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Spatio-temporal pattern analysis of single-trial EEG signals recorded during visual object recognition

Science China(Information Sciences) 2011年第12期54卷 2519-2527页

作者： WANG ChangMing 1 , HU XiaoPing 3 , YAO Li 1,2 , XIONG Shi 2 & ZHANG JiaCai 2 1 National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal university, Beijing 100875, China 2 College of Information Science and technology, Beijing Normal university, Beijing 100875, China 3 biomedical imaging technology center, emory university/georgia institute of technology, atlanta 3032., usa 1. National Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University Beijing 100875 China3. Biomedical Imaging Technology Center Emory University/Georgia Institute of Technology Atlanta 30322 USA2. College of Information Science and Technology Beijing Normal University Beijing 100875 China

Object discrimination is a fundamental cognitive function for human brains. In this study, we utilized an analysis approach for single-trial electroencephalography (EEG) to analyze the spatio-temporal activation patterns of visual objects processing in human brains, and attempted to apply it to discriminate different visual objects. The spatial patterns were respectively extracted from scalp EEG and the reconstructed cortical sources, while the experiment participants were perceiving 4 different categories of visual objects (faces, buildings, cats and cars). By classifying the patterns extracted from single-trial EEG, the presented visual objects could be discriminated by a computer, and the classification accuracies may provide a quantitative index to evaluate the spatial differences of the brain activations related to different visual objects. Our results demonstrated that the spatial patterns on both the scalp and the sources levels resulted in higher classification accuracies than chance rate. We also examined the classification results using temporally non-overlapping time intervals of different event-related potential (ERP) components. The temporal changes of classification accuracies may reflect the temporal distribution of the discriminative information in the EEG responses. The present pattern extraction and classification methods may compose a computational model for single-trial EEG data analysis in investigations of the spatio-temporal activation patterns for object recognition. These spatio-temporal patterns in EEG may be useful to identifying the discriminative spatial areas and time stages to improve the accuracies and efficiencies of object discrimination. In addition, investigating and utilizing humans'cognitive mechanisms of object recognition may improve computers' processing efficiency of visual information.

关键词： EEG spatio-temporal pattern object recognition single-trial analysis visual information processing

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New Approaches for Molecular imaging with MRI

New Approaches for Molecular Imaging with MRI

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中华医学会第十八次全国放射学学术会议

作者： Xiaoping Hu emory university and georgia institute of technology,usa

MRI is playing a growing role in molecular imaging for mapping cellular and molecular signatures of diseases and normal *** this regard,magnetic iron oxide nanoparticles(MION) are most widely used because of their high sensitivity and suitability for in vivo *** our own work,we have taken two approaches in developing MION based molecular ***,we have developed new imaging sequences for improved and quantitative mapping of MION ***,we have

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Characterization and Crystal Structure of a New Holmium(III) Complex with the Macrocyclic Ligand Derived from 2,6-Diformyl-4-methylphenol and Diethylenetriamine

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Chinese Journal of Structural Chemistry 2007年第12期26卷 1429-1434页

作者：胡学雷邱立赵元弟Key Laboratory of biomedical Photonics of Ministry of Education - Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics and Molecular imaging Key Laboratory - Key Laboratory of Molecular Biophysics of the Ministry of Education Huazhong university of Science and technology 潘志权 Key Laboratory of biomedical Photonics of Ministry of Education - Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics and Molecular imaging Key Laboratory - Key Laboratory of Molecular Biophysics of the Ministry of Education Huazhong University of Science and Technology Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical technology Wuhan Institute of Technology

The title compound （13,27-dimethyl-3,6,9,17,20,23-hexaazatricyclo-[23.***.1.1^11.15]- triaconta-l（29）,2,9,11,13,15（30）,16,23,25,27-decaene-29,30-diol-N^3,N^6,N^9,O^29,O^30）-bis（nitrato-O,O＇）- holmium（m） nitrate hydrate has been prepared and characterized by elemental analysis, infrared spectra, and electrospray mass spectra. Its crystal and molecular structures were determined by X-ray diffraction methods. The crystal crystallizes in the monoclinic system, space group C2/c with a = 23.737（12）, b = 14.237（7）, c = 19.801（10） A, β = 91.36（1）^o, Mr = 831.57, V = 6690（6） A^3, Z = 8, Dc = 1.651 g/cm^3, F（000） = 3344, R = 0.0482 and wR = 0.0923. The holmium ion is located in one of the compartments of the macrocyclic ligand and presents a distorted tricapped trigonal prismatic coordination geometry. The macrocycle is coordinated with two oxygen and three nitrogen atoms. Two nitrates are chelated in the opposite positions of the macrocycle, and the third one is ionic.

关键词： crystal structure lanthanide macrocycle

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Design and implementation of an optical simulation environment for bioluminescent tomography studies

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Progress in Natural Science:Materials International 2007年第1期17卷 87-94页

作者： LI Hui, TIAN Jie, LUO Jie, LU Yujie, CONG Wenxiang and WANG Ge ( Department of Education technology, Capital Normal university, Beijing 100037, China Key Laboratory of Complex Systems and Intelligence Science, institute of Automation, Chinese Academy of Sciences, Beijing 100080, China Bioluminescent Tomography Laboratory, Department of Radiology & Department of biomedical Engineering, university of Iowa, Iowa City, Iowa 52242, usa) [a]Departhent of Education technology Capital Normal University Beijing China [b]Key Laboratoiy of Omplex Systems and Intelligence Science Institute of Automation Chinese Academy of Sciences Beijing China [c]Bioluminescent Tomography Laboratoiy Department of Radiology & Department of Biomedical Engineering University of Iowa Iowa City tIowa USA

As a challenging task for bioluminescent tomography simulation, a virtual optical environment is needed to solve the forward problem accurately, that is, to achieve a high precision for bioluminescent signal synthesis on the external body surface of a small animal. The molecular optical simulation environment named MOSE is implemented using the C++ programming language and the OpenGL techniques, including a user-friendly interface with interactive tools facilitating users' operations. The accuracy of the virtual optical environment is verified by error analysis of mesh simplification and comparison between MOSE results and experimental data. This virtual optical environment is accurate, flexible and efficient to simulate the photon propagation in complicated tissues, which has a great potential to become a software platform for bioluminescent tomography studies and other molecular imaging applications.

关键词： molecular imaging biolumlnescent tomography photon propagation Monte Carlo method.

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Modeling for cell crowding effects on the adhesion of flowing cells

Modeling for cell crowding effects on the adhesion of flowin...

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2008年全国生物流变学与生物力学学术会议

作者： Ying Fang~1,Quhuan Li~2,Cheng Zhu~3,Jianhua Wu~1(1.School of Bioscience and Bioengineering,South China university of technology,Guangzhou 510006 2.School of Life Science,Sun Yat-Sen university, Guangzhou 510275 3.Coulter Department of biomedical Engineering,georgia institute of technology, atlanta,GA 30332)

The adhesion of flowing cells to the vascular surface in localized sites will occur in many physiological and pathological processes, such as inflammatory reaction,tumor metastasis,and thrombus *** transport dependent process depends not only on the specific interactions of adhesive molecules but also on the hemodynamics of blood flow.A larger accumulation of adhesion cells may decay the local transport rate of flowing cells,increase the collision events of flowing cells each other or between the tethered and the flowing cells,

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E-Selectin-mediated cell adhesion measuring by an inverted flow Chamber

E-Selectin-mediated cell adhesion measuring by an inverted f...

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2008年全国生物流变学与生物力学学术会议

作者： Quhuan Li~1,Yi Fu~2,Ying Fang~2,Cheng Zhu~3,Jianhua Wu~2(1.School of Life Science,Sun Yat-Sen university, Guangzhou 510275 2.School of Bioscience and Bioengineering,South China university of technology,Guangzhou 510006 3.Coulter Department of biomedical Engineering,georgia institute of technology,atlanta,GA 30332)

The kinetic and mechanical constraints govern selectin-ligand interactions that mediate adhesion of circulating leukocytes with the vessel wall during an inflammatory *** studies have been carried out to elucidate this transport dependent process that depends not only on the specific interactions of adhesive molecules but also on the hemodynamics of blood *** far,there is little known about

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APPLICATION OF SURFACE-ENHANCED HYPER-RAMAN AND NEAR-IR FT-RAMAN SPECTROSCOPY

APPLICATION OF SURFACE-ENHANCED HYPER-RAMAN AND NEAR-IR FT-R...

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中国物理学会光散射专业委员会成立十周年暨第六届学术会议

作者： Nai-Teng Yu~1 and Shuming N■~2 1 Department of Chemistry,The Hong Kong university of Science and technology,Kowloon,Hong Kong 2 School of Chemistry and B■chemistry,georgia institute of technology, atlanta,GA 30332 U.S.A.

＜正＞This lecture present:highlights on biochemical/biophysical/ biomedical applications of two recently developed laser light scattering techniques,i.e.,surface-e■anced hyper-Raman scattering（SEHRS） and near-IR-excited Fourier transform（FT）-*** SEHRS technique has selection rules tha■ are different from those of normal Raman,

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The bonding characteristic of L-and E-selectin contacting to (S)PSGL-1 in micropipette assay

The bonding characteristic of L-and E-selectin contacting to...

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2008年全国生物流变学与生物力学学术会议

作者： Yan Zhang~1,Ning Jiang~2,Cheng Zhu~2(1.institute of biomedical Engineering,Department of Anatomy,Second Military Medical university,800 Xiangyin Road,Shanghai 200433,P.R.China 2.Coulter Department of biomedical Engineering,georgia institute of technology,atlanta,GA 30332-0363,U.S.A.) Coulter Department of biomedical Engineering,georgia institute of technology,atlanta, GA30332-0363,U.S.A.

With acute inflammatory response,the adhesion of leucocytes to the vessel wall and subsequent rolling along endothelial surfaces involve specific selectin-ligand *** selectin family of adhesion molecules inciudes L-,E- and P-selectin.P-selectin glycoprotein ligand-1(PSGL-1 ),a sialomucin on leukocytes is not only a high-affinity ligand for P-selectin but also the ligands for E- and *** research showed selectin played a particularly important role in these rapid kinetics of leukocyte-endothelium ***

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Characterization and optimization of piezoelectric single crystal/polymer composites for high performance ultrasonic transducers

Characterization and optimization of piezoelectric single cr...

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2011年全国压电和声波理论及器件应用研讨会

作者： Zhengbin Wu 1 Shenzhen institute of Advanced Integration technology,Chinese Academy of Sciences/The Chinese university of Hong Kong,Shenzhen institutes of Advanced technology,Chinese Academy of Sciences,Shenzhen 518055 2 Harbin institute of technology Shenzhen Graduate School,Shenzhen 518055 3 institute of biomedical and Health Engineering,Shenzhen institutes of Advanced technology.Chinese Academy of Sciences,Shenzhen 518055 ,

＜正＞As a valid information carrier,ultrasound is widely used in the areas of biomedical imaging,diagnosis,and therapy;industrial non-destructive testing;and underwater sonar,as well as for various topics in remote sensing across a broad range of industrial and individual *** the practical applications,a sufficiently broadband frequency is normally required from the ultrasonic transducers in the whole system,which is especially crucial for non-linear characterization and high resolution *** the past decades,piezoelectric composites comprising piezoelectric single crystal and passive polymer materials have attracted the attention of researchers and industrialists. These have lower acoustic impedance,higher electromechanical coupling coefficient,and broader frequency bandwidth,which are the ideal candidate to manufacture high performance ultrasonic *** to low damped piezoelectric crystal materials such as PZT and PMN-PT,accurate characterization of these lossy piezoelectric composite materials is fundamentally required so that the resulted effects on the structures or devices made from them are then able to be *** the same time,further optimization of the frequency bandwidth of these novel piezoelectric single crystal composite materials is highly *** this talk,we will report the research progress in these *** theoretical and experimental results of novel precise characterization and optimization methods for piezoelectric single crystal composites will be presented,which are promising for their applications in high performance ultrasound transducers.

关键词： Piezoelectric single crystal/polymer composite Characterisation Optimisation Ultrasonic transducers

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Nanotechnology for bioseparations

Nanotechnology for bioseparations

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30th International Symposium on Capillary Chromatography、4th GC×GC Symposium、16th National Symposium and Exhibition on Chromatography,i.e. 1st Dalian International Symposium and Exhibition on Chromatography

作者： Baba Y.~(1-5 *) 1.Department of Applied Chemistry Graduate School of Engineering Nagoya university 2.MEXT Innovative Research center for Preventive Medical Engineering Nagoya university 3.Plasma Nanotechnology Research center Nagoya university 4.Health technology Research center National institute of Advanced Industrial Science and technology (AlST) 5.institute for Molecular Science National institute for Natural Sciences

＜正＞This lecture will describe the recent development of nanobiotechnologies based on the nanofabrication, molecular nanotechnoiogy,and nanomaterials for bioanalysis and biomedical *** technologies allow us to develop novel methods to analyze several biomolecules,including DNA,RNA,protein,peptide, polysaccharide,and *** of nano-pillar,which is 200 nm wide and 4000 nm tall,is successfully applicable to fast separation of DNA within 10-25 ***-ball,fabricated by molecular nanotechnology,of which diameter is 50 nm,is developed and successfully applied for fast separation of DNA fragments from 100 bp to 15 *** cellulose,which is 50 nm diameter biofiber,is found to be useful high sensitive detection of biomolecule based on the optical confined effect as well as fast analysis of *** nano-biodevice is extremely useful for fast separation of protein samples from several kDa to 200 kDa within 15 seconds. Utilizing this technique,complex protein mixture extracted from human T cell line,lymphoblastic Jurkat cells, were separated within 15s with high *** methods we have taken appear suitable for biomedical and clinical applications,including SNPs analysis,mutation analysis,haplotyping,DNA diagnosis,protein expression analysis,immunoassay,protein disease marker detection,point-of-care *** methods are also applicable to molecular imaging of cancer cell and possible photodynamic therapy of cancer.

关键词： Nanotechnoiogy Biodevice Protein DNA Cell

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