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Approximating probabilities of correlated events

Science China Mathematics 2010年第11期53卷 2937-2948页

作者： LI QiZhai1,2, ZHENG Gang3, LIU AiYi4, LI ZhaoHai2,5 & YU Kai2 1Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, China 2biostatistics branch, division of cancer epidemiology and genetics, national cancer institute, bethesda, md 20892, usa 3Office of biostatistics Research, national Heart, Lung and Blood institute, bethesda, md 20892, usa 4biostatistics and Bioinformatics branch, national institute of Child Health and Human Development, bethesda, md 20892, usa 5Department of Statistics, George Washington University, Washington, DC 20052, usa 1. Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China2. Biostatistics Branch Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD 20892 USA3. Office of Biostatistics Research National Heart Lung and Blood Institute Bethesda MD 20892 USA4. Biostatistics and Bioinformatics Branch National Institute of Child Health and Human Development Bethesda MD 20892 USA5. Department of Statistics George Washington University Washington DC 20052 USA

Efron (1997) considered several approximations of p-values for simultaneous hypothesis testing. An extension of his approaches is considered here to approximate various probabilities of correlated events. Compared with multiple-integrations, our proposed method, the parallelogram formulas, based on a one-dimensional integral, not only substantially reduces the computational complexity but also maintains good accuracy. Applications of the proposed method to genetic association studies and group sequential analysis are investigated in detail. Numerical results including real data analysis and simulation studies demonstrate that the proposed method performs well.

关键词： case-control group sequential test genetic association studies MAX parallelogram

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Use of Impella cardiac axial flow pump for cardiogenic shock(A newer alternative)-How good is the evidence?

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BIOCELL 2022年第5期46卷 1139-1150页

作者： RAFIQ AHMED BHAT SYED MANZOOR ALI YOOSUF ALI ASHRAF MUHAMMAD HUSSENBOCUS AKANKSHA RATHI JAVAID AKHTER BHAT ABDUL ALEEM KHAN SYED MAQBOOL RAJA SAQIB IQBAL md MONOWARUL ISLAM YONGSHENG QU YOU ZHANG YUXIAO SUN WENTAO XIAO ABHISHEK TIBREWAL CHUANYU GAO Zhengzhou University People’s Hospital Department of CardiologyFuwai Central China Cardiovascular HospitalZhengzhouChina Department of Cardiology Super Speciality DivisionGovernment Medical CollegeSrinagarIndia Department of Rheumatology and Immunology Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjingChina Department of Community Medicine Vedanta Institute of Medical SciencesPalgharIndia State Key Laboratory of Crop genetics and Germplasm Enhancement Nanjing Agricultural UniversityNanjingChina Department of Orthopaedics Nanjing First HospitalNanjing Medical UniversityNanjingChina Department of Paediatrics Batra Hospital and Medical Research CentreNew DelhiIndia Zhengzhou University First Affiliated Hospital ZhengzhouChina Department of Community Medicine Institute of Biostatistics and EpidemiologyGurgaonIndia

The adverse outcomes of a ventricular heart failure(left,right or biventricular)caused by cardiogenic shock are aggravated by lung oedema and organ mal *** advances in medical sciences,revascularisation and mechanical hemodynamic support have proved ineffective in reducing the mortality rate in such patients.A thorough study of the data available about cardio-vascular diseases reveals that the application of conventional methods of treatment are least helpful to practically restore normal functions of heart when it experiences end-stage systolic ventricular ***,to overcome the challenges and find alternatives to address this issue,percutaneous ventricular support devices/machines were designed and successfully *** devices have revolutionized the treatment of ventricular heart failures and are now in use all over the *** this review paper a newer mechanical circulatory support(MCS)device,Impella,has been discussed and compared with a few other devices like Intra-aortic Balloon Pump(IABP),Extracorporeal Circulation(ECLS)and Veno-arterial Extracorporeal Membrane Oxygenation(VA-ECMO).This article studies the challenges being faced during the treatment of cardiogenic shock,and thoroughly discusses the use and effectiveness of Impella Cardiac Axial Pump in each *** can be said that mechanical circulatory support(MCS)device use during percutaneous coronary intervention(PCI)should be individualized based on multiple factors with a recommended use in patients with the greatest potential benefit and a relatively low risk of device-related *** current literature suggests that the outcomes of use of Impella and other mechanical circulatory support devices like IABP and VA-ECMO are *** there seem to be a few advantages of Impella over the others,sufficiently powered,multi-centric,randomised control trials are needed to establish its superiority.

关键词： Cardiogenic shock Hemodynamic support Impella Cardiac Axial Pump IABP VA-ECMO

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Biological and Molecular Components for Genetically Engineering Biosensors in Plants

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BioDesign Research 2022年第1期2022卷 19-37页

作者： Yang Liu Guoliang Yuan md MahmudulHassan Paul E.Abraham Julie C.Mitchell Daniel Jacobson Gerald A.Tuskan Arjun Khakhar June Medford Cheng Zhao Chang-Jun Liu Carrie A.Eckert Mitchel J.Doktycz Timothy J.Tschaplinski Xiaohan Yang Biosciences division Oak Ridge National LaboratoryOak RidgeTennessee37831USA The Center for Bioenergy Innovation Oak Ridge National LaboratoryOak RidgeTennessee37831USA Department of genetics and Plant Breeding Patuakhali Science and Technology UniversityDumkiPatuakhali8602Bangladesh Departmentof Biology Colorado State UniversityFort CollinsColorado80523USA Shenzhen branch Guangdong Laboratory for Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese A cademy of Agriculural SciencesShenzhen 518120China Biology Department Brookhaven National LaboratoryUptonNew York 11973USA

Plants adapt to their changing environments by sensing and responding to physical,biological,and chemical *** to their sessile lifestyles,plants experience a vast array of external stimuli and selectively perceive and respond to specific *** repurposing the logic circuitry and biological and molecular components used by plants in nature,genetically encoded plant-based biosensors(GEPBs)have been developed by directing signal recognition mechanisms into carefully assembled outcomes that are easily *** allow for in vivo monitoring of biological processes in plants to facilitate basic studies of plant growth and *** are also useful for environmental monitoring,plant abiotic and biotic stress management,and accelerating design-build-test-learn cycles of plant *** the advent of synthetic biology,biological and molecular components derived from alternate natural organisms(e.g.,microbes)and/or de novo parts have been used to build *** this review,we summarize the framework for engineering different types of *** then highlight representative validated biological components for building plant-based biosensors,along with various applications of plant-based biosensors in basic and applied plant science ***,we discuss challenges and strategies for the identification and design of biological components for plant-based biosensors.

关键词： Plants Molecular monitoring

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