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DIAGNOSTIC VALUE OF MINIPROBE ULTRASONOGRAPHY IN ESOPHAGEAL PROTRUDING LESIONS

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Journal of shanghai second medical university(Foreign Language Edition) 2007年第2期19卷 141-146页

作者：应涛胡兵冯亮 department of Ultrasound in medicine the Sixth People's Hospital Shanghai Jiaotong University

Objective To investigate the diagnostic value of miniprobe ultrasonography (MPS) in the protruding lesions of esophagus. Methods Sixty-two patients with protruding lesions of esophagus were examined with MPS. Results The MPS examination showed diseases of esophageal polyp, inflammatory protruding, esophageal leiomyoma, esophageal leiomyosarcoma, esophageal venous aneurysm, esophageal lipoma, esophageal cyst, esophageal carcinoma, and extra esophageal compression including aorta compression, lung tumor compression and spina compression. Fourteen patients were verified by surgical operations and pathological examinations, resulting in 92.86% (13/14) diagnosis accuracy rate. Forty-eight cases had results of gastroscope examination consistent with that of MPS. Twelve cases had results of CT and MRI examination consistent with that of MPS. Follow-up was completed on 22 patients. Conclusion Besides imaging the esophageal layer, MPS can precisely locate the histological layer of the esophageal protruding lesions and predict their characters. This indicates its value in the diagnosis and differential diagnosis of the protruding lesions of esophagus. Furthermore, the miniature probe used in MPS examination can pass the structured esophagus, enabling wider application of the examination.

关键词： miniprobe ultrasonography esophagus protruding lesion diagnosis

垂直加压充填和侧方加压充填对根管壁应力影响的分析

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上海口腔医学 2003年第5期12卷 359-361页

作者：洪瑾夏文薇熊焕国上海第二医科大学附属第九人民医院口腔医学院口腔内科上海200011 上海第二工业大学机械工程系上海200040

目的分析垂直加压充填和侧向加压充填对根管壁应力的影响。方法在模拟逐步后退法修改下颌第一磨牙有限元模型的基础上,选取近中颊侧根管为研究对象,模拟侧压充填和垂直充填法的过程,通过特定有限元分析软件,计算不同加压方法产生的管壁... 详细信息

目的分析垂直加压充填和侧向加压充填对根管壁应力的影响。方法在模拟逐步后退法修改下颌第一磨牙有限元模型的基础上,选取近中颊侧根管为研究对象,模拟侧压充填和垂直充填法的过程,通过特定有限元分析软件,计算不同加压方法产生的管壁最大能量应力及最大应力的位置。结果同样的加压条件下,垂直加压产生的管壁应力大于侧方加压产生的管壁应力,垂直加压的最大应力位于受压面,侧方加压的最大应力位于根上1/3和根中1/3的受压侧。受压位置越低,管壁应力越大。结论侧压充填并不直接造成牙根纵裂。反之,无论何种充填方法,压力过大或操作不当都有造成牙根纵裂的危险。

关键词：垂直加压侧方加压根管壁三维有限元应力分析

口腔癌组织基因表达谱的cDNA微阵列检测结果分析

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上海口腔医学 2003年第5期12卷 344-348页

作者：陶疆周曾同张庆华杜艳姿郑培蒸上海第二医科大学附属第九人民医院口腔医学院口腔综合科上海200011 上海第二医科大学附属第九人民医院口腔医学院口腔内科上海200011 上海第二医科大学附属瑞金医院血液病研究所上海200025

目的运用cDNA微阵列技术,研究口腔鳞状细胞癌组织和癌旁正常组织基因表达谱的变化,为探讨口腔癌发生机制提供筛选资料。方法应用cDNA微阵列技术(含4124条基因),对5例口腔癌患者的癌组织及同一患者的癌旁正常组织进行分析。由2种组织中... 详细信息

目的运用cDNA微阵列技术,研究口腔鳞状细胞癌组织和癌旁正常组织基因表达谱的变化,为探讨口腔癌发生机制提供筛选资料。方法应用cDNA微阵列技术(含4124条基因),对5例口腔癌患者的癌组织及同一患者的癌旁正常组织进行分析。由2种组织中分别抽提TotalRNA后,经逆转录合成荧光分子(Cy3/Cy5)掺入的cDNA链制备表达谱探针,与微阵列芯片杂交,严格洗片后,用荧光扫描仪扫描芯片,获得荧光信号图像,利用计算机分析肿瘤及癌旁正常组织中差异表达的基因,并进行分子生物信息学分析。结果在4124条基因中,口腔癌和癌旁正常组织间存在差异表达的基因。在所检测的5对临床标本中,发现有显著差异表达的基因37条(0.89%)。生物信息学分析显示,该37条显著差异表达的基因与肿瘤的发病机制可能存在相关性。结论cDNA微阵列技术能同时检测2种不同组织中多个基因的差异表达,能为研究肿瘤发病机制提供有价值的筛选资料。

关键词：口腔癌基因表达微阵列

Transgenic tetraploid Isatis indigotica expressing cryIA (c) Bt gene and Pinellia ternata agglutinin showed enhanced resistance to moths and aphids

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Transgenic tetraploid Isatis indigotica expressing cryIA (c)...

中国植物学会七十五周年年会

作者： Ying Xiao~(1,2) Kai Wang~1 Ruxian Ding~1 Hanming Zhang~1 Lei Zhang~1 Wansheng Chen~2 (1.department of pharmacognosy,School of Pharmacy,second Military medical university,shanghai 200433,china 2.department of Pharmacy,Changzheng hospital,second Military medical university,shanghai 200003,china)

Isatis indigotica Fort.,belonging to the family Cruciferae,is a biennial herbaceous plant species distributed widely in *** root of *** (Radix Isatidis),named "Ban-Lan-Gen"as a traditional Chinese medicine,is used for...

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RNA-interference-based functional research on rat epididymis-specific gene 16 and human paternally expressed gene PEG10 and the therapeutic applications of RNA interference in HBV,SARS,liver cancer,liver fibrosis and keloid fibroblast

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RNA-interference-based functional research on rat epididymis...

第四届全国RNA进展研讨会

作者： Shi Y, Xiong J, Zhou XM, Yang DH, Li GM, Gao ZY and Jin YX The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, shanghai Institutes for Biological Sciences, Chinese Academy of Science, shanghai 200031, china. department of Immunology, Wuhan university School of medicine, Wuhan, Hubei 430071, china. Institute of Liver Diseases, Tongji hospital, Tongji medical College, Huazhong university of Science and Technology, Wuhan 430030, china.College of Life Science, South china Normal university, Guangzhou 510631, china. department of Gastroenterology, Xinhua hospital, shanghai second medical university, shanghai 200092, china. department of Plastic Surgery, Changzheng hospital, second Military medical university, shanghai 200003, china.

RNA interference or RNAi is a powerful cellular mechanism of eukaryotic gene regulation in which a short sequence of double-stranded RNA (dsRNA) specifically down-regulates expression of the associated gene. In mammalian cells, siRNAs do not activate interferon pathway genes, thereby making these powerful tools for basic and applied researches. Our application of RNAi ranged from the study of gene function to therapy of diseases. We have designed siRNA targeting the rat epididymis-specific gene 16 and the human paternally expressed gene PEG10 to explore their function.

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TRITERPENES FROM LEAVES OF ROSA LAEVIGATA *** THEIR ANTI-INFLAMMATORY ACTIVITY

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TRITERPENES FROM LEAVES OF ROSA LAEVIGATA *** THEIR ANTI-INF...

中国化学会第八届天然有机化学学术研讨会

作者： Na Zeng,Yang Shen,Ming Yan,Houwen Lin~* Laboratory of Marine Drugs,department of Pharmacy,Changzheng hospital,second Military medical university,shanghai 200003,PR china

＜正＞Rosa laveigata Michx.（Rosaceae）is a shurb,very common in thickets at low altitudes, which is widely distributed throughout Southern *** fruits,known as a commonly used traditional Chinese medicine（TCM）,are p...

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ONE CASE REPORT OF ANGINA TONSILLARIS INDUCED MEDIASTINAL ABSCESS AND THORACIC EMPYEMA

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Journal of shanghai second medical university(Foreign Language Edition) 2009年第1期21卷 64-66,F0003页

作者：李庆云王玺万欢英邓伟吾 department of respiratory medicine Ruijin HospitalSchool of MedicineShanghai Jiaotong University department of Emergency Changzheng Hospital

A 27-year-old female patient with mediastinal abscess and thoracic empyema developed from angina tonsillaris was studied clinically on the manifestations, computed tomography (CT) scan, and the treatment process. The patient was admitted to hospital with a history of fever, sore throat, and chest and neck pain. CT showed air and air-fluid levels within mediastinal dense fatty planes that extended from the thoracic inlet to the sub-carinal region and left pleural empyema. She was cured by mediastinal drainage and extensive debridement of the necrotic tissue under operation and broad spectrum antibiotics treatment. Angina tonsillaris induced acute mediastitis and mediastinal abscess is a relatively rare inflammatory pathology but actually a fatal situation for its high mortality rate. CT scanning is extremely useful for early diagnosis and surgical treatment planning. The main treatment is aggressive and adequate surgical drainage of the abscess and intravenous effective antibiotic treatment.

关键词： acute mediastitis mediastinal abscess thoracotomy broad spectrum antibiotics

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Chairman Address

Chairman Address

2007年第二届杭州（国际）呼吸病研讨会

作者： M.D Ph.D FCCP Chairman 2007 the second Hangzhou International Conference on Progress of respiratory medicine Director Zhejiang university Institute of respiratory Diseases Chairman Zhejiang Thoracic Society of Zhejiang medical Association Director department of respiratory medicine second hospital Zhejiang university

＜正＞First of all,welcome everyone to Hangzhou,an ancient capital with a long history of 2200 years. With the great support from Zhejiang university and Zhejiang medical Association,2007 the second Hangzhou Internati...

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Thyrotropin-releasing hormone excited preganglionic inspiratory tracheal vagal motoneurones via multiple mechanisms

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Thyrotropin-releasing hormone excited preganglionic inspirat...

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Li-Li HOU~(1,2),Xu-Jiao ZHOU~1,Yong-Hua CHEN~1,Dong-Ying QIU~(1,3),Lei ZHU~2,Ji-Jiang WANG~(1,*) 1 The State Key Laboratory of medical Neurobiology and Institute of Brain Sciences,Fudan university shanghai medical College,138-Yi-Xue-Yuan Road,shanghai 200032,china 2 department of respiratory medicine,Fudan university Zhongshan hospital,180 Fenglin Road,shanghai 200032,china.3 department of Gerontology,Fudan university Zhongshan hospital,180 Fenglin Road,shanghai 200032,china

The inspiratorily activated preganglionic tracheobronchial vagal motoneurones(I-TVMs) in the nucleus ambiguus,which predominate in the central control of the tracheobronchial smooth muscles,receive dense inputs from terminals containing thyrotropin-releasing hormone(TRH).TRH microinjection into the nucleus ambiguus caused constriction of the tracheal smooth muscles however the neuronal and synaptic mechanisms are *** this study, the I-TVMs were retrogradedly labeled from the extrathoracic trachea of newborn rats,identified in rhythmically firing brainstem slices,and the effects of TRH were examined using *** voltage clamp TRH(100 nmol L) caused a slow excitatory inward current,enhanced the excitatory inputs and evoked a distinct oscillatory pattern of the baseline *** slow excitatory inward current and the oscillatory pattern were unaffected by blockade of chemical *** junction blocker carbenoxolone(100μmol L) prevented the oscillatory pattern without affecting the slow excitatory inward current and the enhancement of the excitatory ***(1μmol L),a blocker of both the voltage-dependent sodium transient and persistent sodium current,riluzole(20μmol L),a blocker of the persistent the sodium current,and cadmium chloride(200μmol L),a non-selective blocker of the voltagedependent calcium channels,each blocked a major proportion of the slow excitatory inward current and prevented the oscillatory *** current clamp TRH caused a slow depolarization and continuous or oscillatory firing. These results demonstrate that TRH excited the I-TVMs presynaptically via enhancement of the excitatory inputs,and postsynaptically via a slow excitatory inward current and a gap junction-mediated oscillatory pattern.

关键词： thyrotropin-releasing hormone oscillation vagal neuron