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IL-8-induced L-selectin shedding regulates its binding kinetics to PSGL-1

Chinese Science Bulletin 2009年第16期54卷 2786-2793页

作者： JIA XiaoLing1,2,3, CHEN Juan1,2 & LONG Mian1,2 1 national Microgravity laboratory, Institute of Mechanics, Chinese Academy of sciences, beijing 100190, China 2 Center of Biomechanics and Bioengineering, Institute of Mechanics, Chinese Academy of sciences, beijing 100190, China 3 School of Biological Science and Medical Engineering, Beihang University, beijing 100083, China national Microgravity laboratory Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China Center of Biomechanics and Bioengineering Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China School of Biological Science and Medical Engineering Beihang University Beijing 100083 China

L-selectin plays a crucial role in inflammation cascade by initiating the tethering and rolling of leukocytes on endothelium wall. While many L-selectin molecules are rapidly shed from the cell surface upon activation, the remaining membrane-anchored L-selectin may still play an important role in regulating leukocyte rolling and adhesion with different binding kinetics. Here we developed an in vitro model to activate Jurkat cells via interlukin-8 (IL-8) and quantified the two-dimensional (2D) binding kinetics, using a micropipette aspiration assay, of membrane-anchored L-selectin to P-selectin glycoprotein ligand 1 (PSGL-1) ligand coupled onto human red blood cells (RBCs). The data indicated that L-selectin shedding reduced the amount of membrane-anchored L-selectin and lowered both its reverse and forward rates. These results suggested that the rolling dynamics of activated leukocytes was determined by two opposite impacts: reducing the surface presentation would enhance the rolling but lowering the kinetic rates would decrease the rolling. This finding provides a new insight into under-standing how L-selectin shedding regulates leukocyte rolling and adhesion.

关键词：结合动力学选择素配体白细胞介素8 Jurkat细胞诱导细胞表面微管吸吮

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New quantum tunneling steps in Mn_(11)Cr/Mn_(12) mixed crystal

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Science China(Physics,Mechanics & Astronomy) 2010年第9期53卷 1769-1771页

作者： ZHOU YuRong1,LI YanRong1,FAN ZhenJun2 & WANG YunPing1 1beijing national laboratory for Condensed Matter Physics,Institute of Physics,Chinese Academy of sciences,beijing 100190,China 2School of Materials sciences and Technology,China University of Geosciences,beijing 430074,China 1. beijing national laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 China2. School of Materials Sciences and Technology China University of Geosciences Beijing 430074 China

Magnetic properties of Mn11Cr and Mn12 mixed crystal at low temperature are studied.A new set of quantum tunneling steps discovered in magnetization curves suggests that there may exist another kind of single molecula... 详细信息

关键词： quantum tunneling molecular magnet magnetization curve

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A zooarchaeological study of bone assemblages from the Ma'anshan Paleolithic site

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Science China Earth sciences 2010年第3期53卷 395-402页

作者： ZHANG Yue1,2,3, WANG ChunXue1,2, ZHANG ShuangQuan1,2 & GAO Xing1,2 1 Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of sciences, beijing 100044 2 Joint laboratory of Human Evolution and Archaeometry, Chinese Academy of sciences, beijing 100044 3 State Key laboratory of Palaeobiology and Stratigraphy, Nanjing 210008 1. Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of Sciences Beijing 100044 China2. Joint Laboratory of Human Evolution and Archaeometry Chinese Academy of Sciences Beijing 100044 China3. State Key Laboratory of Palaeobiology and Stratigraphy Nanjing 210008 China

Ten thousands of bone fragments were recovered from the Ma’anshan Paleolithic site, of which 4358 pieces can be identified to skeletal elements or species. In this research, the bone assemblages are quantified based on elements of MNI, MNE, and MAU. Then bone surface modifications and skeletal element profiles of the bone assemblages are studied to understand shlepping behaviors and reveal the technique of disarticulating and defleshing the animals’ bodies, etc. Based on the analyses of bone assemblages and the comparative study with the ethnoarchaeological as well as experimental data, it is assumed that later hominids at the site made fuller use of the game animals than the earlier hominids. Incorporating the lines of evidence from chronological dating, paleoenvironment, and polished bone tools between the two cultural layers, here we propose three hypotheses suggesting that the changes of environment, the migrations of the hominids from the North, or the demographic pulses may cause such a behavioral difference. However, it is yet to be determined which hypothesis can better explain the changes.

关键词： Ma’anshan site zooarchaeology Paleolithic hominid behavior

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Lunar surface dielectric constant,regolith thickness, and ~3He abundance distributions retrieved from the microwave brightness temperatures of CE-1 Lunar Microwave Sounder

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Science China Earth sciences 2010年第9期53卷 1365-1378页

作者： WANG ZhenZhan1, LI Yun1,2, JIANG JingShan1 & LI DiHui1 1 national Microwave Remote Sensing laboratory, Center for Space Science and Applied Research, Chinese Academy of sciences, beijing 100190, China 2 Graduate University of Chinese Academy of sciences, beijing 100049, China 1. national Microwave Remote Sensing laboratory Center for Space Science and Applied Research Chinese Academy of Sciences Beijing 100190 China2. Graduate University of Chinese Academy of Sciences Beijing 100049 China

Lunar regolith parameters, such as physical temperature, thickness and dielectric constant, are important in studying regolith features, distribution of lunar resources and evolution of the Moon. There had been no measurement obtained by lunar-orbit-borne microwave radiometer applied to evaluate the properties of lunar regolith before CE-1 Lunar Microwave Sounder (CELMS) being launched. CEMLS is the first passive microwave radiometer in the world to sound the surface of the Moon. The brightness temperatures (TB) sensed by CELMS include complicated information on the above geophysical parameters. In this paper, algorithms of retrieving dielectric constant, regolith thickness, and 3He content from CELMS brightness temperatures are developed, and the results are compared with those from literature. The results show that the regolith thicknesses are mostly in the range of 4.0-6.0 m, and 43% of them are bigger than 5.0 m. The content of 3He evaluated by retrieved regolith thickness is about 1.03 million tons.

关键词： CE-1 Lunar Microwave Sounder (CELMS) lunar regolith dielectric constant lunar regolith thickness 3He retrieval

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Graphene-based hybrid materials and their applications in energy storage and conversion

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Chinese Science Bulletin 2012年第23期57卷 2983-2994页

作者： ZHOU Ding 1,2,CUI Yi 1,2 & HAN BaoHang 1,2 1 national Center for Nanoscience and Technology,beijing 100190,China 2 State Key laboratory of Transducer Technology,Chinese Academy of sciences,Shanghai 200050,China national Center for Nanoscience and Technology State Key laboratory of Transducer Technology Chinese Academy of Sciences

Graphene attracts more and more scientists and researchers owing to its superior electronic,thermal,and mechanical *** material scientists,graphene is a kind of versatile building blocks,and considerable progress has been made in recent ***-based hybrid materials have been prepared by incorporating inorganic species and/or cross-linking of organic species through covalent and/or noncovalent *** graphene-based hybrid materials show improved or excellent performance in various *** this review,we summarize the synthesis of graphene and graphene-based hybrid materials,and their applications in energy storage and conversion.

关键词： graphene hybrid material energy storage energy conversion

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A 3.9 V polyanion-type cathode material for Li-ion batteries

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Progress in Natural Science:Materials International 2011年第3期21卷 211-215页

作者： Lei LIU,Bin ZHANG,Xue-jie HUANG beijing national laboratory for Condensed Matter Physics, Institute of Physics,Chinese Academy of sciences,beijing,100190,China beijing national laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 China

Monoclinic phase LiFeSO4F was synthesized by a simple fast solid state reaction from the mixture of FeSO4·7H2O and LiF pulverized by high energy ball milling.m-LiFeSO4F was confirmed by GITT measurement to be a 3.9 V polyanion-type cathode materials for Li-ion *** electrochemical activity can be enhanced by addition of carbon.A discharge capacity of 105 mA·h/g (70%of theoretical value) was achieved for a m-LiFeSO4F/CNT *** separation behavior during lithium extraction and insertion was observed by ex-situ XRD test.

关键词： LiFeSO4F polyanion cathode Li-ion battery

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Effects of the grain size distribution on the temperature-dependent magnetic susceptibility of magnetite nanoparticles

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Science China Earth sciences 2010年第7期53卷 1071-1078页

作者： ZHAO XiangYu1,2 & LIU QingSong1 1 Paleomagnetism and Geochronology laboratory (SKL-LE), Institute of Geology and Geophysics, Chinese Academy of sciences, beijing 100029, China 2 Graduate University of Chinese Academy of sciences, beijing 100049, China 1. Paleomagnetism and Geochronology laboratory (SKL-LE) Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China2. Graduate University of Chinese Academy of Sciences Beijing 100049 China

Magnetite is an important magnetic remanence carrier in natural samples and therefore is of great interest in paleo-, rock-, and environmental magnetism. The magnetic properties of magnetite depend on many factors, e.g., concentration and grain size distribution (GSD). In this study, we theoretically investigated the temperature-dependent susceptibility (TDS) of magnetite nanoparticles with a lognormal GSD. Results show that the TDS is affected highly by the GSD mainly in three aspects. Firstly, the unblocking process becomes smoother with the increase of distribution width, characterizing as a wider Hopkinson peak on the TDS curve. Secondly, the blocking temperature increases with the increase of the median diameter or/and the distribution width. Thirdly, the maximum susceptibility decreases with the increase of distribution width, and has a logarithmic function relation with the standard deviation of the distribution. As a case study, this model was further applied to the thermal products of the Chinese loess/paleosol samples to determine the granulometry of newly-formed magnetite upon heating based on TDS curves. The results demonstrate the fidelity and feasibility of this method to determine the GSD of nano-sized magnetic particles.

关键词： Néel theory temperature dependence of susceptibility grain size distribution

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Narrow line Seyfert 1 galaxies: where are the broad line regions?

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Science China(Physics,Mechanics & Astronomy) 2010年第12期53卷 2307-2311,2339-2343页

作者： MAO WeiMing 1,2,3 , HU Chen 2 , WANG JianMin 2 , BIAN WeiHao 4 , ZHANG Shu 2 & ZHAO Gang 1 1 Key laboratory of Optical Astronomy, national Astronomical Observatories, Chinese Academy of sciences, beijing 100012, China 2 Key laboratory for Particle Astrophysics, Institute of High Energy Physics, Chinese Academy of sciences, beijing 100049, China 3 Graduate University of the Chinese Academy of sciences, beijing 100049, China 4 Department of Physics, Nanjing Normal University, Nanjing 210011, China 1. Key laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China2. Key Laboratory for Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China3. Graduate University of the Chinese Academy of Sciences Beijing 100049 China4. Department of Physics Nanjing Normal University Nanjing 210011 China

A sample consisting of 211 narrow line Seyfert 1 galaxies (NLS1s) with high quality spectra from the Sloan Digital Sky Survey (SDSS) is selected to explore where broad line regions are in these objects. We find that the Hβ profile can be fitted well by three (narrow, intermediate and broad) Gaussian components, and the FWHM ratios of the broad to the intermediate components hold a constant of 3.0 roughly for the entire sample. If the broad components originate from the region scaled by the well-determined Hβ reverberation mapping relation, we find that the intermediate components originate from the inner edge of the torus, which is scaled by dust K-band reverberation. We find that the IC and the BC are strongly linked dynamically, but the relation of their covering factors is much more relaxed, implying that both regions are clumpy.

关键词： black hole physics galaxies: evolution quasars: general

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Characterization of GLUT4-containing vesicles in 3T3-L1 adipocytes by total internal reflection fluorescence microscopy

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Science China(Life sciences) 2009年第7期52卷 665-671页

作者： WANG Yan1,2,ZHANG JinZhong1,2,CHEN Yu1,2,JIANG Li1,2,JI Wei1,2 & XU Tao1 1 national laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of sciences,beijing 100101,China 2 Graduate University of Chinese Academy of sciences,beijing 100049,China 1. national laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China 2. Graduate University of Chinese Academy of sciences Beijing 100049 China

Insulin-responsive GLUT4(glucose transporter 4) translocation plays a major role in regulating glucose uptake in adipose tissue and *** or not there is a specialized secretory GSV(GLUT4 storage vesicle) pool,and more importantly how GSVs are translocated to the PM(plasma membrane) under insulin stimulation is still under *** the present study,we systematically analyzed the dynamics of a large number of single GLUT4-containing vesicles in 3T3-L1 adipocytes by TIRFM(total internal reflection fluorescence microscopy).We found that GLUT4-containing vesicles can be classified into three groups according to their mobility,namely vertical,stable,and lateral GLUT4-containing *** these groups,vertical GLUT4-containing vesicles exclude transferrin receptors and move towards the PM specifically in response to insulin stimulation,while stable and lateral GLUT4-containing vesicles contain transferrin receptors and show no insulin *** data demonstrate that vertical GLUT4-containing vesicles correspond to specialized secretory GSVs,which approach the PM directly and bypass the constitutive recycling pathway.

关键词： GLUT4 IRAP-pHluorin GSV transferring TIRFM

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Luminescence resonance energy transfer based on β-NaYF_4:Yb,Er nanoparticles and TRITC dye

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Science China Chemistry 2009年第10期52卷 1590-1595页

作者： SUN LingDong, GU JianQin, ZHANG ShuZhuo, ZHANG YaWen & YAN ChunHua beijing national laboratory for molecular sciences, State Key Lab of Rare Earth Materials Chemistry and Applications & PKU-HKU Joint Lab in Rare Earth Materials and Bioinorganic Chemistry, College of Chemistry and molecular Engineering, Peking University, beijing 100871, China 1. beijing national laboratory for molecular sciences State Key Lab of Rare Earth Materials Chemistry and Applications & PKU-HKU Joint Lab in Rare Earth Materials and Bioinorganic Chemistry College of Chemistry and Molecular Engineering Peking University Beijing 100871 China

β-NaYF4:Yb,Er nanoparticles (NPs) are one of the most efficient upconversion materials, which can convert near-infrared light to higher-energy light through multiple photon absorptions or energy transfer. In addition, they may be attractive alternative donors for luminescence resonance energy transfer (LRET) studies, because of their sharp absorption and emission profiles, high quantum yields, large anti-stokes shifts, long lifetime, low toxicity, and superior photo-stability. In principle, many problems of fluorescence resonance energy transfer (FRET), such as excitation of acceptors, emission overlaps between donors and acceptors, high background noise, potential toxicity, and instability, can be overcome using β-NaYF4:Yb,Er NPs as energy donors. Because the organic coating induced separation can significantly reduce the energy transfer efficiency and aqueous FRET system is difficult to be applied in devices, we demonstrate a novel NP-dye LRET system in solid state. The emission of the β-NaYF4:Yb,Er NPs at 539 nm overlaps with the absorption of the tetrametrylrhodarnine isothiocyante (TRITC), satisfying the requirement of LRET process. Since TRITC molecules are adsorbed on the β-NaYF4:Yb,Er NPs by an electrostatic interaction, the interaction distance is suitable for LRET without any further modulation. The resultant solid LRET system is ready for the further applications for devices.

关键词： upconversion emission β-NaYF4:Yb Er nanoparticles TRITC assembly luminescence resonance energy transfer (LRET)

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