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Dynamics of morphological changes for mitochondrial fission and fusion

Science China(Physics,Mechanics & Astronomy) 2010年第4期53卷 680-689页

作者： WANG ShiQi 1,2,4 , FU ChangLiang 1,2 , ZHANG Yan 1,2 , CHEN Quan 3 & LONG Mian 1,2 1 Key laboratory of Microgravity (national Microgravity laboratory), beijing 100190, China 2 Center for Biomechanics and Bioengineering, Institute of Mechanics, Chinese Academy of sciences, beijing 100190, China 3 State Key laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of sciences, beijing 100101, China 4 Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of sciences, beijing 100044, China Key laboratory of Microgravity (national Microgravity laboratory) Beijing China Chinese Academy of sciences Center for Biomechanics and Bioengineering Institute of Mechanics Beijing China (GRID:grid.9227.e) (ISNI:***) Chinese Academy of sciences Institute of Vertebrate Paleontology and Paleoanthropology Beijing China (GRID:grid.9227.e) (ISNI:***) Key laboratory of Microgravity (national Microgravity laboratory) Beijing China (GRID:grid.9227.e) Chinese Academy of sciences Center for Biomechanics and Bioengineering Institute of Mechanics Beijing China (GRID:grid.9227.e) (ISNI:***) Chinese Academy of sciences State Key Laboratory of Biomembrane and Membrane Biotechnology Institute of Zoology Beijing China (GRID:grid.9227.e) (ISNI:***)

Mitochondria experience continuous fusion and fission in a living cell, but their dynamics remains poorly quantified. Here a theoretical model was developed, upon a simplified population balance equation (PBE), to predict the morphological changes induced by mitochondrial fission and fusion. Assuming that both fission and fusion events are statistically independent, the survival probability of mitochondria staying in the fission or fusion state was formulated as an exponentially-decayed function with time, which depended on the time-dependent distribution of the mitochondrial volume and the fission and fusion rates. Parametric analysis was done for two typical volume distributions. One was Gamma distribution and the other was Gaussian distribution, derived from the measurements of volume distribution for individual mitochondria in a living cell and purified mitochondria in vitro. The predictions indicated that the survival probability strongly depended on morphological changes of individual mitochondria and was inversely correlated to the fission and fusion rates. This work provided a new insight into quantifying the mitochondrial dynamics via monitoring the evolution of the mitochondrial volume.

关键词： mitochondria morphology fission fusion dynamics modeling

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Density functional theory study of the magnetic properties of rare earth complexes:the magnetic coupling mechanism in Y~Ⅲ and Gd~Ⅲ complexes with nitronyl nitroxide

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Science China Chemistry 2009年第11期52卷 1961-1968页

作者： REN Jie1,2,WANG BingWu1 & CHEN ZhiDa1 1 beijing national laboratory for molecular sciences,State Key laboratory of Rare Earth Materials Chemistry and Applications,College of Chemistry and molecular Engineering,Peking University,beijing 100871,China 2 College of Science,Hebei University of Science and Technology,Shijiazhuang 050018,China beijing national laboratory for molecular sciences State Key Laboratory of Rare Earth Materials Chemistry and Applications College of Chemistry and Molecular Engineering Peking University Beijing China College of Science Hebei University of Science and Technology Shijiazhuang China

The magnetic coupling interactions of the nitronyl nitroxide radicals bound to diamagnetic(YⅢ) and paramagnetic(GdⅢ) rare earth ions in two model magnetic systems based on novel rare earth organic radical complexes Ln(hfac)3(NITPhOCH3)2(Ln=YⅢ 1,GdⅢ 2;hafc = hexafluoroacetylacetonate;NIT-PhOCH3 = 4'-methoxyo-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide) have been investigated by density functional theory(DFT).The magnetic coupling mechanisms were also explored from the viewpoint of molecular orbital and spin density *** calculations show that the empty 4d-orbitals of YⅢ and 5d-orbitals of GdⅢ play an important role in the antiferromagnetic coupling between the two nitronyl nitroxide radical ligands,and that the ferromagnetic coupling between the GdⅢ ion and the radical magnetic centers can be attributed to the nearly complete localization of the isotropic 4f-shell and singly occupied magnetic orbital(π) of the nitronyl nitroxide.

关键词： magnetic coupling density functional theory rare earth ion gadolinium(Ⅲ) complexes yttrium(Ⅲ) complexes

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Influenza A virus H5N1 entry into host cells is through clathrin-dependent endocytosis

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Science China(Life sciences) 2009年第5期52卷 464-469页

作者： WANG HongLiang & JIANG ChengYu national Key laboratory of Medical molecular Biology, Institute of Basic Medical sciences, Chinese Academy of Medical sciences and Peking Union Medical College, beijing 100005, China national Key laboratory of Medical molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100005 China.

Influenza A virus H5N1 presents a major threat to human health. The entry of influenza virus into host cells is believed to be mediated by hemagglutinin (HA), a virus surface glycoprotein that can bind terminal sialic acid residues on host cell glycoproteins and glycolipids. In this study, we elucidated the pathways through which H5N1 enters human lung carcinoma cell line A549. We first proved that H5N1 can enter A549 cells via endocytosis, as lysosomotropic agents, such as bafilomycin A1 and chloroquine, can rescue H5N1-induced A549 cell death. By using specific inhibitors, and siRNAs that target the clathrin pathway, we further found that H5N1 could enter A549 cells via clathrin-mediated endocytosis, while inhibitors targeting caveolae-mediated endocytosis could not inhibit H5N1 cell entry. These findings expand our understanding of H5N1 pathogenesis and provide new information for anti-viral drug research.

关键词： influenza A H5N1 endocytosis lysosomotropic agents clathrin

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A new DNA algorithm to solve graph coloring problem

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Progress in Natural Science:Materials International 2007年第6期17卷 733-738页

作者： Jiang Xingpeng1, Li Yin2, Meng Ya3 and Meng Dazhi2(1. national laboratory of Pattern Recognition,Institute of Automation, Chinese Academy of sciences, beijing 100080, China 2. College of Applied sciences, beijing University of Technology, beijing 100022, China 3. School of Science, beijing Institute of Technology, beijing 100081, China) national laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Beijing 100080 China national High Magnetic Field laboratory Florida State University 1800 East Paul Dirac Drive Tallahassee Florida 32306 USA

Using a small quantity of DNA molecules and little experimental time to solve complex problems successfully is a goal of DNA computing. Some NP-hard problems have been solved by DNA computing with lower time complexity than conventional computing. However, this advantage often brings higher space complexity and needs a large number of DNA encoding molecules. One example is graph coloring problem. Current DNA algorithms need exponentially increasing DNA encoding strands with the growing of problem size. Here we propose a new DNA algorithm of graph coloring problem based on the proof of four-color theorem. This algorithm has good properties of needing a relatively small number of operations in polynomial time and needing a small number of DNA encoding molecules (we need only 6R DNA encoding molecules if the number of regions in a graph is R).

关键词： DNA computing NP-hard problem graph coloring problem.

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In Memoriam: Professor Ray WU

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Science China(Life sciences) 2010年第4期53卷 531-532页

作者： HUANG Bing-Ren national laboratory of Medical molecular Biology, Department of Biochemistry and molecular Biology, Peking Union Medical College & Chinese Academy of Medical sciences, beijing 100005, China national laboratory of Medical molecular Biology Department of Biochemistry and Molecular Biology Peking Union Medical College & Chinese Academy of Medical Sciences

During the Chinese New Year holidays in 2008, Professor Zhang Nai-Heng, former chair of the Department of Biochemistry, beijing Medical College, informed me of the sad news that Professor Ray Wu had passed away in Ith... 详细信息

关键词： In Memoriam very Professor Ray WU DNA

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Spectroscopic study of globular clusters in the halo of M31 with the Xinglong 2.16 m telescope

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Research in Astronomy and Astrophysics 2011年第11期11卷 1298-1310页

作者： Zhou Fan1,2,Ya-Fang Huang1,2,Jin-Zeng Li1,2,Xu Zhou1,2,Jun Ma1,2,Hong Wu1,2,Tian-Meng Zhang1,2 and Yong-Heng Zhao1,2 1 national Astronomical Observatories,Chinese Academy of sciences,beijing 100012,China 2 Key laboratory of Optical Astronomy,national Astronomical Observatories,Chinese Academy of sciences,beijing 100012,China national Astronomical Observatories Chinese Academy of Sciences Key laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences

We present spectroscopic observations for 11 confirmed globular clusters(GCs) of M31 with the OMR spectrograph on the 2.16 m telescope at the Xinglong site of national Astronomical Observatories,Chinese Academy of *** of our sample clusters are located in the halo of M31 and the most remote one is out to a projected radius of 78.75 kpc from the galactic *** all our sample clusters,we measured the Lick absorption-line indices and radial *** is noted that most GCs in our sample are distinct from the HI rotation curve of galaxy M31,especially for B514,MCGC5,H12 and B517,suggesting that most of our sample clusters do not have a kinematic association with the star-forming young disk of the *** separately fitted the absorption line indices from the updated stellar population model of Thomas et *** two different tracks of Cassisi and Padova,by applying the χ2 minimization *** fitting results show that all our sample clusters are older than 10 Gyr,and metal-poor(2.38 ≤ [Fe/H] ≤ 0.91 dex).After merging the spectroscopic metallicity of our work with the previously published ones,we extended the cluster sample out to a projected radius of 117 kpc from the galaxy's *** found the metallicity gradient exists for all the confirmed clusters with a slope of 0.028 ± 0.001 dex kpc ***,the slope turns out to be 0.018 ± 0.001 dex kpc 1 for all the halo clusters,which is much *** we only consider the outer halo clusters with rp > 25 kpc,the slope becomes 0.010 ± 0.002 dex kpc 1 and if one cluster G001 is excluded from the outer halo sample,the slope is 0.004 ± 0.002 dex kpc ***,we conclude that the metallicity gradient for M31's outer halo clusters is not significant,which agrees well with previous findings.

关键词： galaxies individual(M31) — galaxies star clusters — globular clusters general — star clusters general

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Influence of magnetic current on the ground state entanglement in an isotropic transverse XY chain

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Progress in Natural Science:Materials International 2007年第10期17卷 1147-1151页

作者： Liu Dan1,2 , Zhang Yong3 and Long Guilu1,2(1. Key laboratory for Atomic and molecular Nanosciences, and Department of Physics, Tsinghua University, beijing 100084, China 2. Center of Quantum Information Science and Technology, Tsinghua national laboratory for information Science and Technology, beijing 100084, China 3. Institute of Physics, School of sciences, beijing University of Posts and Telecommunications, beijing 100876, China) Key laboratory for Atomic and molecular Nanosciences and Department of Physics Tsinghua University Beijing 100084 China

We study the ground state entanglement in a three-qubit XY chain under the influence of a magnetization current. It is found that the ground state changes from a W state to a disentangled state as the magnetic field varies. When the Lagrange multiplier λ>3, namely under a strong magnetic current, the ground state holds onto a W state for a large range of the magnetic field strength. A phase transition to the magnetization-current phase occurs under a certain condition.

关键词： Heisenberg-XY chain magnetic-current phase transition.

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FTIR Spectroscopic Study of Crystallization of Uniaxial Drawn Syndiotactic Polystyrene/Carbon Nanotube Nanocomposite Films

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Chemical Research in Chinese Universities 2012年第1期28卷 153-155页

作者： ZHANG Jin-hao1,2, YANG Ji-ping1, YUAN Cui-ping1,2 and CHEN Guang-ming2 1. School of Materials Science and Engineering, Beihang University, beijing 100191, P. R. China 2. beijing national laboratory for molecular sciences(BNLMS), Institute of Chemistry, Chinese Academy of sciences, beijing 100190, P. R. China School of Materials Science and Engineering Beihang University Beijing 100191 Institute of Chemistry Chinese Academy of Sciences Beijing National Laboratory for Molecular Sciences (BNLMS) Beijing 100190

The crystallization of uniaxial hot drawn syndiotactic polystyrene/multi-walled carbon nanotube （sPS/MWCNT） nanocomposite films was studied by FTIR spectroscopy. The effects of MWCNT content, draw ratio and drawing temperature on the sPS crystallinity were investigated. The sPS/MWCMT nanocomposite films show reduced crystallinities with the increase of MWCNT content. In addition, with the increase of draw ratio, both the pure sPS and the sPS/MWCNT nanocomposite drawn films exhibit increased crystallinity. The effect of drawing temperature on the sPS crystallization is complex. In a temperature range of 100―135 °C, the crystallinity decreases with drawing temperature, whereas it increases at 140 °C for both pure sPS and its nanocomposite films.

关键词： Carbon nanotube Crystallization FTIR spectroscopy Nanocomposite Syndiotactic polystyrene

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Phase separation of ploy(ethylene glycol) + n-butanol mixture induced by supercritical CO_2

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Chinese Chemical Letters 2007年第6期18卷 738-740页

作者： Min Qiang Hou, Shu Guang Liang, Ji Yuan Song, Xiao Yong Li, Zhao Fu Zhang, Tao Jiang, Bu Xing Han beijing national laboratory for molecular sciences, Institute of Chemistry, Chinese Academy of sciences, beijing 100080, China beijing national laboratory for molecular sciences Institute of ChemistryChinese Academy of SciencesBeijing 100080China

The phase behavior of supercritical (SC) CO2 + PEG 1000 (PEG with average molecular weight of 1000 g/mol) + n-butanol system was studied. It was demonstrated that SC CO2 could induce phase separation of PEG 1000 + n-butanol system under suitable conditions. This hints that SC CO2 has potential applications in the separation of mixtures of PEG + organic compound.

关键词： PEG1000 CO2 n-Butanol Phase behavior Separation

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A brief account on the study of the insulin crystal structure In retrospect:Forty years after the determination of insulin’s crystal structure by Chinese scientists

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Science China(Life sciences) 2010年第1期53卷 13-15页

作者： WANG Da-Cheng1 & GU XiaoCheng2 1 national laboratory of Macromolecules,Institute of Biophysics,Chinese Academy of sciences,beijing 100101,China 2 College of Life sciences,Peking University,beijing 100871,China national laboratory of Macromolecules Institute of Biophysics Chinese Academy of Sciences College of Life sciences Peking University

"Standards there as high as achieved elsewhere";news delivered to the world by Science in China Approximately forty years ago when China was undergoing a period of great difficulty, Science in China,

关键词： A brief account on the study of the insulin crystal structure In retrospect

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