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Correlation of Behavior Changes and BoLD Signal in Alzheimer-like Rat Model

Acta Biochimica et Biophysica Sinica 2004年第12期36卷 803-810页

作者： Zheng-Hui HU#, Xiao-Chuan WANG1#, Li-Yun LI3, Mai-Li LIU3, Rong LIU1, Zhiqun LING1, Qing TIAN1, Xiao-Wei TANG, Yi-Gen WU2*, and Jian-Zhi WANG1* Department of physics and Bio-X disciplinary laboratory, Zhejiang University, Hangzhou 310027,china 1 Department of pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, china 2institute of high energy physics and key laboratory of nuclear analysis techniques, chinese academy of sciences, p.o. box 918, beijing 100039, china 3Wuhan institute of physics and Mathematics, State key laboratory of Magnetic Resonance and Atomic and Molecular physics, chinese academy of sciences, Wuhan 430071, china Department of physics and Bio-X disciplinary laboratory Zhejiang UniversityHangzhou 310027China Department of pathophysiology Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030 China Wuhan institute of physics and Mathematics State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Chinese Academy of SciencesWuhan 430071 China institute of high energy physics and key laboratory of nuclear analysis techniques Chinese Academy of SciencesP.O. Box 918 Beijing 100039 China

To exp.o.e a potential means for the early diagnosis of Alzheimer disease, we studied the relationship.o. resting T2* signal and tau hyperp.o.p.o.ylation/spatial memory deficit. The rat model with tau hyperp.o.p.o.ylation and spatial memory deficit was established by bilateral hip.o.ampi injection of isop.o.erenol (Ip). Then, the correlative alteration between resting T2* signal and spatial memory retention was assessed with blood oxygenation level dependent (BoLD) functional magnetic resonance imaging (fMRI) study and Morris Water Maze test, and Western blot was emp.o.ed to confirm tau hyperp.o.p.o.ylation. The analysis showed following results. (1) Tau p.o.p.o.ylation at Ser396/Ser404 and Ser199/Ser202 was signifi- cantly increased in Ip-injected rats as detected by pHF-1 and tau-1, respectively. (2) An AD-like spatial memory retention disturbance was induced at 24 h after isop.o.erenol injection. (3) A sensitivity threshold of resting T2* signal intensity, which separated the Ip-treated rats from vehicle control, was obtained by applying linear regression analysis, and an estimated sensitivity statistical threshold was at 32.62. These results suggest that resting T2* signal may serve as a noninvasive quantitative marker in predicting AD-like spatial memory deficits and tau hyperp.o.p.o.ylation.

关键词： Alzheimer disease (AD) functional magnetic resonance imaging (fMRI) isop.o.erenol (Ip) Morris Water Maze diagnosis

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Zircon and apatite fission track analyses on mineralization ages and tectonic activities of Tuwu-Yandong porphyry copper deposit in northern Xinjiang, china

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Science china Earth sciences 2007年第12期50卷 1787-1795页

作者： YUAN WanMing1,BAo ZengKuan2,DoNG JinQuan2,GUo ZhaoJie3 & DENG Jun1 1 State key laboratory of Geological p.o.esses and Mineral Resources,china University of Geosciences,beijing100083,china 2 laboratory of nuclear analysis techniques,institute of high energy physics,chinese academy of sciences,beijing 100039,china 3 Department of Geology,peking University,beijing 100871,china State key laboratory of Geological p.o.esses and Mineral Resources China University of Geosciences Beijing China laboratory of nuclear analysis techniques Institute of High Energy Physics Chinese Academy of Sciences Beijing China Department of Geology Peking University Beijing China

The mineralization ages reported in the past in the Tuwu-Yandong copper district not only are different,but also fall into the Hercynian *** study has achieved 9 zircon and 7 apatite fission track analysis *** zircon fission track ages range from 158 Ma to 289 Ma and the apatite ages are between 64 Ma and 140 *** mineralization accords with the regional tectonics in the copper *** consider that the zircon fission track age could reveal the mineralization age based on annealing zone temperature of 140―300℃ and retention temperature of ～250℃ for zircon fission track,and metallogenetic temperature of 120―350℃ in this ore *** three mineralization epochs have been identified,i.e.,289―276 Ma,232―200 Ma and 165―158 Ma,and indicate occurrence of the min-eralization in the Indosinian and Yanshan *** to apatite fission track ages,the three tectonic-mineralizing epochs are 140―132 Ma,109―97 Ma and 64 Ma,which means age at about 100℃ after the *** three epochs lasted 146 Ma,108 Ma and about 100 Ma from ～250℃ to ～100℃ and trend decrease from early to *** is shown by the fission track modeling that this district underwent three stages of geological thermal histories,stable in Cretaceous and cooling both before Cretaceous and after 20 Ma.

关键词： mineralization age, tectonic epoch, fission track, zircon, apatite, Tuwu-Yandong, Xinjiang

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A template of rat brain based on fMRI T2* imaging

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p.o.ress in Natural Science:Materials International 2005年第6期15卷 502-506页

作者： HU Zhenghui1, WU Yigen2, WANG Xiaochuan3, WANG Jianzhi3, CHEN Feiyan1 and TANG Xiaowei1*(1. Department of physics and Bio-X laboratory, Zhejiang University, Hangzhou 310027, china 2. institute of high energy physics and key laboratory of nuclear analysis techniques, chinese academy of sciences,beijing 100039, china 3. Department of pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, china) Department of physics and Bio-X laboratory Zhejiang University Hangzhou 310027 China key laboratory of nuclear analysis techniques Institute of High Energy Physics Chinese Academy of Sciences Beijing 100039 China Department of pathophysiology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

The development of functional magnetic resonance imaging (fMRI) technology has made it possible to carry out functional brain imaging experiments in small animals. Usually, group data is required to form the assessment of population, which can not only increase the sensitivity of the overall experiment, but also allow the generalization of the conclusion to the whole population. In order to average the signals of functional brain images from different subjects, it is necessary to put all the mapping images into the same standard space (template image). However, up to now, most animal brain templates remain unavailable and it must be done by ourselves. In this study, a template image based on the brains of eight male Wistar rats is obtained, and it is successfully used in our present Alzheimer disease (AD)-like rat model studies as template for spatially normalizing images to the same stereotaxical space. The fMRI results p.o.essed with statistical parametric mapping (SpM99) software are in agreement with the results from immunohistochemical experiment, which p.o.es that this method is universally applicable to the pathologic models of other small animals and to human brain lesion studies.

关键词： fMRI animal model atlas template normalization T*2.

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Heavy ion reactions around the Coulomb barrier

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中国科学：物理学、力学、天文学英文版 2011年第S1期54卷 6-13页

作者： ZHANG HuanQiao1, LIN ChengJian1, JIA HuiMing1, ZHANG ChunLei1,2, ZHANG GaoLong1,3, YANG Feng1, LIU ZuHua1, AN Guangpeng1, WU ZhenDong1, XU XinXing1 & JIA Fei1 1 china institute of Atomic energy, p. o. box 275(10), beijing 102413, china 2 particle Astrophysics Center, institute of high energy physics, chinese academy of sciences, beijing 100039, china 3 School of physics and nuclear energy Engineering, Beihang University, beijing 100191, china china institute of Atomic energy Beijing China particle Astrophysics Center Institute of High Energy Physics Chinese Academy of Sciences Beijing China School of physics and nuclear energy Engineering Beihang University Beijing China

The angular distributions of fission fragments for the 32S+184W reaction near Coulomb barrier energies are measured. The ex perimental fission excitation function is obtained. The measured fission cross sections are decomposed into fusion-fission, quasi-fission and fast fission contributions by the dinuclear system (DNS) model. The hindrance to completing fusion both at small and large collision energies is explained. The fusion excitation functions of 32S+90,96Zr in an energy range from above to below the Coulomb barrier are measured and analyzed within a semi-classical model. The obvious effect of positive Q-value multi-neutron transfers on the sub-barrier fusion enhancement is observed in the 32S+96Zr system. In addition, the excitation functions of quasi-elastic scattering at a backward angle have been measured with high precision for the systems of 16o+208pb, 196pt, 184W, and 154,152Sm at energies well below the Coulomb barrier. Considering the deformed coupling effects, the extracted diffuseness parameters are close to the values extracted from the systematic analysis of elastic and inelastic scattering data. The elastic scattering angular distribution of 17F+12C at 60 MeV is measured and calculated by using the continuum-discretized coupled-channels (CDCC) app.o.ch. It is found that the diffuseness parameter of the real part of core-target potential has to be increased by 20% to rep.o.uce the experimental result, which corresponds to an increment of potential depth at the surface re gion. The breakup cross section and the coupling between breakup and elastic scattering are small.

关键词： fusion-fission quasi-fission fusion hindrance fusion enhancement surface diffuseness parameter exotic nuclei

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pIXE and INAA studies on ancient potteries from Guangfulin relics in Shanghai

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p.o.ress in Natural Science:Materials International 2007年第11期17卷 1348-1356页

作者： Lin Jiawei1, Cheng Huansheng1, Zhang Zhengquan1, Zhang Bin1, Feng Songlin2, Song Jian3, Gao Menghe4 and Zhu Dan1(1. Applied Ion Beam physics laboratory, key laboratory of the Ministry of Education, institute of Modern physics, Fudan University, Shanghai 200433, china 2. key laboratory of nuclear Analytical techniques, institute of high energy physics, beijing 100039, china 3. Shanghai Museum, Shanghai 200003, china 4. Department of Cultural Heritage and Museology, Fudan University, Shanghai 200433, china) Applied Ion Beam physics laboratory Institute of Modern Physics Fudan University Shanghai 200433 China key laboratory of nuclear Analytical techniques Institute of High Energy Physics Beijing 100039 China Shanghai Museum Shanghai 200003 China Department of Cultural Heritage and Museology Fudan University Shanghai 200433 China

This paper reports the study of ancient potteries unearthed from the Guangfulin site in Shanghai. From the external features of these potteries, archeologists can classify them into two different cultural types: Liangzhu culture (local culture) and a new culture which might be derived elsewhere, but they can not recognize whether they were p.o.uced in the same place. p.o.on induced X-ray emission (pIXE) and instrumental neutron activation analysis (INAA) were used to measure the chemical compositions of the samples and the results were analyzed using multivariate statistics. We found that the two methods can complement each other and their database can be mutually referenced in the study of ancient potteries. Experimental results show that the compositions of the potteries from the two cultural types are different, which means that the materials for ancient potteries of new culture originate from elsewhere. This sup.o.ts the archaeologists’ speculation that a group.o. ancient p.o.le migrated to Shanghai from some other places 4000 years ago.

关键词： pIXE INAA factor analysis Guangfulin ancient pottery

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fMRI time series analysis based on stationary wavelet and spectrum analysis

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p.o.ress in Natural Science:Materials International 2006年第11期16卷 1171-1176页

作者： ZHI Lianhe~ 1,2,3 , ZHAo Xia~4, SHAN Baoci~1**, pENG Silong~5, YAN Qiang~1, YUAN Xiuli~1 and TANG Xiaowei~ 1,6 (1. key laboratory of nuclear analysis techniques, institute of high energy physics, chinese academy of sciences, beijing 100049, china 2. Graduate School of chinese academy of sciences, beijing 100049, china 3. Department of physics, Zhoukou Normal University, Zhoukou 466100, china 4. Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas 78229, USA 5. National ASIC Design and Engineering Center, institute of Automation, chinese academy of sciences, beijing 100049, china 6. Department of physics, Zhejiang University, Hangzhou 310027, china) key laboratory of nuclear analysis techniques Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Graduate School of chinese academy of sciences Beijing 100049 China Department of physics Zhoukou Normal University Zhoukou 466100 China Research Imaging Center University of Texas Health Science Center San Antonio TX 78229 United States National ASIC Design and Engineering Center Institute of Automation Chinese Academy of Sciences Beijing 100049 China Department of physics Zhejiang University Hangzhou 310027 China

The low signal to noise ratio (SNR) of functional MRI (fMRI) prefers more sensitive data analysis methods. Based on stationary wavelet transform and spectrum analysis, a new method with high detective sensitivity was developed for analyzing fMRI time series, which does not require any prior assumption of the characteristics of noises. In the p.o.osed method, every component of fMRI time series in the different time-frequency scales of stationary wavelet transform was discerned by the spectrum analysis, then the components from noises were removed using the stationary wavelet transform, finally the components of real brain activation were detected by cross-correlation analysis. The results obtained from both simulated and in vivo visual experiments illustrated that the p.o.osed method has much higher sensitivity than the traditional cross-correlation method.

关键词： fMRI stationary wavelet transform spectrum analysis data analysis.

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Neutron Diffraction Studies of the Magnetic Structure of Ho_2Fe_9Ga_(8～x)Alx

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chinese journal of nuclear physics 1997年第1期19卷 44-47页

作者： Chen Dongfeng Gou Cheng Sun Kai china institute of Atomic energy,p.o.box 275-30,beijing 102413Yan Qiwei Zhang panlin Shen Baogen Cheng Zhaohua State key laboratory of Magnetism,Intstitute of physics,the chinese academy of sciences,p.o.box 603,beijing 100080 中国原子能科学院北京中科院物理所磁学国家重点实验室北京

The crystallographic and magnetic structures of Ho2Fe9Ga8～xAlx（x=2,4 and 6）arestudied by powder neutron diffraction at room *** atom fractional occupancies ofGa and AI and the atom magnetic moments of Ho and Fe are obtained by Rietveld *** magnetic structure of the phase with x=2 shows an easy-axis anisotropy and themagnetic moments of all atoms are parallel to c *** saturation magnetization and Curietemperatures of samples with x in the range 0～8 are investigated.

关键词： Neutron diffraction Magnetic structure

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Re-study of Nucleon pole Contribution in J/ψ→N(?)π Decay

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Communications in Theoretical physics 2006年第9期46卷 507-513页

作者： ZoNG Yuan-Yuan,~(1,2) SHEN peng-Nian,~(1,3,4) ZoU Bing-Song,~(1,3,4) LIU Ji-Feng,~2 LIANG Wei-Hong~2 1 institute of high energy physics, the chinese academy of sciences, p.o. box 918(4), beijing 100049, china 2 Department of physics, Guangxi Normal University, Guilin 541004, china 3 Center of Theoretical nuclear physics, National laboratory of Heavy Ion Accelerator, Lanzhou 730000, china 4 institute of Theoretical physics, the chinese academy of sciences, beijing 100080, china institute of high energy physics the Chinese Academy of Sciences P.O. Box 9184 Beijing 100049 Department of physics Guangxi Normal University Guilin 541004

We re-study nucleon pole contribution in J/ψ→NNπ decays by including the imaginary part for the p.o.agator of the off-shell nucleon with energy above πN threshold. It is found that when including the imaginary part in the p.o.agator, the branching ratio of the decay width will descend about 11% compared with the result without including the imaginary part, no matter whether including the off-shell form factors or not. It also leads to a phase of up to 25° for the off-shell nucleon p.o.agator at invariant mass around 1400 MeV. This effect needs to be considered for detailed partial wave analysis of N* resonances around this mass region.

关键词： J/ψ decay form factor

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positron annihilation study of defects induced by helium and hydrogen mixed ions irradiation in CLAM steel

Positron annihilation study of defects induced by helium and...

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第十四届全国核物理大会暨第十届会员代表大会

作者： Yong Xin1, Xin Ju1, Jie Qiu1, Bao Yi Wang2 1Department of physics, University of Science and Technology beijing, beijing, 100083, p. R. china 2 key laboratory of nuclear analysis techniques, institute of high energy physics, chinese academy of sciences, beijing 100049, china

china Low Activation Martensitic(CLAM)steel was irradiated by helium and hydrogen mixed ions at room *** experiment can be divided into two parts:the first

关键词： positron annihilation ion irradiation CLAM steel

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HYBRID NEUTRoN ACTIVATIoN analysis FoR STUDY oF oRGANIC HALoGENS IN pRECIpITATIoN IN beijing,china

HYBRID NEUTRON ACTIVATION ANALYSIS FOR STUDY OF ORGANIC HALO...

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第十二届全国活化分析学术交流会

作者： D.Xu~*,L.Ma,Y.Chen,Z.Chai key Lab.for nuclear Analytical techniques,institute of high energy physics,chinese academy sciences,beijing 100049,china

Due to their severe carcinogenicity,mutagenicity and teratogenicity,as well as persistence and bioaccumulation,organic halogens have gained utmost attention all over the *** particular,wet deposition has been monitored,as dry deposition only contributes to a minor extent of the total deposition of pCBs and *** this study,the concentrations of extractable organic halogens(EoX),persistent extractable

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