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胶原蛋白/葡甘聚糖共混膜的制备及性能表征

中国组织工程研究与临床康复 2008年第10期12卷 1885-1888页

作者：景森陈庆华潘兴华张峰董会昆明理工大学材料与冶金工程学院云南省昆明市650093 解放军成都军区昆明总医院医学实验科云南省昆明市650032

以葡甘聚糖和胶原蛋白为主要原料,甘油、氨水为添加剂通过共混的方法制备胶原蛋白/葡甘聚糖膜。通过红外光谱、X-射线衍射、显微镜对共混膜进行性能表征,同时测定了共混膜的透光率、力学性能、吸水率及水蒸气透过系数。结果表明:葡甘聚... 详细信息

以葡甘聚糖和胶原蛋白为主要原料,甘油、氨水为添加剂通过共混的方法制备胶原蛋白/葡甘聚糖膜。通过红外光谱、X-射线衍射、显微镜对共混膜进行性能表征,同时测定了共混膜的透光率、力学性能、吸水率及水蒸气透过系数。结果表明:葡甘聚糖1.0g,胶原蛋白0.6g,甘油0.4mL,氨水1.0mL,蒸馏水100mL为制膜最佳配方,共混膜的力学性能和水蒸气透过系数得到改善,葡甘聚糖和胶原蛋白之间有强烈的相互作用和良好的相容性,作为一种潜在的皮肤组织工程支架将具有良好的应用前景。

关键词：葡甘聚糖胶原蛋白共混膜生物材料

The use of intracardiac echocardiography and method to guide noncoronary cardiac interventions

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The use of intracardiac echocardiography and method to guide...

中华医学会心电生理和起搏分会第十次全国学术年会

作者： Tao Guo1,Guicheng Liang2 1.The first affiliated hospital in kunming medical college 2.The Second Peoples hospital of Guilin

Objective we sought to assess the utilization and strategy of intracardiac echocardiography(ICE) during noncoronary Cardiac Interventions,to evaluate the feasibility and accuracy guided with and without the help of ICE. Methods A consecutive series of 46 patients were selected from the cardiology department of the first affiliated hospital in kunming medical college,who underwent transcatheter closure of interatrial communications,ablations of supraventricular tachycardia and implantations of pacemakers through jugular with ICE(groupl:23patients,12men,llwomen,45.78±21.54 years) and without ICE(group2: 23patients,12men,11 women,49.22±24.79years).We measured the fluoroscopy time and the total procedure time,compared the difficulty of the procedure,locations of the ablation catheters and the complications between the two groups,assessed the feasibility,safety of using ICE for the guidance of noncoronary cardiac interventions.A level of statistical significance was set to P<0.05. Results①All the 23 patients with the ICE guidance in group land the another 23 without ICE were completed the whole procedure,and none sever complements or damage of cardiac structure was observed,②During the procedure for closure of ASD,the diameter measured with ICE and TEE were correlated with each *** predict diameter of ASD with ICE was trended to be larger(by 2～4mm) than the measurement.③During the ablation procedure,ICE could provide imaging e of the movement and position of the sheaths and catheters,guide the transseptal puncture,monitor the damage to adjacent structure,improve the whole procedure.④During the implant procedure,ICE could provide the visualization images of the movement of the cathodes,embedment of screw-in electrodes.⑤The total fluoroscopy time in patients guided with ICE were shorter than those guided with TEE:(13.87±5.63) min versus(25.09±10.32) min. Conclusion①The closure of ASD guided with ICE was superior to those with *** suggest to chose the diameter of t

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Clnical Study of the Treatment of Patients with a Metastatic Spinal Tumor by Percutaneous Vertebroplasty under the Guidance of DSA

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Clnical Study of the Treatment of Patients with a Metastatic...

中华医学会第八届骨科学术会议暨第一届国际COA学术大会

作者： YANG Zuozhang XU Jianbo JIN Congguo LIU Pengjie YUAN Tao QIAN Baosheng ZHANG Jinyu LI Wengzhong LI Jianlin XIAO Yanbin PENG Ming LI Yu LUAN Li department of Orthopaedics The Third affiliated hospital of kunming medical college Tumor hospital of yunnan province kunming yunnan 650118 china

＜正＞OBJECTIVE: To explore the clinical effect in patients with metastatic spinal tumors treated by percutaneous vertebroplasty （ PVP ） under the guidance of digital subtraction angiography （DSA ） . METHODS A total of 110 cases with a metastatic spinal tumor were divided into 55 cases in the treatment group （group A ） and 55 cases in the control group （group B ） .

关键词： percutaneous vertebroplasty spine metastatic tumor intervention bone cement

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树鼩血栓性脑缺血磁共振成像研究

临床放射学杂志 2012年第10期31卷 1492-1496页

作者：何波韩丹何亮张峰睿李树清昆明医科大学第一附属医院医学影像中心 650032 昆明医科大学病理生理教研室 650500

目的研究树鼩血栓性脑缺血动物模型的MRI表现,探讨其动态演变规律。方法采用3.0 T MR在缺血后4 h、24 h、48 h及72 h对树鼩脑部行MRI,观察各时间点MRI表现,测量和计算出各时间点扩散加权成像(DWI)、T2WI异常信号体积;分别应用HE染色、... 详细信息

目的研究树鼩血栓性脑缺血动物模型的MRI表现,探讨其动态演变规律。方法采用3.0 T MR在缺血后4 h、24 h、48 h及72 h对树鼩脑部行MRI,观察各时间点MRI表现,测量和计算出各时间点扩散加权成像(DWI)、T2WI异常信号体积;分别应用HE染色、红四氮唑(2,3,5-triphenyltetrazolium chloride,TTC)染色技术显示脑缺血后不同时间点病理改变和皮层梗死体积的变化。结果缺血后4 h MRI可见信号改变,T2WI为高信号,T1WI为低信号,DWI为高信号,增强扫描可见强化;TTC染色所测体积与MRI体积比较,4 h时DWI及T2WI所测体积大于TTC(P24 h梗死灶体积增大明显(P<0.05);光镜示缺血后中心区神经元可见皱缩,脱失明显,出现嗜酸神经元。结论 MRI可动态反映树鼩血栓性脑缺血动物模型缺血后不同时间点的病理演变过程。

关键词：树鼩光化学脑缺血磁共振成像

转移性结直肠癌抗EGFR治疗耐药机制研究进展

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中国普通外科杂志 2024年第6期33卷 996-1011页

作者：徐昆明许云华陈锡光付广黄秋林肖帅南华大学附属第一医院胃肠外科湖南衡阳421001 南华大学附属第一医院肿瘤疾病研究所湖南衡阳421001

转移性结直肠癌(mCRC)是结直肠癌进展的晚期阶段,治疗选择多样,但患者预后通常不佳。表皮生长因子受体(EGFR)信号通路在mCRC的发展中扮演核心角色,涉及多个关键分子。EGFR异常活化与肿瘤生长、转移及治疗耐药紧密相关。因此,EGFR靶向治... 详细信息

转移性结直肠癌(mCRC)是结直肠癌进展的晚期阶段,治疗选择多样,但患者预后通常不佳。表皮生长因子受体(EGFR)信号通路在mCRC的发展中扮演核心角色,涉及多个关键分子。EGFR异常活化与肿瘤生长、转移及治疗耐药紧密相关。因此,EGFR靶向治疗对mCRC至关重要,但治疗耐药常常导致治疗失败,且分子机制复杂。在此,笔者综述mCRC抗EGFR治疗耐药的相关分子机制及干预研究进展,为深入理解抗EGFR耐药机制,优化治疗策略提供参考。

关键词：结直肠肿瘤肿瘤转移 ErbB受体分子靶向治疗抗药性,肿瘤综述

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臂丛神经损伤的多种神经电生理诊断

实用骨科杂志 1997年第4期3卷 214-217页

作者：许虹昆明医学院附一院神经内科电生理室 650032

本文对96例臂丛神经损伤患者进行肌电图与运动神经传导速度检查,结果发现损伤神经支配的肌肉肌电图有纤颤电位、正相电位等神经原损害表现;受损的臂丛神经运动神经传导速度有不同程度的减慢或缺失。18例臂丛神经损伤的病人还同时测定了... 详细信息

本文对96例臂丛神经损伤患者进行肌电图与运动神经传导速度检查,结果发现损伤神经支配的肌肉肌电图有纤颤电位、正相电位等神经原损害表现;受损的臂丛神经运动神经传导速度有不同程度的减慢或缺失。18例臂丛神经损伤的病人还同时测定了感觉神经动作电位和体感诱发电位,以判断臂丛神经损伤在节前或节后,并与手术发现作了对比。本文认为用多种神经电生理检查方法能客观、准确地诊断臂丛神经损伤的部位、程度,对确定治疗、估计预后有重要意义。

关键词：臂丛神经损伤肌电图运动神经传导速度感觉神经动作电位体感诱发电位

A comparative study on the therapeutic results of transurethral enucleation of the prostate and Nesbit resection method for BPH

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A comparative study on the therapeutic results of transureth...

第十五届全国泌尿外科学术会议

作者： LUO Yu-hui , SHEN Ji-hong Dept.of Urology,The 1st affiliated hospital of kunming medical college 650032

Objective:A total of 314 Patients Who were diagnosed with BPH from September 2006 to October 2007 in our hospital were divided into two groups randomly, transurethral enucleation of the prostate group and Nesbit metho...

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支气管激发试验对咳嗽变异型哮喘的临床诊断价值及其评价

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中国实用内科杂志 2008年第S2期28卷 34-37页

作者：李建华张力燕王华宋丰贵昆明医学院第一附属医院呼吸内科昆明650032

目的探讨支气管激发试验(BPT)在慢性咳嗽及咳嗽变异型哮喘(CVA)诊断中的价值。方法对1155例慢性咳嗽患者进行乙酰甲胆碱支气管激发试验,检测其气道高反应性。结果1155例慢性咳嗽患者中,各年龄组肺功能参数比较无显著差异。BPT阳性584例... 详细信息

目的探讨支气管激发试验(BPT)在慢性咳嗽及咳嗽变异型哮喘(CVA)诊断中的价值。方法对1155例慢性咳嗽患者进行乙酰甲胆碱支气管激发试验,检测其气道高反应性。结果1155例慢性咳嗽患者中,各年龄组肺功能参数比较无显著差异。BPT阳性584例,阴性571例,阳性率50.6%。确诊为CVA547例;其余37例BPT阳性慢性咳嗽患者中25例为感染后咳嗽,12例为慢性支气管炎。BPT诊断CVA的特异度为93.9%。小于30岁年龄组CVA比例最高,占慢性咳嗽68.8%;大于60岁的老年入CVA百分比最低,为23.5%。结论CVA是慢性咳嗽的主要病因,对不明原因的慢性咳嗽患者应及时进行BPT,有助于早期明确诊断并施以正确治疗。

关键词：慢性咳嗽咳嗽变异型哮喘:支气管激发试验

Multi-center clinical study of the prevalence rate of senile osteoporotic fracture in china

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Multi-center clinical study of the prevalence rate of senile...

International Conference on Osteoporosis and Bone Research 2008

作者： Zhenming Hu~1 Xianzheng Luo~2 Kerong Dai~3 Xiaolin Li~4 Tianzun Tao~5 Lihua Zhu~6 Hanchang Lao~7 Yanling Zhao~8 Shou Zhang~9 Fachou Zhang~(10) Gang Zhao~(11) Jie Hao~1 Xuesong Li~8 ~1 department of Orthopaedic Surgery The first affiliated hospital Chongqing medical University Chongqing china ~2 department of Orthopaedic Surgery The affiliated Beijing Friendship hospital Capital medical University Beijing china ~3 department of Orthopaedic Surgery The affiliated Shanghai 9th hospital Shanghai Jiao Tong University Shanghai china ~4 department of Orthopaedic Surgery The affiliated Shanghai 6th hospital Shanghai Jiao Tong University Shanghai china ~5 department of Orthopaedic Surgery The 2nd affiliated hospital Harbin medical University Heilongjiang china ~6 department of Orthopaedic Surgery Nanjing Gulou hospital Nanjing medical University Jiangsu china ~7 department of Orthopaedic Surgery The 2nd affiliated hospital kunming medical college yunnan china ~8 Chinese Osteoporosis Foundation of CHPF Beijing china ~9 department of Orthopaedic Surgery Haikou Peoples hospital Hainan china ~10 department of Orthopaedic Surgery Beijing hospital Beijing china ~11 department of Orthopaedic Surgery The 3rd affiliated hospital kunming medical college yunnan china

＜正＞Objective:To study the prevalence of senile osteoporotic fracture in ten clinical center patients in china,in order to afford many epidemiology evidences for prevention of the different kinds of osteoporotic fra...

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