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Treatment outcomes for different subgroups of nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy

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Chinese Journal of Cancer 2011年第8期30卷 565-573页

作者： Sheng-Fa Su 1,2,3,Fei Han 1,2,Chong Zhao 1,2,Ying Huang 1,2,Chun-Yan Chen 1,2,Wei-Wei Xiao 1,2,Jia-Xin Li 1,2 and Tai-Xiang Lu 1,2 1 State Key Laboratory of oncology in South china,Guangzhou,Guangdong 510060,p.r.china.2 department of radiation oncology,Sun Yat-sen University Cancer Center,Guangzhou,Guangdong 510060,p.r.china.3 department of oncology,guiyang medical college hospital,tumor hospital of guizhou,guiyang,guizhou 550003,p.r.china. State Key Laboratory of oncology in South china Guangzhou Guangdong 510060 P. R. China.

Although many studies have investigated intensity-modulated radiation therapy (IMrT) for nasopharyngeal carcinoma (NpC),sample sizes in the reported studies are usually small and different in outcomes in different T and N subgroups are seldom ***,we evaluated the outcomes of NpC patients treated with IMrT and further explored treatment strategy to improve such *** collected clinical data of 865 NpC patients treated with IMrT alone or in combination with chemotherapy,and classified all cases into the following prognostic categories according to different TNM stages:early stage group (T1-2N0-1M0),advanced local disease group (T3-4N0-1M0),advanced nodal disease group (T1-2N2-3M0),and advanced locoregional disease group (T3-4N2-3M0).The 5-year overall survival (OS),local relapse-free survival (LrFS),and distant metastases-free survival (DMFS) were 83.0%,90.4%,and 84.0%,*** early disease group had the lowest treatment failure rate,with a 5-year OS of 95.6%.The advanced local disease group and advanced nodal disease group had similar failure pattern and treatment outcomes as well as similar hazard ratios for death (4.230 and 4.625,respectively).The advanced locoregional disease group had the highest incidence of relapse and death,with a 5-year DMFS and OS of 62.3% and 62.2%,respectively,and a hazard ratio for death of *** with IMrT alone,IMrT in combination with chemotherapy provided no significant benefit to locoregionally advanced *** results suggest that the decision of treatment strategy for NpC patients should consider combinations of T and N stages,and that IMrT alone for early stage NpC patients can produce satisfactory ***,for advanced local,nodal,and locoregional disease groups,a combination of chemotherapy and radiotherapy is recommended.

关键词：放射治疗强度调制鼻咽癌患者调控样本大小临床资料结合治疗

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Evidence-based expert consensus on clinical management of safety of Bruton’s tyrosine kinase inhibitors(2024)

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Chinese Journal of Cancer research 2024年第3期36卷 240-256页

作者： Zaiwei Song Dan Jiang Lingling Yu Yixuan Chen Daobin Zhou Yue Li Depei Wu Lingli Zhang Liyan Miao Jun Ma Jun Zhu Hongmei Jing rongsheng Zhao the Steering Committee,the Consensus panel and the Evidence Synthesis Group Evidence-based pharmacy professional Committee of Chinese pharmaceutical Association(CpA) hospital pharmacy professional Committee of Chinese pharmaceutical Association(CpA) Division of Therapeutic Drug Monitoring of Chinese pharmacological Society(CpS) Expert Committee on Lymphoma of Chinese Society of Clinical oncology(CSCO) Expert Committee on Leukemia of Chinese Society of Clinical oncology(CSCO) Society of Integrative Cardio-oncology of china Anti-Cancer Association(CACA) Chinese Society of Hematology of Chinese medical Association(CMA) hospital pharmacy professional Committee of Cross-Straits Medicine Exchange Association(SMEA) department of pharmacy Peking University Third HospitalBeijing 100191China Institute for Drug Evaluation Peking University Health Science CenterBeijing 100191China Therapeutic Drug Monitoring and Clinical Toxicology Center Peking UniversityBeijing 100191China department of pharmacy Administration and Clinical pharmacy School of Pharmaceutical SciencesPeking UniversityBeijing 100191China department of Hematology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China department of Cardiology the First Affiliated HospitalHarbin Medical UniversityHarbin 150001China department of Hematology the First Affiliated Hospital of Soochow UniversitySuzhou 215006China department of pharmacy Evidence-based Pharmacy CenterWest China Second HospitalSichuan UniversityChengdu 610041China department of pharmacy the First Affiliated Hospital of Soochow UniversitySuzhou 215006China department of Hematology and oncology Harbin Institute of Hematology and OncologyHarbin 150010China Key Laboratory of Carcinogenesis and Translational research(Ministry of Education/Beijing) Department of LymphomaPeking University Cancer Hospital&InstituteBeijing 100142China department of Hematology Peking University Third HospitalBeijing 100191China 不详

Bruton’s tyrosine kinase inhibitors(BTKis)have revolutionized the treatment of B-cell ***,safety issues related to the use of BTKis may hinder treatment continuity and further affect clinical efficacy.A comprehensive and systematic expert consensus from a pharmacological perspective is lacking for safety issues associated with BTKi treatment.A multidisciplinary consensus working group was established,comprising 35 members from the fields of hematology,cardiovascular disease,cardio-oncology,clinical pharmacy,and evidencebased *** evidence-based expert consensus was formulated using an evidence-based approach and the Delphi *** Joanna Briggs Institute Critical Appraisal(JBI)tool and Grading of recommendations Assessment,Development,and Evaluation(GrADE)approach were used to rate the quality of evidence and grade the strength of recommendations,*** consensus provides practical recommendations for BTKis medication based on nine aspects within three domains,including the management of common adverse drug events such as bleeding,cardiovascular events,and hematological toxicity,as well as the management of drug-drug interactions and guidance for special *** multidisciplinary expert consensus could contribute to promoting a multi-dimensional,comprehensive and standardized management of BTKis.

关键词： Consensus BTK inhibitors safety adverse drug events drug-drug interactions

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Effects of Dan-Shao-Hua-Xian on the expression of collagen type I and III in rats with hepatic fibrosis

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Hepatobiliary & pancreatic Diseases International 2004年第4期3卷 558-563页

作者： Xiao-Xia Geng, Qin Yang, ru-Jia Xie, Xin-Hua Luo, Cheng-Xiu Li and Ming-Liang Cheng guizhou, china department of Infectious Diseases, Affiliated hospital of guiyang medical college department of pathophysiology, guiyang medical college Depart- ment of Infectious Diseases, people’ s hospital of guizhou province and department of pharmacology, guiyang medical college department of Infectious Diseases Affiliated Hospital of Guiyang Medical College Guizhou 550004 China.

BACKGrOUND: Hepatic fibrosis is the common patholo gical change in various chronic liver diseases,and its major cause is the imbalance between the production and degra dation of the extracellular matrix, which is mainly com posed of collagens. Dan-Shao-Hua-Xian ( DSHX) cap sule, a traditional Chinese herbal compound, has shown marked preventive effects on hepatic fibrosis in rats in our previous studies. The present study was designed to further investigate its therapeutic actions on hepatic fibrosis in rats and its possible mechanisms. METHODS: Eighty male Wistar rats were randomly divid- ed into normal control group, hepatic fibrosis group, non DSHX-treated group, low-dose-treated group, and high dose-treated group. The rat models of hepatic fibrosis were established by subcutaneous injecton of CC14 , drinking al- cohol , giving diet of hyperliprosis and hypoprotein for 8 weeks. The two DSHX-treated groups were treated respec- tively with low dose (0.5 g/kg) and high dose (1.0 g/kg) of DSHX capsule p. o. everyday for 8 weeks. At the end of the experiment, liver indexes were calculated in each group in addition to the levels of the serum hyaluronic acid and alanine aminotransferase. Their degree of hepatic fibrosis and urinary excretion of hydroxyproline and expression of collagen , were detected. rESULTS: Comparison of the indexes of the hepatic fibro- sis group and non-DSHX-treated group revealed that the liver indexes, levels of serum hyaluronic acid and alanine aminotransferase, and stage of hepatic fibrosis were all sig- nificantly reduced in the two DSHX treated groups. The urinary excretion of hydroxyproline was increased and the expression of collagen I and HI in liver tissue was lessened. These alterations were more obviously observed in the high-dose-treated group. CONCLUSION: DSHX capsule has certain therapeutic effect on hepatic fibrosis in rats.

关键词： liver fibrosis collagen hyaluronic acid hydroxyproline traditional Chinese herbs

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New data regarding acritarch biostratigraphy from the Early-Middle Cambrian Kaili Formation in Chuandong,guizhou province,china

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progress in Natural Science:Materials International 2009年第1期19卷 107-114页

作者： Leiming Yin a,ruidong Yang b,Jin peng c,Fanfan Kong a a Nanjing Institute of Geology and palaeontology,Chinese Academy of Sciences,Nanjing 210008,china b college of resource and Environment of guizhou University,guiyang 550003,china c department of Sciences of Nanjing University,Nanjing 210093,china [a]Nanjing Institute of Geology and palaeontology Chinese Academy of Sciences Nanjing 210008 China [b]College of Resource and Environment of Guizhou University Guiyang 550003 China [c]Department of Sciences of Nanjing University Nanjing 210093 China

previous studies had evaluated acritarchs from the Balang and pingzhai sections of the Early-Middle Cambrian Kaili Formation in east guizhou,*** results of these studies suggest that the acritarchs in these sections have potential biostratigraphic *** recently,34 samples collected from 83 m lower part of the Lower-Middle Cambrian Kaili Formation in the Jianshan section of Chuandong,guizhou province were prepared for palynological *** of these samples revealed a distinct change in the acritarch assemblages at the bed,which was approximately 46 m above the bottom of the Kaili *** findings suggest a boundary represented by an important alteration of the ecological *** addition,the position of the acritarch biostratigraphic change is somewhat higher than the boundary between Cambrian Series 2 and Series 3 based on trilobites found in the same *** indicates that the distinct change in acritarch assemblages is similar to the change in trilobite assemblages that occurs around the boundary between Cambrian Series 2 and Series ***,acritarch biostratigraphy can provide data that can be used to define the base of Cambrian Series 3 in this region,and possibly worldwide.

关键词： Acritarchs Lower-Middle Cambrian Kaili Formation Jianshan section Chuandong

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Effect of Maotai liquor on the liver: an experimental study

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Hepatobiliary & pancreatic Diseases International 2004年第1期3卷 93-98页

作者： Ming-Liang Cheng, Jun Wu, Wen-Sheng Zhang, Hai-Qin Wang, Cheng-Xiu Li, Neng-Hui Huang, Yu-Mei Yao, Lan-Gen ren, Lan Ye and Lin Li guiyang, china department of Infectious Diseases, Affiliated hospital, guiyang medical college, guiyang 550004, china department of pharmacology, Gui- yang medical college, guiyang 550004, china department of Infectious Diseases Affiliated Hospital Guiyang Medical College Guiyang 550004 China. chengml@***

BACKGrOUND: Epidemiology investigation showed that no worker drunk Maotai liquor for nearly 30 years died of hepatic diseases, and no obvious hepatic fibrosis and cirrho- sis were found in 99 workers who had drunk Maotai liquor for a long period by epidemiology investigation and needle biopsy. The same finding was detected in rats that were drunk by Maotai liquor continued for 56 days. This study was to investigate the effects of Maotai liquor on the liver and its mechanism of preventing hepatic fibrosis. METHODS: After ingestion of Maotai for 56 consecutive days, male SD rats were killed for detecting the levels of metallothionein and malondialdehyde (MDA) in liver tis- sues. rat hepatic stellate cells (HSCs) and human HSCs were cultured in vitro to observe the effect of Maotai on HSCs proliferation and collagen synthesis. After ingestion of Maotai for 14 consecutive weeks, the livers of male SD rats were harvested for pathohistological examination. rESULTS: The level of metallothionein in the liver of Mao- tai-induced rats increased by 22 folds, whereas the levels of hepatic lipid peroxide and MDA was decreased significantly ( p ring from CCl4. Maotai demonstrated obvious inhibitory effect on prolifera- tion of HSCs and the inhibition was concentration-depen- dent. Gene expression and protein secretion of collagens could also be inhibited by Maotai. In alcoholic group, typi- cal liver cirrhosis was observed. In Maotai group, however, though fatty degeneration of hepatocytes and mild fibrosis of the interstitium were observed, no obvious hepatic fibro- sis and cirrhosis were found. CONCLUSION: It might be an important mechanism of interfering the progress of hepatic fibrosis that Maotai in- creases the level of metallothionein in the liver and inhibits the activation of HSCs and the synthesis of collagen pro- teins.

关键词： liver cirrhosis metallothionein hepatocytes Maotai liquor

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STAT1 Antisense Oligonucleotides Attenuate the proinflammatory Cytokine release of Alveolar Macrophages in Bleomycin-Induced Fibrosis

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Cellular & Molecular Immunology 2005年第3期2卷 211-217页

作者： Xianming Fan~(1,3) Zengli Wang~2 ~1department of respiratory Medicine,the Affiliated hospital of Luzhou medical college,Luzhou 646000,china ~2department of respiratory Medicine,West china hospital,Sichuan University,Chengdu 610041,china ~3Corresponding to:Dr.Xianming Fan,department of respiratory Medicine,the Affiliated hospital of Luzhou medical college,Luzhou 646000,china. department of respiratory Medicine the Affiliated Hospital of Luzhou Medical College Luzhou 646000 China. fxm129@***

To investigate the effect of signal transducers and activators of transcription 1 （STAT1） antisense oligonucleotides （ASON） on concentrations of TNF-α IL-8, NO secreted by alveolar macrophages （AMs） in bleomycin-induced rat pulmonary fibrosis, five adult female Wistar rats were intratracheally instilled with bleomycin. After 7 days, the rats were killed by right ventricle of heart exsanguinations under ketamine anaesthesia and bronchoalveolar lavage （BAL） was performed to obtain AMs. AMs were divided into four groups, treated with STAT1 ASON, STAT1 sense oligonucleotides （SON）, dexamethasone （DEX） and medium alone （control）, respectively. AMs and media were collected after culture for 36 h. The mrNA and protein expressions of STAT1 and ICAM-1 in AMs were detected by rT-pCr and ELISA, respectively. The concentrations of TNF-α IL-8, NO in cultured medium were detected. The STAT1 mrNA expression by AMs in the STAT1 ASON group was lower than those of AMs in the STAT1 SON group, the DEX group and the control group （p 〈 0.05）. Moreover, the STAT1 mrNA expression by AMs in the DEX group was also lower than those of AMs in the STAT1 SON group and the control group （p 〈 0.05）, but the STAT1 mrNA expression by AMs in the STAT1 SON group was not different from that of the control group （p 〉 0.05）. The protein expressions of STAT1 and ICAM-1 and the mrNA expression of ICAM-1 showed similar changes to the STAT1 mrNA expression by AMs. The concentrations of TNF-α IL-8, NO in cultured medium from STAT1 ASON group were lower than those from STAT1 SON, DEX and the control groups （p 〈 0.05）. Moreover, the concentrations of TNF-α IL-8, NO in cultured medium from DEX group were also lower than those from the control and STAT1 SON group （p 〈 0.05）, but no difference between STAT1 SON group and the control （p 〉 0.05）. The results suggest that STAT1 ASON could inhibit the secretion of TNF-α IL-8, NO in AMs, and STAT1 could become a target of treating pulmonary fibrosis. Cellular ＆ Molecul

关键词： STAT1 pulmonary fibrosis alveolar macrophage ASON

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Carrier Screening and prenatal Gene Diagnosis of β-thalassemia by pCr-rDB Technique

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Journal of Huazhong University of Science and Technology(medical Sciences) 2003年第1期23卷 55-56页

作者：张宏秀单可人惠春林何燕袁筑华窦友莲曾金琳谢渊修瑾 department of Obstetrics and Gynecology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology guiyang medical college department of Obstetrics and Gynecology Affiliated Hospital Guiyang Medical College

In order to identify the distribution of gene types of β-thalassemia and reduce the birthrates of β-thalassemia major in guiyang area, 1054 pregnant women and their spouses from Affiliated hospital, guiyang medical college were screened. The positive samples were analyzed with polymerase chain reaction and reverse dot blot method (pCr-rDB). When both partners were heterozygous identified as carriers for β- thalassemia, the risk of having a fetus who was homozygous or compound heterozygous was 2.66 %; the ratio of male to female was 1/1.15. Seven types of mutation were identified. CD17 and CD41-42 were dominant among them. Among the 4 cases subject to prenatal gene diagnosis, one fetus was completely normal and 3 fetuses were diagnosed as having β-thalassemia major (1 homozygous and 2 compound heterozygous). The fetuses diagnosed as β-thalassemia major were selectively terminated within two weeks. It was concluded that the birthrate of β-thalassemia major in guiyang area was reduced and the target of improving birth outcome and child development has been achieved.

关键词： thalassemia polymerase chain reaction reverse dot blot prenatal gene diagnosis

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Bathynotus:A key trilobite taxon for global stratigraphic boundary correlation between Cambrian Series 2 and Cambrian Series 3

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progress in Natural Science:Materials International 2009年第1期19卷 99-105页

作者： Jin peng a,b,Yuanlong Zhao b,Jinliang Yuan c,Lu Yao b,Hong Yang b a department of Earth Sciences,Nanjing University,Nanjing 210093,china b college of resource and Environmental Engineering,guizhou University(Caijiaguan Campus),guiyang 550003,china c Nanjing Institute of Geology and palaeontology,Chinese Academy of Sciences,Nanjing 210008,china [a]department of Earth Sciences Nanjing University Nanjing 210093 China [b]College of Resource and Environmental Engineering Guizhou University (Caijiaguan Campus) Guiyang 550003 China [c]Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences Nanjing 210008 China

The Cambrian trilobite Bathynotus is a special morphology of redlichiid,which is characterized by a wider thorax axis and an 11th macropleural segment bearing a long,backwardly directed ***,its 12th and 13th pleural segments are narrow and they terminate at a fulcrum where they fuse together and to the posterior edge of the long macropleural *** genus is widely distributed,occurring in North America,Siberia,the Altay-Sayan fold belt of russia,South china,the Tarim Basin of china,and *** occurs primarily in deposits of the upper part of the continental slope,at the transition between stable platform settings and subsiding margins of the late Early ***,we recognize three species of Bathynotus from china,including *** which is widespread around the *** six species of Bathynotus have been reported from Siberia and the Altay-Sayan fold belt area of russia,data presented here suggest that only three of these species are *** exhibits a short geological range,with its first occurrence late in the unnamed Cambrian Series 2 and the last appearance datum of Bathynotus at the boundary of Cambrian Series 2 and Cambrian Series *** late appearance datum(LAD) of Bathynotus provides an important global stratigraphic marker of the boundary between Cambrian Series 2 and Cambrian Series 3.

关键词： Bathynotus Age Cambrian Series 2 Boundary Correlation

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胰腺癌树突状细胞免疫治疗

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中国新药与临床杂志 2004年第6期23卷 382-383页

作者：孙早喜贵阳医学院附属医院外科贵州贵阳550004

目前 ,胰腺癌等消化道肿瘤免疫治疗的主要方法有特异性主动免疫治疗、单克隆抗体导向治疗、细胞因子治疗和过继性细胞免疫治疗。人树突状细胞 (denderiticcell,DC)是人体内抗原递呈能力最强的细胞 ;同时 ,它通过提供双信号刺激、细胞辅... 详细信息

目前 ,胰腺癌等消化道肿瘤免疫治疗的主要方法有特异性主动免疫治疗、单克隆抗体导向治疗、细胞因子治疗和过继性细胞免疫治疗。人树突状细胞 (denderiticcell,DC)是人体内抗原递呈能力最强的细胞 ;同时 ,它通过提供双信号刺激、细胞辅助作用、细胞因子等直接或间接地启动特异性细胞免疫及辅助B细胞产生特异性抗体 ,介导细胞免疫和体液免疫 ,在细胞免疫应答、体液免疫中发挥重要作用。

关键词：胰腺肿瘤树突状细胞免疫治疗

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Danshao Huaxian capsule in treatment of decompensated cirrhosis resulting from chronic hepatitis B

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Hepatobiliary & pancreatic Diseases International 2006年第1期5卷 48-51页

作者： Ming-Liang Cheng, Tong Lu, Yu-Mei Yao and Xiao-Xia Geng department of Infectious Diseases, Affiliated hospital of guiyang medical college, guiyang 550004, china and department of Internal Medicine, University of Arkansas for medical Sciences, Little rock, Arkansas, USA department of Infectious Diseases Affiliated Hospital of Guiyang Medical College Guiyang 550004 China. chengml@***

BACKGrOUND: The prognosis of decompensated cirrhosis resulting from chronic hepatitis B is poor, and the benefits of treatment with interferon are ourweight serious sideeffects and the risk of fatal exacerbation of disease. Danshao Huaxian capsule rapidly reduces hepatitis B virus(HBV)-DNA in serum to undetectable levels. METHODS: A total of 35 patients with chronic hepatitis B and decompensated cirrhosis were treated with Danshao Huaxian 1.2g. po. tid daily. Before the treatment, HBVDNA in serum was positive in all patients. Ten patients had Child-pugh class B and 25, class C hepatitis B. Seven patients underwent liver transplantation within 6 months of initial treatment. Of the 10 patients of class B, 5 died within 6 months, and the other 5 did not complete the treatment for some reasons; the 25 patients of class C were treated for at least 6 months (mean =19 months). rESULTS: In most of the 25 patients, liver function was improved slowly but markedly after 9 months of treatment, showing a decreased level of serum bilirubin from 67±13 to 30±4μmol/L (preased level of serum albumin from 27±1 to 34±1 g/L(preased level of Child-pugh score from 10.3±0.4 to 7.5+0.5 (pree patients developed resistance to Danshao Huaxian because of a mutation in the YMDD motif, but liver function was not deteriorated. Inhibition of viral replication with Danshao Huaxian resulted in a significant improvement of liver function in patients with decompensated HBV cirrhosis, but the long-term results remain uncertain. CONCLUSION: Danshao Huaxian capsule is effective in inhibiting viral DNA replication in patients with decompensated cirrhosis and making clinical improvement.

关键词： Danshao Huaxian capsule decompensated cirrhosis chronic hepatitis B prognosis

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