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AAV-mediated BDNF gene therapy to protect retinal ganglion cells in a rat glaucoma model

野生动物生态与资源保护第三届全国学术研讨会

作者： ZHOU Youbing~(1,2) ZHANG Shuyi~2 CHEN Jin~1 (1 Xishuangbanna Tropical Botanical Garden,chinese academy of sciences,Mengla,Yunnan 666303,china 2 institute of Zoology,chinese academy of sciences,beijing 10080 china)

＜正＞Frugivory and seed dispersal by Paguma larvata were conducted in a fragmented habitat at Yangtze River valley of ***-fruits of 78 wild and cultivate plants with more than 67% of frequency of occurrence and 58% of ingested biomass by fecal analysis were main food composition and about 400,000 seeds（67 species,all wild fruited plants）were defecated by these *** civets had a tendency of flesh-preferring fruit choice,their fruit consumption strongly related with wild fruit plants distribution in

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AAV-mediated BDNF gene therapy to protect retinal ganglion c...

A research on development of agritourism in china-a case study of beijing

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Ruo-Tong REN,Shi-Gang HE~* State Key Laboratory of Brain and Cognitive sciences,institute of Biophysics,chinese academy of sciences,beijing 100101,china

Objective Glaucoma is an optic neuropathy characterized by the progressive degeneration of both axons and cell bodies of retinal ganglion cells(RGCs).Elevated intraocular pressure(IOP) is a major risk factor for glaucomatous RGC *** delivery to the retina by viral vectors,such as Adeno-associated viral(AAV) vectors,has been shown to be effective in reducing structural and functional damage in several models of ocular *** present study is to test that using AAV vector expressing brain-derived neurotrophic factor(BDNF) could be protective in experimental glaucoma model by mimicking normal treatment *** Rat RGCs were labeled retrogradely by Fluorogold(FG) injection in superior colliculi *** glaucoma was induced by sterile saline injection into the anterior chamber of rat eyes to elevate the IOP to 130 mmHg for 45 minutes,followed by intravitreal injection of normal saline, AAV2-BDNF/His-tag,or AAV-green fluorescent protein(GFP).Survival of RGCs was estimated by counting FG-positive RGCs in retinal whole mounts after 2 weeks of elevated *** expression was assessed by immunohistochemistry and direct visualization of *** Two weeks after acute high IOP treatment followed by AAV injection,the density of survival RGCs was(387.00±15.00) cells/mm

关键词： glaucoma gene therapy adeno-associated virus(AAV) BDNF retinal ganglion cell(RGC)

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Journal of Geographical sciences 2000年第4期10卷 82-88页

作者： GUO Huan-cheng, WANG Yun-cai (institute of Geographic sciences and Natural Resources Research, CAS, beijing 100101, china) 中科院地理科学与资源所北京

Agritourism is a new kind of industry which combined agriculture with tourism and started from the 1970s with the development of agricultural economy and meeting the demand of touring consumption. It is an important way to exploit natural resources sufficiently, change the simplistic structure and promote the high efficient agriculture. It provides a new space for people to enjoy themselves and appreciate rural scenery. In light of its function, it can be classified into sightseeing, dietetics, shopping, recreation, leisure, health and vocationing. At present, most agritourism is concentrated at the suburbs of big cities, comparative developed regions along the seashore, scenic spots nationalities inhabited areas and regions of special agriculture. beijing is a metropolis where tourism is comparatively well developed with advantageous conditions. Agricultural landscape is the theoretical base of agritourism. So it is important to construct agricultural landscape and artificial landscape is the premise to develop agritourism.

关键词： agritourism agritourism types agricultural landscape distribution principle

Systematic Study of Stability of Super Heavy Nuclei

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Communications in Theoretical Physics 2004年第12期 871-874页

作者： ZHANG Hong-Fei,~(1,4) ZUO Wei,~(1,2,3) Soojae Im,~(1,2) ZHOU Xiao-Hong,~1 LI Jun-Qing~(1,2,3)~1institute of Modern Physics,the chinese academy of sciences,Lanzhou 730000,china~2Center of Theoretical Nuclear Physics,National Laboratory of Heavy Ion Accelerator of Lanzhou,Lanzhou 730000,china~3Institut f(?)r Theoretische Physik,Justus-Liebig-Universit(?)t,Heinrich-Buff-Ring 16,D 35392 Giessen,Germany~4Graduate School of the chinese academy of sciences,beijing 100039,china

A systematic overview on the characteristics of super heavy nuclei from Z=101 to Z=130 based on thedata by P.M(?)ller et *** *** nuclei which have the biggest mean binding energy in each of their isotopechain show systematic regular behavior,indicating that the mean binding energy is a good criterion to classify superheavy nuclei by their *** investigation on the nuclear data at and after Z=127 has been suggested.

关键词： superheavy nucles binding energy stability

Collective Forest Tenure Reform in Nature Reserves in china:Problems and Countermeasures

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chinese Forestry Science and Technology 2009年第2期8卷 12-18页

作者： CHEN Jie Research institute of Forestry Policy and Information,chinese academy of Forestry,beijing 100091,P.R.china

Collective forest tenure reform is now carried out throughout china with the aim to clarify the property,increase forest farmers' income and motivate the development of *** the collective forest tenure reform in nature reserves comes to a *** current implemented laws and regulations provide that forests and trees in nature reserves shall be under strict protection,while the forest farmers hope to improve their livelihood in the *** paper discussed the problems encountered in the c...

关键词： collective forest tenure reform nature reserve forest land eco-compensation community co-management

万事胚胎始于州县乎?——从命案之代验再论清代佐杂审理权限

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法制与社会发展 2011年第4期17卷 95-103页

作者：茆巍中国社会科学院法学研究所北京100720

清人谓"万事胚胎始于州县",今人亦多认为佐杂系闲曹,但事实并非如此。清代的佐杂逐渐获得命案的检验权,且配有仵作,其权限亦逐渐完整,从原来需印官覆验,发展到直接由佐杂在验后填格取结即可。命案在州县官的审理权中具有核心意义,检验... 详细信息

清人谓"万事胚胎始于州县",今人亦多认为佐杂系闲曹,但事实并非如此。清代的佐杂逐渐获得命案的检验权,且配有仵作,其权限亦逐渐完整,从原来需印官覆验,发展到直接由佐杂在验后填格取结即可。命案在州县官的审理权中具有核心意义,检验则在命案处理中又具有核心意义,佐杂在获得检验权的同时,亦获得了命案事实上的审理权,并由此必然获得其他案件的审理权。因此,必须承认佐杂在州县之下发挥着一级审判机关的作用,万事胚胎亦由他们始。

关键词：佐杂命案代验审判权限

Heat flow distribution in chinese continent and its adjacent areas

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Progress in Natural Science:Materials International 2008年第7期18卷 843-849页

作者： Wei Tao a,*, Zhengkang Shena,b a State Key Laboratory of Earthquake Dynamics, institute of Geology, china Earthquake Administration, beijing 100029, china b Department of Earth and Space sciences, University of California, Los Angeles, CA 90095-1567, USA State Key Laboratory of Earthquake Dynamics Institute of Geology China Earthquake Administration Beijing 100029 China Department of Earth and Space sciences University of California Los Angeles CA 90095-1567 USA

Using a compilation of 6980 heat flow measurements, we produce a new heat flow map for the chinese continent and its adjacent areas. We develop an objective and integrated method to interpolate the heat flow data, taking into account both the uniformity within geological units and coherency of regional heat flow. The geologic units are outlined based on Zhang et al.’s active tectonic block model. Our heat flow model is presented in two formats: a contour map and a heat flow dataset with values on a 1×1° grid for the chinese continent and its adjacent areas, reflecting detailed variations in some regions. Also provided is a resolution map which helps understand the reliability of the heat flow model. Our results reveal that (1) Heat flows in the eastern part of the chinese continent are relatively higher than those in the western part except that in the Tibetan Plateau area. (2) Heat flows in the Ordos and North china blocks are around 60 mW/m2, and are 50–55 mW/m2 in South china except for the continental marginal sea regions. (3) Heat flow is the lowest in the Junggar Basin, only 35–45 mW/m2, and is 45–55 mW/m2 in the Tarim Basin. The results of this study provide an important data- set for studies on thermal and rheological structures of the chinese continent and its adjacent areas.

关键词： Heat flow chinese continent and its adjacent areas Geological units Contour map Resolution map

Geochemical and isotopic characteristics of volcanic rocks from the northern East china Sea shelf margin and the Okinawa Trough

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Acta Oceanologica Sinica 2010年第4期29卷 48-61页

作者： ZENG Zhigang YU Shaoxiong WANG Xiaoyuan FU Yongtao YIN Xuebo ZHANG Guoliang WANG Xiaomei CHEN Shuai Seafloor Hydrothermal Activity Laboratory of the Key Laboratory of Marine Geology and Environment Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China Graduate School of chinese academy of sciences Beijing 100049 China

Volcanic rocks both from the northern East china Sea （NECS） shelf margin and the northern Okinawa Trough are subalkaline less aluminous,and lower in High Field Strength Elements （HFSE）.These rocks are higher in Large Ion Lithophile Elements （LILE）,thorium and uranium contents,positive lead anomalies,negative Nb-Ta anomalies,and enrichment in Light Rare Earth Elements （LREE）.Basalts from the NECS shelf margin are akin to Indian Ocean Mid-Ocean Ridge Basalt （MORB）,and rhyolites from the northern Okinawa Trough have the highest 207 Pb/ 204 Pb and 208 Pb/ 204 Pb *** NECS shelf margin basalts have lower 87 Sr/ 86 Sr ratios,ε N d and σ 18 O than the northern Okinawa Trough silicic *** to 40 K– 40 Ar isotopic ages of basalts from the NECS shelf margin,rifting of the Okinawa Trough may have been active since at least 3.65–3.86 *** origin of the NECS shelf margin basalt can be explained by the interaction of melt derived from Indian Ocean MORB-like mantle with enriched subcontinental *** basalts from both sides of the Okinawa Trough may have a similar origin during the initial rifting of the Okinawa Trough,and the formation of basaltic magmas closely relates to the thinning of continental *** source of the formation of the northern Okinawa Trough silicic rocks was different from that of the middle Okinawa Trough,which could have been generated by the interaction of basaltic melt with an enriched crustal *** the Ryukyu island arc to East china,the Cenozoic basalts have apparently increasing trends of MgO contents and ratios of LREE to Heavy Rare Earth Elements （HREE）,suggesting that the trace element variabilities of basalts may have been influenced by the subduction of the Philippine Sea plate,and that the effects of subduction of the Philippine Sea plate on the chemical composition of basaltic melts have had a decreasing effect from the Ryukyu island arc to East china.

关键词： volcanic rocks geochemical characteristics northern East china Sea shelf margin Okinawa Trough

GEOCHEMICAL EVIDENCE FOR TWO TYPES OF BASALT IN THE HONGLIUGOU OPHIOLITE MELANGE IN THE ALTYN FAULT BELT, china

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Scientia Geologica Sinica 2001年第2期 133-142页

作者： Wu Jun, Lan Chaoli, Li Jiliang, and Yu Liangjun Laboratory of Lithosphere Tectonic Evolution, institute of Geology and Geophysics, chinese academy of sciences, beijing, 100029 Wang Yitian institute of Geology, chinese academy of Geological sciences, Beij

This paper further provides geochemical evidence for the Hongliugou ophiolite melange. The two types of basalt (MORB and OIB) indicates that an ocean, perhaps a large one, once existed in this region during Early Paleozoic. Their coexistence is clearly the result of late tectonic migrations. Considering a similar assemblage of MORB and OIB in north Qilian Mountains, the strike-slip distance along the Altun fault belt will be estimated possibly.

关键词： OIB meta GEOCHEMICAL EVIDENCE FOR TWO TYPES OF BASALT IN THE HONGLIUGOU OPHIOLITE MELANGE IN THE ALTYN FAULT BELT china