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Oncogenesis of RON receptor tyrosine kinase:a molecular target for malignant epithelial cancers

Acta Pharmacologica Sinica 2006年第6期27卷 641-650页

作者： Ming-hai WANG~(2,3,4)Hang-ping YAO~2 Yong-qing ZHOU~2 2 Laboratory of Chang-Kung Scholars Program for Tumor biology,First Affiliated Hospital,Zhejiang university school of Medicine,Hangzhou 310003.China 3 cancer biology center and department of pharmaceutical sciences,texas tech university health sciences center school of pharmacy,amarillo,tx 79106,usa Laboratory of Chang-Kung Scholars Program for Tumor biology First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China cancer biology center and department of pharmaceutical sciences Texas Tech University Health Sciences Center School of Pharmacy Amarillo USA

Recepteur d’origine nantais(RON)belongs to a subfamily of receptor tyrosinekinases(RTK)with unique expression patterns and biological *** isactivated by a serum-derived growth factor macrophage stimulating protein(MSP).The RON gene transcription is essential for embryonic development and critical inregulating certain physiological *** studies have indicated thataltered RON expression contributes significantly to cancer progression *** primary tumors,such as colon and breast cancers,overexpressionof RON exists in large numbers and is often accompanied by the generation ofdifferent splicing *** RON variants direct a unique program thatcontrols cell transformation,growth,migration,and invasion,indicating that al-tered RON expression has the ability to regulate motile/invasive *** activities were also seen in transgenic mice,in which targeted expression ofRON in lung epithelial cells resulted in numerous tumors with pathological fea-tures of human bronchioloalveolar ***,abnormal RON activation isa pathogenic factor that transduces oncogenic signals leading to uncontrolledcell growth and subsequent malignant *** these facts,RON and its variants can be considered as potential targets for *** using small interfering RNA and neutralizing mono-clonal antibodies demonstrated that suppressing RON expression and activationdecreases cancer cell proliferation,increases apoptotic death,prevents tumorformation in nude mice,and reduces malignant ***,blocking RONexpression and activation has clinical significance in reversing malignant pheno-types and controlling tumor growth.

关键词： growth factor receptor signal transduction tumorigenesis monoclonal antibody small molecule inhibitor therapeutics

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The Anti-inflammatory Activity of HMGB1 A Box is Enhanced When Fused with C-terminal Acidic Tail

The Anti-inflammatory Activity of HMGB1 A Box is Enhanced Wh...

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重庆市生物化学与分子生物学学术会议

作者： Wei Gong1,Yingru Zheng2,Fan Chao1,Yuan Li1,Zhizhen Xu1,Gang Huang1,Xiang Gao3,Song Li3,Fengtian He1 (1 department of Biochemistry and Molecular biology,College of Basic Medical sciences,Third Military Medical university,Chongqing 400038,China 2 department of Obstetrics and Gynecology, Research Institute of Surgery,Daping Hospital,Third Military Medical university,Chongqing 400042, China 3 center for Pharmacogenetics,department of pharmaceutical sciences,school of pharmacy, university of Pittsburgh,Pittsburgh,PA 15261,usa)

HMGB1,composed of the A box,B box and C tail domains,is a critical proinflammatory cytokine involved in diverse inflammatory *** B box mediates proinflammatory activity,while the A box alone acts as a specific antagonist of *** C tail contributes to the spatial structure of A box and regulates HMGB1 DNA binding *** is unknown whether the C tail can enhance the

关键词： High-mobility group box 1 A box C-terminal acidic tail Inflammation Fusion protein

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