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Acta Biochimica et Biophysica Sinica 2004年第5期36卷 360-364页

作者： Cong-Jing FENG1,2 and Wen-Jun FU1* 1Institute of Plant Physiology and Ecology, Shanghai Institute for Biological sciences, the chinese academy of sciences, Shanghai 200025, China 2the graduateschool of the chinese academy of sciences, beijing 10003., China Institute of Plant Physiology and Ecology Shanghai Institute for Biological Sciences the Chinese Academy of Sciences The Graduate School of the chinese academy of sciences

Using ammonium sulphate precipitation, Blue-Sepharose CL-6B, Phenyl-Sepharose CL-4B, prophenoloxidase (PPO) was isolated and purified from hemolymph of Ostrinia furnacalis larvae. This zy- mogen was a heterodimer, and composed of two subunits with the relative molecular mass ranging from 66.2 kD to 97.4 kD determined by SDS-PAGE. Western blotting and indirect immunofluorescence test showed that PPO was present in integument, hemolymph plasma and cell membrane of granular hemocytes and oenocytoids of O. furnacalis larvae.

关键词： Ostrinia furnacalis prophenoloxidase tissue distribution purification

2023 Guideline for the management of hypertension in the elderly population in China

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Journal of Geriatric Cardiology 2024年第6期21卷 589-630页

作者： Hypertension Branch of chinese Geriatrics Society,beijing Hypertension Association,National Clinical Research Center of the Geriatric Diseases Qi HUA Li FAN Zeng-Wu WANG Jing LI 不详 Xuanwu Hospital Capital Medical UniversityBeijingChina chinese PLA General Hospital BeijingChina Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Preamble Hypertension is one of the most common chronic diseases and the primary risk factor for stroke,myocardial infarction and even cardiovascular *** than half of the elderly population has high blood *** people are a unique group,and strategies for the prevention,diagnosis,evaluation,and treatment of hypertension in elderly individuals differ significantly from those in the general population.

关键词： hypertension prevention diagnosis

Geometry of Broad Line Regions of Active Galactic Nuclei

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chinese Journal of Astronomy and Astrophysics 2008年第1期8卷 50-62页

作者： Xiao-Rong Lü1 Key Laboratory for Particle Astrophysics, Institute of High Energy Physics, chinese academy of sciences, beijing 100049 2 Graduate School of chinese academy of sciences, beijing 100049 Key Laboratory for Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 and Graduate School of chinese academy of sciences Beijing 100049

It has long remained an open question as to the geometry of the broad line region （BLR） in active galactic nuclei （AGNs）. The reverberation mapping technique which measures the response of the broad emission lines to the ionizing continuum, when combined with multiwavelength continuum fitted by sophisticated accretion disks, provides a way of probing the BLR geometry. We analyze a sample of 35 AGNs, which have been monitored by the reverberation mapping campaign. In view of energy budget, the reverberation-based BH masses are found to be in agreement with those obtained by accretion disk models in two thirds of the present sample while the reverberation mapping methods underestimate the BH masses in about one third of objects, as also suggested by CoUin et al. in a recent work. We point out that there are obviously two kinds of BLR geometry, which are strongly dependent on the Eddington ratio, and separated by the value LBol/LEdd - 0.1. These results prefer a scenario of the disk and wind configuration of the BLR and identify the Eddington ratio as the physical driver regulating the wind in the BLR.

关键词： accretion, accretion disks - galaxies active - galaxies Seyfert - quasars general

chinese Guidelines for the Diagnosis and Management of Atrial Fibrillation

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Journal of Geriatric Cardiology 2024年第3期21卷 251-314页

作者： Chang-Sheng MA Shu-Lin WU Shao-Wen LIU Ya-Ling HAN chinese Society of Cardiology chinese Medical Association Heart Rhythm Committee of chinese Society of Biomedical Engineering beijing Anzhen Hospital Capital Medical University Guandong Provincial People’s Hospital Shanghai First People’s Hospital General Hospital of Northern Theater Command 不详

Atrial fibrillation(AF)is the most common sustained cardiac arrhythmia,significantly impacting patients’quality of life and increasing the risk of death,stroke,heart failure,and *** the past two decades,there have been significant breakthroughs in AF risk prediction and screening,stroke prevention,rhythm control,catheter ablation,and integrated *** this period,the scale,quality,and experience of AF management in China have greatly improved,providing a solid foundation for the development of guidelines for the diagnosis and management of *** further promote standardized AF management,and apply new technologies and concepts to clinical practice in a timely and comprehensive manner,the chinese Society of Cardiology of the chinese Medical Association and the Heart Rhythm Committee of the chinese Society of Biomedical Engineering have jointly developed the chinese Guidelines for the Diagnosis and Management of Atrial *** guidelines have comprehensively elaborated on various aspects of AF management and proposed the CHA2DS2-VASc-60 stroke risk score based on the characteristics of AF in the Asian *** guidelines have also reevaluated the clinical application of AF screening,emphasized the significance of early rhythm control,and highlighted the central role of catheter ablation in rhythm control.

关键词： prevention sustained diagnosis

Ionization state of cosmic hydrogen by early stars and quasars

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Research in Astronomy and Astrophysics 2009年第6期9卷 665-681页

作者： Xiao-Chun Mao1,2 1 National Astronomical Observatories, chinese academy of sciences, beijing 100012, China 2 Graduate University of chinese academy of sciences, beijing 100049, China National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Graduate University of chinese academy of sciences Beijing 100049 China

Cosmic hydrogen is reionized and maintained in its highly ionized state by the ultraviolet emission attributed to an early generation of stars and quasars. The Lyα opacity observed in absorption spectra of high-redshift quasars permits more stringent constraints on the ionization state of cosmic hydrogen. Based on density perturbation and structure formation theory, we develop an analytic model to trace the evolution of the ionization state in the post-overlap epoch of reionization, in which the bias factor is taken into account. For quasars, we represent an improved luminosity function by utilizing a hybrid approach for the halo formation rate that is in reasonable agreement with the published measurements at 2 ≤ z ≤ 6. Comparison with the classic Press-Schechter mass function of dark matter halos, we demonstrate that the biased mass distribution indeed enhances star formation efficiency in the overdense environment by more than 25 per cent following the overlap of ionized bubbles. In addition, an alternative way is introduced to derive robust estimates of the mean free path for ionizing photons. In our model, star-forming galaxies are likely to dominate the ionizing background radiation beyond z = 3, and quasars contribute equally above a redshift of z ～ 2.5. From 5 ≤ z ≤ 6, the lack of evolution in photoionization rate can thus be explained by the relatively flat evolution in star formation efficiency, although the mean free path of ionizing photons increases rapidly. Moreover, in the redshift interval z ～ 2 - 6, the expected mean free path and Gunn-Peterson optical depth obviously evolve by a factor of ～ 500 and ～50 respectively. We find that the relative values of critical overdensities for hydrogen ionization and collapse could be 430% at z ≈2 and 2% at z ≈6, suggesting a rapid overlap process in the overdense regions around instant quasars following reionization. We further illustrate that the absolute estimates of the fraction of neutral hydrogen computed fr

关键词： cosmology theory -- formation galaxies -- quasars general -- diffuse radiation -- intergalactic medium

Infrared Galaxies in the Nearby Universe

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chinese Journal of Astronomy and Astrophysics 2008年第6期8卷 643-652页

作者： Jian-Ling Wang 1 National Astronomical Observatories,chinese academy of sciences,beijing 100012,China 2 Graduate School of chinese academy of sciences,beijing 100049,China National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Graduate School of chinese academy of sciences Beijing 100049 China

We used the Sloan Digital Sky Survey （SDSS） Data Release 5 （DR5） to study the morphological properties of 113. nearby infrared （IR） galaxies, most of which are brighter than 15.9 mag in r-band. This sample was drawn from a cross-correlation of the Infra-Red Astronomical Satellite （IRAS） point source catalog redshift survey with DR5 at z ≤ 0.08. Based on this IR galaxy sample, we constructed five volume-limited sub-samples with IR luminosity ranging from 10^9.5 L⊙ to 10^12L⊙. By deriving the IR luminosity functions （LF） for different morphological types, we found that normal spiral galaxies are the dominant population below LIR ~ 8 ~ 10^10 L⊙; while the fraction of barred spiral galaxies increases with increasing IR luminosity and becomes dominant in spiral galaxies beyond LIR ≈ 5 × 10^10L⊙. As the IR luminosity decreases, the IR galaxies become more compact and have lower stellar masses. The analysis also shows that normal spiral galaxies give the dominant contribution to the total comoving IR energy density in the nearby universe, while, in contrast, the contribution from peculiar galaxies is only 39%.

关键词： galaxies evolution galaxies interactions galaxies starburst infrared galaxies galaxies luminosity function

High Throughput SNP Genotyping with Two Mini-sequencing Assays

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Acta Biochimica et Biophysica Sinica 2004年第6期36卷 379-384页

作者： Chunqing LUO1,2#, Libin DENG1#, and Changqing ZENG1,2* The Institute of Genetic and Developmental Biology, the chinese academy of sciences, beijing 100101, China 2beijing Genomics Institute, the chinese academy of sciences, beijing 1013.0, China The Institute of Genetic and Developmental Biology the Chinese Academy of SciencesBeijing 100101 China beijing Genomics Institute the Chinese Academy of SciencesBeijing 101300 China

Two mini-sequencing methods, FP-TDI (template-directed dye-terminator incorporation with fluorescence-polarization) and MassArray (matrix assisted laser desorption ionization time of flight detection mass spectrometry), were optimized. A numeric standard was introduced to evaluate the SNP scoring quality of FP-TDI assay, thus made the optimization work easier. At the same time, using multi-PCR technology, 8-plex genotyping of MassArray assay was successfully carried out, some softwares were developed and the data process of MassArray was highly automated. Then these two methods were applied to high throughput SNP genotyping, the accuracy, efficiency and robustness were compared. The result shows FP-TDI is more sensitive to the concentration of SNPprimer and PCR product, as well as extension cycles, the SNPprimer length of FP-TDI should be 24–30 bp long, whereas MassArray assay prefers to be as short as only 16 *** 6440 SNP sites of human chromosome 3 were genotyped in a sample of 90 individuals, 4792 sites by FP-TDI assay and 1648 sites by MassArray assay, the success rates of FP-TDI and MassArray were 67.7% and 93.6% respectively. The throughput of MassArray was higher than FP-TDI, and the cost of MassArray was lower, MassArray was more suitable for high throughput SNP genotyping.

关键词： SNP genotyping FP-TDI MassArray high throughput

Vilnius Photometry and Reddening of the Young Open Cluster NGC 6913

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chinese Journal of Astronomy and Astrophysics 2001年第4期1卷 333-343页

作者： Jun-Jie Wang and Jing-Yao Hu (National Astronomical Observatories, chinese academy of sciences, beijing 100012 beijing Astronomical Observatory, chinese academy of sciences, beijing 100012 chinese academy of sciences-Peking University Joint beijing As chinese academy of sciences-Peking University Joint beijing Astrophysical Center Beijing 100871

stars in the NGC 6913.field with both UBV and Vilnius photometry are selected to be the sample. The membership probability of the stars is greater than 50%. The correlation among Vilnius photometry, UBV photometry and reddening in the cluster is reviewed. It is found that the photometry in the Vilnius X, Y and Z bands can be used to make rough spectral classification. The values of E(B - V) are well correlated with the Vilnius colors of X - Y, Y - Z, Z - V and V - S in NGC 6913. The ratio of (V - S)/(Y - Z) of the MPCM (Most Possible Cluster Members) is a constant (1.30 -±0.06), and has no effect on the values of E(B - V), (B - V)0 and V0. Comparing with the observational data of all the stars of NGC 6913.region, we propose that the value of (V - S)/(Y - Z) can probably be used to select the preliminary candidates of one open cluster. In addition, 12 variable stars are discovered in the NGC 6913.region, in which star #155 has a variation with an amplitude of 4.25 mag.

关键词： Galaxy: open clusters and associations - ISM: dust extinction

Observation results of relativistic electrons detected by Fengyun-1 satellite and analysis of relativistic electron enhancement (REE) events

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Science China(Physics,Mechanics & Astronomy) 2008年第12期51卷 1947-1956页

作者： YANG XiaoChao1,2↑ & WANG ShiJin1 1 Center for Space Science and Applied Research, chinese academy of sciences, beijing 100190, China 2 Graduate University of chinese academy of sciences, beijing 100049, China 1. Center for Space Science and Applied Research Chinese Academy of Sciences Beijing 100190 China 2. Graduate University of chinese academy of sciences Beijing 100049 China

The space particle component detector on Fengyun-1 satellite which works at the sun-synchronous orbit of about 870 km altitude has detected relativistic electrons for a long time. In comparison with the SAMPEX satellite observations during 1999–2004, the relativistic electron data from Fengyun-1 satellite from June 1999 to 2005 are used to analyze the relativistic electron enhancement (REE) events at the low earth orbit, and the possible correlation among REE events at the low earth orbit, high-speed solar wind and geomagnetic storms is discussed. The statistical result presents that 45 REE events are found in total during this time period, and the strong REE events with the maximum daily average flux > 400 cm?2·srt-1·s?1 occur mostly during the transition period from solar maximum to solar minimum. Among these 45 REE events, four strong REE events last a longer time period from 26-to 51-day and correlate closely with high speed solar wind and strong geomagnetic storms. Meanwhile, several strong geomagnetic storms occur continuously before these REE events, and these continuous geomagnetic storms would be an important factor causing these long-lasting strong REE events. The correlation analysis for overall 45 events indicates that the strength of the REE events correlates with the solar wind speed and the strength of the geomagnetic storm, and the correlation for strong REE events is much stronger than that for weak REE events.

关键词： relativistic electron enhancement low earth orbit high-speed solar wind geomagnetic storm

Direct Optimization of Low-thrust Many-revolution Earth-orbit Transfers

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chinese Journal of Aeronautics 2009年第4期22卷 426-433页

作者： Gao Yang academy of Opto-Electronics,chinese academy of sciences,beijing 100190,China [a]academy of Opto-Electronics Chinese Academy of Sciences Beijing 100190 China

Low-thrust Earth-orbit transfers with 10^- 5-order thrust-to-weight ratios involve a large number of orbital revolutions which poses a real challenge to trajectory optimization. This article develops a direct method to optimize minimum-time low-thrust many-revolution Earth-orbit transfers. A parameterized control law in each orbit, in the form of the true optimal control, is proposed, and the time history of the parameters governing the control law is interpolated through a finite number of nodal values. The orbital averaging method is used to significantly reduce the computational workload and the trajectory optimization is conducted based on the orbital averaging dynamics expressed by nonsingular equinoctial elements. Furthermore, Earth＇s shadowing and perturbation effects are taken into account. The optimal transfer problem is thus converted to the parameter optimization problem that can be solved by nonlinear programming. Taking advantage of the mapping between the parameterized control law and the Lyapunov control law, a technique is proposed to acquire good initial guesses for optimization variables, which results in enlarged convergence domain of the direct optimization method. Numerical examples of optimal Earth-orbit transfers are presented.

关键词： low thrust orbital transfer optimization direct method orbital averaging Lyapunov method