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Cardiovascular Risk Factors in china

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Journal of Geriatric Cardiology 2024年第2期21卷 153-199页

作者： Sheng-Shou HU the Writing Committee of the Report on Cardiovascular Health and Diseases in china Fuwai hospital National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina 不详

The Annual Report on Cardiovascular Health and Diseases in china(2022) intricate landscape of cardiovascular health in china. This section dissects cardiovascular risk factors in china which including hypertension, dyslipidemia, diabetes mellitus, chronic kidney disease, metabolic syndrome and air pollution. Hypertension prevalence has steadily increased in china,with efforts to control it facing challenges in achieving optimal rates, especially in rural areas. Interventions like salt substitutes and intensive blood pressure control show promise but need improvement. Abnormal lipid levels, indicative of dyslipidemia,have risen significantly, posing a risk for cardiovascular diseases. Despite efforts, many patients struggle to achieve target lipid levels, necessitating improved treatment strategies. Both type 1 and type 2 diabetes mellitus affect millions of adults in china,with long-term complications adding to the disease burden. Early intervention and effective management are crucial to mitigate its impact. Prevalent among older adults, chronic kidney disease is associated with diabetes mellitus, hypertension, and cardiovascular diseases, necessitating comprehensive management approaches. The prevalence of metabolic syndrome, characterized by a cluster of risk factors, has increased in both adults and adolescents, calling for lifestyle modifications and public health interventions. Ambient and household air pollution remain significant environmental risk factors, despite some improvements in air quality. Continued efforts to reduce emissions are essential for mitigating associated health risks. Addressing these risk factors requires a multifaceted approach, including public health initiatives, policy interventions, and individual-level strategies to promote healthy lifestyles and reduce environmental exposures. Surveillance and research efforts are crucial for monitoring trends and developing effective strategies to lessen the burden of cardiovascular diseases in

关键词： landscape adding spite

Effects of tanshinone on neuropathological changes induced by amyloid β-peptide(1-40)injection in rat hippocampus

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Acta Pharmacologica Sinica 2004年第7期25卷 15-22页

作者： Long-xuan LI2, Jia-pei DAI3. Li-qiang RU4, Guang-fu YIN4, Bin ZHAO Department of Neurology, affiliated hospital, Guangdong medical {3., Zhanjiang 524001, china 3.he Netherlands Institute for Brain Research, Amsterdam 1105AZ, the Netherlands 4Department of Neurobiology, Tongjimedical {3. of Huazhong Universityof Science and Technology, Wuhan 43.03., china Department of Neurology Affiliated Hospital Guangdong Medical College Zhanjiang 524001 China. Longxuanlee30@ hotmail.co

AIM: To investigate the effect of tanshinone (Tan) on the neuropathological changes induced by amyloid β- peptide1-40(Aβ1-40) injection in hippocampus in rats. METHODS: Aβ1-4010 μg was injected bilaterally into the dorsal blade of the dentate gyrus in the hippocampus. The level of acetylcholinesterase (AChE) in hippocampus was evaluated by histochemistry. The expressions of neuronal nitric oxide synthase (nNOS) and inducible form of NOS (iNOS) were detected by immunohistochemistry and Western blot. Aβ1-40-injected rats were treated ig with Tan, the major active ingredient from Salvia miltiorrhiza of chinese herb extract. RESULTS: The level of AChE positive fibers of each subfield in Aβ1-40-injected hippocampus decreased significantly compared with those of control (P2 toCA3.(CA2-3.,and dentategyrus (DG)subfields (P<0.01). CONCLUSION: Tan can protect the neuropathological changes induced by Aβ1-40 injection in hippocampus.

关键词： tanshinone amyloid beta-protein acetylcholinesterase nitric oxide synthase hippocampus

Heart failure in china:epidemiology and current management

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Journal of Geriatric Cardiology 2024年第6期21卷 631-641页

The Annual Report on Cardiovascular Health and Diseases in china(2022)intricate landscape of cardiovascularhealth in *** connection with the previous section,this sixth section of the report offers a comprehensive analysis of heart failure(HF)in *** is one of the most important cardiovascular disease in the 21st *** mortality is equivalent to that of *** is an important public health problem that seriously affects the health of chinese *** recent years,with the deepeningof understanding,the change of treatment principles,the innovation of treatment methods and the update of treatment guidelines,the in-hospital mortality of HF patients has declined,and the long-term prognosis is also ***,there are stilldifferences in the management level of HF among different hospitals in *** to improve the standardized diagnosis andtreatment level of HF in china remains an important challenge.

关键词： epidemiology diagnosis treatment

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磁共振小肠造影检查及报告书写规范专家共识

中华放射学杂志 2024年第10期58卷 986-994页

作者：中华医学会放射学分会腹部学组不详国家癌症中心国家肿瘤医学研究中心中国医学科学院北京协和医学院肿瘤医院影像诊断科北京100021 华中科技大学同济医学院附属同济医院放射科武汉430030 哈尔滨医科大学附属第二医院影像科哈尔滨150086 哈尔滨医科大学附属第二医院影像科

磁共振小肠造影(MRE)已成为常规小肠成像检查技术, 用于评估肠道疾病, 如炎症性肠病、小肠肿瘤及某些先天性及系统性疾病等, 但是该技术的操作、诊断和报告流程在我国不同地区依然存在差异。为此, 中华医学会放射学分会腹部学组组织腹... 详细信息

磁共振小肠造影(MRE)已成为常规小肠成像检查技术, 用于评估肠道疾病, 如炎症性肠病、小肠肿瘤及某些先天性及系统性疾病等, 但是该技术的操作、诊断和报告流程在我国不同地区依然存在差异。为此, 中华医学会放射学分会腹部学组组织腹部放射学专家, 参阅国际上多个相关指南及国内外大量文献, 结合我国的临床实践, 经反复讨论, 就MRE的检查前准备、技术规范、临床应用和报告内容等方面达成了共识, 以期MRE在临床实践中规范应用。

关键词：磁共振成像小肠造影炎症性肠病技术规范结构化报告

Transgenic mice designed to express human α-1,2-fucosyltransferase in combination of human DAF and CD59 to avoid xenograft rejection

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Science china(Life Sciences) 2008年第3期51卷 199-204页

作者： LIU BingQian1, CHENG ChuanYu1, WU YuDong1, WEI JinXing1, LI GuangSan2 & MA TengXiang3.1 Department of Urology, the First affiliated hospital of Zhengzhou University, Zhengzhou 450052, china 2 Institute of Genetics and Development Biology, {3. Academy of Sciences, Beijing 100101, china 3.Tianjin Institute of Urology, Second hospital of Tianjin medical University, Tianjin 3.0211, china Department of Urology the First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 China Institute of Genetics Development Biology Chinese Academy of Sciences Beijing 100101 China Tianjin Institute of Urology Second Hospital of Tianjin Medical University Tianjin 300211 China

The expression of human α-1,2-fucosyltransferase (HT) or complement regulatory proteins has been proved as an strategy to overcome hypercute rejection in discordant xenogeneic organ transplantation. In this study, we examined whether peripheral blood mononuclear cells (PBMCs) from polytransgenic mice expressing the human HT, and complement regulatory proteins (DAF and CD59), can provide more effective protection against xenograft rejection. Transgenic mice were produced by co-injection of gene constructs for human HT, DAF and/or CD59. Flow Cytometry (FCM) was used to screen the positive transgenic mice. PBMCs from transgenic mice were incubated with 15% human serum to evaluate natural antibody binding, complement activation and expression of adhesion molecules. Three transgenes were strongly expressed in PBMCs of transgenic mice, and HT expression signifi- cantly reduced expression of the major xenoepitope galactose-α-1,3.galactose (α-Gal). Functional studies with PBMCs showed that co-expression of HT and DAF or CD59 markedly increased their re- sistance to human serum-mediated cytolysis when compared with single transgenic PBMCs. Moreover, the combined expression of triple transgenes in PBMCs led to the greatest protection against human serum-mediated cytolysis, avoided hyperacute rejection and reduced expression of adhesion mole- cules. Strong co-expression of triple transgenes was completely protected from xenograft hyperacute rejection and partially inhibited acute vascular rejection. The studies suggest that engineering mice to express triple molecules represents an critical step toward prolonging xenograft survival and might be more suitable for xenotransplantation.

关键词： α-1 2-fucosyltransferase complement regulatory proteins galactose-α-1 3.galactose hyperacute rejection acute vascular rejection

Stress Echocardiography for Chronic Coronary Syndrome:Clinical Practice Guidelines(2023.

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Journal of Geriatric Cardiology 2024年第5期21卷 475-505页

作者： Peng-Fei ZHANG Jia-Wei TIAN Tian-Gang ZHU Jue-Fei WU Xiao-Ping LENG Yi WANG Meng-Meng LI Xin-Hao LI Qian-Qian WANG Xiao-Peng FENG Jia-Yan LV Li-Xue YIN Yun ZHANG Mei ZHANG chinese Society of Echocardiography,Superficial Tissue and Vascular Group of chinese Society of Ultrasound in Medicine,Ultrasound Professional Committee of chinese Medicine Education Association State Key Laboratory for Innovation and Transformation of Luobing Theory Key Laboratory of Cardiovascular Remodeling and Function ResearchChinese Ministry of EducationChinese National Health Commission and Chinese Academy of Medical SciencesDepartment of CardiologyQilu Hospital of Shandong UniversityJinanChina The Second affiliated hospital of Harbin medical University HaerbinChina Peking University People's hospital BeijingChina Sichuan Province People's hospital ChengduChina Nanfang hospital Southern Medical UniversityGuangzhouChina Peking Union medical college hospital Chinese Academy of Medical SciencesBeijingChina 不详

In the context of the People's Republic of china,coronary artery disease(CAD)presents a sig-nificant clinical challenge,with over 11.3.mil-lion patients ***,the diagnos-is of CAD has predominantly relied on invasive coronary angiography.[1]However,recent advances in clinical research have revealed a notable trend:a substantial 82% of patients subjected to such invas-ive diagnostics do not necessitate interventional therapy.

关键词： coronary clinical patients

Histological changes following surgically-assisted rapid tooth movement through resistance reduction and distraction osteogenesis in dogs

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Journal of Pharmaceutical Analysis 2010年第2期22卷 139-142页

作者： Xi Chen1,Jian-Lin Liu2,Juan Dai3.Shuang Wang4,Ya-Li Huang11. Department of Stomatology,the First affiliated hospital,medical School of Xi’an Jiaotong University,Xi’an 710061 2. Department of Stomatology,No.2 Traditional {3. medical hospital,Shenzhen 51803. 3. Department of Orthodontics,School of Stomatology,Fourth Military medical University,Xi’an 71003. 4. Department of Orthodontics,Stomatological hospital of Xi’an Jiaotong University,Xi’an 710004,china. Department of Stomatology First Affiliated Hospital Medical School of Xi'an Jiaotong University Xi'an 710061 China Department of Stomatology No. 2 Traditional Chinese Medical Hospital Shenzhen 518034 China Department of Orthodontics School of Stomatology Fourth Military Medical University Xi'an 710032 China Department of Orthodontics Stomatological Hospital of Xi'an Jiaotong University Xi'an 710004 China

Objective To investigate the histological changes of rapid tooth movement in dogs treated by resistance reduction and distraction osteogenesis,aiming to establish an animal model and further to reveal the remodeling mechanism of rapid tooth movement. Methods A total of 8 local hybrid dogs were selected as subjects for this study. The second pre-molar was extracted on both sides. The experimental side underwent alvelor surgery for resistance reduction and a home-made tooth-borne intraoral distraction device was installed for rapid tooth movement,while for the other side (control side) only tooth-borne intraoral distraction device was used for rapid tooth movement. The longest active force-delivery span was 2 weeks,followed by 6-week retention. The distance between the moved tooth and anchor unit was recorded weekly,and radiography was performed for each side before and after distraction. The surrounding tissues including periodontal ligament and alveolar bone were sectioned for histological analysis. Results The average distance of tooth movement was 3.55mm on the experimental side and 1.11mm on the control side. The rate of tooth movement was notably higher (P<0.01) and no significant apical root resorption was detected by X-ray on the experimental side. The active alvelor bone remodeling was found on the tension and pressure sides. However,there was no significant difference between the experimental side and the control side after the retention period. Conclusion The rate of orthodontic tooth movement can be accelerated through resistance reduction and periodontal distraction without any unfavorable effects but at minimal anchorage loss.

关键词： periodontal ligament distraction osteogenesis resistance reduction rapid tooth movement

Advances in early diagnosis and therapy of pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2011年第2期10卷 128-135页

作者： Qiang Xu, Tai-Ping Zhang and Yu-Pei ZhaoDepartment of General Surgery, Peking Union medical college hospital, Peking Union medical college & chinese Academy of Medial Sciences, Beijing 10073., china Department of General Surgery Peking Union Medical College Hospital Peking Union Medical College & Chinese Academy of Medial Sciences Beijing 100730 China

BACKGROUND: Pancreatic cancer remains a devastating disease with a 5-year survival rate of less than 5%. Recent advances in diagnostic methods and therapeutic approaches have increased the possibility of improving the existing poor prognosis. DATA SOURCES: English-language articles reporting early diagnosis and therapy of pancreatic cancer were searched from the MEDLINE and PubMed databases, chinese-language articles were from CHKD (china hospital Knowledge Database) RESULT: The current literature about pancreatic cancer was reviewed from three aspects: statistics, screening and early detection, and therapy. CONCLUSIONS: Early detection and screening of pancreatic cancer currently should be limited to high risk patients Surgical resection is the only curative approach available, with some recent improvement in outcomes. Gemcitabine has been a standard treatment during the last decade. Gemcitabine based combination treatment, especially combined with newer molecular targeted agents, is promising. The rationale for radiotherapy is controversial, but with the recent development of modern radiation delivery techniques, radiotherapy should be intensified. Patients with borderline pancreatic cancer could benefit from neoadjuvant therapy but more evidence is needed and the best neoadjuvant regimen is still to be determined.

关键词： pancreatic neoplasm early diagnosis biomarkers surgery adjuvant therapy neoadjuvant therapy borderline resectable tumor

Investigation of the effect of berberines alkaloids in Coptis chinensis Franch on Bacillus shigae growthby microcalorimetry

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Science china Chemistry 2007年第5期50卷 638-642页

作者： YAN Dan1,2,3. JIN Cheng1, XIAO XiaoHe1 & DONG XiaoPing2 1 Institute of chinese Medicine, 3.2 hospital of People’s Liberation Army, Beijing 10003., china 2 Chengdu University of Traditional chinese Medicine, Chengdu 610075, china 3.Chongqing Institute of Technology, Chongqing 400050, china Institute of chinese Medicine 302 Hospital of People's LiberationArmyBeijing 100039China Chengdu University of Traditional chinese Medicine Chengdu610075China Chongqing Institute of Technology Chongqing 400050China

The inhibitory effects of five berberines alkaloids (BAs) from rhizoma ofCoptis chinensis Franch,a traditional chinese medicinal (TCM) herb,on Bacillus shigae(***)growth were investigated by *** power-time curves of *** with and without BAswere acquired;meanwhile,the extent and duration of inhibitory effects on the metabolism wereevaluated by growth rate constants (k1,k2),half inhibitory ratio (IC50),maximum heat output(P_(max)),and peak time (t_p).The values of k1 and k2 of a shigae in the presence of the five BAsdecreased with the increasing concentrations of ***,P_(max) was reduced,and the value oft_p increased with increasing concentrations of the five *** inhibitory activity varied withdifferent ***50 of the five BAs was respectively 75 mu g/mL for berberine,90 ng/mL forcoptisine,115 mu g/mL for palmatine,220 mu g/mL for epiberberine,and 400 mu g/mL *** sequence of antimicrobial activity of the five BAs:berberine > coptisine >palmatine > epiberberine > *** functional groups methylenedioxy at C2 and C3.on phenylring improve antimicrobial activity more strongly than methoxyl at C2 and C3.on ***,the effect of bacteriostasis is not significant with methylenedioxy or methoxyl at C9and C10 on phenyl ring.

关键词： berberines alkaloids, microcalorimetry, Bacillus shigae, inhibitory effect