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Phorbol-induced surface expression of NR2A subunit homologues in HEK293 cells

Acta Pharmacologica Sinica 2006年第12期27卷 1580-1585页

作者： Chan-ying ZHENG~2 Xiu-juan YANG~3 Zhan-yan FU~4 Jian-hong LUO~(2,5)2 Department of Neurobiology,Zhejiang University School of Medicine,Hangzhou 310031,china 3 institute of neuroscience,shanghai institutes for biological sciences,the chinese academy of sciences,shanghai 200031,china 4 Department of Physiology and Biophysics,Georgetown University School of Medicine Washington 20057,USA DepartmentofNeurobiology ZhejiangUniversitySchoolofMedicineHangzhou310031China instituteofneuroscience ShanghaiInstitutesforBiologicalSciencestheChineseAcademyofSciencesShanghai200031China

Aim:N-methyl-D-aspartate receptors(NMDAR)are heteromeric complexes pri-marily assembled from NR1 and NR2 *** normal conditions,NR2 sub-units assemble into homodimers in the endoplasmic reticulum(ER).Thesehomodimers remain in the ER until they coassemble with NR1 dimers and aretrafficked to the cell ***,it still remains unclear whether functionalhomomeric NMDAR exist in physiological or pathological ***:We transfected GFP-NR2A alone into HEK293 cells,treated the cells with PKCactivator 12-myristate-13 acetate(PMA),and then detected surface NR2A sub-units with a live cell immunostaining *** also used a series of NR2Amutants with a partial deletion of its C-terminus to identify the regions that areinvolved in the PMA-mediated surface expression of NR2A ***:NR2A subunits were expressed on the cell membrane after incubation with PMA(200 nmol/L,30 min),although no functional NMDA channels were detected afterPMA-induced membrane *** with an ER marker alsorevealed that NR2A subunits were exported from the ER after PMA ***,the deletion of amino acids between 1149-1347 or 1354-1464 ofNR2A inhibited PMA-induced surface expression ofNR2A ***:First,our data suggests that PMA treatment can induce the surface expression ofhomomeric NR2A ***,this process is probably mediated bythe NR2A C-terminal region between positions 1149 and 1464.

关键词： NMDA receptor NR2A subunit PMA surface expression HEK293 cells

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Axon guidance and neuronal migration research in china

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Science china(Life sciences) 2010年第3期53卷 304-314页

作者： YUAN XiaoBing institute of neuroscience,shanghai institutes for biological sciences,chinese academy of sciences,shanghai 200031,china 1. institute of neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

Proper migration of neuronal somas and axonal growth cones to designated locations in the developing brain is essential for the assembly of functional neuronal *** progress in research of axon guidance and neuronal migration has been made in the last twenty *** researchers began their exploration in this field ten years ago and have made significant contributions in clarifying the signal transduction of axon guidance and neuronal *** unique experimental approaches,including the migration assay of single isolated neurons in response to locally delivered guidance cues,have been developed by chinese neuroscientists to investigate the molecular machinery underlying these guidance events.

关键词： axon guidance neuronal migration development neuronal circuits

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Recent progress in neurodegenerative disorder research in china

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Science china(Life sciences) 2010年第3期53卷 348-355页

作者： ZHOU JiaWei institute of neuroscience,shanghai institutes for biological sciences,chinese academy of sciences,shanghai,200031 1. institute of neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

Neurodegenerative disorders,including Alzheimer's disease(AD) and Parkinson's disease(PD),are common disorders of the central nervous system among aging *** the last 10 years insights concerning the etiology,diagnosis and pathogenesis of these diseases have come from research carried out by chinese *** findings include the description of chinese patients with autosomal recessive early-onset PD,the function of the tau protein,molecular mechanisms underlying protein aggregation,and the identification of biomarkers for AD diagnosis and molecules/compounds with potential neuroprotective activities.

关键词： neurodegenerative disorders pathogenesis diagnosis neuroprotection Alzheimer’s disease Parkinson’s disease

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Progress in glial cell studies in some laboratories in china

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Science china(Life sciences) 2010年第3期53卷 330-337页

作者： DUAN ShuMin institute of neuroscience,State Key Laboratory of neuroscience,shanghai institutes for biological sciences,chinese academy of sciences,shanghai china,200031 1. institute of neuroscience State Key Laboratory of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China 200031

Glial cells in the central nervous system(CNS) consist of a heterogeneous population of cell types,each characterized by distinct morphological features,physiological properties,and specific *** contrast to the previous view that glial cells were passive elements in the brain,accumulating evidence suggests that glial cells are active participants in various brain functions and brain *** review summarizes recent progress of glial cell studies from several groups in china,ranging from studies about the mechanisms of neuron-glia crosstalking to investigations on the roles of glial cells in various CNS disorders.

关键词： neuron-glia interaction ATP plasticity pain ischemia neural injury and repair

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Synapse formation and remodeling

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Science china(Life sciences) 2010年第3期53卷 315-321页

作者： LUO ZhenGe institute of neuroscience and State Key Laboratory of neuroscience,shanghai institutes for biological sciences,chinese academy of sciences,shanghai 200031,china 1. institute of neuroscience and State Key Laboratory of neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

Synapses are specialized structures that mediate information flow between neurons and target cells,and thus are the basis for neuronal system to execute various functions,including learning and *** are around 1011 neurons in the human brain,with each neuron receiving thousands of synaptic inputs,either excitatory or inhibitory.A synapse is an asymmetric structure that is composed of pre-synaptic axon terminals,synaptic cleft,and postsynaptic *** formation involves a number of cell adhesion molecules,extracellular factors,and intracellular signaling or structural *** the establishment of synaptic connections,synapses undergo structural or functional changes,known as synaptic plasticity which is believed to be regulated by neuronal activity and a variety of secreted *** review summarizes recent progress in the field of synapse development,with particular emphasis on the work carried out in china during the past 10 years(1999-2009).

关键词： synapse development neuronal activity synaptic plasticity

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Pain research in china

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Science china(Life sciences) 2010年第3期53卷 356-362页

作者： ZHANG Xu institute of neuroscience,State Key Laboratory of neuroscience,shanghai institutes for biological sciences,chinese academy of sciences,shanghai 200031,china 1. institute of neuroscience State Key Laboratory of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

In addition to investigating the anatomy,neurochemistry and neurophysiology of pain pathways,chinese researchers have extended their work into the molecular and cellular mechanisms of sensory afferent transmission at the spinal cord level as well as cognitive processing in the *** mechanism underlying acupuncture analgesia remains a subject of special interest for chinese pain researchers,with the aim of combining clinical practice with the understanding of pain transmission and analgesic mechanism.

关键词： dorsal root ganglion spinal cord nociception receptors ion channels gene expression

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Ion channels in neuronal survival

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Science china(Life sciences) 2010年第3期53卷 342-347页

作者： WANG YiZheng & XU TianLe institute of neuroscience and State Key Laboratory of neuroscience,shanghai institutes for biological sciences,chinese academy of sciences,shanghai 200031,china 1. institute of neuroscience and State Key Laboratory of neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

The study of ion channels represents one of the most active fields in neuroscience research in *** the last 10 years,active research in various chinese neuroscience institutions has sought to understand the mechanisms responsible for sensory processing,neural development and neurogenesis,neural plasticity,as well as *** addition,extensive studies have been directed to measure ion channel activity,structure-function relationships,as well as many other biophysical and biochemical *** review focuses on the progress achieved in the investigation of ion channels in neuronal survival during the past 10 years in china.

关键词： ion channels neuronal survival and ischemia.

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Conus Peptides-A Rich Pharmaceutical Treasure

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Acta Biochimica et Biophysica Sinica 2004年第11期36卷 713-723页

作者： Cheng-Zhong WANG and Cheng-Wu CHIinstitute of Biochemistry and Cell Biology, shanghai institute of biological sciences, the chinese academy of sciences, shanghai 200031, china institute of neuroscience, the chinese academy of sciences, shanghai 200031, china institute of Protein Research, Tongji University, shanghai 200092, china institute of Biochemistry and Cell Biology Shanghai Institute of Biological Sciences the Chinese Academy of Sciences institute of neuroscience the Chinese Academy of Science institute of Protein Research Tongji University

Marine predatory cone snails (genus Conus) with over 500 species represent what is arguably the largest single genus of marine animals alive today. All Conus are venomous and utilize a complex mixture of Conus peptide... 详细信息

关键词： Conus peptide conotoxin neuropathic disorder pharmaceutical potency

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Visual neuroscience research in china

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Science china(Life sciences) 2010年第3期53卷 363-373页

作者： YAO HaiShan,LU HaiDong & WANG Wei institute of neuroscience,State Key Laboratory of neuroscience,shanghai institutes for biological sciences,chinese academy of sciences,shanghai 200031,china 1. institute of neuroscience State Key Laboratory of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

Historically,vision research in china was one of a few distinct research programs within the chinese academy of sciences(CAS).With improved funding opportunities and research environment in neuroscience,vision research at several research institutes within the academy has made significant progress not only in the quantity of publications,but also in the quality of the *** on our own expertise,this review is mainly focused on the findings that have advanced the understanding of visual processing in the central visual pathway,visual perceptual learning,visual development and eye diseases.

关键词： visual cortices contextual modulation feedback feature binding motion processing perceptual learning functional brain imaging eye movement visual development and senescence

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The first protein ever synthesized in vitro—a personal reminiscence of the total synthesis of crystalline insulin

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Science china(Life sciences) 2010年第1期53卷 16-18页

作者： ZHANG YouShang institute of Biochemistry and Cell Biology,shanghai institutes for biological sciences,chinese academy of sciences shanghai 200031,china 1. institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

The total synthesis of crystalline bovine insulin started in 1958 was fully accomplished in 1965. This formidable task was a collaboration of the institute of Biochemistry in shanghai,

关键词： The first protein ever synthesized in vitro a personal reminiscence of the total synthesis of crystalline insulin

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