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Codes From Strongly Regular (α,β)-reguli

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Journal of shanghai jiaotong university(science) 2008年第4期13卷 491-494页

作者：李秀丽 Department of Mathematics Shanghai Jiaotong University

Strongly regular (α,β)-reguli are a class of incidence structures with given conditions which were introduced by Hamilton and Mathon. We introduce two classes of codes constructed from strongly regular (α,β)-regul... 详细信息

关键词： two-weight codes strongly regular (α,β)-reguli

Strain Softening and Hardening Behavior in AZ61 Magnesium Alloy

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Journal of Materials science & technology 2004年第6期20卷 691-693页

作者： Haitao ZHOU, Liufa LIU, Qudong WANG, Da LU, Xiaoqin ZENG and Wenjiang DINGNational Engineering Research Center of Light Alloys Net Forming, School of Materials science and Engineering, shanghai Jiao Tong university, shanghai 200030, china Ctr. of Light Alloys Net Forming Sch. of Mat. Sci. and Eng. Shanghai Jiaotong Univ. Shanghai 200030 China

The deformation behavior of AZ61 Mg alloy during hot deformation has been investigated in wide temperature and strain rate range by a Gleeble simulator. Specimens are deformed in compression in the temperature range of 523-673 K and at strain rates of 0.001-1 s-1. It is found that the flow curves exhibit a peak and then decrease towards steady-state of classical DRX, which decrease with rising temperature and decreasing strain rate. The deformation behavior of the specimens can be attributed to the occurrence of strain hardening and softening. As stress decreases, the strain hardening rate declines at a fast rate when temperature rises or strain rate decreases. The shapes of θ-σ curves indicate some important features such as subgrain formation, the criticai stress, the peak stress and steady stress. The onset of DRX can be determined by the point of inflection on θ-σ or Inθ-σ curves.

关键词： AZ61 Mg alloy Recrystallization Strain hardening and softening

Denitrification in Chongming east tidal flat sediment, Yangtze estuary, china

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science china Earth sciences 2006年第10期49卷 1090-1097页

作者： WANG Dongqi1,2, CHEN Zhenlou1,3, XU Shiyuan1,2, HU Lingzhen1 & WANG Jun1,2 1. college of Resources & Environment, East china Normal university, shanghai 200062, china 2. State Key Laboratory of Estuarine and Coastal Sediment Dynamics and Morphodynamics, East china Normal university, shanghai 200062, china 3. Key Laboratory of Geographical Information science of Ministry of Education,East china Normal university,shanghai 200062, china 1. college of Resources & Environment East China Normal University Shanghai 200062 China 2. State Key Laboratory of Estuarine and Coastal Sediment Dynamics and Morphodynamics East China Normal University Shanghai 200062 China 3. Key Laboratory of Geographical Information science of Ministry of Education East China Normal University Shanghai 200062 China

From July 2003 to July 2004, samples were collected on Chongming Island east tidal flat every two months. The research showed that the nitrous oxide (N2O) production rate was very low in the water, Chongming east tidal flat (CM) sediment was the N2O source of the water. Sediment N2O natural production rate was between -0.08 and 1.74 μmolN·m-2·h-1. N2O natural production rate was higher in the summer. The difference of the N2O natural production rate in the different tidal flats, the correlation between the N2O natural production rate and the denitrification rate, and those with the temperature and DO indicate that middle tidal flat sediment denitrification was the main process of the N2O production, while in the low tidal flat sediment, the production of the N2O came from several processes of the nitrogen cycling. Tidal flat sediment denitrification reaction was stronger in summer and winter but relatively lower in the late autumn and early spring. Seasonal change of the sediment denitrification rate was wide, from 1.12 to 33.34 μmolN·m-2·h-1. Temperature, DO and the coactions of them had the prominent effect on the tidal flat sediment denitrification.

关键词： Yangtze estuary, tidal flat sediment, denitrification, nitrous oxide, effect factor.

Comprehensive Evaluation Method of Urban Remnant Natural Area: A Case study of shanghai, china

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Journal of shanghai jiaotong university(science) 2008年第5期13卷 589-594页

作者：车生泉王云宫宾 college of Agriculture and Biology Shanghai Jiaotong University

Urban remnant natural area (URNA), located in the urban or suburb area, less disturbed by dwellers in the process of urbanization, is an important part of complex urban ecosystem and provides significant opportunity for urban sustainable development. Despite that there is a considerable amount of scientific researches on the urban nature in urban and suburb area, the comprehensive research of URNA is still rare. After analyzing the concept and value of URNA, this paper presented a methodology for comprehensive evaluation of URNA by adopting methods of document analysis, prior-selection process, analytic hierarchy process and vector resemblance-degree. As a result, the comprehensive evaluation index of URNA includes target level A, rule level B(ecological environment value, ecological recreation value, social culture value, scientific research value), index level C( diversity,singularity,nature,area,stability,recreation,landscape element,aesthetics,history,scientific), and index level D(20 items). Each index weight of comprehensive evaluation system of URNA of shanghai was confirmed finally.

关键词： urban remnant natural area (URNA) urban nature preservation ecological planning compre- hensive evaluation

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靶向表皮生长因子受体的全新小分子配体筛选

生物化学与生物物理进展 2005年第2期32卷 180-186页

作者：邓宏伟郭妍孙烨徐宇虹上海交通大学生命科学技术学院上海200030 上海交通大学药学院上海200030

肿瘤靶向分子的筛选一直是肿瘤治疗和早期诊断的研究热点. 表皮生长因子受体(EGFR) 在很多肿瘤细胞表面过量表达,是一个理想的药物输送靶点. 选择了EGFR表面不同于表皮生长因子(EGF) 结合位点的一个凹陷部位作为计算机模拟筛选的结合位... 详细信息

肿瘤靶向分子的筛选一直是肿瘤治疗和早期诊断的研究热点. 表皮生长因子受体(EGFR) 在很多肿瘤细胞表面过量表达,是一个理想的药物输送靶点. 选择了EGFR表面不同于表皮生长因子(EGF) 结合位点的一个凹陷部位作为计算机模拟筛选的结合位点,然后使用DOCK软件包对DTP-Plated有机小分子数据库进行了两遍筛选,最后选择了7个有机小分子作为可能的靶向分子. BIAcore体外结合实验对所选择的小分子样品进行了进一步的验证,结果表明,小分子NSC51186能特异地与EGFR结合. 小分子NSC51186和EGFR之间的动力学常数也得到进一步的测定. 新的靶向分子和药物、纳米粒子或者基因载体相连,将有可能用于靶向于EGFR的肿瘤治疗和诊断.

关键词：计算机辅助药物设计筛选靶向表皮生长因子受体(EGFR) BLAcore

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支持信息采集的标准化Web课件制作管理

计算机工程 2002年第1期28卷 239-241页

作者：申瑞民许彦青上海交通大学计算机科学与工程系上海200030

论述了技术在远程教育领域中的一个应用——标准化课件的制作与管理,设计开发了一套基于规范的标准化课件制作XMLIMSWeb管理工具,并支持对学生学习信息的自动采集。

关键词： IMS规范 XML 远程教育标准化Web课件信息采集

Wholly smoothing cutter orientations for five-axis NC machining based on cutter contact point mesh

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science china(Technological sciences) 2010年第5期53卷 1294-1303页

作者： BI QingZhen,WANG YuHan,ZHU LiMin & DING Han State Key Laboratory of Mechanical System and Vibration,School of Mechanical Engineering,shanghai jiaotong university,shanghai 200240,china 1. State Key Laboratory of Mechanical System and Vibration School of Mechanical Engineering Shanghai Jiaotong University Shanghai 200240 China

Cutting forces with respect to different cutter orientations are analyzed for five-axis NC machining of a ball-end cutter.A measure is then defined to quantify the effects of cutter orientation *** to the measure,a novel model and algorithm are proposed to wholly optimize cutter orientations based on a cutter contact(CC) point *** method has two *** is that the cutter orientation smoothnesses along the feed direction and pick-feed direction are both wholly *** other is that only the accessibility cones of mesh points are required to compute and the computation efficiency is *** advantages are shown by simulating the machining efficiency,the stability of feed velocities and the smoothness of cutting force.A computational example and a cutting experiment are finally given to illustrate the validity of the proposed method.

关键词： five-axis machining tool path accessibility cone cutter orientation

Reconstruction of the most recent common ancestor sequences of SARS-Cov S gene and detection of adaptive evolution in the spike protein

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Chinese science Bulletin 2004年第12期49卷 1311-1313页

作者： ZHANG Yuan1, ZHENG Nan2,3, HAO Pei4,5 & ZHONG Yang6 1. Laboratory of Systematic and Evolutionary Botany, Institute of Bot- any, Chinese Academy of sciences, Beijing 100093, china 2. college of life sciences, Beijing Normal university, Beijing 100875, china 3. Institute of Viral Disease Control and Prevention, Chinese CDC, Beijing 100052, china 4. Bioinformation Center, shanghai Institutes for Biological sciences, Chinese Academy of sciences, shanghai 200031, china 5. shanghai Center for Bioinformation technology, shanghai 200235, china 6. School of life sciences, Fudan university, shanghai 200433, china 1. Laboratory of Systematic and Evolutionary Botany Institute of Botany Chinese Academy of Sciences 100093 Beijing China 2. college of life sciences Beijing Normal University 100875 Beijing China 3. Institute of Viral Disease Control and Prevention Chinese CDC 100052 Beijing China 4. Bioinformation Center Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 200031 Shanghai China 5. shanghai Center for Bioinformation technology 200235 Shanghai China 6. School of life sciences Fudan University 200433 Shanghai China

The genome oiganization and expression strategy of severe acute respiratory syndrome coronavirus (SARS-CoV) have been described extensively. As a structural glycoprotein on the virion surface, the spike protein is responsible for binding to host cellular receptors and for the fusion between the viral envelope and the cellular membrane. It also induces neutralizing antibodies in the host and mediates cellular immunity. Previous studies suggested that amino acid replacements in the spike protein coulddramatically alter the pathogenesis and virulence of some coronaviruses. It is therefore reasonable to test the hypothesis that radical amino acid replacements in the spike protein, favored by environmental selective pressure during the process of SARS-CoV interspecific transmission, might make this pathogen adapt to a new host, In this study, we investigated a total of 108 complete sequences of the SARS-CoV S gene from Gen-Bank (until March 23, 2004). After omission of those records containing frame-shift mutations or low quality sequences, e.g. ZJ01, and selection of one sequence for identical records, an alignment of 42 sequences was obtained using the program Clustal-X. Then, we reconstructed the most recent common ancestor (MRCA) sequences of theSARS-CoV S gene and detected the adaptive evolution in the spike protein.

关键词： SARS冠状病毒自适应进化基因表达糖蛋白分子免疫学波峰病毒

东方鲎Factor C中的结构域在结合脂多糖中的作用

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生物化学与生物物理进展 2004年第8期31卷 736-740页

作者：孙向军王东宁张惟杰吴祥甫上海交通大学农业与生物技术学院上海201101 上海交通大学生命科学与技术学院上海200030 中国科学院上海生命科学研究院生物化学与细胞生物学研究所上海200031

FactorC是鲎血细胞中的一种丝氨酸蛋白酶原 ,因其能以高亲和力结合脂多糖 (LPS) ,在医药产品的内毒素检测中起着重要的作用 .以往研究表明处于N端的 3个Sushi结构域对FactorC的LPS结合活性起着关键作用 ,而FactorCN端的其他 3个结构域 ... 详细信息

FactorC是鲎血细胞中的一种丝氨酸蛋白酶原 ,因其能以高亲和力结合脂多糖 (LPS) ,在医药产品的内毒素检测中起着重要的作用 .以往研究表明处于N端的 3个Sushi结构域对FactorC的LPS结合活性起着关键作用 ,而FactorCN端的其他 3个结构域 ,包括Cys rich结构域、EGF like结构域和Lectin like结构域对LPS结合活性的影响尚不清楚 .利用Bac to Bac昆虫细胞表达系统可使rFactorC及其 4个截短的片段rCES12 3L ,rCES12 3,rS12 3L和rS12 3获得表达 ,并且可采用亲和层析柱将这 5个重组表达产物纯化 .通过测定 5个重组表达产物的LPS结合活性及抑菌活性 ,可以确定FactorC的LPS结合位点位于S12 3区域 .尽管Cys rich结构域、EGF like结构域和Lectin like结构域中不存在LPS结合位点 ,但当这 3个结构域同时存在时 ,可提高FactorC或CES12 3L的LPS结合能力 ,因此rCES12 3L具有与rFactorC非常相近的LPS结合能力 .实验结果表明 ,rCES12 3L在昆虫细胞中的表达量比rFactorC高出 4倍 ,预示出rCES12

关键词：东方鲎血细胞丝氨酸蛋白酶原体外抑菌活性细菌内毒素脂多糖