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Protective effects of L-arginine on pulmonary oxidative stress and antioxidant defenses during exhaustive exercise in rats

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Acta Pharmacologica Sinica 2005年第8期26卷 992-999页

作者： Wan-teng LIN~(2,5), Suh-ching YANG~3, Kung-tung CHEN~4, Chi-chang HUANG~3, Ning-yuean LEE~(2,6) ~2 Department of Nutrition and Food Sciences, Fu-Jen Catholic University, Taipei, china ~3 School of Nutrition and Health Sciences, Taipei Medical University, Taipei, china ~4 Department of General education, Ming Hsin University of Science and Technology Hsinchu, china ~5 De Lin institute of Technology, Taipei, china Department of Nutrition and Food Sciences Fu-Jen Catholic University Taipei China De Lin institute of Technology Taipei China School of Nutrition and Health Sciences Taipei Medical University Taipei China Department of General education Ming Hsin University of Science and Technology Hsinchu China

Aim: To assess the effects of L-arginine (L-Arg) supplementation on pulmonary oxidative stress and antioxidant defenses in rats after exhaustive exercise. Methods: Rats were randomly divided into four groups: sedentary control (SC), sedentary control with L-Arg treatment (SC+Arg), exhaustive exercise with control diet (E) and exhaustive exercise with L-Arg treatment (E+Arg). Rats in groups SC+Arg and E+Arg received a 2% L-Arg diet. Rats in groups E and E+Arg underwent an exhaustive running test on a motorized treadmill. Pulmonary oxidative stress indices [xanthine oxidase (XO), myeloperoxidase (MPO), and malondialdehyde (MDA)] and antioxidant defense systems [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione reductase (GR), and glutathione (GSH)] were investigated in this study. Results: L-Arg supplementation significantly reduced exercise-induced elevations of XO and MPO activities in lung. LArg reversed the exercise-induced increase in SOD and GR activities, but increased CAT and GPX activities. L-Arg administration also significantly increased the GSH levels in plasma. Conclusion: L-Arg supplementation can prevent elevations of XO and MPO activities in the lung and favorably influence pulmonary antioxidant defense systems after exhaustive exercise.

关键词： L-arginine oxidative stress xanthine oxidase myeloperoxidase exhaustive exercise lung

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A new elliptic-parabolic yield surface model revised by an adaptive criterion for granular soils

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Science china(Technological Sciences) 2010年第8期53卷 2152-2159页

作者： LIU HanLong 1,2 ,XIAO Yang 1,2 ,LIU JinYuan 3 &LI GuoYing 4 1 Key Laboratory of Ministry of education for Geomechanics and Embankment Engineering,Hohai University, Nanjing 210098,china 2 Geotechnical Research institute,Hohai University,Nanjing 210098,china 3Department of Civil Engineering,Ryerson University,Toronto,Canada 4 Department of Geotechnical Engineering,Nanjing Hydraulic Research institute,Nanjing 210014,china Key Laboratory of Ministry of education for Geomechanics and Embankment Engineering Hohai University Nanjing China Geotechnical Research institute Hohai University Nanjing China Department of Civil Engineering Ryerson University Toronto Canada Department of Geotechnical Engineering Nanjing Hydraulic Research Institute Nanjing China

An adaptive criterion for shear yielding as well as shear failure of soils is proposed in this paper to address the fact that most criteria,including the Mohr-Coulomb criterion,the Lade criterion and the Matsuoka-Nakai criterion,cannot agree well with the experimental results when the value of the intermediate principal stress parameter is too *** new criterion can adjust an adaptive parameter based on the experimental results in order to make the theoretical calculations fit the test results more *** original elliptic-parabolic yield surface model can capture both soil contraction and dilation ***,it normally over-predicts the soil strength due to its application of the Extended Mises criterion.A new elliptic-parabolic yield surface mode is presented in this paper,which introduces the adaptive criterion in three-dimensional principal stress *** new model can well model the stress-strain behavior of soils under general stress *** to the original model which can only simulate soil behavior under triaxial compression conditions,the new model can simulate soil behaviors under both triaxial compression conditions and general stress conditions.

关键词： principal stress space intermediate principal stress yield surface failure criterion constitutive model

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Comparison between CMM2 & ISO9001

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Wuhan University Journal of Natural Sciences 2001年第Z1期6卷 516-523页

作者： Pan Qiu ling, Liu Zong tian, Wu Peng cheng Research institute of Microcomputer, hefei University of Technology, hefei 230009, china Research institute of Microcomputer Hefei University of Technology Hefei China

The Capability Maturity Model(CMM) and ISO9001 are probably the two best known and most widely used models for software organization quality assurance and improvement. As they both continue to evolve, each has a series of versions which own new aspects. This paper discusses the similarities and differences between the two models, based on the CMM version 2.0 c and the 1997 release of ISO9001, examines 20 clauses in ISO9001 and maps them to practices in the latest CMM. In the end, their implementations in china are presented.

关键词： software quality assurance ISO9001 CMM v2.0 c

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Synthesis of superheavy nuclei with ^(238)U target

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Science china(Physics,Mechanics & Astronomy) 2009年第10期52卷 1482-1488页

作者： LIU ZuHua1,3 & BAO JingDong2,4 1 Key Laboratory of Beam Technology and Material Modification of Ministry of education,Beijing Normal University,Beijing 100875,china 2 Department of Physics,Beijing Normal University,Beijing 100875,china 3 china institute of Atomic Energy,Beijing 102413,china 4 Center of Theoretical Nuclear Physics,National Laboratory of Heavy Ion Accelerator of Lanzhou,Lanzhou 730000,china Key Laboratory of Beam Technology and Material Modification of Ministry of education Beijing Normal University Beijing China china institute of Atomic Energy Beijing China Department of Physics Beijing Normal University Beijing China Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator of Lanzhou Lanzhou China

The production of superheavy nuclei with Z=108-116 via hot fusion reactions of the neutron-rich projectiles with 238U target is systematically *** results show that the production cross sections of superheavy nuclei do not decrease monotonously as the atomic number Z *** cross sections of the superheavy nuclei at Z = 112 and 115 are enhanced as compared with the whole Z-trend in synthesis of the superheavy nuclei,which clearly illustrates that the reactions with large negative Q-value and shell correction are more favorable to synthesize superheavy nuclei.

关键词： superheavy nuclei fusion reaction cross section 238U target

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AICAR inhibits proliferation and induced S-phase arrest,and promotes apoptosis in CaSki cells

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Acta Pharmacologica Sinica 2007年第12期28卷 1984-1990页

作者： Tong-ju GUAN~2,Feng-jin QIN~3,Jian-hai DU~4,Li Geng~3,You-yi ZHANG~(4,5),Min LI~(2,5)~2 institute of Pathology,The School of Basic Medicine,Lanzhou University,Lanzhou 730000,china ~3 Department of Gynaecology andObstetrics,Peking University Third Hospital,Beijing 100083,china ~4 institute of Vascular Medicine,Peking University Third Hospital andKey Laboratory of Molecular Cardiovascular Sciences Ministry of education,Beijing 100083,china institute of Pathology The School of Basic Medicine Lanzhou University Lanzhou China Department of Gynaecology and Obstetrics Peking University Third Hospital Beijing China institute of Vascular Medicine Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education Beijing China

Aim:The aim of the present study was to determine the effect of 5-aminoimidazole-4-carboxamide-ribonucleoside （AICAR） on proliferation,cell cycle,and apoptosisin the human epithelial cervical cancer cell line CaSki ***:Cell countand 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide assay were usedto determine cell proliferation and *** 33258 staining was con-ducted to distinguish the apoptotic *** cycle and Annexin-V/propidiumiodide staining were analyzed by fluorescence-activated cell sorting （FACS）.AWestern blot assay was used to evaluate the expression of AKT （also known asprotein kinase B）,mammalian target of rapamycin （mTOR）,p53,and extracellularsignal-regulated kinase （ERK）.Results:AICAR （500 μmol/L） significantly inhibi-ted the proliferation of CaSki cells treated for 24,48,and 72 h as determined by *** cells at the G1and G2phases were dramatically decreased while cells atthe S phase were increased in response to AICAR treatment for 24,48,and 72 *** MTT assay showed less viable cells and Hoechst fluorescent staining showedmore apoptotic cells upon AICAR *** results of the Annexin-Vstaining demonstrated a time-dependent increase of apoptosis in cells treatedwith AICAR for 24,36,and 48 ***,AICAR activated caspase-3 in atime-dependent *** was also found that AICAR inhibited the phosphory-lation of AKT and mTOR,which are important kinases regulating cell growth *** stimulation obviously increased the expression of the tumorsuppressor p53 and the phosphorylation of ***:AICAR inhibitedproliferation and induced S phase arrest and promoted apoptosis in CaSki cells,which might be mediated by the downregulation of the AKT/mTOR pathway andthe upregulation of the p53/ERK pathway.

关键词： AICAR proliferation apoptosis CaSki cells

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STUDY OF Ag DIFFUSION INTO Cu SINGLE CRYSTALS BY RUTHERFORD BACKSCATTERING SPECTROMETRY

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Acta Metallurgica Sinica(English Letters) 2003年第5期16卷 332-334页

作者： R.Wang 1) Key Laboratory of Beam Technology and Materials Modification, Ministry of education, Beijing 100875, china2) institute of Low Energy Nuclear Physics, Beijing Normal University, Beijing 100875, china3) Beijing Radiation Center, Beijing 100875, china Lab. of Beam Technol. Inst. of Low Energy Nucl. Phys. Beijing Normal Univ. Beijing 100875 China Beijing Radiation Ctr. Beijing 100875 China

4.0Me V 7Li++ RBS was used for investigations of thermal diffusion of Ag in Cu single crystals. The annealing of samples was carried out in vacuum in the temperature range from 498K to 613K. The element depth concentration profiles transformed from RBS spectra indicate that the diffusion of Ag into Cu is a typical volume diffusion. The Arrhenius parameters corresponding to the diffusion were obtained.

关键词： Ag diffusion single crystal

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Formation mechanism of carbonate cemented zones adjacent to the top overpressured surface in the central Junggar Basin,NW china

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Science china Earth Sciences 2010年第4期53卷 529-540页

作者： YANG Zhi1,2,ZOU CaiNeng1,3,HE Sheng2,LI QiYan1,HE ZhiLiang3,WU HengZhi5,CAO Feng1,MENG XianLong4,WANG FuRong2 & XIAO Qilin21 State Key Laboratory of EOR,Research institute of Petroleum Exploration & Development,Petrochina,Beijing 100083,china 2 Key Laboratory of Tectonics and Petroleum Resources of Ministry of education,china University of Geosciences,Wuhan 430074,china 3 State Key Laboratory of EOR,Research institute of Petroleum Exploration & Development,Petrochina,Beijing 100083,china 4 Research institute of Petroleum Exploration and Production,SINOPEC,Beijing 100083,china 5 Southwest Branch Company,SINOPEC,Chengdu 610051,china State Key Laboratory of EOR Research Institute of Petroleum Exploration & Development PetroChina Beijing China Key Laboratory of Tectonics and Petroleum Resources of Ministry of education China University of Geosciences Wuhan China State Key Laboratory of EOR Research Institute of Petroleum Exploration & Development Petrochina Beijing China Southwest Branch Company SINOPEC Chengdu China Research institute of Petroleum Exploration and Production SINOPEC Beijing China

Carbonate cemented zones are normally adjacent to the top overpressured surface in the central Junggar Basin,NW *** carbon and oxygen isotopic compositions and petrological investigations of carbonate cements in the carbonate cemented zones indicate that:(1) carbonate cements are composed dominantly of ferrocalcite,ferroan dolomite,and ankerite;(2) carbonate cements are formed under a high temperature circumstance in the subsurface,and organic fluid migration has an important effect on the formation of them;and(3) carbon and oxygen ions in the carbonate cements migrate from the underlying overpressured *** suggests that the occurrence of carbonate cemented zones in this region results from multiple phases of organic fluid expulsion out of the overpressure compartment through geological *** study provides a plausible mechanism of the formation of carbonate cemented zones adjacent to the top overpressured surface in the clastic sedimentary basins,and has an important implication for understanding the internal correlation between the formation of carbonate cemented zones adjacent to top overpressured surface and geofluids expulsion out of overpressured system.

关键词： carbonate cemented zones formation mechanism stable carbon and oxygen isotopic top overpressured surface central Junggar Basin coal-bearing strata

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Identification of human dopamine D1-like receptor agonist using a cellbased functional assay

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Acta Pharmacologica Sinica 2005年第10期26卷 1181-1186页

作者： Nan JIANG~2, Ke-qing OU-YANG~3, Shao-xi CAI~3, Ying-he HU~2, Zhi-liang XU~(2,4) ~2 Shanghai institute of Brain Functional Genomics and Key Lab of Brain Functional Genomics, Ministry of education, Science and Technology Commission of Shanghai Municipality, East china Normal Uuiversitv, Shanghai 200062 ~3 College of Bioengineering, Chongqing University, Chongqing 400044, china Shanghai institute of Brain Functional Genomics and Key Lab of Brain Functional Genomics Ministry of Education Science and Technology Commission of Shanghai Municipality East China Normal University Shanghai China College of Bioengineering Chongqing University Chongqing China

Aim: To establish a cell-based assay to screen human dopamine D1 and D5 receptor agonists against compounds from a natural product compound library. Methods: Synthetic responsive elements 6xcAMP response elements （CRE） and a mini promoter containing a TATA box were inserted into the pGL3 basic vector to generate the reporter gene construct pCRE/TA/Luci. CHO cells were co-trans- fected with the reporter gene construct and human D1 or D5 receptor cDNA in mammalian expression vectors. Stable cell lines were established for agonist screening. A natural product compound library from over 300 herbs has been established. The extracts from these herbs were used for human D1 and D5 receptor agonist screenings. Results: A number of extracts were identified thatactivated both D1 and D5 receptors. One of the herb extracts, SBG492, demonstrated distinct pharmacological characteristics with human D1 and D5 receptors. The EC50values of SBG492 were 342.7 μg/mL for the D1 receptor and 31.7 μg/mL for the D5 receptor. Conclusion: We have established a cell-based assay for high-throughput drug screening to identify D1-like receptor agonists from natural products. Several extracts that can active D1-like receptors were discovered. These compounds could be useful tools for studies onthe functions of these receptors in the brain and could potentially be developed into therapeutic drugs for the treatment of central nervous system diseases.

关键词： dopamine DI receptors drug screening Chinese herbal drugs

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Whole fossil plants of Ephedra and their implications on the morphology,ecology and evolution of Ephedraceae (Gnetales)

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Chinese Science Bulletin 2010年第15期55卷 1511-1519页

作者： WANG Xin 1,2 & ZHENG ShaoLin 3 1 Nanjing institute of Geology and Palaeontology,Chinese Academy of Sciences,Nanjing 210008,china 2 Fairy Lake Botanical Garden,Shenzhen 518004,china 3 Shenyang institute of Geology and Mineral Resources,Shenyang 110034,china Nanjing institute of Geology and Palaeontology Chinese Academy of Sciences Nanjing China Fairy Lake Botanical Garden Shenzhen China Shenyang institute of Geology and Mineral Resources Shenyang China

Although there are many reports of fossil Ephedraceae,whole plant fossil record remains *** to a lack of trust on partially preserved fossil materials,scholars working on molecular clock proposed a recent origin of Ephedra and cast doubt on the earlier origin time of *** better the understanding on this interesting group,here we report whole plants of Ephedra hongtaoi ***.(Ephedraceae,Gnetales) from the Yixian Formation (Early Cretaceous) in western Liaoning,*** whole plants of Ephedra demonstrate clearly the characters of Ephedra,including shrubby growth habit,decussate branching pattern,and terminal ovuliferous unit with micropylar *** whole-plant preservation of the fossils provides more convincing fossil evidence of Early Cretaceous Ephedra,helps to resolve the controversy over the origin time of Ephedra,and sheds light on the whole plant morphology,growth habit,ecology and evolution of Ephedraceae.

关键词：化石植物生态学麻黄形态学进化材料保存早白垩世生长习性

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The productivity evaluation model and its application for finite conductivity horizontal wells in fault block reservoirs

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Petroleum Science 2010年第4期7卷 530-535页

作者： Jiang Hanqiao Ye Shuangjiang Lei Zhanxiang Wang Xing Zhu Guojin Chen Minfeng Key Laboratory of Petroleum Engineering Ministry of Education China University of Petroleum Beijing 102249 China Research institute of Petroleum Exploration and Development PetroChina Beijing 100083 China Research institute of china National Offshore Oil Corporation Beijing 100027 China

It is very difficult to evaluate the productivity of horizontal wells in fault block reservoirs due to the influence of fault *** the basis of the method of images and source-sink theory,a semianalytical model coupling reservoir and finite conductivity horizontal wellbore flow dynamics was built,in which the influence of fault sealing was taken into *** distribution of wellbore flow and radial inflow profiles along the horizontal interval were also *** impact of the distance between the horizontal well and the fault on the well productivity was quantitatively *** on this analysis,the optimal distance between the horizontal well and the fault in banded fault block reservoirs could be *** to the field application,the relative error calculated by the model proposed in this paper is within ±15%.It is an effective evaluation method for the productivity of horizontal wells in fault block *** productivity of the horizontal well increases logarithmically as the distance between the horizontal well and the fault *** optimal distance between the horizontal well and the fault is 0.25-0.3 times the horizontal well length.

关键词： Fault block reservoir horizontal well finite conductivity productivity evaluation well location design

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