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Chemical Research in Chinese Universities 2012年第1期28卷 57-60页

作者： LIU Wei-dong2, DENG Xi-ling2, ZHANG Zhi-li2, WANG Xiao-wei2 and LIU Jun-yi1,2 1. state key laboratory of Natural and Biomimetic Drug, 2. Department of Chemical Biology, {3. of Pharmaceutical Sciences, peking university, beijing 100191, P. R. china peking Univ Sch Pharmaceut Sci State Key Lab Nat & Biomimet Drug Beijing 100191 Peoples R China peking Univ Sch Pharmaceut Sci Dept Biol Chem Beijing 100191 Peoples R China

6-（Bromomethyl）-4-methoxy-5,6,7,8-tetrahydropyrido[3.2-d]pyrimidin-2-ol（compound 9） was synthe sized from 6-methylpyrimidine-2,4-diol（compound 1） through the crucial steps of 6-methyl alkylating and intramo lecular cyclization. The assignment of the structure of compound 9 was performed by its spectral data, 1H NMR, 13. NMR, HMBC, and HRMS spectra.

关键词： Heterocycle Carbanion Alkylation Reduction Cyclization

Multilayer Film Fabrication and Photoelectric Conversion Property of Two Pyrrolidinofullerene Carboxylic Acid Derivatives

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Chinese Chemical Letters 2000年第2期11卷 161-164页

作者： Tian Xin WEI Jin ZHAI Liang Bing GAN Chun Hui HUANG (state key laboratory of Rare Earth Materials Chemistry and Applications, PKU-HKU Joint laboratory on Rare Earth Materials and Bioinorganic Chemistry peking university, beijing 100871) peking Univ State Key Lab Rare Earth Mat Chem & Applicat PKU HKU Joint Lab Rare Earth Mat & Bioinorgan Che Beijing 100871 Peoples R China

Two multilayer films of pyrrolidinofullerene carboxylic acid derivatives, which exhibit photoelectric conversion property, are reported here. The first monolayers were fabricated on hydrophilic indium-tin-oxide (ITO), quartz, and mica by esterification reaction. The multilayers were characterized by contact angle and UV spectrum. The photoelectric conversion properties of both multilayer films were studied.

关键词： self-assembled multilayer film fullerene derivative photoelectric conversion

EFFECT OF MOLECULAR WEIGHT OF PEO ON THE STRUCTURE AND PROPERTIES OF PDMAEMA/PEO HYDROGELS

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Chinese Journal of Polymer Science 2006年第1期24卷 35-40页

作者： Zhu-gen Liu Min Yi Mao-lin Zhai and Hong-fei Ha Department of Applied Chemistry and The key laboratory of Polymer Chemistry and Physics of Ministry of Education,College of Chemistry & Molecular Engineering,peking university,{3.,china peking Univ Coll Chem & Mol Engn Dept Appl Chem Beijing 100871 Peoples R China peking Univ Coll Chem & Mol Engn Minist Educ Key Lab Polymer Chem & Phys Beijing 100871 Peoples R China

A new kind of binary hydrogels composed of poly（dimethylaminoethylmethacrylate）（PDMAEMA） and poly（ethylene oxide）（PEO） with varying weight average molecular weights （M^-w = 5 × 10^4, 1 × 10^5 and 2.5 × 10^6） were prepared by У-irradiation technology. The properties of PDMAEMA/PEO hydrogels obtained were evaluated in terms of gel fraction, gel strength, thermal characterization and swelling behavior. The gel strength and swelling degree of the hydrogels could be improved obviously after adding PEO into the PDMAEMA system, while the degree of improvement decreased with increasing M^-w of PEO. The temperature sensitivity of PDMAEMA/PEO was retained only in the sample with PEO of M^-w = 5 × 10^4, and the pH sensitivity was retained in samples with PEO of M^-w = 5 × 10^4 and 1 × 10^5. When DMAEMA/PEO mixtures containing PEO of M^-w = 5 × 10^4 were irradiated, the main reaction could be the cross-linking of DMAEMA, and the linear PEO molecular chains could penetrate into the cross-linked network of PDMAEMA. With increasing M^-w of PEO, some side reactions were induced, such as grafting of DMAEMA onto PEO molecules, the scission or cross-linking of PEO.

关键词： Poly(dimethylaminoethylmethacrylate) Poly(ethylene oxide) Molecular weight Binary hydrogels Irradiation.

The Isovector Channel of the Energy Density Functional

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The Isovector Channel of the Energy Density Functional

Sodium hydrosulfide alleviated pulmonary vascular structural remodeling induced by high pulmonary blood flow in rats

第十三届全国核结构研讨会暨第九次全国“核结构与量子力学”专题讨论会

作者： Xiaobao Wang~1 Chong Qi~2 Furong Xu~(1,3. 1 school of Physics,and state key {3.oratory of nuclear Physics and technology,peking university,beijing 100871,china 2 KTH,Alba Nova university Center,SE-10691 Stockholm,Sweden. 3.Center for Theoretical nuclear Physics,National {3.oratory for Heavy Ion Physics,Lanzhou 73.000,china

Both relativistic and non-relativistic energy density functional models have been widely used in describing the nuclear many-body *** calculations show that both relativistic and non-relativistic models give quite similar results for the ground state properties and low-energy dynamics of stable ***,significant differences are found when calculations go to the extreme cases of high isospin and high *** origin of these differences is still not *** non-relativistic Skyrme-Hartree-Fock (SHF) model has been extensively employed in the investigation of nuclear structure since the first work of Vautherin and *** 1970s,almost at the same time as SHF,the Relativistic-Mean-Field(RMF) model was developed to give a competitive description of finite *** relativistic Quark-Meson-Coupling model(QMC) was proposed by ***,the Hartree approximation is usually used in both RMF and QMC *** real treatment of the Fock term remains *** comparisons between relativistic models within the non-relativistic Hartree-Fock approximation and the Skyrme model can be instructive in clearing the *** this work,we compare the non-relativistic approximations of the QMC and RMF models and SHF models,with focusing on possible *** list the QMC energy density functional within the Hartree-Fock approximation and make comparison with RMF and Skyrme *** find that the discrepancy of these models is mainly caused by the isovector channel of the energy density functional.A new Skyrme parametrization is obtained by the *** also give the calculation results of the new parametrization.

关键词： energy density functional non-relativistic approximation Skyrme parametrization

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Acta Pharmacologica Sinica 2006年第8期27卷 971-980页

作者： Xiao-hui LI~2 Jun-bao DU~(2,6) Ding-fang BU~3.Xiu-ying TANG~4 Chao-shu TANG~5 ~1Department of Pediatrics,peking university First Hospital,key laboratory of Molecular Cardiovascular Diseases,Ministry of Education ~3.laboratory Center ~4laboratory of Electron Microscopy,peking university First Hospital,beijing 10003.,china ~5Department of Physiology,peking university Health Science Center,beijing 100083.china Department of Pediatrics Peking University First Hospital Key Laboratory of Molecular Cardiovascular Diseases Ministry of Education

Aim:To explore the possible role of endogenous hydrogen sulfide （H2S）,a novelgasotransmitter,in the pathogenesis of pulmonary vascular structural remodeling（PVSR） induced by high pulmonary blood ***:Thirty-two Sprague-Dawley male rats were randomly divided into sham,shunt,sham+NaHS （a H2Sdonor） and shunt+NaHS *** in shunt and shunt+NaHS groups under-went an abdominal aorta-inferior vena cava shunt,and rats in shunt+NaHS andsham+NaHS groups were intraperitoneally injected with *** was inves-tigated using optical microscope and transmission electron *** H2S was evaluated by sulfide-sensitive *** oxide synthase（NOS）,heme oxygenase （HO-1）,proliferative cell nuclear antigen （PCNA） andextracellular signal-regulated kinase （ERK） activation were analyzed by ***:After 11 weeks of shunting,PVSR developed with a decrease inlung tissue H2S production and an increase in nitric oxide （NO）.However,lungtissue carbon monoxide （CO） did not *** the treatment with NaHS for11 weeks,H2S donor ameliorated PVSR and downregulated PCNA expression andERK activation with an increase in lung tissue CO production and HO-1 proteinexpression but a decrease in NO production,NOS activity and eNOS proteinexpression in shunted ***:H2S exerted a regulatory effect on PVSRinduced by high pulmonary blood ***,H2S down-regulated theERK/MAPK signal pathway,inhibited the NO/NOS pathway and enhanced theCO/HO pathway in rats with high pulmonary blood flow.

关键词： hydrogen sulfide pulmonary hypertension structure remodeling nitric oxide/nitric oxide synthase carbon monoxide/heme oxygenase

A New Self-Assembled Monolayer of Fullerene Derivative and ItsPhotoelectric Conversion Property

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Chinese Chemical Letters 1999年第5期10卷 421-424页

作者： Jin ZHAI Tian Xin WEI Jun Hao GE Liang Bing GAN Chun Hui HUANG(state key laboratory of Rare Earth Materials Chemistry and Applications. {3..Beijng 100871) peking Univ State Key Lab Rare Earth Mat Chem & Applicat Beijing 100871 Peoples R China

A new self-assembled monolayer (SAM) of fullerene derivative has been fabricated and their photoelectric conversion property has been observed. The SAM was fabricated on indium-tin-oxide (ITO) and quartz by amide bonding. It was characterized bq contact angle, UV spectrum. and cyclic voltammetry. The mild fabrication conditions and the stability of the SAM provides a way to build three-dimensional structure more easily.

关键词： self-assembled monolayer C-60 derivatives photoelectric conversion

LARGE-EDDY SIMULATIONS OF TURBULENT CAVITY FLOWS WITH DYNAMIC SGS MODEL AND LBM ALGORITHM

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Transactions of Nanjing university of Aeronautics and Astronautics 2001年第Z1期18卷 60-63页

作者： Guan Hui (College of Science, PLA of university of Science and technology Nanjing 211101,P.R.china) Wu Chuijie ({3. key lab. of Turbulence Study, peking university beijing 100871,P.R.china) College of Science PLA of University of Science and Technology Nanjing 211101P. R. China state key lab. of Turbulence Study Peking University Beijing 100871 P. R. China

A new method of dynamic SGS model with LBM is described in detail and a new average method of eliminating the inherent unphysical oscillation of LBM are given in this paper. Results using the method to simulate the tw... 详细信息

关键词： dynamic subgrid model lattice Boltzmann method turbulence

Ghrelin protects myocardium from isoproterenol-induced injury in rats

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Acta Pharmacologica Sinica 2004年第9期 29-35页

作者： Lin CHANG, Jing ZHAO, Gui-zhong LI, Bin GENG2, Chun-shui PAN, Yong-fen QI, Chao-shu TANGInstitute of Cardiovascular Disease Research, the First Hospital beijing 10003., china key {3. for Cardiovascular Biology of Education Ministry, china, beijing 100083. china Department of Physiology, peking university, beijing 100083. chinaDepartment of Ningxia Medical College, Yinchuan 750004, china

AIM: To investigate the cardiac protective effects of ghrelin in rat with myocardial injury induced by isoproterenol (ISO). METHODS: Rats were subcutaneously injected ISO 40 mg·kg-1·d-1 with or without ghrelin 1 or 10 nmol·kg-1·d-1 for 2 d. Hemodynamic parameters including mean arterial blood pressure and left ventricular pressure were measured at 12 h after the last injection

关键词： ghrelin hemodynamics endothelin-1 lactate dehydrogenase malondialdehyde isoproterenol heart rats

FABRICATION OF SELF-ASSEMBLY DNA-C_(60) MULTILAYER FILMS

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Chinese Journal of Polymer Science 2002年第6期20卷 591-593页

作者： Shu-guang Yang Yong-jun Zhang Xin-hua Dai Wen-hong Tang Chun-yan Liu Wei-xiao Cao Yu-liang Li Jian Xu state key laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences,{3. 100080, china technology Institute of Physics and Chemistry Chinese Academy of Sciences, {3. 100101, china College of Chemistry and Molecular Engineering peking university beijing 100871, china Chinese Acad Sci Inst Chem State Key Lab Polymer Phys & Chem Beijing 100080 Peoples R China Chinese Acad Sci Technol Inst Phys & Chem Beijing 100101 Peoples R China peking Univ Coll Chem & Mol Engn Beijing 100871 Peoples R China

Electrostatic layer-by-layer self-assembly multilayer films were successfully fabricated from C-60-ethylenediamine adduct (C-60-EDA) and DNA. Under visible light irradiation, DNA is ready to be cleaved and the films a... 详细信息

关键词： self-assembly photo-induced cleavage DNA C-60

Microscopic analysis of order parameters in nuclear quantum phase transitions

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Microscopic analysis of order parameters in nuclear quantum ...