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Design and construction of charged-particle telescope array for study of exotic nuclear clustering structure

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Nuclear science and Techniques 2024年第8期35卷 114-123页

作者： Zheng‑Li Liao xi‑Guang Cao Yu‑Xuan Yang chang‑Bo Fu xian‑Gai Deng Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China university of Chinese Academy of sciences Beijing 100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Zhengzhou university Zhengzhou 450001China Key Laboratory of Nuclear Physics and Ion‑beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics NSFC and Fudan university Shanghai 200438China

The exploration of exotic shapes and properties of atomic nuclei,e.g.,αcluster and toroidal shape,is a fascinating field in nuclear *** study the decay of these nuclei,a novel detector aimed at detecting multipleα-particle events was designed and *** detector comprises two layers of double-sided silicon strip detectors(DSSD)and a cesium iodide scintillator array coupled with silicon photomultipliers array as light sensors,which has the advantages of their small size,fast response,and large dynamic *** coupled with cesium iodide crystal arrays are used to distinguish multipleα*** detector array has a compact and integrated design that can be adapted to different experimental *** detector array was simulated using Geant4,and the excitation energy spectra of someα-clustering nuclei were reconstructed to demonstrate the *** simulation results show that the detector array has excellent angular and energy resolutions,enabling effective reconstruction of the nuclear excited state by multipleαparticle *** detector offers a new and powerful tool for nuclear physics experiments and has the potential to discover interesting physical phenomena related to exotic nuclear structures and their decay mechanisms.

关键词： Cluster decay Toroidal structure Telescope array SiPM Energy resolution

Neural stem cells promote neuroplasticity: a promising therapeutic strategy for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2024年第3期19卷 619-628页

作者： Jun chang Yujiao Li xiaoqian Shan xi Chen Xuhe Yan Jianwei Liu Lan Zhao First Teaching Hospital of Tianjin university of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina Tianjin university of Traditional Chinese Medicine TianjinChina

Recent studies have demonstrated that neuroplasticity,such as synaptic plasticity and neurogenesis,exists throughout the normal lifespan but declines with age and is significantly impaired in individuals with Alzheimer’s ***,promoting neuroplasticity may represent an effective strategy with which Alzheimer’s disease can be *** to their significant ability to self-renew,differentiate,and migrate,neural stem cells play an essential role in reversing synaptic and neuronal damage,reducing the pathology of Alzheimer’s disease,including amyloid-β,tau protein,and neuroinflammation,and secreting neurotrophic factors and growth factors that are related to *** events can promote synaptic plasticity and neurogenesis to repair the microenvironment of the mammalian ***,neural stem cells are considered to represent a potential regenerative therapy with which to improve Alzheimer’s disease and other neurodegenerative *** this review,we discuss how neural stem cells regulate neuroplasticity and optimize their effects to enhance their potential for treating Alzheimer’s disease in the clinic.

关键词： Alzheimer’s disease amyloid-β cell therapy extracellular vesicle neural stem cell synaptic plasticity tau

Development and validation of a prognostic immunoinflammatory index for patients with gastric cancer

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World Journal of Gastroenterology 2024年第24期30卷 3059-3075页

作者： Zhi-chang Ba xi-Qing Zhu Zhi-Guo Li Yuan-Zhou Li Department of Radiology Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina Department of Gastrointestinal Surgery Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina

BACKGROUND Studies have demonstrated the influence of immunity and inflammation on the development of *** single biomarkers of immunity and inflam-mation have been shown to be clinically predictive,the use of biomarkers integrating both to predict prognosis in patients with gastric cancer remains to be *** To investigate the prognostic and clinical significance of inflammatory biomarkers and lymphocytes in patients undergoing surgical treatment for gastric *** Univariate COX regression analysis was performed to identify potential prognostic factors for patients with gastric cancer undergoing surgical *** absolute shrinkage and selection operator-COX(LASSO-COX)regression analysis was performed to integrate these factors and formulate a new prognostic immunoinflammatory index(PII).The correlation between PII and clinical charac-teristics was statistically *** incorporating the PII score were devised and validated based on the time-dependent area under the curve and decision curve *** Patients exhibiting elevated neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,and systemic immune inflammatory index displayed inferior progression-free survival(PFS)and overall survival(OS).Conversely,low levels of CD3(+),CD3(+)CD8(+),CD4(+)CD8(+),and CD3(+)CD16(+)CD56(+)T lymphocytes were associated with improved PFS and OS,while high CD19(+)T lymphocyte levels were linked to worse PFS and *** PII score demonstrated associations with tumor characteristics(primary tumor site and tumor size),establishing itself as an independent prognostic factor for both PFS and ***-dependent area under the curve and decision curve analysis affirmed the effectiveness of the PII-based nomogram as a robust prognostic predictive *** PII may be a reliable predictor of prognosis in patients with gastric cancer undergoing surgical treatment,and it offers insights into cancer-related immune-inflammatory re

关键词： Gastric cancer Immunity Inflammation Prognosis Nomogram

One-step conversion of methane and formaldehyde to ethanol over SA-FLP dual-active-site catalysts: A DFT study

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Chinese Chemical Letters 2024年第4期35卷 544-548页

作者： Tao Ban xi-Yang Yu Hai-Kuo Tian Zheng-Qing Huang Chun-Ran chang Shaanxi Key Laboratory of Energy Chemical Process Intensification School of Chemical Engineering and TechnologyXi'an Jiaotong UniversityXi'an 710049China Shaanxi Key Laboratory of Low Metamorphic Coal Clean Utilization School of Chemistry and Chemical EngineeringYulin UniversityYulin 719000China

One-step conversion of methane and formaldehyde into ethanol is a 100% atom-efficient process for carbon resources utilization and environment protection but still faces eminent challenges due to the lacking of efficient catalysts. Therefore, developing active and stable catalysts is crucial for the co-conversion of methane and formaldehyde. Herein, twelve kinds of “Single-Atom”-“Frustrated Lewis Pair”(SA-FLP)dual-active-site catalysts are designed for the direct conversion of methane and formaldehyde to ethanol based on density functional theory(DFT) calculations and microkinetic simulations. The results show that the SA-FLP dual active sites can simultaneously activate methane at the SA site and activate formaldehyde at the FLP site. Among the twelve designed SA-FLP catalysts, Fe1-FLP shows the best performance in the co-conversion of methane and formaldehyde to ethanol with the rate-determining barrier of 1.15 e *** is proved as the main product with the turnover frequency of 1.32 × 10^(-4)s^(-1)at 573 K and 3 *** work provides a universal strategy to design dual active sites on metal oxide materials and offers new insights into the effective conversion of methane and formaldehyde to desired C_(2) chemicals.

关键词： Single-atom Frustrated Lewis pairs Methane conversion Dual active sites Ethanol synthesis

Bone tissue engineering scaffold materials: Fundamentals, advances, and challenges

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Chinese Chemical Letters 2024年第2期35卷 176-186页

作者： chang Xu Zhize Liu xi Chen Yang Gao Wenjun Wang xijing Zhuang Hao Zhang Xufeng Dong Department of Cardiovascular Surgery Central Hospital of Dalian University of TechnologyDalian 116089China School of Materials science and Engineering Dalian University of TechnologyDalian 116024China Department of Orthopaedics Central Hospital of Dalian University of TechnologyDalian 116089China Department of Dermatology Allergologyand VenereologyUniversity of LübeckLübeck 23562Germany

Bone damage caused by trauma and tumors is a serious problem for human health, therefore, three-dimensional (3D) scaffolding materials that stimulate and promote the regeneration of broken bone tissues have become the focus of current research in the field of bone damage *** this regard, a preferential combination of materials and preparation techniques is considered crucial for the preparation of advanced bone tissue engineering scaffolds to better facilitate the regeneration of broken *** this review, current research advances and challenges in bone tissue engineering scaffolds are discussed and analyzed in ***, we elucidated the structure and self-healing mechanism of bone ***, the main applications of different materials, including inorganic and organic materials, in bone tissue engineering scaffolds are ***, we overview the latest research progress of the mainstream preparation strategies of bone tissue engineering scaffolds, and provide an in-depth analysis of the different advantages of each ***, promising future directions and challenges of bone tissue engineering scaffolds are systematically discussed.

关键词： Biomaterials Bone defects Tissue engineering Scaffolds Osteogenesis

Studies of an event-building algorithm of the readout system for the twin TPCs in HFRS

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Nuclear science and Techniques 2024年第4期35卷 82-95页

作者： Jing Tian Zhi-Peng Sun Song-Bo chang Yi Qian Hong-Yun Zhao Zheng-Guo Hu xi-Meng Chen Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear science and Technology University of LanzhouLanzhou 730000China School of Nuclear science and Technology University of Chinese Academy of SciencesBeijing 100049China Advanced Energy science and Technology Guangdong LaboratoryHuizhou 516000China

The High-energy Fragment Separator(HFRS),which is currently under construction,is a leading international radioactive beam *** sets of position-sensitive twin time projection chamber(TPC)detectors are distributed on HFRS for particle identification and beam *** twin TPCs'readout electronics system operates in a trigger-less mode due to its high counting rate,leading to a challenge of handling large amounts of *** address this problem,we introduced an event-building *** algorithm employs a hierarchical processing strategy to compress data during transmission and *** addition,it reconstructs twin TPCs'events online and stores only the reconstructed particle information,which significantly reduces the burden on data transmission and storage *** studies demonstrated that the algorithm accurately matches twin TPCs'events and reduces more than 98%of the data volume at a counting rate of 500 kHz/channel.

关键词： High counting rate Twin TPCs Trigger-less Readout electronics Event building Hierarchical data processing

High temperature polyimide nanocomposites containing twodimensional nanofillers for improved thermal stability and capacitive energy storage performance

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Nano Research 2024年第8期17卷 7746-7755页

作者： Ding Ai Yuting Han Zongliang xie xi Pang Yuan chang He Li Chenglong Wu Yonghong Cheng Guanglei Wu State Key Laboratory of Electrical Insulation and Power Equipment School of Electrical EngineeringXi’an Jiaotong UniversityXi’an 710049China Institute of Materials for Energy and Environment State Key Laboratory of Bio-Fibers and Eco-TextilesCollege of Materials Science and EngineeringQingdao UniversityQingdao 266071China

Future electronic devices toward high integration and miniaturization demand reliable operation of dielectric materials at high electric fields and elevated ***,the electrical deterioration caused by Joule heat generation remains a persistent challenge to ***,the solution-processed polyimide(PI)nanocomposites with unique two-dimensional(2D)alumina nanoplates are *** improvements in the breakdown strength,charge–discharge efficiency and discharged energy density at elevated temperatures have been demonstrated in the composites,owing to simultaneously suppressed conduction loss and increased thermal conductivity upon the incorporation of 2D Al_(2)O_(3) nanofillers possessing excellent dielectric insulation and thermophysical *** predominance of Al_(2)O_(3) nanoplates in enhancing thermal stability and high-temperature capacitive performance over nanoparticles and nanowires is validated experimentally and is further rationalized via finite element ***,the Al_(2)O_(3) nanoplates filled PI nanocomposite exhibits a hightemperature capability up to 200℃ and remarkable efficiency(e.g.≥95% at 200 MV/m)over a wide temperature range,which outperforms commercial dielectric polymers and rivals the state-of-the-art polyimide nanocomposites.

关键词： capacitors polymer nanocomposites high temperature energy storage thermal stability

Optimal regulation of flexible loads in rural residential buildings considering mobile batteries:A case study in Shaanxi Province

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Building Simulation 2024年第7期17卷 1065-1083页

作者： xi Luo WenceShi School of Building Services science and Engineering Xian University of Architecture and Technology(XAUAT)Xi'an 710055China State Key Laboratory of Green Building Xi'an 710055China

While the grid-connected capacity of rural household photovoltaics is increasing rapidly,achieving dynamic supply-demand matching despite fluctuations in solar energy is *** the rapid development of rural electrification,battery-powered technologies,such as electric vehicles and electric agricultural machinery,are becoming increasingly popular in rural *** this context,utilizing idle mobile batteries to assist in energy storage for rural residential buildings offers a new way to solve the problem of dynamic supply-demand *** this study,a field survey was conducted on several typical fruit-growing villages in the Central Shaanxi Plain in Shaanxi Province of *** rural households were selected to calculate the electricity loads of the residential buildings,with due consideration to the intervention of mobile *** the premise of installing 3 kW household photovoltaic systems in rural households,an economical efficiency-oriented model was built for the optimal regulation of flexible *** results were compared in the context of two patterns of electricity consumption,i.e.,unidirectional charging of mobile batteries from buildings and bidirectional charging and discharging between mobile batteries and *** bidirectional pattern significantly increased the photovoltaic consumption of typical rural households on various typical ***,during both scenarios of not implementing time-of-use and implementing time-of-use,the typical day of the winter slack farming season exhibited the best photovoltaic consumption effect among all types of typical ***,the bidirectional pattern also result in a significant increase in the annual electricity sales revenues for typical rural households.

关键词： demand-side response flexible load mobile battery household photovoltaics

3D-Printed Monolith Metallic Ni-Mo Electrodes for Ultrahigh Current Hydrogen Evolution

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Energy & Environmental Materials 2024年第5期7卷 228-237页

作者： Yanran Xun Hongmei Jin Yuemeng Li Shixiang Zhou Kaixi Zhang xi Xu Win Jonhson Shuai chang Teck Leong Tan Jun Ding Department of Materials science and Engineering National University of Singapore Institute of High Performance Computing (IHPC) Agency for Science Technology and Research (ASTAR) Key Laboratory of Flexible Electronics of Zhejiang Province Ningbo Institute of Northwestern Polytechnical University State Key Laboratory of Advanced Welding and Joining Harbin Institute of Technology

In this work, we reported a series of monolithic 3D-printed Ni–Mo alloy electrodes for highly efficient water splitting at high current density(1500 mA cm-2) with excellent stability, which provides a solution to scale up Ni–Mo catalysts for HER to industry use. All possible Ni–Mo metal/alloy phases were achieved by tuning the atomic composition and heat treatment procedure, and they were investigated through both experiment and simulation, and the optimal NiMo phase shows the best performance.

关键词： 3D-printed electrode Ni–Mo catalyst phase tuning ultra-high current density HER