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中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Fan-Ping KONG~1,Xue-Qun CHEN~(1,*),Jun LIN~2,Ping-Ping WANG~1,Jian WANG~3,Ji-Zeng DU~(1,*) 1 Laboratory of Neurobiology and Physiology,Department of Physiology,School of Medicine 2 The First Affiliated Hospital,School of Medicine 3 college of education,zhejiang university,hangzhou,310058,china

Hypoxia is not only a component of many disease processes,but occurs under physiological conditions. When oxygen uptake becomes limited or oxygen consumption becomes excessive,cellular metabolism decreases oxidative phosphorylation and relies on glycolysis as the primary ATP production pathway by upregulating the expression of glycolytic enzymes,such as lactate dehydrogenase(LDH) and its *** hypothalamic-pituitary -adrenal(HPA) axis,one of the principal pathways which respond to stress,can be active under hypoxia. The HPA axis plays roles via the hypothalamic hormone,corticotrophin releasing hormone(CRH),which regulates the secretion of adrenocorticotrophin from the anterior pituitary,and then regulates the secretion of glucocorticoids, such as Cortisol in humans and corticosterone in *** designed two type of exercise,climbing up stairs to the 18 floor within 4 min(about 80 m in height and 130 m in distance) and bicycling for 10 min at a constant power. We developed a new method for evaluating the hypoxic response using 5μL of saliva to test CRH and Cortisol. Forty-eight volunteers from zhejiang university(20-24 years old,males and females) supplied saliva and blood samples for *** were collected at 7:00,10:00,11:00(before and after exercise) and 23:*** rate and saturated O(So,finger monitor) were measured as indicators of oxygen *** exercises led to an increase of salivary and plasma CRH,Cortisol and *** levels of salivary CRH,Cortisol and LDH were associated with the intensity of *** found the increased CRH,Cortisol,and LDH in saliva and plasma, decreased So after exercise,and the change of salivary CRH and Cortisol had good positive correlations with the changes of the plasma CRH and Cortisol(correlation coefficient,0.84 and 0.87) after *** showed that salivary CRH and Cortisol changed in parallel with plasma CRH and *** method using salivary CRH and Cortisol is simple and noninvasive,and t

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3D time-domain regular grid infinite element in elastic foundation

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Science china(Technological Sciences) 2010年第5期53卷 1413-1423页

作者： YAN XiShui,YE HuiFei,ZHAO YongQian & GE Wei college of Civil Engineering and Architecture,zhejiang university,hangzhou 310058,china 1. college of Civil Engineering and Architecture Zhejiang University Hangzhou 310058 China

The normal dynamic infinite element in elastic foundation cannot be used in time-domain due to it's inclusive frequency term.A novel 3D regular grid infinite element is constructed to deal with the time-domain *** new infinite element method can easily transform the frequency terms of mass matrix and stiffness matrix to the terms in higher-order dynamic equation,thus a higher-order dynamic equilibrium equation is *** on the second-order Wilson-θ dynamic equation,a new time-domain numeric formula of higher-order dynamic equation is deduced,and the time-domain calculation coupling with finite element and infinite element can be *** classic 3D fluctuation problem in elastic foundation is employed as an illustrative example to investigate the accuracy and validity of this new infinite *** result indicates that the new dynamic infinite element has a high accuracy.

关键词： infinite element 3D time domain elastic foundation regular grid

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Use of the modified viral satellite DNA vector to silence mineral nutrition-related genes in plants: silencing of the tomato ferric chelate reductase gene, FRO1, as an example

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Science china(Life Sciences) 2008年第5期51卷 402-409页

作者： HE XiuXia1,2,JIN ChongWei1, LI GuiXin3, YOU GuangYi4, ZHOU XuePing3 & ZHENG ShaoJian4 1 Key Laboratory for Environmental and Ecosystem Health of the Ministry of education, college of Environmental and Resource Science, zhejiang university, hangzhou 310029, china 2 college of Life Science, Changchun university of Science and Technology, Changchun 130022, china 3 Institute of Biotechnology, zhejiang university, hangzhou 310029, china 4 State Key Laboratory of Plant Physiology and Biochemistry, college of Life Science, zhejiang university, hangzhou 310058, china 1. Key Laboratory for Environmental and Ecosystem Health of the Ministry of education College of Environmental and Resource Science Zhejiang University Hangzhou 310029 China 2. college of Life Science Changchun University of Science and Technology Changchun 130022 China 3. Institute of Biotechnology Zhejiang University Hangzhou 310029 China 4. State Key Laboratory of Plant Physiology and Biochemistry College of Life Science Zhejiang University Hangzhou 310058 China

Virus-induced gene silencing (VIGS) is potentially an attractive reverse-genetics tool for studies of plant gene function, but whether it is effective in silencing mineral nutritional-related genes in roots has not been demonstrated. Here we report on an efficient VIGS system that functions in tomato roots using a modified viral satellite DNA (DNAmβ) associated with Tomato yellow leaf curl china virus (TYLCCNV). A cDNA fragment of the ferric chelate reductase gene (FRO1) from tomato was inserted into the DNAmβ vector. Tomato roots agro-inoculated with DNAmβ carrying both a fragment of FRO1 and TYLCCNV used as a helper virus exhibited a significant reduction at the FRO1 mRNA level. As a consequence, ferric chelate reductase activity, as determined by visualization of the pink FeBPDS3 complex was significantly decreased. Our results clearly demonstrated that VIGS system can be employed to investigate gene function associated with plant nutrient uptake in roots.

关键词： virus-induced gene silencing roots ferric chelate reductase

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Resting state brain activity and functional brain mapping

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Progress in Natural Science:Materials International 2007年第5期17卷 511-519页

作者： Zhao Xiaohu , Wang Peijun and Tang Xiaowei (college of life Sciences in zhejiang university, hangzhou 310058, china Imaging Department of Tong Ji Hospital of Tong Ji university, Shanghai 200065, china Bio-X Lab, Department of Physics, zhejiang university, hangzhou 310027, china) [a]college of life Sciences in zhejiang university Hangzhou China [b]Imaging Department of Tong Ji Hospital of Tong Ji university Shanghai China [c]Bio-X Lab Department of Physics Zhejiang University Hangzhou China

Functional brain imaging studies commonly use either resting or passive task states as their control conditions, and typically identify the activation brain region associated with a specific task by subtracting the resting from the active task conditions. Numerous studies now suggest, however, that the resting state may not reflect true mental "rest" conditions. The mental activity that occurs during "rest" might therefore greatly influence the functional neuroimaging observations that are collected through the usual subtracting analysis strategies. Exploring the ongoing mental processes that occur during resting conditions is thus of particular importance for deciphering functional brain mapping results and obtaining a more comprehensive understanding of human brain functions. In this review article, we will mainly focus on the discussion of the current research background of functional brain mapping at resting state and the physiological significance of the available neuroimaging data.

关键词： resting state brain activity default mode brain networks BOLD deactivation OEF.

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Does population increase alone ensure the long-term survival of endangered species?

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Chinese Science Bulletin 2011年第24期56卷 2521-2522页

作者： FANG ShengGuo Special Topic Editor college of Life Sciences, zhejiang university, hangzhou 310058, china college of Life Sciences Zhejiang University

Over the past three decades, wildlife conservation in china has achieved a number of successes. Endangered animals such as the Chinese alligator and the crested ibis, and plants such as the dawn redwood and Dysosma versipellis have recovered from the brink of extinction after considerable in situ and ex situ conservation efforts. However, population increase alone does not ensure the longterm survival of rare and endangered species, which also requires support from different fields of conservation biology.

关键词：人口增长濒危物种野生动物保护保护生物学濒危动物迁地保护扬子鳄朱鹮

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Managing Soil Erosion Potential by Integrating Digital Elevation Models with the Southern china's Revised Universal Soil Loss Equation——A Case Study for the West Lake Scenic Spots Area of hangzhou,china

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Journal of Mountain Science 2007年第3期4卷 237-247页

作者： WANG Weiwu college of civil engineering and architecture Zijinggang Campus Zhefiang University Hangzhou 310058 China

In china, many scenic and tourism areas are suffering from the urbanization that results from physical development of tourism projects, leading to the removal of the vegetative cover, the creation of areas impermeable to water, in-stream modifications, and other problems. In this paper, the risk of soil erosion and its ecological risks in the West Lake Scenic Spots （WLSS） area were quantitatively evaluated by integrating the revised universal soil loss equation （RUSLE） with a digital elevation model （DEM） and geographical information system （GIS） software. The standard RUSLE factors were modified to account for local climatic and topographic characteristics reflected in the DEM maps, and for the soil types and vegetation cover types. An interface was created between the Areinfo software and RUSLE so that the level of soil erosion and its ecological risk in the WLSS area could be mapped immediately once the model factors were defined for the area. The results from an analysis using the Areinfo-RUSLE interface showed that the risk value in 93 % of the expanding western part of the WLSS area was moderate or more severe and the soil erosion risk in this area was thus large compared with that in the rest of the area. This paper mainly aimed to increase the awareness of the soil erosion risk in urbanizing areas and suggest that the local governments should consider the probable ecological risk resulting from soil erosion when enlarging and developing tourism areas.

关键词： West Lake Scenic Spots RUSLE model modification GIS digital elevation model ecological risk of soil erosion china

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A New (t, n) Threshold Signature Scheme Withstanding the Conspiracy Attack

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Wuhan university Journal of Natural Sciences 2005年第1期10卷 107-110页

作者： XIE Qi 1,2, YU Xiu-yuan 3 1.Department of Mathematics, zhejiang university, hangzhou 310027, zhejiang,china 2.School of Information and Engineering, hangzhou Teachers college, hangzhou 310012, zhejiang, china 3.hangzhou Teachers college, hangzhou 310012, zhejiang, china zhejiang university Department of Mathematics Hangzhou China (GRID:grid.13402.34) (ISNI:***) Hungzhou Teachers college School of Information and Engincering Hangzhou China (GRID:grid.13402.34) hangzhou Teachers college Hangzhou China (GRID:grid.13402.34)

A ccmspiracy attack is proposed to show that Wang-Li's scheme is instcure,because any t or more group members can impersonate other t member to sign any message withoutholding the responsibility. To avoid the conspiracy attack, this paper prestentsa new (t,n)threshold signature scheme with traceablt signers. A (t. n) threshold signature scheme allows t ormore group members of the group lo generate a signature on behalf of the group, Any less than tmembers cannot generate a valid signature, andany set of the group cannot impersonate another set ofmembers to sign any message without holding the responsibility. In case of disputes., the thresholdsignature can be opened, so that the original signers ean be traced without repealing the secretkeys.

关键词： cryptography threshold signature conspiracy attack identifier tracing

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Characteristics of fMRI BOLD signal and its neurophysiological mechanism

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Progress in Natural Science:Materials International 2007年第6期17卷 630-638页

作者： Zhao Xiaohu1,2, Wu Yigen3 and Guo Shengli3(1. college of Life Sciences, zhejiang university, hangzhou 310058, china 2. Imaging Department of Tongji Hospital of Tongji university, Shanghai 200065, china 3. college of Mathematics and Physics, Nanjing university of Information Science and Technology, Nanjing 210044, china) college of Life Sciences Zhejiang University Hangzhou 310058 China Imaging Department of Tongji Hospital of Tongji university Shanghai 200065 China college of Mathematics and Physics Nanjing University of Information Science and Technology Nanjing 210044 China

The functional magnetic resonance imaging (fMRI) based on blood oxygen level dependent (BOLD) contrast has emerged as one of the most potent noninvasive tools for mapping brain function and has been widely used to explore physiological, pathological changes and mental activity in the brain. Exploring the nature and property of BOLD signal has recently attracted more attentions. Despite that great progress has been made in investigation of the characteristics and neurophysiological basis, the exact nature of BOLD signal remains unclear. In this paper we discuss the characteristics of BOLD signals, the nonlinear BOLD response to external stimuli and the relation between BOLD signals and neural electrophysiological recordings. Furthermore, we develop our new opinions regarding nonlinear BOLD response and make some perspectives on future study.

关键词： functional magnetic resonance imaging blood oxygen level dependent nonlinear response neural electrophysiological activity.

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Guided wave propagation in multilayered piezoelectric structures

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Science china(Physics,Mechanics & Astronomy) 2009年第7期52卷 1094-1104页

作者： GUO YongQiang1, CHEN WeiQiu2,3 & ZHANG YongLiang4 1 Key Laboratory of Mechanics on Disaster and Environment in Western china, Ministry of education, and School of Civil Engineering and Mechanics, Lanzhou university, Lanzhou 730000, china 2 Key Laboratory of Soft Soils and Geoenvironmental Engineering, Ministry of education, and Department of Civil Engineering, zhejiang university, hangzhou 310058, china 3 Department of Engineering Mechanics, zhejiang university, hangzhou 310027, china 4 School of Civil Engineering, Lanzhou Jiaotong university, Lanzhou 730070, china Key Laboratory of Mechanics on Disaster and Environment in Western china Ministry of Education and School of Civil Engineering and Mechanics Lanzhou University Lanzhou 730000 China Key Laboratory of Soft Soils and Geoenvironmental Engineering Ministry of Education and Department of Civil Engineering Zhejiang University Hangzhou 310058 China Department of Engineering Mechanics Zhejiang University Hangzhou 310027 China School of Civil Engineering Lanzhou Jiaotong University Lanzhou 730070 China

A general formulation of the method of the reverberation-ray matrix (MRRM) based on the state space formalism and plane wave expansion technique is presented for the analysis of guided waves in multilayered piezoelectric structures. Each layer of the structure is made of an arbitrarily anisotropic piezoelectric material. Since the state equation of each layer is derived from the three-dimensional theory of linear piezoelectricity, all wave modes are included in the formulation. Within the framework of the MRRM, the phase relation is properly established by excluding exponentially growing functions, while the scattering relation is also appropriately set up by avoiding matrix inversion operation. Consequently, the present MRRM is unconditionally numerically stable and free from computational limitations to the total number of layers, the thickness of individual layers, and the frequency range. Numerical examples are given to illustrate the good performance of the proposed formulation for the analysis of the dispersion characteristic of waves in layered piezoelectric structures.

关键词： multilayered piezoelectric structures the method of reverberation-ray matrix guided waves dispersion characteristic

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Variations in Laboratory-Scale Actinomycete Communities Exposed to Cadmium as Assessed by Denaturing Gradient Gel Electrophoresis Profiles

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Pedosphere 2010年第2期20卷 174-184页

作者： YUAN Hai-Ping,MIN Hang 2,LIU Ji,YAN Bo and L Zhen-Mei college of Life Science,zhejiang university,hangzhou 310058 (china) [a] college of Life Science Zhejiang University Hangzhou 310058 (China)

The actinomycete populations and functions in cadmium （Cd） contaminated soil were investigated by the cultivation- independent molecular methods. The genomic DNA was extracted and purified from soil adulterated with various con- centrations of Cd in the laboratory. The partial 16S rDNA genes were amplified by polymerase chain reaction （PCR） using specific primers bound to evolutionarily conserved regions within these actinomycete genes. The diversity in PCR- amplified products, as measured by denaturing gradient gel electrophoresis （EGGE）, was used as a genetic fingerprint of the population. Principle component analysis and Shannon-Weaver diversity index （H） analyses were used to analyze the DGGE results. Results showed that the two principal components accounted for only a low level of the total variance. The value H in contaminated soil was lower than that in the control at later stages of cultivation, whereas at earlier stages it was higher. Among the six sampling time points, the first, fifth and sixth weeks had the highest values of H. Significantly negative correlations between bioavallable Cd concentration and H values existed in the samples from weeks 2 （R = 0.929, P 〈 0.05） and 4 （R = 0.909, P 〈 0.05）. These results may shed light on the effect of Cd on the soil environment and the chemical behavior and toxicity of Cd to actinomycetes.

关键词： denaturing gradient gel electrophoresis genes principal component analysis Shannon-Weaver diversity index

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