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Journal of Otology 2010年第2期5卷 104-110页

作者： SHEN Peng1,FENG Guo-dong2,CAO Tian-yang 3.GAO Zhi-qiang 2,LI Xi-sheng 3.1 Department of Otolaryngology,Chuiyangliu hospital of Beijing 2 Department of Otolaryngology,Peking Union medical college hospital,chinese Academy of medical Sciences and Peking Union medical college,Beijing,china 3.School of Information & Engineering,University of Science and Technology Beijing,Beijing,china Department of Otolaryngology Chuiyangliu Hospital of Beijing Department of Otolaryngology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China School of Information & Engineering University of Science and Technology Beijing Beijing China

Objective To test a modified otologic drill under different drilling conditions for its ability to identify drilling faults and stop *** Based on force analysis and previous works,an otologic drill was modified and equipped with three *** various conditions,the drill was used to simulate three drilling faults and normal drilling,and signals from the drill were analyzed to extract the characteristic signal.A multi-sensor information fusion system and a stop program were designed to recognize drilling faults and stop *** Signals from each sensor changed consistently in response to drilling condition changes,with high repeatability and *** average identification rate was 72.625%,68.575%,70.5% and 81.3. respectively for the three simulated drilling faults and normal *** stop program stopped drilling in 0.2～ 0.3.seconds when a drilling faults was *** This study shows that the forces acting on the drill bit change predictably in the three simulated drilling conditions;that using suitable BP neural networks,the drilling faults can be reliably identified,and that a stop program based upon characteristic signal recognition can stop drilling quickly upon detecting drilling *** lays a foundation for development of a system capable of predicting drilling faults and automatic drill *** studies are being undertaken for practical application of such a system.

关键词： drill otologic surgery force sensor back propagation(BP) neural network

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Effect of angiotensin II receptor 1 antisense oligodoexynucleotides on physiological and pathophysiological growth of cardiomyocytes

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Acta Pharmacologica Sinica 2004年第5期25卷 19-27页

作者： Ying WANG2, Jin-ming WANG2, Shu-xun Yan3. Ming-jiang LI2,4, Jian-jun LI22Department of Cardiology, Renmin hospital, Wuhan University, Wuhan 43.060, china 3.ubei college of Traditional {3. Medicine, Wuhan 43.061,china Department of Cardiology Renmin Hospital Wuhan University China Hubei college of Traditional chinese Medicine China

AIM: To evaluate the role of angiotensin II receptor 1 antisense oligodexynucleotides (AT1R-AS-ODNs) on physi-ological and pathophysiological growth of cardiomyocytes from normotensive rats. METHODS: Cardiomyocyteswere transfected with AT1R-AS-ODNs (200 nmol/L) followed by treatment with or without angiotensin II (1 mol/L).In situ hybridization and Western blot were used for AT1R mRNA and protein detection, respectively. c-Jun N-terminal protein kinase (JNK) activity was characterized by immune complex kinase assay. c-Jun protein expres-sion was examined by immunocytochemistry. DNA content was detected by flow cytometric assay. Atrial natri-uretic factor (ANF) expression was identified by radioimmunoassay. RESULTS: Treatment with AT1R-AS-ODNsfor 24 h resulted in 51.2 % decrease in AT1R mRNA and 60.7 % in protein (P3. min, both p46JNK and p54JNK wererobustly activated. By 2 h, c-Jun protein expression was increased. By 24 h, angiotensin II caused a markedincrease both in G0/G1 and G2/M DNA content, and increased ANF expression by 1.8-fold. All these were inhibitedby AT1R-AS-ODNs pretreatment. In contrast, sense sequence was ineffective. CONCLUSION: Decrease ofAT1R expression by AS-ODNs did not interfere with normal growth, but protected cardiomyocytes from angio-tensin II-dependent pathophysiological growth.

关键词： antisense oligodeoxynucleotides angiotensin receptors angiotensin II myocardium hypertrophy mitogen-activated protein kinases

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Human hepatopoietin augmenter of liver regeneration──A hepatotrophic factor for liver regeneration, and its potential antihepatitis effect in vivo

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chinese Science Bulletin 1998年第12期43卷 1026-1031页

作者： YANG Xiaoming 1, WANG Aimin 2, ZHOU Ping 3. XIE Ling 1, WANG Qingming 1, WU Zuze 1 and HE Fuchu 1 1. Institute of Radiation Medicine, Beijing 100850, china 2. No. 252 hospital of PLA, Baoding 071000, china 3. General hospital of the Air Institute of Radiation Medicine Beijing China No. 252 hospital of PLA Baoding China General hospital of the Air Force of PLA Beijing China

The effect of human hapatopoietin i.e. augmenter of liver regeneration (hALR) was determined on hepatocyte DNA synthesis, and on CCl 4-induced hepatitis in animal in vitro and in vivo. It is found that ALR could directly stimulate DNA synthesis of hepatocytes in primary culture in a dose-dependent manner. In 3.% hepatectomied rats, significant DNA synthesis occurred in control rats ; even so, exogenous hALR gene encoding protein increased DNA synthesis of regeneration liver by 2.3.fold compared with control rats. A lower dose of CCl 4 was administrated in rats and the effect of ALR on DNA synthesis of regenerating liver 48 h after CCl 4 administration was analyzed. Few Budr-labeled hepatocytes were visible in control rats. However, exogenous hALR markedly increased the number of labeled cells in a dose-dependent manner. Statistical analysis showed that 10 or 40 μg·kg -1 ALR protein stimulated DNA synthesis by 1.7 and 4.8 fold respectively. In addition to enhancing cell growth, adiministration of hALR achieved a significant improvement in reversing the lethality of rat hepatic failure when compared with that of control group; the elevation of cytosolic enzymes was dramatically suppressed by exogenous hALR in CCl 4-treated mice in vivo and in vitro; histologically, hepatocytes around the central vein were necrotic, and the degree of hepatocyte necrosis in control mice was more prominent than that in the mice given 40 μg·kg-1 hALR 48 h after CCl 4 administration. We also noted that hALR had a strong antihepatitis effect in vitro which was determined with primary cultured rat hepatocytes. These findings suggest that hALR protects the integrity of hepatocytes against severe hepatitis, and indicate that ALR may be an important regulator of liver regeneration and play a major role in liver injury repair. It proves ALR adminstration to be a useful treatment to accelerate liver regeneration and to prevent the onset of hepatitis or intrahepatic cholestasis induced by toxin.

关键词： liver regeneration hepatopoietin DNA synthesis hepatitis.

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Clinical and genetic analysis of two chinese families with benign familial neonatal convulsions

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Progress in Natural Science:Materials International 2005年第8期15卷 757-760页

作者： LI Haiyan1, TANG Beisha1*, XIA Kun2, CAO Guifang3. SHEN Lu1, JIANG Hong1, PAN Qian2, SONG Yanmin1 and CAI Fang2(1. Department of Neurology, Xiangya hospital, Central South University, Changsha 410008, china 2. National Laboratory of medical Genetics of china, Changsha 410008, china 3. Department of Neurology, the First affiliated hospital, Tsinghua University, Beijing 100061, china) Department of Neurology Xiangya Hospital Central South University Changsha 410008 China. National Laboratory of medical Genetics of china Changsha 410008 China. Department of Neurology First Affiliated Hospital Tsinghua University Beijing 100061 China

Benign familial neonatal convulsions (BFNC) is a rare autosomal dominant inherited epilepsy syndrome. Two voltage-gated potassium channel genes, KCNQ2 and KCNQ3. have been identified as the genes responsible for BFNC. Here we report two chinese families with clinical histories of typical BFNC. Using six microsatellite markers, two located at KCNQ2 locus and four at KCNQ3.locus, linkage analysis was performed in the two families, which excluded the linkage of BFNC to KCNQ3. but could not exclude the linkage to KCNQ2. Direct DNA sequencing of the KCNQ2 gene in the two families was performed, and two formerly unknown polymorphisms were identified, but no KCNQ2 mutation was found in the two families. Our study suggests the genetic heterogeneity in chinese families with BFNC and proves the existence of a new gene locus for BFNC.

关键词： BFNC epilepsy potassium channel linkage analysis mutation analysis.

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Retrorectal tumors in adults:Magnetic resonance imaging findings

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World Journal of Gastroenterology 2010年第46期16卷 5822-5829页

作者： Bo-Lin Yang,Yun-Fei Gu,Wan-Jin Shao,Hong-Jin Chen,Gui-Dong Sun,Department of Coloproctology,The affiliated hospital of Nanjing University of chinese Medicine,Nanjing 210029,{3. Hei-Ying Jin,Department of Coloproctology,The 3.d affiliated hospital of Nanjing University of chinese Medicine,Nanjing 210029,{3. Xin Zhu,Department of Radiology,The affiliated hospital of Nanjing University of chinese Medicine,Nanjing 210029,{3. Department of Radiology The Affiliated Hospital of Nanjing University of Chinese Medicine No.155 Hanzhong Road Nanjing 210029 China. 66zhuxin@***

AIM:To retrospectively evaluate the magnetic resonance imaging (MRI) features of adult retrorectal tumors and compare with histopathologic ***:MRI features of 21 patients with preoperative suspicion of retrorectal tumors were analyzed based on the histopathological and clinical ***:Fourteen benign cystic lesions appeared hypointense on T1-weighted images,and hyperintense on T2-weighted images with regular peripheral *** or dermoid cysts were unilocular,and tailgut cysts were *** of intracystic intermediate signal intensity was observed in one case of tailgut cyst with a component of *** solid tumors were malignant lesions and showed heterogeneous intensity on *** adenocarcinomas showed high signal intensity on T2-weighted and mesh-like enhancing areas on fat-suppressed T2-weighted *** was a fistula between the mass and anus with an internal opening in mucinous adenocarcinomas arising from anal *** stromal tumors displayed low signal intensity on T1-weighted images,and intermediate to high signal intensity on T2-weighted *** necrosis could be seen as a high signal on T2-weighted ***:MRI is a helpful technique to define the extent of the retrorectal tumor and its relationship to the surrounding structures,and also to demonstrate possible complications so as to choose the best surgical approach.

关键词： Retrorectal tumor Presacral lesions Magnetic resonance imaging Congenital cyst Malignant tumor Diagnosis

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中国遗传性血色病诊疗指南

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中华肝脏病杂志 2024年第9期32卷 787-798页

作者：中华医学会肝病学分会贾继东徐小元不详首都医科大学附属北京友谊医院肝病中心北京100050 北京大学第一医院感染科北京100034

遗传性血色病(HH)是由于铁调节相关基因变异所引起的铁过载性疾病,因大量的铁沉积在肝脏、心脏、皮肤、胰腺及性腺等器官并导致相应的多系统损害。HH在欧美人群相对常见,主要由HFE基因突变引起;在中国和其他亚洲国家罕见,主要由非HEF基... 详细信息

遗传性血色病(HH)是由于铁调节相关基因变异所引起的铁过载性疾病,因大量的铁沉积在肝脏、心脏、皮肤、胰腺及性腺等器官并导致相应的多系统损害。HH在欧美人群相对常见,主要由HFE基因突变引起;在中国和其他亚洲国家罕见,主要由非HEF基因突变引起。其临床特征是原因不明的慢性肝炎或肝硬化,伴有血清铁蛋白升高和/或转铁蛋白饱和度升高,MRI显示肝脏铁沉积,肝活检显示肝细胞铁沉积,基因检测有助于确诊HH。放血治疗是治疗HH的首选疗法,对于不能耐受者可采用铁螯合剂治疗,发展至终末期肝病者需行肝移植。为帮助临床医师在HH的诊治中做出合理决策,中华医学会肝病学分会组织临床、分子遗传学、病理学、影像学和临床研究方法学等领域的专家,系统总结了国内外有关研究进展,共同制订了本指南。

关键词：遗传性血色病诊断治疗指南

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Function of chymase in the heart angiotensin Ⅱ formation in transgenic mice

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chinese Science Bulletin 2001年第11期46卷 922-925页

作者： LI Peng & CHEN LanyingCardiovascular Institute & Fu Wai hospital, chinese Academy of medical Sciences & Peking Union medical college, Beijing 10003., china Cardiovascular Institute & Fu Wai hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China

The myosin light chain 2 promoter-human heart chymase (MLC2-hChymase) transgenic mice founded by our laboratory were used as the model to study the function of chymase in the heart angiotension Ⅱ (Ang Ⅱ) formation and heart remodeling. Tissue-specific expression of human heart chymase gene and transcriptional expression of type Ⅰ and type Ⅲ collagens genes were analyzed by RT-PCR. Activities of chymase, ACE and the levels of Ang Ⅱ in heart and plasma were determined with radioimmunoas-say (RIA) kit. Activity of heart matrix metalloproteinase-9 (MMP-9) was detected using gelatin zymography. The cardiac hypertrophic phenotypes were also observed with the physiological and morphological methods. The results in the MLC2-hChymase transgenic mice indicated: ( i ) human heart chymase gene was expressed specially in the heart; (u) heart chymase activity increased markedly in the transgenic mice vs non-transgenic mice (control) (0.27±0.07 U/mg vs. 0.15±0.02 U/mg, P<0.05) with no significant difference in

关键词： chymase transgenic mice angiotensin Ⅱ heart remod- eling collagen.

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DSA检查技术临床应用专家共识

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中华放射学杂志 2024年第10期58卷 995-1005页

作者：中华医学会影像技术分会中国医师协会医学技师专业委员会中国医药教育协会医学影像技术学专业委员会不详华中科技大学同济医学院附属协和医院放射科武汉430022 四川大学华西医院放射科成都610041 首都医科大学附属北京同仁医院放射科北京100730 广州市第一人民医院介入医学中心哈尔滨医科大学附属肿瘤医院影像中心

本专家共识系统地叙述DSA检查前准备、手术基本操作、相关应急预案、常用应用技术、人体各个部位的DSA成像技术参数选用、图像质量控制、注意事项及必要的辐射防护等内容。重点叙述了DSA成像时, 人体各个部位正确的造影体位, 设备的成... 详细信息

本专家共识系统地叙述DSA检查前准备、手术基本操作、相关应急预案、常用应用技术、人体各个部位的DSA成像技术参数选用、图像质量控制、注意事项及必要的辐射防护等内容。重点叙述了DSA成像时, 人体各个部位正确的造影体位, 设备的成像技术参数选用, 对比剂的注射参数优选, 以及图像质量控制和注意事项。

关键词：血管造影术, 数字减影成像技术应用规范

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Community-based prevention and treatment of cardiovascular diseases

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Journal of Geriatric Cardiology 2024年第3期21卷 315-322页

作者： Sheng-Shou HU The Writing Committee of the Report on Cardiovascular Health and Diseases in china Fuwai hospital National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

The Annual Report on Cardiovascular Health and Diseases in china(2022)intricate landscape of cardiovascular health in *** is the third section of the report with a specific focus on community-based prevention and treatment of cardiovascular diseases(CVD).This section of the report underscores the importance of initiatives outlined in the"Healthy china 203. Plan,"emphasizing the comprehensive prevention and control strategy for chronic diseases.A key aspect of this plan involves the establishment of national demonstration areas aimed at comprehensive prevention and control of chronic *** 2020,488 such areas had been set up across china,surpassing the initial target and covering a significant proportion of counties and *** report highlights the successful implementation of these strategies in Lishan district,Anshan city,where demonstration areas for comprehensive prevention and control of chronic diseases were launched in *** the course of seven years,the number of healthy units increased substantially,leading to improvements in managing risk factors for CVD among *** reductions in prevalence rates of overweight,obesity,smoking,passive smoking,and drinking were observed,along with the development of healthier behaviors among ***,Qiaokou district in Wuhan City,designated as a national demonstration area in 2014,implemented comprehensive public health promotion ***,special clinics for hypertension intervention were established,contributing to an increase in self-reported rates of hypertension,a slight decrease in prevalence,and a remarkable improvement in the control rate among treated ***,these efforts underscore the effectiveness of community-based approaches in driving positive health outcomes and advancing the comprehensive prevention and control of chronic diseases,particularly cardiovascular diseases,in china.

关键词： prevention district treatment

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Clinical manifestation, imageological and pathological characteristics of Wernicke encephalopathy

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Neural Regeneration Research 2006年第8期1卷 697-701页

作者： Shunchang Han 1,2, Chuanqiang Pu2, Qiuping Gui3. Xusheng Huang2, Senyang Lang2, Weiping Wu2, Peifu Wang2 1Department of Neurology, Second hospital affiliated to china {3. University, Shenyang 110003. Liaoning Province, china 2Department of Neurology, 3.epartment of Pathology, General hospital of chinese PLA, Beijing 100853. china Department of Neurology China Medical University Shenyang 110003 Liaoning Province China Department of Neurology General Hospital of Chinese PLA Beijing 100853 China Department of Pathology General Hospital of Chinese PLA Beijing 100853 China

BACKGROUND: The clinical manifestations of Wernicke encephalopathy(WE) are atypical and short of effective auxiliary examination means. The effects of magnetic resonance imaging (MRI) in the diagnosis of WE have been reported successively. But its imageological detection needs to be further investigated. OBJECTIVE: To analyze the characteristics of clinical manifestations, skull MRI examination and pathological results in patients with WE. DESIGN: Retrospective analysis. SETTING: The General hospital of chinese PLA. PARTICIPANTS: Ten patients of WE admitted to the Department of Neurology, General hospital of chinese PLA were recruited. Among them, five patients were diagnosed pathologically after death. Their pathological changes accorded with the pathological characteristics of WE. The other 5 patients were diagnosed clinically before death. Their pathological changes accorded with clinical and imageological manifestations and had definite reaction to the treatment of thiamine. Ten patients, 7 males and 3.females, were aged (47±13. years ranging from 3. to 73.years. Their disease courses averaged 6 weeks ranging from 3.to 10 weeks. They all were non-alcoholics. Four patients developed WE after acute pancreatitis, two patients after the recurrence of gastric cancer, two patients after cholecystectomy, one patient after hepatitis medicamentosa, one patient after Alzheimer disease. Informed consents were obtained from all the patients and their relatives. METHODS: After admission, clinical manifestations of patients were observed and recorded. Five patients underwent skull MRI examination and their detected results were recorded. Five dead patients underwent autopsy and brain pathological examinations. Neuropathological examination involved cerebrum, cerebellum and brain stem. MAIN OUTCOME MEASURES: Clinical manifestations, MRI examination results, pathological analysis results and prognosis of all the patients. RESULTS: Ten patients with WE were involved in the final

关键词： Clinical manifestation imageological and pathological characteristics of Wernicke encephalopathy

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