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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 89-97页

作者： Ke-Jia Shan changcheng Wu Xiaolu Tang Roujian Lu Yaling Hu Wenjie Tan Jian Lu State Key Laboratory of Protein and Plant Gene Research Center for BioinformaticsSchool of Life SciencesPeking UniversityBeijing 100871China Sinovac Biotech Ltd. Beijing 100085China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 100052China

The monkeypox virus(mpox virus,MPXV)epidemic in 2022 has posed a significant public health ***,the evolutionary principles of MPXV remain largely ***,we examined the evolutionary patterns of protein sequences and codon usage in *** first demonstrated the signal of positive selection in OPG027,specifically in the CladeⅠlineage of ***,we discovered accelerated protein sequence evolution over time in the variants responsible for the 2022 ***,we showed strong epistasis between amino acid substitutions located in different *** codon adaptation index(CAI)analysis revealed that MPXV genes tended to use more non-preferred codons compared to human genes,and the CAI decreased over time and diverged between clades,with CladeⅠ>Ⅱa andⅡb-A>Ⅱ*** the decrease in fatality rate among the three groups aligned with the CAI pattern,it remains unclear whether this correlation was coincidental or if the deoptimization of codon usage in MPXV led to a reduction in fatality *** study sheds new light on the mechanisms that govern the evolution of MPXV in human populations.

关键词： Mpox virus Positive selection OPG027 Accelerated evolution Codon usage bias

Novel Static Security and Stability Control of Power Systems Based on Artificial Emotional Lazy Q-Learning

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Energy Engineering 2024年第6期121卷 1713-1737页

作者： Tao Bao Xiyuan Ma Zhuohuan Li Duotong Yang Pengyu Wang changcheng Zhou Digital Grid Research Institute Southern Power GridGuangzhou510000China

The stability problem of power grids has become increasingly serious in recent years as the size of novel power systems *** order to improve and ensure the stable operation of the novel power system,this study proposes an artificial emotional lazy Q-learning method,which combines artificial emotion,lazy learning,and reinforcement learning for static security and stability analysis of power ***,this study compares the analysis results of the proposed method with those of the small disturbance method for a stand-alone power system and verifies that the proposed lazy Q-learning method is able to effectively screen useful data for learning,and improve the static security stability of the new type of power system more effectively than the traditional proportional-integral-differential control and Q-learning methods.

关键词： Artificial sentiment static secure stable analysis Q-learning lazy learning data filtering

Mpox(formerly monkeypox):pathogenesis,prevention,and treatment

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Signal Transduction and Targeted Therapy 2024年第1期9卷 234-248页

作者： Junjie Lu Hui Xing Chunhua Wang Mengjun Tang changcheng Wu Fan Ye Lijuan Yin Yang Yang Wenjie Tan Liang Shen Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and ScienceHubei ProvinceXiangyang 441021China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China College of Biotechnology Tianjin University of Science&TechnologyTianjin 300457China Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for infectious diseaseState Key Discipline of Infectious DiseaseShenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China

In 2022,a global outbreak of Mpox(formerly monkeypox)occurred in various countries across Europe and America and rapidly spread to more than 100 countries and *** World Health Organization declared the outbreak to be a public health emergency of international concern due to the rapid spread of the Mpox ***,nations intensified their efforts to explore treatment strategies aimed at combating the infection and its ***,the available therapeutic options for Mpox virus infection remain *** far,only a few numbers of antiviral compounds have been approved by regulatory *** the high mutability of the Mpox virus,certain mutant strains have shown resistance to existing pharmaceutical *** highlights the urgent need to develop novel antiviral drugs that can combat both drug resistance and the potential threat of ***,there is a lack of comprehensive literature on the pathophysiology and treatment of *** address this issue,we conducted a review covering the physiological and pathological processes of Mpox infection,summarizing the latest progress of anti-Mpox *** analysis encompasses approved drugs currently employed in clinical settings,as well as newly identified small-molecule compounds and antibody drugs displaying potential antiviral efficacy against ***,we have gained valuable insights from the process of Mpox drug development,including strategies for repurposing drugs,the discovery of drug targets driven by artificial intelligence,and preclinical drug *** purpose of this review is to provide readers with a comprehensive overview of the current knowledge on Mpox.

关键词： prevention treatment intensified

Restoring cellular calcium homeostasis to rescue ER stress by 1,2-bis(2-aminophenoxy)ethane-N,N,N’,N’-tetraacetic acid acetoxymethyl ester-loaded lipid-mPLGA hybrid-nanoparticles for acute kidney injury therapy

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Chinese Chemical Letters 2024年第3期35卷 337-345页

作者： Jingwen Zhang Jiahui Yan Yanan Wang Hong Liu Xueping Sun Yuchao Gu Liangmin Yu changcheng Li Jun Wu Zhiyu He Frontiers Science Center for Deep Ocean Multispheres and Earth System and Key Laboratory of Marine Chemistry Theory and TechnologyMinistry of EducationOcean University of ChinaQingdao 266100China College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266100China School of Medicine and Pharmacy Ocean University of ChinaQingdao 266003China Sanya Oceanographic Institution Ocean University of ChinaQingdao 572024China Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology(Guangzhou)NanshaGuangzhou 511400China Division of Life Science The Hong Kong University of Science and TechnologyHong Kong 999077China

Early pathogenesis of ischemia-reperfusion(I/R)-induced acute kidney injury(AKI)is dominated by intracellular calcium overload,which induces oxidative stress,intracellular energy metabolism disorder,inflammatory activation,and a series of pathologic cascaded reactions that are closely intertwined with self-amplifying and interactive feedback loops,ultimately resulting in cell damage and kidney ***,most nanomedicines originate from the perspective of antioxidant stress,which can only quench existing reactive oxide species(ROS)but cannot prevent the continuous production of ROS,resulting in insufficient *** a safe and promising drug,BAPTA-AM is hydrolyzed into BAPTA by intracellular esterase upon entering cells,which can rapidly chelate with overloaded Ca^(2+),restoring intracellular calcium homeostasis,thus inhibiting ROS regeneration at the ***,we designed a KTP-targeting peptide-modified yolk-shell structure of liposome–poly(ethylene glycol)methyl ether-block-poly(L-lactide-co-glycolic)(mPLGA)hybrid nanoparticles(3)and the inflammatory pathway(TNF-α–NF-κB–IL-6 axes),thus alleviating pathological changes in kidney tissue,thereby inhibiting the expression of renal tubular marker kidney injury mole

关键词： BAPTA-AM Calcium overload Acid-responsive AKI ER stress

Experimental design of paraffin/methylated melamine-formaldehyde microencapsulated composite phase change material and the application in battery thermal management system

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Journal of Materials Science & Technology 2024年第2期169卷 124-136页

作者： Que Huang Silong Wang Jichun He Dengji Xu Safaa NAbdou Mohamed MIbrahim Shiqi Sun Yanjun Chen Handong Li Ben Bin Xu changcheng Liu Zeinhom M.El-Bahy Zhanhu Guo School of Environment and Safety Engineering North University of ChinaTaiyuan 030051China Institute of Advanced Energy Materials and Systems North University of ChinaTaiyuan 030051China School of Resources and Safety Engineering Central South UniversityChangsha 410010China School of Medical and BioInformation Engineering Northeastern UniversityShenyang 110819China Department of Chemistry Khurmah University CollegeTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Department of Chemistry College of ScienceTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Mechanical and Construction Engineering Faculty of Engineering and EnvironmentNorthumbria UniversityNewcastle Upon Tyne NE18STUK College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr City 11884CairoEgypt

In order to maintain the optimal operating temperature of the battery surface and meet the demand for thermal storage technology,battery thermal management system based on phase change materials has attracted increasing *** this work,a kind of core-shell structured microcapsule was synthesized by an in-situ polymerization,where paraffin was used as the core,while methanol was applied to mod-ify the melamine-formaldehyde shell to reduce toxicity and improve thermal ***,three different types of heat conductive fillers with the same content of 10 wt.%,i.e.,nano-Al_(2)O_(3),nano-ZnO and carbon nanotubes were added,generating *** microcapsules were uniform,and were not affected by the thermal fillers,which were evenly dispersed *** composite sample with carbon nanotubes(10 wt.%)showed the highest thermal conductivity of 0.50 W/(m K)and latent heat of 139.64 J/***,according to the leakage testing and battery charge/discharge experiments,compared with Al_(2)O_(3)and ZnO,the addition of carbon nanotubes remarkably enhances the heat storage ability as latent heat from 126.98 J/g for the prepared sample with Al_(2)O_(3)and 125.86 J/g for the one with ZnO,then to 139.64 J/g,as well as dissipation performance as a cooling effect by decreasing the sur-face temperature of battery from 2%to 12%of microcapsule,composite sample with carbon nanotubes presents a broad application prospect in battery thermal management system and energy storage field.

关键词： Microcapsule Phase change material Battery Carbon nanotube Safety

Flexibility potential of Cs_(2)BX_(6)(B=Hf,Sn,Pt,Zr,Ti;X=I,Br,Cl)with application in photovoltaic devices and radiation detectors

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Journal of Energy Chemistry 2024年第8期95卷 271-287,I0006页

作者： Songya Wang changcheng Chen Shaohang Shi Ziyi Zhang Yan Cai Shuli Gao Wen Chen Shuangna Guo Elyas Abduryim Chao Dong Xiaoning Guan Ying Liu Gang Liu Pengfei Lu School of Science Xi’an University of Architecture and TechnologyXi’an 710055ShaanxiChina Key Laboratory of Eco Planning&Green Building Ministry of EducationTsinghua UniversityBeijing 100080China State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China School of Physics and Optoelectronic Engineering Ludong UniversityYantai 264025ShandongChina

As interest in double perovskites is growing,especially in applications like photovoltaic devices,understanding their mechanical properties is vital for device *** extensive exploration of structure and optical properties,research on mechanical aspects is *** article builds a vacancyordered double perovskite model,employing first-principles calculations to analyze mechanical,bonding,electronic,and optical *** show Cs_(2)Hfl_(6),Cs_(2)SnBr_(6),Cs_(2)SnI_(6),and Cs_(2)PtBr_(6)have Young's moduli below 13 GPa,indicating *** parameters explain flexibility variations with the changes of B and X site *** characteristic exploration reveals the influence of B and X site electronegativity on mechanical ***_(2)SnBr_(6)and Cs_(2)PtBr_(6)are suitable for solar cells,while Cs_(2)HfI_(6)and Cs_(2)TiCl_(6)show potential for semi-transparent solar *** property calculations highlight the high light absorption coefficients of up to 3.5×10^(5) cm^(-1)for Cs_(2)HfI_(6)and Cs_(2)TiCl_(6).Solar cell simulation shows Cs_(2)PtBr_(6)achieves 22.4%of conversion ***_(2)ZrCl_(6)holds promise for ionizing radiation detection with its 3.68 eV bandgap and high absorption ***-ordered double perovskites offer superior flexibility,providing valuable insights for designing stable and flexible *** understanding enhances the development of functional devices based on these perovskites,especially for applications requiring high stability and flexibility.

关键词： Double perovskite Mechanical properties Flexible Photovoltaic Radiation detectors

The metabolic profiling of Chinese yam fermented by Saccharomyces boulardii and the biological activities of its ethanol extract in vitro

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Food Science and Human Wellness 2024年第5期13卷 2718-2726页

作者： Xue Li Yiwen Shao Limin Hao Qiaozhen Kang Xiaolong Wang Jiaqing Zhu changcheng Zhao Yanling Shi Jike Lu Juanjuan Yi School of Life Sciences Zhengzhou UniversityZhengzhou 450001China Food Laboratory of Zhongyuan Zhengzhou UniversityLuohe 462300China Systems Engineering Institute Academy of Military Sciences(AMS)Beijing 100010China Henan Yinfeng Biological Engineering Technology Co. Ltd.Zhengzhou 450000China

Chinese yam(Dioscorea opposita Thunb.),as one of the medicinal and edible homologous plants,is rich in various nutrients and functional *** this study,Chinese yam fermented by Saccharomyces boulardii was performed to investigate its bioactive components and metabolic *** then,the main bioactive components and biological activities of fermented Chinese yam ethanol extract(FCYE)were *** showed that there were 49 up-regulated metabolites and 52 down-regulated metabolites in fermented Chinese yam compared to unfermented Chinese ***,corresponding metabolic pathways analysis initially revealed that the distribution of bioactive substances was concentrated on alcoholsoluble small molecular ***,the total polyphenol content and the total flavonoid content in FCYE were significantly increased,and the corresponding antioxidant and immunomodulatory activities in vitro were also significantly *** study provided a new reference for the comprehensive utilization of Chinese yam and laid a theoretical foundation for the development and application of natural probiotic-fermented products.

关键词： Chinese yam Saccharomyces boulardii Metabolites Antioxidant Immunomodulation

Differential Transcriptional Responses in Corneal and Lung Epithelial Cells to Seasonal Influenza With Potential Function of LGALS9

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Infectious Microbes & Diseases 2024年第3期6卷 141-151页

作者： Yang Han Ting Zhang Dan Bai changcheng Wu Beiwei Ye Jianfang Zhou Yingze Zhao George F.Gao Jun Liu National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouChina State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouChina NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention(China CDC)BeijingChina Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanningChina National Key Laboratory of Intelligent Tracking and Forecasting for InfectiousDiseases(NITFID) National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijingChina

Seasonal flu,primarily caused by influenza A H1N1 and H3N2 subtype viruses or influenza B viruses,is the most prevalent respiratory tract infection globally and leads to substantial morbidity andmortality *** the influenza virus being initially recognized as a respiratory pathogenwithwell-characterized transmission through respiratory droplets,its impact on the ocular epithelium and associated gene expression remains relatively *** this study,we investigated the transcriptional profiles of immortalized human corneal epithelial cells(HCE-S)and A549 human lung epithelial cells infected with H1N1 and H3N2 influenza *** comparison with A549 cells,a reduced number of differentially expressed geneswas observed in HCE-S upon influenza virus ***,there was a significant upregulation of the genes IFI44L and OAS1,along with lower release of the CCL5/RANTES ***,our findings revealed uniquely upregulated LGALS9(encoding galectin-9)in HCE-S following infection with the 2009 pandemic H1N1 ***,targeted knockdown of LGALS9 in these cells resulted in a measurable decrease in viral infection,highlighting its role in the cellular responses to influenza virus and suggesting a novel avenue for antiviral ***,our findings provide insight into the distinct mechanisms of influenza virus interactions with different epithelial cells and underscore the importance of studying the ocular surface in understanding influenza pathogenesis.

关键词： immortalized human corneal epithelial cell line human pulmonary epithelial cell line influenza A virus transcriptome sequencing LGALS9

The Early-Middle Triassic Supervolcano in the Yangtze Block,South China and associated obstacles to biotic recovery

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Geoscience Frontiers 2024年第1期15卷 69-83页

作者： Haifeng Chen Hao Zou MSantosh Huawen Cao Franco Pirajno changcheng Huang Mingcai Hou State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of TechnologyChengduSichuan 610059China College of Earth Science Chengdu University of TechnologyChengduSichuan 610059China School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China Department of Earth Science University of AdelaideAdelaideSA 5005Australia Yonsei Frontier Lab Yonsei UniversitySeoulSouth Korea Centre of Exploration Targeting The University of Western Australia35 Stirling HighwayCrawleyWA 6009Australia

The end-Permian mass extinction was one of the major global crises spanning the entire Early Triassic or *** of volcanos were one of the factors that delayed the biotic recovery after this *** eruptions can cause catastrophic effects on global environment,climate,and *** we investigate the tuff layers from Early-Middle Triassic boundary in the Yangtze Block and identify a supervolcano eruption *** zircon U-Pb ages of the section-Langdai,section-Daijiagou and section-Longmendong tuff samples are 247.1±1.9 Ma,247.6±2.0 Ma and 247.7±1.7 Ma,*** ages mark the Olenekian-Anisian *** zircon grains from the tuff layers have negativeεHf(t)(-15.3 to-0.8),two-stage Hf model(TDM2)ages(1.7 to 2.2 Ga)and display high-δ18O values(mostly>10‰).Clay minerals and quartz dominate the rock *** whole rock compositions show that the tuff layers were derived from magma of intermediate to felsic composition,which formed by the remelting of Paleoproterozoic materials of continental *** volcanic eruption site is located in the Jinshajiang-Ailaoshan-Song Ma suture zone in the southwestern margin of the Yangtze Block.A combination of the closure of the Paleo-Tethys Ocean Basin and the collision of the Indochina Block and South China contributed to the eruption,which was a supervolcano eruption under the active continental margin arc *** speculate that this supervolcano eruption might have contributed to the delayed biotic recovery after the end-Permian mass extinction.

关键词： Early-Middle Triassic Tuff layer Supervolcano Yangtze Block Biotic recovery