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A NOVEL SECOND-ORDER TRANSITION IN ORGANIC HYBRIDS CONSISTING OF POLYMERS AND SMALL MOLECULES

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Chinese Journal of Polymer Science 2001年第5期19卷 455-466页

作者： Chi-fei Wu department of Chemistry and Chemical Engineering Kanazawa university 2-40-20 Kodatsuno Kanazawa, Ishikawa 920-8667 japan Kanazawa Univ Dept Chem & Chem Engn Kanazawa Ishikawa 9208667 Japan

A novel transition appeared above thc glass transition temperature of chlorinated polyethylene (CPE) for binaryblends of CPE and additives such as organic small molecules or oligomers. This transition was assigned to the dissociation ofintermolecular hydrogen bonds between the polymer ard additive within the edditive rich phase. Of particular interest is thata novel pyramid crystal was observed in the annealed CPE/hindered phenol blends. Another intriguing observation is thatthese polymer/small molecule blends organized by intermolecular hydrogen bonding have several potential properties, suchas shape-memorization, self-restoration, self-adhesiveness and super damping.

关键词： Organic hybrid Second-order transition Shape memory effect Damping Self restoration

Wave reflection, transmission and harmonics due to different submerged structures

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Acta Oceanologica Sinica 2000年第2期19卷 111-125页

作者： Gao Xueping1 Inouchi Kunimitsu2 Kakinuma Tadao3 (1. Hydraulics Institute, Faculty of Civil Engineering, Tianjin university, Tianjin 300072, China 2. Center for Cooperative Research and Development, Ehime university, 3 Bunkyo-cho, Matsuyama 790 - 8577, japan 3. Nagasaki Comprehensive university, Aba-cho 536, Nagasaki 851 - 0193, japan) Hydraulics Institute Faculty of Civil Engineering Tianjin University Tianjin 300072 China

Comparisons of wave reflection, transmission and harmonics due to different types of sub merged structures are investigated by a numerical method, the boundary-fitted coordinate (BFC) method. The types of submerged structures include a submerged horizontal plate, submerged breakwa ters (rectangular and trapezoidal) and a step-type structure (topography). First, the BFC method is ver ified by comparing the computed results with the experimental data, including wave surface elevations, reflected and transmitted wave heights, and amplitudes of higher harmonics, showing that the method is a reasonable one to predict wave deformations due to the submerged structures. Secondly, the wave sur face elevations and the higher harmonics over different submerged structures are compared. Thirdly, re flected and transmitted waves due to different submerged structures are investigated.

关键词： Harmonic wave reflected wave transmitted wave submerged structure boundary-fitted coordinate method

Effects of astragaloside IV on pathogenesis of metabolic syndrome in vitro

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Acta Pharmacologica Sinica 2006年第2期27卷 229-236页

作者： Ming-en XU~(2,3,4) Shang-zhi XIAO~3 Yong-hong SUN~3 Yang OU-YANG~3 Xiao-xiang ZHENG~(3,4) ~2department of Biomedical Engineering,Hangzhou Dianzi university.Hangzhou 310018 ~3department of Biomedical Engineering.Zhejiang university.Hangzhou 310027.China department of Biomedical Engineering Hangzhou Dianzi UniversityHangzhou 310018 China. xumingen@***

Aim:To investigate the diverse pharmacological actions of astragaloside IV fromthe perspective of metabolic syndrome,and to investigate the effect of the drugon the pathogenesis of metabolic ***:Adipogenesis was usedas an indicator of the effect of astragaloside Ⅳ on preadipocyte differentiation,and was measured by using an oil red O *** uptake was determined bymeasuring the transport of [2-3H]-deoxyglucose into the *** concentrationsof peroxisome proliferator-activated receptor-γ（PPARγ）and aP2 mRNA were de-termined by using reverse transcription-polymerase chain *** viability loss of endothelial cells were detected by using flow cytometry andthe WST-1 assay,*** free Ca2+was labeled with Fluo-3 AMand measured by using a laser scanning confocal ***:Astragaloside Ⅳ can significantly potentiate insulin-induced preadipocyte differ-entiation at concentrations of 3,10,and 30 μg/mL,improve high glucose-inducedinsulin resistance in adipocytes at a concentration of 30 μg/mL,and prevent tumornecrosis factor（TNF）-α-induced apoptosis and viability loss at concentrations of10 and 30 μg/mL,and 30 μg/mL,respectively,in endothelial ***,wefound that these effects were partly due to the promotion of PPARγ expressionand to the inhibition of abnormal TNF-α-induced intracellular free Ca2+accumula-tion in endothelial ***:The diverse pharmacological actions ofastragaloside 1V can all be linked to metabolic syndrome *** studyprovides a new insight into the mechanism by which astragaloside Ⅳ exerts itseffect.

关键词： astragaloside Ⅳ metabolic syndrome X insulin resistance peroxisome proliferatoractivated receptors apoptosis calcium

Effect of transforming growth factor-beta on activity of connective tissue growth factor gene promoter in mouse NIH/3T3 fibroblasts

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Acta Pharmacologica Sinica 2004年第4期25卷 87-91页

作者： Qing ZHAO, Nan CHEN2, Wei-ming WANG, Jian LU3,Bing-bing DAI3 department of Nephrology, Ruijin Hospital 3department of Biochemistry, Shanghai Second Medical university, Shanghai 200025, China department of Nephrology Ruijin Hospital

AIM: To investigate the regulatory mechanism of transforming growth factor-betaon activity of connective tissue growth factor promoter in mouse NIH/3T3 fibroblasts. METHODS: The regulation fragment of the 5' flanking region of the human CTGF gene was linked to pGL3-Basic vector, a firefly luciferase reporter construct without promoter. The recombinant plasmid pCTGF-luc was transiently transfected to NIH/3T3 fibroblasts. The activity of CTGF promoter after treatment of TGF-β1 and MAPK pathway inhibitors were assayed with luciferase reporter gene assay system. RESULTS: TGF-β1-induced increase of CTGF promoter activity was concentration-dependent, with a plateau at 5 μg/L by 2.67-fold vs control (P3580 (10 μmol/L), the p38 MAP kinaseinhibitor, decreased basal and TGF-β1-induced activation of CTGF promoter. However, inhibition of c-Jun-N-terminal kinase/stress-activated protein kinase by SP600125 (20 μmol/L) was without effect. CONCLUSION: TGF-β1stimulated the transcriptional activity of CTGF gene promoter in NIH/3T3 fibroblasts in a dose- and time-dependent manner. MAPK pathway may play a role in the regulation of TGF-β1-induced CTGF expression.

关键词： transforming growth factor-beta connective tissue growth factor promoter mitogen-activated protein kinases signal transduction

A local spin evaluation into the active site models of [2Fe2S] ferrodoxin [Fe_2S_2(SR)_4]^(2-) (R=-H, -CH_3)

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Science China Chemistry 2007年第3期50卷 327-334页

作者： WEI JiChong1,2, WANG Yan3 & JU GuanZhi2,3 1 department of Chemistry, Hainan Normal university, Haikou 571158, China 2 State Key Laboratory of Theoretical and Computational Chemistry, Jilin university, Changchun 130023, China 3 department of Chemistry, Nanjing university, Nanjing 210093, China 1. department of Chemistry Hainan Normal University Haikou 571158 China 2. State Key Laboratory of Theoretical and Computational Chemistry Jilin University Changchun 130023 China 3. department of Chemistry Nanjing University Nanjing 210093 China

To test the feasibility of local spin theory of Davidson and Clark for ferrodoxin clusters, the models [Fe2S2(SR)4]2- (R=-H, -CH3) are chosen for evaluation. This purpose is realized by calculating the local spin expectation values , , and mA and discussing the connection between these expected values and the Heisenberg spin model (HSM) and the Noodleman broken-symmetry approach. In practical calculation, the spin-unrestricted Hartree-Fock (UHF) and spin-polarized density functional theory (DFT) are used and the calculational qualities of these two methods are also discussed. In addition, the theoretical magnetic coupling constants JAB of these models are calculated by various computational schemes for comparison with both theoretical and experimental results previously reported.

关键词： local spin iron-sulfur protein model density function theory magnetic coupling constant

Global existence and blow-up of solutions to a parabolic system with nonlocal sources and boundaries

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Science China Mathematics 2007年第9期50卷 1251-1266页

作者： Ling-hua KONG~(1+) Ming-xin WANG~(2,3) 1 department of Applied Mathematics,Dalian university of Technology,Dalian 116024,China 2 department of Mathematics,Southeast university,Nanjing 210018,China 3 department of Mathematics,Xuzhou Normal university,Xuzhou 221116,China 1. department of Applied Mathematics Dalian University of Technology Dalian 116024 China 2. department of Mathematics Southeast University Nanjing 210018 China 3. department of Mathematics Xuzhou Normal University Xuzhou 221116 China

This paper deals with a semi-linear parabolic system with nonlinear nonlocal sources and nonlocal boundaries. By using super-and sub-solution techniques, we first give the sufficient conditions that the classical solution exists globally and blows up in a finite time respectively, and then give the necessary and sufficient conditions that two components u and ν blow up simultaneously. Finally, the uniform blow-up profiles in the interior are presented.

关键词： parabolic system nonlocal sources nonlocal boundary conditions blow-up set simultaneous blow-up uniform blow-up profile 35K15 35K65

Circadian expression of clock genes and angiotensin Ⅱ type 1 receptors in suprachiasmatic nuclei of sinoaortic-denervated rats

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Acta Pharmacologica Sinica 2007年第4期28卷 484-492页

作者： Hui LI~2,Nmg-ling SUN~(2,4),Jin WANG~3,Ai-jun LIU~3,Ding-feng SU~(3,4)~2department of Cardiology,Peking university People's Hospital,Beijing 100044,China ~3department of Pharmacology,Second MilitaryMedical university,Shanghai 200433,China department of Cardiology Peking University People's Hospital Beijing China department of Pharmacology Second Military Medical University Shanghai China

Aim:To investigate whether the circadian expression of central clock genes andangiotensin Ⅱ type 1 (AT1) receptors was altered in sinoaortic-denervated (SAD)***:Male Sprague-Dawley rats underwent sinoaortic denervation or asham operation at the age of 12 *** weeks after the operation,bloodpressure and heart period were measured in the conscious state in a group ofsham-operated (n=10) and SAD rats (n=9).Rest SAD and sham-operated ratswere divided into 6 groups (n=6 in each group).The suprachiasmatic nuclei (SCN)tissues were taken every 4 h throughout the day from each group for the determi-nation of the mRNA expression of clock genes (Per2 and Bmal1) and the AT1receptor by RT-PCR;the protein expression of Per2 and Bmal1 was determined byWestern ***:Blood pressure levels in the SAD rats were similar tothose of the sham-operated ***,blood pressure variabilities signifi-cantly increased in the SAD rats compared with the sham-operated *** variation of clock genes in the SCN of the sham-operated rats was char-acterized by a marked increase in the mRNA and protein expression during ***2 and Bmal1 mRNA levels were significantly lower in the SAD rats,especially during dark *** blot analysis confirmed an attenuation ofthe circadian rhythm of the 2 clock proteins in the SCN of the SAD ***1receptor mRNA expressions in the SCN were abnormally upregulated in the lightphase,changed to a 12-h cycle in the SAD ***:The circadian varia-tion of the 2 central clock genes was attenuated in the SAD *** baroreflexdysfunction also induced a disturbance in the expression of AT1 receptors in theSCN.

关键词： circadian rhythm arterial baroreflex clock genes sinoaortic denervation reninangiotensin system

ω-Gorenstein injective modules and dimensions

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Science China Mathematics 2011年第3期54卷 421-436页

作者： ZHU HaiYan1,2 & DING NanQing3 1department of Mathematics, Zhejiang university, Zhejiang 310027, China 2department of Mathematics, Zhejiang university of Technology, Zhejiang 310023, China 3department of Mathematics, Nanjing university, Nanjing 210093, China 1. department of Mathematics Zhejiang University Zhejiang 310027 China2. Department of Mathematics Zhejiang University of Technology Zhejiang 310023 China3. Department of Mathematics Nanjing University Nanjing 210093 China

Gorenstein injective modules and dimensions have been studied extensively by many authors. In this paper, we investigate Gorenstein injective modules and dimensions relative to a Wakamatsu tilting module.

关键词： Wakamatsu tilting module ω-Gorenstein injective module ω-Gorenstein injective dimension cotilting module

The maximal super-singular integral operators on product spaces

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Science China Mathematics 2011年第12期54卷 2615-2626页

作者： WANG Hui1 & CHEN JieCheng2,3, 1department of Mathematics, Xidian university, Xi’an 710071, China 2department of Mathematics, Zhejiang Normal university, Jinhua 321004, China 3department of Mathematics, Zhejiang university, Hangzhou 310027, China 1. department of Mathematics Xidian University Xi’an 710071 China2. Department of Mathematics Zhejiang Normal University Jinhua 321004 China3. Department of Mathematics Zhejiang University Hangzhou 310027 China

We study the maximal super-singular integral operator T＊Ω,α,β（f）（x,y）=sup ∈1〉0,∈2〉0｜∫｜u｜〉ε1,｜v｜〉ε2 b1（｜u｜）b2（｜u｜）Ω（u＇,u＇）/｜u｜^n＋α｜u｜^m＋β-f（x-u,y-u）dudu｜defined on all f ∈ S（R^n ×R^m）, where 0 ≤ α,β〈∞, b1 b2 ∈ L∞（R＋1 ）,Ω satisfies certain cancellation conditions and Ω∈L1（S^n-1×S^m-1）in the case α,β〉0;Ω∈L（log＋L）（S^n-1×S^m-1）in the case αβ=0 and α＋β 〉0. It is proved that, for 1〈p〈∞.T＊Ω,α,βis a bounded operator from the homogeneous Sobolev space Lα,β^p（R^n×R^m）to the Lebesgue space L^p（R^n×R^m）.

关键词： super-singular integral maximal operator product spaces