检索结果-南通市图书馆

IL-6 Family of Cytokines Mediates Isoproterenolinduced Delayed STAT3 Activation in Mouse Heart

在线全文

学校读者我要写书评

暂无评论

IL-6 Family of Cytokines Mediates Isoproterenolinduced Delay...

2002全国青年药理学英文学术会议

作者： YIN Feng, ZHANG You-yi, HAN Qi-de(institute of Vascular Medicine, peking university Third Hospital,peking university institute of cardiovascular science, 100083 beijing)

AIM: To elucidate the molecular mechanism of Isoproterenol-induced hypertrophic response, we examined the role of Isoproterenol in activation of Signal Transducers and Activators of Transcription (STAT) in mouse heart. METHODS: Male, 8-week-old Balb/c mice were treated with Isoproterenol (15 mg/kg body weight) or vehicle by intraperitoneal injection. Mice were killed at various time points, and extracts from left ventricles were used to detect tyrosine phosphorylation of STAT3 by Western Blot analysis. RT-PCR analysis was performed to determine the expression of IL-6 family cytokines mRNA in

关键词： Isoproterenol signal transducers and activators of transcription Interleukin-6 Myocardium

Coherent coupling of vibrational states in the MEH-PPV film investigated through Multi-Color Photon Echo

在线全文

cnki会议

学校读者我要写书评

暂无评论

science china(Physics,Mechanics & Astronomy) 2010年第6期53卷 1020-1023页

作者： YU GuoYang 1 ,SONG YunFei 1 ,WANG YingHui 1 ,LIU YuQiang 1 ,MO YueQi 2 & YANG YanQiang 1 1 center for Condensed Matter science and Technology,Department of Physics,Harbin institute of Technology,Harbin 150001,china 2 College of Materials science and Engineering,South china university of Technology,Guangzhou 51064.,china center for Condensed Matter science and Technology Department of Physics Harbin Institute of Technology Harbin China College of Materials science and Engineering South China University of Technology Guangzhou China

The poly-[2-methoxy,(5-2′-ethyl-hexyloxy)-p-phenylene vinylene](MEH-PPV) film is investigated by means of the Multi-Color Photon Echo(MCPE) technique. Under the three-order nonlinear response theory,the reason for the occurrence of the quantum beats in the time domain and the relations among signal wavevector,pulse sequence and response function are discussed. The analysis of the Raman spectrum of MEH-PPV and the fast Fourier transformation(FFT) results of photon echo(PE) signal dynamics demonstrate the coherent coupling between the C==C bonds and the CC-H bonds and the coherent coupling between the C-C stretching of the phenyl group and the C==C stretching of the vinylene group.

关键词： MCPE quantum beats coherent coupling

在线全文

学校读者我要写书评

暂无评论

四川晚二叠世生物礁层序地层岩相古地理编图

石油学报 2004年第2期25卷 47-50页

作者：徐强刘宝珺何汉漪朱同兴北京大学地球与空间科学学院成都地质矿产研究所四川成都610082 中国海洋石油研究中心北京100027 成都地质矿产研究所中国海洋石油研究中心

为了探索层序地层岩相古地理编图方法 ,对四川盆地晚二叠世生物礁层序地层岩相古地理进行了编图试验 ,以四川盆地晚二叠世生物礁各层序地层的海退低点及海侵高点作为相对等时面编制了 8幅层序地层岩相古地理图。层序地层岩相古地理图不... 详细信息

为了探索层序地层岩相古地理编图方法 ,对四川盆地晚二叠世生物礁层序地层岩相古地理进行了编图试验 ,以四川盆地晚二叠世生物礁各层序地层的海退低点及海侵高点作为相对等时面编制了 8幅层序地层岩相古地理图。层序地层岩相古地理图不仅能极大地减少由传统的压缩法和优势相编图法所造成的模糊失真现象。

关键词：四川盆地晚二叠世生物礁编图层序地层岩相古地理

Resibufogenin induces apoptosis and the G2/M cell cycle arrest of human HeLa cells

在线全文

学校读者我要写书评

暂无评论

Resibufogenin induces apoptosis and the G2/M cell cycle arre...

遗传学进步与人口健康高峰论坛

作者： Junzheng Yang~1 Baiyan Wu~1 Yixiu Xiao~2 Hongye Liang~1 Chuanshe Wang~3 Haihao Zhu~4.Dean Guo~3 (1.Department of Medical Genetics,peking university health science {4. beijing 100083,china 2.School of Public health and Family Medicine, Capital Medical university.beijing I00083 P.R.china 3.The State Key Laboratory of Natural and Biomimetic Drugs,peking university beijing 100083,china 4.Neuroscience Research institute,peking university,beijing 100083,china)

Resibufogenin,one of the components of bufadienolides in the traditional Chinese medicine,chan’su,was reported to exert cytotoxic activity on PLC/PRF5 cells and growth-inhibitory activities on 1L-6-dependent MH-60 cells,but the underlying mechanism remains largely *** investigated the changes of HeLa cells treated with different concentrations and different time courses of resibufogenin,by employing MTT assay,electron microscopy,DNA fragmentation analysis,flow

关键词：

瑞舒伐他汀治疗中国高胆固醇血症患者疗效和安全性的随机双盲多中心对照研究

在线全文

cnki会议

学校读者我要写书评

暂无评论

中华心血管病杂志 2007年第3期35卷 207-211页

作者： Rosuvastatin Registration Clinical Trial Group.cardiovascular institute and Fu Wai Hospital,peking Union Medical College and Chinese Academy of Medical science,{4. 100037,china 瑞舒伐他汀中国注册临床研究协作组

目的评价瑞舒伐他汀治疗中国高胆固醇血症患者的疗效和安全性。方法采用随机、双盲、多中心研究。患者经6周筛选后符合 LDL-C≥4.14.mmol/L(160 mg/dl),<6.50 mmol/L(250 mg/dl)、TG<4.52 mmol/L(4.0 mg/dl)者以2:1随机接受瑞舒伐他汀10... 详细信息

目的评价瑞舒伐他汀治疗中国高胆固醇血症患者的疗效和安全性。方法采用随机、双盲、多中心研究。患者经6周筛选后符合 LDL-C≥4.14.mmol/L(160 mg/dl),4.52 mmol/L(4.0 mg/dl)者以2:1随机接受瑞舒伐他汀10 mg/d 或阿托伐他汀10mg/d 治疗。12周后瑞舒伐他汀组 LDL-C 未达到 ATPⅢ治疗目标者,予瑞舒伐他汀20 mg 延续治疗8周。结果 304.进入随机治疗阶段,瑞舒伐他汀10 mg/d 组201例,阿托伐他汀10 mg/d 组103例。意向治疗人群290例,符合方案人群263例。瑞舒伐他汀组治疗12周后血 LDL-C 显著下降,下降幅度为4..6%,显著大于阿托伐他汀组的39.0%(P35.0%),但差异未达到统计学意义。瑞舒伐他汀降低 TG(-22.8%)以及升高 HDL-C(+6.6%)和ApoA-1(+12.5%)的幅度与阿托伐他汀组差别无统计学意义(分别为-16.6%,+4.3%和+9.8%)。29例患者接受20 mg/d 瑞舒伐他汀延续治疗,22例完成治疗患者中10例(4..5%)LDL-C达标。研究中未发现药物相关的严重不良反应事件。结论本组研究显示瑞舒伐他汀10 mg 降低LDL-C 的疗效优于同等剂量的阿托伐他汀,治疗3个月安全性与之类似。

关键词：高胆固醇血症降血脂药治疗结果

High-density lipoprotein nitration and chlorination catalyzed by myeloperoxidase impairs its effects in promoting endothelial repair

在线全文

学校读者我要写书评

暂无评论

中国病理生理杂志 2012年第11期 2053-2053页

作者： PAN Bing,YU Bao-qi,ZHENG Le-min(The institute of cardiovascular sciences and Key Laboratory of Molecular cardiovascular sciences,Ministry of Education,School of Basic Medical sciences,peking university health science center,beijing 100191,china)

High-density lipoprotein(HDL)plays a key role in protecting against *** cardiovascular disease,HDL can be nitrated and chlorinated by myeloperoxidase(MPO).In the current study,we discovered that MPO oxidized HDL is dy... 详细信息

关键词： HDL High-density lipoprotein nitration and chlorination catalyzed by myeloperoxidase impairs its effects in promoting endothelial repair

Characterization of the oligomerization of influenza A virus Ml protein

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Characterization of the oligomerization of influenza A virus...

第十七届国际生物物理大会;第十二届中国生物物理大会

作者： Ke Zhang~(1,4..Zhao Wang~2,Xiaoling Liu~1,Changcheng Yin~2,Bin Xia~3,Wenjun Liu~1 1.center for Molecular Virology,CAS Key Laboratory of Pathogenic Microbiology and Immunology,institute of Microbiology,Chinese Academy of sciences,beijing 100101,{4. 2.Department of Biophysics,health science center,peking university,beijing 100191,{4. 3.beijing Nuclear Magnetic Resonance center,peking university,beijing 100871,{4. 4.Graduate university of Chinese Academy of sciences,beijing 100101,{4.

Influenza A virus matrix 1 protein(Ml) is a multifunctional protein and it plays an important role in virus life ***,structural and functional studies suggest that self-association of M1 is essential for assembly and ... 详细信息

关键词： Ml oligomerization

The synthesis and crystal structure of heteronuclear complex of lanthanide with sulfo-salicylic acid [Na3YLa2(C7H3SO6)4.26H2O]n

在线全文

cnki会议

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 1995年第2期13卷 150-155页

作者： SUN, Hong-Ye HUANG, Chun-Hui GAN, Liang-Bing XU, Guang-XianState Key Laboratory of Rare Earth Material Chemistry and Applications, peking university, beijing 100871, chinaMA, Zhe-Sheng SHI, Ni-Cheng china university of Geoscience, beijing 100083,china State Key Laboratory of Rare Earth Material Chemistry and Applications Peking University Beijing 100871 China china university of Geoscience Beijing 100083 China

The titled complex has been synthesized by the reaction of sodium sulfo-salicylate with lanthanum and yttrium perchlorate. The crystal structure has been determined by single crystal X-ray diffractometry. The crystal is monoclinic with space group C2/c. The unit cell parameters are as follows: a=16.289(8), b=18.323(8), c=22.04.(8) A, β=106.34.2)°, V=6314.6) A3, Z=4.and Dc=1.764.g/cm3. The structure was solved by direct method. The least-square refinement based on 3776 observed reflections [F > 6σ(F)] converged to a final R=8.6% and F(000) is 354.. Yttrium ion with eight-coordinate is located in central of the molecule, the two lanthanum ions with ten-coordinate are located at the two sides of yttrium ion. There are two positions for Na in the molecule, one is in the C2 axis with six coordinate, the other one is in a general position with five-coordinate.

关键词： Crystal structure heteronucleax complex lanthanide elements sulfo-salicylic acid.

PI3K-like kinases restrain Pim gene expressions in endothelial cells

在线全文

学校读者我要写书评

暂无评论

PI3K-like kinases restrain Pim gene expressions in endotheli...

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Xin-Wen MUST~1,Yin-Fang WANG~2,Jie TANG~3,Ming-Hua YU~3,Han-Qin WANG~3,Li-Bing ZHAO~1,Nan-Ping WANG~4.Han-Dong YANG~1,Peng ZHANG~(1,2,*) 1 institute of cardiovascular science,DongFeng Hospital 2 Department of Physiology 3 Department of Anatomy,Hubei Medical College,Shiyan 4.2000,china 4.institute of cardiovascular science,peking university,beijing 100871,china

＜正＞Pim kinases contribute to the tumor formation and development of lymphoma which showed enhanced DNA replication,recombination and *** cells（ECs） express all the three members of Pim kinase gene *** hypothesized that DNA repair gene would regulate Pim expressions in *** data showed that LY294.02 and wortmannin,phosphatidylinositol 3-kinase（PI3K） and PI3K-like kinases inhibitors,increased Pim mRNA expressions in ECs without altering the mRNA *** interference（RNAi） targeting DNA-PKcs and ATM increased Pim-3 and Pim-1 mRNA expressions *** of Akt decreased Pim-1 instead of Pim- 2 and Pim-3 gene expression in *** etoposide,a nucleoside analogue,which can activate DNA-PKcs and ATM,can increase instead of decrease Pim expressions in *** study indicates that Pim kinases expressions are physiologically related to DNA-PKcs and ATM and diversely regulated by cell cycle and genotoxic insults in ECs.

关键词： endothelial cell Pim PI3K DNA-PKcs ATM