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Effects of salvianolic acid B on proliferation, neurite outgrowth and differentiation of neural stem cells derived from the cerebral cortex of embryonic mice

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Science china(Life Sciences) 2010年第6期53卷 653-662页

作者： GUO GuoQing1,LI Bin1,WANG YuanYuan1,SHAN AiJing1,SHEN WeiZai1,YUAN Lin2 & ZHONG ShiZhen2 1Department of Anatomy,medical college of Jinan university,Guangzhou 510630,china 2institute of clinical Anatomy,Key Laboratory of Tissue Construction and Detection of Guangdong Province,Southern medical university,Guangzhou 510150,china 1. Department of Anatomy Medical College of Jinan University Guangzhou 510630 China2. Institute of Clinical Anatomy Key Laboratory of Tissue Construction and Detection of Guangdong Province Southern Medical University Guangzhou 510150 China

Salvianolic acid B is isolated from Salvia miltiorrhiza,the root of which is widely used as a traditional Chinese medicine to treat ***,little is known about how salvianolic acid B influences growth characteristics of neural stem cells (NSCs).The purpose of the present study was to evaluate the effects of salvianolic acid B on proliferation,neurite outgrowth and differentiation of NSCs derived from the cerebral cortex of embryonic mice using MTT,flow cytometry,immunofluorescence and *** was found that 20 μg mL·1 and 40 μg mL·1 salvianolic acid B had similar effects on proliferation of NSCs,and a suitable concentration of salvianolic acid B increased the number of NSCs and their derivative *** growth-promoting activity of salvianolic acid B was dependent on and associated with an accumulation in the G2/S-phase cell *** acid B also promoted the neurite outgrowth of NSCs and their differentiation into *** mRNA for tau,GFAP and nestin were present in differentiating neurospheres induced by salvianolic acid ***,high-level expression of tau mRNA and low-level expression of GFAP mRNA was detected in differentiated cells,in contrast to the control *** collective evidence indicates that exogenous salvianolic acid B is capable of promoting proliferation of neurospheres and differentiation towards the neuronal lineage in vitro and may act in the proliferation of NSCs and may promote NSC differentiation into neuronal cells.

关键词： salvianolic acid B proliferation differentiation neurite outgrowth neural stem cells cerebral cortex embryonic mouse

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An Energy Minimization Algorithm based on Synergy Choice for Resourceconstrained Wireless Senor Network

An Energy Minimization Algorithm based on Synergy Choice for...

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2009 ISECS International Colloquium on Computing, Communication, Control, and Management

作者： Long Cheng-zhi 1,2,Chen Hui3,Li Li-hong 4,Wu Wei-ling 2,Xiang Man-tian5 1 School of Information Engineering,nanchang university,nanchang,330031 china 2 School of Information Engineering,Beijing university of Posts and Telecommunications,Beijing,100876 china 3 School of Foreign Studies,nanchang university,nanchang,330031 china 4 Software college,nanchang university,nanchang,330031 china 5 School of Electronicsand Information,Northwestern Polytechnicaluniversity,Xian,710072 china

Cooperative diversity can be applied to energyconstrained resource-constrained wireless sensor network s to significantly reduce node energy ***,cooperation synergy must be carefully selected and coordinated to practically exploit this energy saving *** this paper we investigate synergy choice for energy minimization algorithm in a resource-constrained wireless sensor *** formulate novel and computationally efficient synergy choice heuristics for sensor nodes based on either global or local knowledge of average path loss values in the *** present extensive simulation results of cooperation in a resource-constrained wireless sensor network to show that the proposed heuristics achieve near-optimally energy efficient synergy ***,our simple synergy choice heuristics form the basis of an effective distributed cooperation protocol for improving the energy efficiency of a resource-constrained wireless sensor *** importantly from the point of view of practical implementation,we show that our synergy choice heuristic based on local information is the most effective cooperation strategy for resource-constrained resource-constrained wireless sensor networks,as it yields superior energy conservation results while enabling fully distributed and scalable cooperation.

关键词： cooperative diversity synergy choice energy efficiency resource-constrained wireless sensor networks

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Study on a new technique of casting—rolling strips for semi-solid magnesium alloys

Study on a new technique of casting—rolling strips for semi...

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第九届全国塑性工程学术年会、第二届全球华人先进塑性加工技术研讨会

作者： XIE Shui-sheng, GENG Mao-peng, ZHOU Xin-min, ZHANG Ying, ZHANG Song-yang, WANG Yan-chun, HUANG Guo-jie (State Key Laboratory for Fabrication & Processing of Non-ferrous Metals, General Research institute for Non-ferrous Metals, Beijing 100088,china Mechanical and Electronical college, nanchang university nanchang 330029, jiangxi, china china National Nonferrous Metals Industry Techno-economic institute, Beijing 100083, china)

It is studied that the conjugation of semi-solid process technique and casting-rolling technique applied to produce the magnesium strips in this paper. The purpose is to gain the high quality magnesium alloy strips with non-dendritic structure and to solve the processing problems of magnesium alloy strips to a certain *** study include that to set up a experimental device, to prepare the semi-solid slurry, to optimize the casting-rolling techniques of magnesium alloy, to study the influence on the structure by the casting-rolling techniques and to study on the processability of the casting-rolling strips with non-dendritic *** main parameter of the experimental device, the diameter of the roller is 210mm, its length is 280mm, both rollers are driven by magneto uniflow momental electric engine which is driven though BW12-11 type cycloid redactor, the velocity of the roller is 0-110 turn per minute, the cooling method of the roller is by pressure-air cooling, the roll gap is 0-20mm and adopt by manual *** semi-solid slurry has prepared continuously by the mechanical method and its temperature is controlled strictly at the same time. In order to insulate the magnesium fused mass and air, it must be considered that the design of airproof and adopt mulch and shielding gas (SF6) at the different ***91D casting magnesium alloys has been applied to the experiment. The casting-rolling strips with non-dendritic structure have obtained and its main mechanical property is better, such as its yield stress is 110MPa and its elongation is higher than 18%. It shows that the casting-rolling has a remarkable influence on its structure. The casting-rolling can make the structure with round and regular grain. The author thinks that the effects are by the friction of solid with fluid or solid with solid. The casting-rolling strip and its structure as follows ***, the casting-rolling strip has been tested by the cold rolling and hot rolling. It s

关键词： casting-rolling semi-solid magnesium alloy AZ91D

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论信息时代与教育的变革

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外国教育研究 2005年第11期32卷 10-14页

作者：李和平邱婷钟志贤江西师范大学传播学院江西南昌330027 江西师范大学课程与教学研究所江西南昌330027

文章在勾勒信息时代的主要特征基础上,从教育观念、学习方式和师生角色等几个角度,论述了信息时代引发的教育变革。同时指出,把握信息时代的特征,自觉地适应时代对教育变革的需求,是教育产生促进社会发展和人的发展功能作用的关键性前提。

关键词：信息时代教育观念学习方式师生角色变革

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Culture Teaching in English Language Classes

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时代教育 2007年第26期 64-66页

作者： Wu Qixuan1 Zhao Shuncai2(1 college of foreign languages,Hainan university,Danzhou 571737)(2 institute of Modern Physics,nanchang university,nanchang 330047)

Language is closely related to *** expresses and embodies cultural reality,in the meantime,culture exerts enor-mous influences on ***,language learning is often culture *** author,based on the negligence of culture teaching in English language classes,illustrates the influences of cultural knowledge on reading,translating and intercultural communicating,and propos-es suggestions on culture teaching in English language teaching (ELT).

关键词： Culture teaching Influences Suggestions

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Study on the Pharmacokinetics and Relative Bioavailability of Irbesartan Capsules in Healthy Volunteers

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Journal of Huazhong university of Science and Technology(medical Sciences) 2002年第1期22卷 14-16页

作者：顾世芬陈汇邱应海师少军曾繁典 institute of clinical pharmacology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 institute of Medicine of Zhuhai Mintong Zhuhai 519041

The pharmacokinetics and relative bioavailability were studied in 18 healthy volunteers. A single oral dose of 150 mg irbesartan capsule (test) or tablet (reference) was given to each volunteer according to a randomized 2 way crossover study. The concentrations in plasma were determined by HPLC UV method. The main parameters of irbesartan capsules were: C max : 1.502±0.295 μg/ml, t max : 1.44±0.34 h, t 1/2 : 20.21±14.71 h, AUC 0 t : 11.087±3.443 μg/ml -1 ·h. The relative bioavailability of capsule to tablet was (101.4±28.9) %. The results of statistical analysis showed that two formulations were bioequivalent.

关键词： irbesartan pharmacokinetics bioavailability HPLC

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γ-hydroxybutyrate protects the liver from warm ischemia-reperfusion injury in rat

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Hepatobiliary & Pancreatic Diseases International 2004年第2期3卷 245-249页

作者： Zheng- Zhuan Wei and Sui-Sheng Xia Wuhan, china institute of Organ Transplantation, Tongji Hospital, Tongji medical college, Huazhong university of Science and Technology, Wuhan 430030, china institute of Organ Transplantation Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China. weizhz@***

BACKGROUND: Ischemia-reperfusion (I/R) syndrome remains an important clinical consideration in hepatic sur- gery, hemorrhagic shock, and liver transplantation, -y-hy- droxybutyrate (GHB) has been reported to exert protective effects against ischemia-reperfusion injury to various or- gans. To investigate whether GHB protects the liver from warm ischemia-reperfusion injury, we performed this study in rats. METHODS: Thirty male Wistar rats were randomly divided into a sham-operation group, a control group, and three I/R groups pretreated with GHB, GHB plus naloxone or naloxone. After 30 minutes of partial ischemia, followed by 60 minutes of reperfusion in the liver, histomorphological and enzymological changes, lipid peroxidation, apoptosis, and the plasma level of endothelin-1 were observed. RESULTS: I/R increased the serum levels of alanine ami- notransferase, aspartate aminotransferase and lactate dehy- drogenase and the plasma level of endothelin-1 significantly (P<0.01), in addition to increase of apoptotic index (AI) from 0.28%±0.25% to 17.68%±1.91%. The levels of he- patic malondialdehyde were markedly increased, whereas the activities of superoxide dismutase were markedly de- creased. GHB pretreatment prevented the liver from warm ischemia-reperfusion injury significantly, but naloxone par- tially blocked this effect. CONCLUSION: GHB may significantly protect the liver from hepatic warm ischemia-reperfusion injury via several different mechanisms.

关键词： γ-hydroxybutyrate liver ischemia-reperfusion injury apoptosis

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Activation of ERK/CREB pathway in spinal cord contributes to chronic constrictive injury-induced neuropathic pain in rats

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Acta Pharmacologica Sinica 2005年第7期26卷 789-798页

作者： Xue-song SONG~2 Jun-li CAO~(3,4,5) Yan-bing XU~3 Jian-hua HE~3 Li-cai ZHANG~3 Yin-ming ZENG~(3,4)2 Department of Anesthesiology,First clinical college of N.Bethune Centre of Health Sciences,Jilin university,Changchun 130021,china 3 Department of Anesthesiology,Affiliated Hospital of Xuzhou medical college,Xuzhou 221002,china 4 Jiangsu institute of Anesthesiology,Xuzhou 221002,china DepartmentofAnesthesiology FirstClinicalCollegeofN.BethuneCentreofHealthSciencesJilinUniversityChangchun130021China

Aim:To investigate whether activation and translocation of extracellular signal-regulated kinase(ERK)is involved in the induction and maintenance of neuro-pathic pain,and effects of activation and translocation of ERK on expression ofpCREB and Fos in the chronic neuropathic ***:Lumbar intrathecalcatheters were chronically implanted in male Sprague-Dawley *** left sciaticnerve was loosely ligated proximal to the sciatica's trifurcation at approximately 1.0mm intervals with 4-0 silk *** mitogen-activated protein kinase kinase(MEK)inhibitor U0126 or phosphorothioate-modified antisense oligonucleotides(ODN)were intrathecally administered every 12 h,1 d pre-chronic constrictioninjury(CCI)and 3 d *** and mechanical nociceptive thresholdswere assessed with the paw withdrawal latency(PWL)to radiant heat and vonFrey *** expression of pERK,pCREB,and Fos were assessed by bothWestern blotting and immunohistochemical ***:Intrathecal injec-tion of U0126 or ERK antisense ODN significantly attenuated CCI-induced me-chanical allodynia and thermal *** significantly increased the ex-pression of p-ERK-IR neurons in the ipsilateral spinal dorsal horn to injury,not inthe contralateral spinal dorsal *** time courses of pERK expression showedthat the levels of both cytosol and nuclear pERK,but not total ERK,were in-creased at all points after CCI and reached a peak level on postoperative d *** significantly increased the expression of pCREB and ***-CREB-positive neurons were distributed in all laminae of the bilateral spinal cord and Foswas expressed in laminae I and II of the ipsilateral spinal dorsal *** of U0126 or ERK antisense ODN markedly suppressed the increase ofCCI-induced pERK,pCREB and c-Fos expression in the spinal ***:The activation of ERK pathways contributes to neuropathic pain in CCI rats,andthe function of pERK may partly be accomplished via the cAMP

关键词： extracellular signal-regulated kinases cyclic AMP-response DNA-binding protein pain hyperalgesia spinal cord

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Fluorescence spectra of human arteries usingXe－lamp as an excitation light source

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吉林大学学报(医学版) 1995年第2期 150-151页

作者： Lu Erbin,Gu Chunming ,Wang Lingyan,Ma Junzhi(The Third clinical college of Norman university of medical Sciences, Changchun institute of Optics and Fine Mechanics)

ＦｌｕｏｒｅｓｃｅｎｃｅｓｐｅｃｔｒａｏｆｈｕｍａｎａｒｔｅｒｉｅｓｕｓｉｎｇＸｅ－ｌａｍｐａｓａｎｅｘｃｉｔａｔｉｏｎｌｉｇｈｔｓｏｕｒｃｅＬｕＥｒｂｉｎ，ＧｕＣｈｕｎｍｉｎｇ，ＷａｎｇＬｉｎｇｙａｎ，ＭａＪｕｎｚ... 详细信息

ＦｌｕｏｒｅｓｃｅｎｃｅｓｐｅｃｔｒａｏｆｈｕｍａｎａｒｔｅｒｉｅｓｕｓｉｎｇＸｅ－ｌａｍｐａｓａｎｅｘｃｉｔａｔｉｏｎｌｉｇｈｔｓｏｕｒｃｅＬｕＥｒｂｉｎ，ＧｕＣｈｕｎｍｉｎｇ，ＷａｎｇＬｉｎｇｙａｎ，ＭａＪｕｎｚｈｉ（ＴｈｅＴｈｉｒｄＣｌｉｎｉｃ...

关键词： arteries human excitation as lamp light of source spectra usingXe

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红壤坡地果园不同耕作措施的水土保持效应研究

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水土保持学报 2004年第3期18卷 12-15页

作者：左长清马良江西省水土保持科学研究所南昌330029 江西农业大学国土资源与环境学院南昌330045

针对南方广大红壤坡地果园因耕作不当而导致的水土流失,开展了系列研究。通过翔实的观测数据认真分析了不同耕作措施差异,找出了多种措施的优劣,分别是横坡耕作、顺坡耕作、果园清耕和裸露对照,得出了增加植被、改进耕作有明显的保持水... 详细信息

针对南方广大红壤坡地果园因耕作不当而导致的水土流失,开展了系列研究。通过翔实的观测数据认真分析了不同耕作措施差异,找出了多种措施的优劣,分别是横坡耕作、顺坡耕作、果园清耕和裸露对照,得出了增加植被、改进耕作有明显的保持水土作用,单纯的耕作措施仍不能杜绝水土流失,欲要从根本上控制,还应与其他措施配合的结论。

关键词：红壤坡地果园耕作措施水土保持效应

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