervical cancer phylogeography molecular evolution

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A remark on p- harmonic heat flows

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Chinese Science Bulletin 1997年第6期42卷 441-444页

作者： LIU XiangaoInstitute of Mathematics, fudan university, shanghai 200433, china Institute of Mathematics Fudan University Shanghai China

IN this note we prove the existence of the global weak solutions of p-harmonic heat flows, in particular 11 (see Lemma 2), and it is in itself a significance.

关键词： harmonic map heat flows existence.

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Expression of pro-inflammatory and anti-inflammatory cytokines in brain of atherosclerotic rats and effects of Ginkgo biloba extract

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Acta Pharmacologica Sinica 2005年第7期26卷 835-839页

作者： Ya-bin JIAO~2 Yao-cheng RUI~3 Tie-jun LI Peng-yuan YANG Yan QIU Department of Pharmacology,school of pharmacy,the Second Military Medical university,shanghai 200433,china 2 Now in Department of Pharmacology,school of pharmacy,shanghai university of Traditional Chinese Medieine,shanghai 201203,china. Department of Pharmacology School of Pharmacy the Second Military Medical University Shanghai China

Aim:To study the protein and mRNA expressions of pro-inflammatory and anti-inflammatory cytokines in the brain of rats with atherosclerosis(AS)and theeffects of Ginkgo biloba extract(GbE)on expressions of ***:The expermental model of AS in rats were established by intraperitioneal injectionof vitamin D3 with high fat/cholesterol *** 100 mg/kg was administered torats by *** 8 weeks,the expressions of IL-1β,TNF-α,IL-10,and 1L-10R in thebrain tissues of AS rats were detected by enzyme-linked immunosorbant assay,immunohistochemistry,Western blotting,and reverse transcriptase polymerasechain ***:The protein and mRNA expressions of IL-1β,TNF-α,andIL-10 in the brains were markedly higher in AS groups than that in control groups(6.11±0.15,1.55±0.14,0.54±0.04 ng/g wet weight vs 0.80±0.14,0.33±0.09,and0.33±0.02 ng/g wet weight,respectively).The protein and mRNA expres-sions of IL-1β and TNF-α in the brains were markedly lower in GbE groups(3.82±0.54,0.95±0.08 ng/g wet weight)than that in AS groups,the protein andmRNA expressions of IL-10 and 1L-10R in the brains were markedly higher in GbEgroups(0.85±0.06 ng/g wet weight)than that in AS ***:GbEinhibited production of pro-inflammatory cytokines IL-1β and TNF-α,but up-regulated the production of anti-inflammatory cytokines,1L-10 and IL-10R in brain,which might be related with its anti-AS actions.

关键词： atherosclerosis cytokine interleukin-1 tumor necrosis factor interleukin-10 Ginkgo biloba rats

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Synthesis of adamantane on zeolite catalysts

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Chinese Journal of Chemistry 1994年第1期12卷 52-57页

作者： GAO, Zi YANG, Xiao-BoDepartment of Chemistry, fudan university, shanghai 200433, china Department of Chemistry Fudan University Shanghai 200433 China

The synthesis of adamantane from tetrahydrodicyclopentadiene on zeolites with different framework structures was studied. The adamantane yield on HY zeolites is higher than on HM and HZSM-5 zeolites. Among various types of dealuminated HY zeolites the HEY and HUSY zeolites give higher adamantane yields than conventional HY zeolite. The changes in activity and selectivity of the main and side reactions are correlated with the acidity and the pore structure of the zeolites. To ion-exchange the HY and HUSY zeolites with Ni2+ and La3+ cations may further improve the activity and selectivity of the zeolite catalysts.

关键词： Adamantance zeolite catalysis ion-exchange.

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Optimal Control of Semilinear Elliptic Variational Bilateral Problem

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Acta Mathematica Sinica,English Series 2000年第1期16卷 123-140页

作者： Qihong Chen Institute of Mathematics,fudan university,shanghai 200433,P.R.china shanghai Normal university,shanghai 200023,P.R.china Institute of Mathematics Fudan University Shanghai 200433 P.R. China shanghai Normal university Shanghai 200023 P.R. China

This paper is concerned with an optimal control problem for semilinear elliptic variational inequalities associated with bilateral *** and optimality conditions of the optimal pair are established.

关键词： Elliptic bilateral variational inequality Optimal control Existence Optimality condition

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Sorafenib in treatment of patients with advanced hepatocellular carcinoma:a systematic review

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Hepatobiliary & Pancreatic Diseases International 2012年第5期11卷 458-466页

作者： Xin Zhang, Xin-Rong Yang, Xiao-Wu Huang, Wei-Min Wang, Ruo-Yu Shi, Yang Xu, Zheng Wang, Shuang-Jian Qiu, Jia Fan ,Jian Zhou Liver Cancer Institute, Zhongshan Hospital, fudan university, shanghai Key laboratory for Organ Transplantation, shanghai 200032, china,Institute of Biomedical Sciences, fudan university, shanghai 200032, china Liver Cancer Institute Zhongshan Hospital Fudan University and Shanghai Key Laboratory for Organ Transplantation Shanghai 200032 Shanghai China Institute of Biomedical Sciences Fudan University Shanghai 200032 Shanghai China

BACKGROUND: Sorafenib has become the standard first-line treatment for patients with advanced hepatocellular carcinoma (HCC). This study aimed to assess the efficacy and safety of sorafenib in advanced HCC patients and explore its true value for specific subgroups. DATA SOURCES: A computer-based systematic search from January 2005 to June 2011 with 'sorafenib' and 'advanced hepatocellular carcinoma' as search terms was performed for possible clinical trials. Hazard ratios (HR) and their 95% confidence intervals (CI) for overall survival (OS) and time to progression (TTP), rates of partial response (PR), rates of toxicity effects, and details of subgroup analysis were extracted. Meta-analyses were done using the software Review Manager (version 5.0). RESULTS: Six trials with 1164 patients were included. Based on three randomized controlled trials, the pooled HR (sorafenib/ placebo) was 0.66 for OS (95% CI: 0.56-0.78; P3.56 (95% CI: 1.22-10.39; P=0.02). Subgroup analysis indicated that sorafenib was less effective in patients with extrahepatic spread (with: P=0.13 vs without: P3/4 hand-foot skin reaction, diarrhea, fatigue, and rash/***: Sorafenib-based therapy benefits advanced HCC patients. Meanwhile, sorafenib is less effective for patients with extrahepatic spread, with normal AFP level and with elevated level of bilirubin.

关键词： advanced hepatocellular carcinoma sorafenib systematic review

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